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    Method and apparatus for determining consensus secondary structures for nucleic acid sequences
    11.
    发明授权
    Method and apparatus for determining consensus secondary structures for nucleic acid sequences 失效
    用于确定核酸序列的共有二级结构的方法和装置

    公开(公告)号：US5843732A

    公开(公告)日：1998-12-01

    申请号：US470939

    申请日：1995-06-06

    申请人： Jeffrey P. Davis ,  Nebojsa Janjic ,  Dominic A. Zichi

    发明人： Jeffrey P. Davis ,  Nebojsa Janjic ,  Dominic A. Zichi

    IPC分类号： C07K1/00 ,  C12Q1/68 ,  G06F17/50 ,  G06F19/16 ,  G06F19/22 ,  G01N33/00

    CPC分类号： G06F19/16 ,  C07K1/00 ,  G06F19/22 ,  Y10T436/143333

    摘要： An interactive computer program generates a composite dot matrix representation of secondary structure elements from a set of functionally related oligonucleotides. The composite image facilitates visual detection of conserved secondary structure motifs with similar sequence sets. The complete pattern displaying all possible base pairings can be readily pruned with two progressive filters to provide the user with a simplified figure displaying only the most stable and conserved regions. Additional simplification of the structure matrix image can be achieved by eliminating mutually exclusive structures. Alignment editing provided within the program facilitates refinement of the consensus secondary structure.

    摘要翻译： 交互式计算机程序从一组功能相关寡核苷酸生成二级结构元件的复合点阵表示。 合成图像有助于用类似的序列组来观察保守的二级结构基序。 显示所有可能的碱基配对的完整图案可以用两个渐进式过滤器轻松修剪，以向用户提供仅显示最稳定和保守区域的简化图。 可以通过消除互斥结构来实现结构矩阵图像的额外简化。 程序内提供的对齐编辑有助于细化共识二级结构。

    Lung Cancer Biomarkers and Uses Thereof
    13.
    发明申请
    Lung Cancer Biomarkers and Uses Thereof 审中-公开
    肺癌生物标志物及其用途

    公开(公告)号：US20130116150A1

    公开(公告)日：2013-05-09

    申请号：US13808751

    申请日：2011-07-11

    申请人： Sheri Wilcox ,  Deborah Ayers ,  Nebojsa Janjic ,  Larry Gold ,  Michael Riel-Mehan ,  Thale Jarvis

    发明人： Sheri Wilcox ,  Deborah Ayers ,  Nebojsa Janjic ,  Larry Gold ,  Michael Riel-Mehan ,  Thale Jarvis

    IPC分类号： G01N33/68 ,  G06F19/10 ,  C12Q1/68

    CPC分类号： G01N33/6893 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/16 ,  G01N33/57423 ,  G16B20/00 ,  G16B25/00 ,  G16B40/00 ,  G16B99/00

    摘要： The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of lung cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose lung cancer or permit the differential diagnosis of pulmonary nodules as benign or malignant. In another aspect, methods are provided for diagnosing lung cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 18, Table 20, or Table 21, wherein the individual is classified as having lung cancer, or the likelihood of the individual having lung cancer is determined, based on the at least one biomarker value.

    摘要翻译： 本申请包括用于肺癌的检测和诊断的生物标志物，方法，装置，试剂，系统和试剂盒。 在一个方面，该应用提供可以单独使用或以各种组合使用以诊断肺癌或允许肺结节的鉴别诊断为良性或恶性的生物标志物。 在另一方面，提供了用于诊断个体中的肺癌的方法，其中所述方法包括在来自个体的生物样品中检测至少一种对应于选自表18中提供的生物标志物组的至少一种生物标志物的生物标记值 ，表20或表21，其中基于所述至少一种生物标记值将个体分类为具有肺癌或确定患有肺癌的个体的可能性。

    Nucleic Acid Ligands Which Bind to Hepatocyte Growth Factor/Scatter Factor (HGF/SF) or its Receptor c-met
    17.
    发明申请
    Nucleic Acid Ligands Which Bind to Hepatocyte Growth Factor/Scatter Factor (HGF/SF) or its Receptor c-met 审中-公开
    与肝细胞生长因子/分散因子（HGF / SF）或其受体c-met结合的核酸配体

    公开(公告)号：US20090075922A1

    公开(公告)日：2009-03-19

    申请号：US11747953

    申请日：2007-05-14

    申请人： Ross Rabin ,  Michael Lochrie ,  Nebojsa Janjic ,  Larry Gold

    发明人： Ross Rabin ,  Michael Lochrie ,  Nebojsa Janjic ,  Larry Gold

    IPC分类号： A61K31/7088 ,  C07H21/04 ,  A61P35/00

    CPC分类号： C12Q1/6811 ,  C12Q1/6886

    摘要： The invention provides nucleic acid ligands to hepatocyte growth factor/scatter factor (HGF) and its receptor c-met. The nucleic acid ligands of the instant invention are isolated using the SELEX method. SELEX is an acronym for Systematic Evolution of Ligands by EXponential enrichment. The nucleic acid ligands of the invention are useful as diagnostic and therapeutic agents for diseases in which elevated HGF and c-met activity are causative factors.

    摘要翻译： 本发明提供了肝细胞生长因子/分散因子（HGF）及其受体c-met的核酸配体。 使用SELEX方法分离本发明的核酸配体。 SELEX是指数浓缩的配体的系统演化的缩写。 本发明的核酸配体可用作其中升高的HGF和c-met活性是致病因子的疾病的诊断和治疗剂。