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11.发明申请公开(公告)号：US20250002587A1
公开(公告)日：2025-01-02
申请号：US18274118
申请日：2022-01-25
Inventor： Dean Sheppard , Scott Bidlingmaier , Bin Liu , Amha Atakilit , Melinda K. Duncan , Mahbubul H. Shihan
Abstract: Methods to treat or prevent posterior capsular opacification (PCO) using antibodies that inhibit αvβ8 ligand adhesion are provided.
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12.发明申请公开(公告)号：US20240425601A1
公开(公告)日：2024-12-26
申请号：US18274069
申请日：2022-01-25
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Dean Sheppard , Scott Bidlingmaier , Bin Liu , Amha Atakilit
IPC: C07K16/28 , A61K39/395 , A61K45/06 , A61P35/00
Abstract: Compositions and methods comprising integrin β8 antibodies are provided.
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13.发明公开公开(公告)号：US20240307550A1
公开(公告)日：2024-09-19
申请号：US18271206
申请日：2022-01-06
Applicant: The Regents of the University of California
Inventor： Bin Liu , Yang Su , Scott Bidlingmaier
IPC: A61K47/68 , A61K31/18 , A61K31/4166 , A61K31/567 , A61K31/573 , A61K31/58 , A61P35/00
CPC classification number: A61K47/6849 , A61K31/18 , A61K31/4166 , A61K31/567 , A61K31/573 , A61K31/58 , A61P35/00
Abstract: A method to upregulate CD46 cell surface expression and combination therapies for various cancers employing an anti-CD46 antibody, an androgen signaling inhibitor (ASI), a STAT3 inhibitor and/or a glucocorticoid receptor agonist or modular (SEGRAM) are provided.
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公开(公告)号：US11447563B2
公开(公告)日：2022-09-20
申请号：US16714566
申请日：2019-12-13
Applicant: The Regents of the University of California
Inventor： Bin Liu
IPC: C40B40/10 , C07K16/30 , G01N33/574 , C12N15/10 , G01N33/68 , A61K47/68 , C07K16/28 , A61K45/06 , A61K49/00 , C07K16/00
Abstract: Methods are provided for identifying and selecting antibodies that are internalized into cells via the macropinocytosis pathway. Additionally antibodies that are internalized via this pathway are provided as well as immunoconjugates comprising such antibodies.
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公开(公告)号：US11208493B2
公开(公告)日：2021-12-28
申请号：US16517401
申请日：2019-07-19
Applicant: The Regents of the University of California
Inventor： Bin Liu
IPC: C07K16/28 , G01N33/574 , A61K51/10 , C07K16/30 , A61K47/68
Abstract: In various embodiments various cancer specific antibodies and immunoconjugates are provided. In certain embodiments the antibodies specifically bind and are internalized into a prostate cancer cell, where the antibodies specifically binds cells that express or overexpress a CD46, and where the antibodies specifically bind sushi domain 1 of said CD46 (CD46 CPP1).
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Patent Agency Ranking
公开(公告)号：US10948485B2
公开(公告)日：2021-03-16
申请号：US16802327
申请日：2020-02-26
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Guillermo C. Bazan , Brent S. Gaylord , Shu Wang , Bin Liu
IPC: G01N33/542 , G01N33/58 , C12Q1/6818 , C09B11/02 , C09B69/10 , C09K9/02 , C09K11/06 , G01N33/52 , B82Y15/00
Abstract: Light harvesting luminescent multichromophores that are configured upon excitation to transfer energy to, and amplify the emission from, an acceptor signaling chromophore in energy-receiving proximity therewith are provided. Also provided are compositions for labelling a target. The labelling composition may include a donor light harvesting multichromophore and an acceptor signaling chromophore in energy-receiving proximity to the donor light harvesting multichromophore. Also provided is an aqueous composition for labelling a target, including: a donor light harvesting multichromophore; an acceptor signaling chromophore in energy-receiving proximity therewith; and a sensor biomolecule. Methods for using the subject compositions are also provided.
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公开(公告)号：US09347141B2
公开(公告)日：2016-05-24
申请号：US13658707
申请日：2012-10-23
Applicant: The Regents of the University of California
Inventor： Peidong Yang , Candace Chan , Jianwei Sun , Bin Liu
IPC: C25B1/04 , C25B11/03 , C25B9/00 , C25B1/00 , C25B3/04 , H01L31/18 , C25B11/02 , C25B9/08 , B82Y40/00
CPC classification number: C25B11/035 , B82Y40/00 , C25B1/003 , C25B3/04 , C25B9/00 , C25B9/08 , C25B11/02 , H01L31/18 , Y02E60/368
Abstract: This disclosure provides systems, methods, and apparatus related to a nanowire mesh solar fuels generator. In one aspect, a nanowire mesh solar fuels generator includes (1) a photoanode configured to perform water oxidation and (2) a photocathode configured to perform water reduction. The photocathode is in electrical contact with the photoanode. The photoanode may include a high surface area network of photoanode nanowires. The photocathode may include a high surface area network of photocathode nanowires. In some embodiments, the nanowire mesh solar fuels generator may include an ion conductive polymer infiltrating the photoanode and the photocathode in the region where the photocathode is in electrical contact with the photoanode.
Abstract translation: 本公开提供了与纳米线网状太阳能燃料发生器相关的系统，方法和装置。 一方面，纳米线网状太阳能燃料发生器包括（1）配置为进行水氧化的光电阳极和（2）配置为进行减水的光电阴极。 光电阴极与光电阳极电接触。 光电阳极可以包括光电纳米线的高表面积网络。 光电阴极可以包括光电阴极纳米线的高表面积网络。 在一些实施例中，纳米线网状太阳能燃料发生器可以包括在光电阴极与光电阳极电接触的区域中渗透光电阳极和光电阴极的离子导电聚合物。
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公开(公告)号：US08759444B2
公开(公告)日：2014-06-24
申请号：US13726520
申请日：2012-12-24
Applicant: The Regents of the University of California
Inventor： Guillermo C. Bazan , Bin Liu
CPC classification number: C08G61/02 , C08G61/122 , C08G61/123 , C12Q1/6818 , C12Q1/6837 , G01N21/6428 , G01N21/6452 , G01N2021/6419 , G01N2021/6439 , C12Q2563/131 , C12Q2537/119 , C12Q2525/107
Abstract: Disclosed are multichromophores, and methods, articles and compositions employing them. Disclosed are methods, articles and compositions for the detection and analysis of biomolecules in a sample. Provided assays include those determining the presence of a target biomolecule in a sample or its relative amount, or the assays may be quantitative or semi-quantitative. The methods can be performed on a substrate or in an array format on a substrate. Disclosed are detection assays employing sensor biomolecules that do not comprise a fluorophore that can exchange energy with the cationic multichromophore. Disclosed are biological assays in which energy is transferred between one or more of the multichromophore, a label on the target biomolecule, a label on the sensor biomolecule, and/or a fluorescent dye specific for a polynucleotide, in all permutations.
Abstract translation: 公开了多重色谱和其使用它们的方法，制品和组合物。 公开了用于检测和分析样品中生物分子的方法，制品和组合物。 提供的测定包括确定样品中靶生物分子的存在或其相对量的那些，或者测定可以是定量或半定量的。 该方法可以在衬底上以阵列形式在衬底上进行。 公开了使用不包含可与阳离子多重色素交换能量的荧光团的传感器生物分子的检测测定。 公开了在所有排列中能量在一个或多个多色素，目标生物分子上的标记，传感器生物分子上的标记和/或多核苷酸特异的荧光染料之间转移能量的生物测定。
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公开(公告)号：US20130105305A1
公开(公告)日：2013-05-02
申请号：US13658707
申请日：2012-10-23
Applicant: The Regents of the University of California
Inventor： Peidong Yang , Candace Chan , Jianwei Sun , Bin Liu
CPC classification number: C25B11/035 , B82Y40/00 , C25B1/003 , C25B3/04 , C25B9/00 , C25B9/08 , C25B11/02 , H01L31/18 , Y02E60/368
Abstract: This disclosure provides systems, methods, and apparatus related to a nanowire mesh solar fuels generator. In one aspect, a nanowire mesh solar fuels generator includes (1) a photoanode configured to perform water oxidation and (2) a photocathode configured to perform water reduction. The photocathode is in electrical contact with the photoanode. The photoanode may include a high surface area network of photoanode nanowires. The photocathode may include a high surface area network of photocathode nanowires. In some embodiments, the nanowire mesh solar fuels generator may include an ion conductive polymer infiltrating the photoanode and the photocathode in the region where the photocathode is in electrical contact with the photoanode.
Abstract translation: 本公开提供了与纳米线网状太阳能燃料发生器相关的系统，方法和装置。 一方面，纳米线网状太阳能燃料发生器包括（1）配置为进行水氧化的光电阳极和（2）配置为进行减水的光电阴极。 光电阴极与光电阳极电接触。 光电阳极可以包括光电纳米线的高表面积网络。 光电阴极可以包括光电阴极纳米线的高表面积网络。 在一些实施例中，纳米线网状太阳能燃料发生器可以包括在光电阴极与光电阳极电接触的区域中渗透光电阳极和光电阴极的离子导电聚合物。
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公开(公告)号：US12252746B2
公开(公告)日：2025-03-18
申请号：US17815514
申请日：2022-07-27
Applicant: The Regents of the University of California
Inventor： Bin Liu , Daniel W. Sherbenou , Blake T. Aftab , Yang Su , Christopher R. Behrens
IPC: C12Q1/6886 , A61K39/00 , A61K47/68 , A61P35/00 , C07K16/00 , C07K16/28 , C07K16/30 , G01N33/574
Abstract: Disclosed herein are methods of treating a subject having a cancer characterized by a modification at biomarker 1q21, which comprises administering to the subject a therapeutically effective amount of an anti-CD46 antibody.
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