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22 条记录 (耗时 0.063 秒)

    1H-indazole compounds
    14.
    发明授权
    1H-indazole compounds 失效
    1H-吲唑化合物

    公开(公告)号：US07541376B2

    公开(公告)日：2009-06-02

    申请号：US11202234

    申请日：2005-08-12

    申请人： Hitoshi Oinuma ,  Norihito Ohi ,  Nobuaki Sato ,  Motohiro Soejima ,  Hidenori Seshimo ,  Taro Terauchi ,  Takashi Doko ,  Naohiro Kohmura

    发明人： Hitoshi Oinuma ,  Norihito Ohi ,  Nobuaki Sato ,  Motohiro Soejima ,  Hidenori Seshimo ,  Taro Terauchi ,  Takashi Doko ,  Naohiro Kohmura

    IPC分类号： A61K31/40 ,  C07D231/56

    CPC分类号： C07D231/56

    摘要： The present invention provides a novel 1H-indazole compound having an excellent JNK inhibitory action. More specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. Wherein R1 is a C6-C14 aromatic cyclic hydrocarbon group etc.; R2, R4 and R5 each independently represent a hydrogen atom, a halogen atom, a cyano group etc.; L is a single bond, or a C1-C6 alkylene group etc.; X is a single bond, or a group represented by —CO—NH— or —NH—CO—, etc.; and Y is a C3-C8 cycloalkyl group, a C6-C14 aromatic cyclic hydrocarbon group or a 5- to 14-membered aromatic heterocyclic group etc.

    摘要翻译： 本发明提供了具有优异JNK抑制作用的新颖的1H-吲唑化合物。 更具体地，它提供由下式表示的化合物，其盐或它们的水合物。 其中R1是C6-C14芳族环烃基等; R2，R4和R5各自独立地表示氢原子，卤素原子，氰基等; L是单键或C1-C6亚烷基等; X是单键，或由-CO-NH-或-NH-CO-等表示的基团; Y为C3-C8环烷基，C6-C14芳族环状烃基或5〜14元芳香族杂环基等。

    1H-indazole compounds
    16.
    发明授权
    1H-indazole compounds 失效
    1H-吲唑化合物

    公开(公告)号：US07776890B2

    公开(公告)日：2010-08-17

    申请号：US12426818

    申请日：2009-04-20

    申请人： Hitoshi Oinuma ,  Norihito Ohi ,  Nobuaki Sato ,  Motohiro Soejima ,  Hidenori Seshimo ,  Taro Terauchi ,  Takashi Doko ,  Naohiro Kohmura

    发明人： Hitoshi Oinuma ,  Norihito Ohi ,  Nobuaki Sato ,  Motohiro Soejima ,  Hidenori Seshimo ,  Taro Terauchi ,  Takashi Doko ,  Naohiro Kohmura

    IPC分类号： A61K31/44 ,  C07D23/56

    CPC分类号： C07D231/56

    摘要： The present invention provides a novel 1H-indazole compound having an excellent JNK inhibitory action. More specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. Wherein R1 is a C6-C14 aromatic cyclic hydrocarbon group etc.; R2, R4 and R5 each independently represent a hydrogen atom, a halogen atom, a cyano group etc.; L is a single bond, or a C1-C6 alkylene group etc.; X is a single bond, or a group represented by —CO—NH— or —NH—CO—, etc.; and Y is a C3-C8 cycloalkyl group, a C6-C14 aromatic cyclic hydrocarbon group or a 5- to 14-membered aromatic heterocyclic group etc.

    摘要翻译： 本发明提供了具有优异JNK抑制作用的新颖的1H-吲唑化合物。 更具体地，它提供由下式表示的化合物，其盐或它们的水合物。 其中R1是C6-C14芳族环烃基等; R2，R4和R5各自独立地表示氢原子，卤素原子，氰基等; L是单键或C1-C6亚烷基等; X是单键，或由-CO-NH-或-NH-CO-等表示的基团; Y为C3-C8环烷基，C6-C14芳族环状烃基或5〜14元芳香族杂环基等。

    1H-indazole compound
    17.
    发明授权
    1H-indazole compound 失效
    1H-吲唑化合物

    公开(公告)号：US06982274B2

    公开(公告)日：2006-01-03

    申请号：US10469399

    申请日：2002-04-15

    申请人： Hitoshi Oinuma ,  Norihito Ohi ,  Nobuaki Sato ,  Motohiro Soejima ,  Hidenori Seshimo ,  Taro Terauchi ,  Takashi Doko ,  Naohiro Kohmura

    发明人： Hitoshi Oinuma ,  Norihito Ohi ,  Nobuaki Sato ,  Motohiro Soejima ,  Hidenori Seshimo ,  Taro Terauchi ,  Takashi Doko ,  Naohiro Kohmura

    IPC分类号： A61K31/44 ,  C07D23/56 ,  A61P25/00

    CPC分类号： C07D231/56

    摘要： The present invention provides a novel 1H-indazole compound having an excellent JNK inhibitory action. More specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. Wherein R1 is a C6-C14 aromatic cyclic hydrocarbon group etc.; R2, R4 and R5 each independently represent a hydrogen atom, a halogen atom, a cyano group etc.; L is a single bond, or a C1-C6 alkylene group etc.; X is a single bond, or a group represented by —CO—NH— or —NH—CO—, etc.; and Y is a C3-C8 cycloalkyl group, a C6-C14 aromatic cyclic hydrocarbon group or a 5- to 14-membered aromatic heterocyclic group etc.

    摘要翻译： 本发明提供了具有优异JNK抑制作用的新颖的1H-吲唑化合物。 更具体地，它提供由下式表示的化合物，其盐或它们的水合物。 其中R 1是C 6 -C 14芳族环状烃基等; R 2，R 4和R 5各自独立地表示氢原子，卤素原子，氰基等; L是单键或C 1 -C 6亚烷基等; X是单键，或由-CO-NH-或-NH-CO-等表示的基团; 和Y是C 3 -C 8环烷基，C 6 -C 14芳族环状烃基 或5〜14元芳香族杂环基等

    Cyclopropane compound
    20.
    发明授权
    Cyclopropane compound 有权
    环丙烷化合物

    公开(公告)号：US08268848B2

    公开(公告)日：2012-09-18

    申请号：US13237205

    申请日：2011-09-20

    申请人： Taro Terauchi ,  Ayumi Takemura ,  Takashi Doko ,  Yu Yoshida ,  Toshiaki Tanaka ,  Keiichi Sorimachi ,  Yoshimitsu Naoe ,  Carsten Beuckmann ,  Yuji Kazuta

    发明人： Taro Terauchi ,  Ayumi Takemura ,  Takashi Doko ,  Yu Yoshida ,  Toshiaki Tanaka ,  Keiichi Sorimachi ,  Yoshimitsu Naoe ,  Carsten Beuckmann ,  Yuji Kazuta

    IPC分类号： A01N43/54 ,  A61K31/505

    CPC分类号： C07D401/12 ,  C07D239/34

    摘要： A cyclopropane compound represented by the following formula (A) or a pharmaceutically acceptable salt thereof has orexin receptor antagonism, and therefore has a potencial of usefulness for the treatment of sleep disorder for which orexin receptor antagonism is effective, for example, insomnia: wherein Q represents —CH— or a nitrogen atom, R1a and R1b each independently represent a C1-6 alkyl group and the like, R1c represents a hydrogen atom and the like, R2a, R2b, R2c and R2d each independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group and the like, R3a, R3b and R3c each independently represent a hydrogen atom, a halogen atom and the like, and R3d represents a hydrogen atom and the like.

    摘要翻译： 由下式（A）表示的环丙烷化合物或其药学上可接受的盐具有食欲肽受体拮抗作用，因此具有治疗食欲肽受体拮抗作用有效的睡眠障碍的潜在用途，例如失眠症：其中Q表示 -CH-或氮原子，R1a和R1b各自独立地表示C1-6烷基等，R1c表示氢原子等，R2a，R2b，R2c和R2d各自独立地表示氢原子，卤素原子 C 1-6烷基等，R 3a，R 3b和R 3c各自独立地表示氢原子，卤素原子等，R 3d表示氢原子等。