公开(公告)号：US06218264B1

公开(公告)日：2001-04-17

申请号：US09314410

申请日：1999-05-19

Applicant: Johann W. Bartha ,  Thomas Bayer ,  Johann Greschner ,  Martin Nonnenmacher ,  Helga Weiss

Inventor： Johann W. Bartha ,  Thomas Bayer ,  Johann Greschner ,  Martin Nonnenmacher ,  Helga Weiss

IPC: H01L21311

CPC classification number: G01Q40/02 ,  Y10S438/975 ,  Y10S977/852 ,  Y10S977/878 ,  Y10T428/24926

Abstract: A calibration standard comprises a supporting structure (1) of single crystal material with at least one pair of different kinds of structures consisting of a raised line (2) and a trench (3). These structures have the identical width in the range of about 500 nm. The single crystal material preferably is silicon with (110)-orientation. A method of producing the calibration standard comprises the steps: providing two polished wafers of the same single crystal material and with the same crystal orientation, forming an oxide layer on the polished surface of the first wafer, bonding the second wafer to the first oxidized wafer with the polished surfaces of the wafers facing each other, cutting the bonded structure transverse to the polished surfaces, selectively etching both the wafers to a defined depth to expose a portion of the oxide layer, masking the portions of the oxide layer now representing the raised line (2) and selectively etching the oxide layer in the unmasked areas to a defined depth to form the trench (3). The calibration standard overcomes the problem of measuring the diameter of an ultrafine tip for AFM/STM profilometry in the sub-nanometer range.

Abstract translation: 校准标准包括具有由凸起线（2）和沟槽（3）组成的至少一对不同种类的结构的单晶材料的支撑结构（1）。 这些结构具有在约500nm范围内相同的宽度。 单晶材料优选为具有（110）取向的硅。 一种生产校准标准的方法包括以下步骤：提供相同单晶材料的两个抛光晶片并具有相同的晶体取向，在第一晶片的抛光表面上形成氧化物层，将第二晶片接合到第一氧化晶片 其中晶片的抛光表面彼此面对，切割与抛光表面横向的结合结构，选择性地将两个晶片刻蚀到限定的深度以暴露氧化物层的一部分，掩盖现在代表凸起的氧化物层的部分 线（2），并且将未掩模区域中的氧化物层选择性蚀刻到限定的深度以形成沟槽（3）。 校准标准克服了在亚纳米范围内测量AFM / STM轮廓测量法的超细尖端直径的问题。

公开(公告)号：US5382795A

公开(公告)日：1995-01-17

申请号：US209682

申请日：1994-03-10

Applicant: Thomas Bayer ,  Johann Greschner ,  Yves Martin ,  Helga Weiss ,  Hemantha K. Wickramasinghe ,  Olaf Wolter

Inventor： Thomas Bayer ,  Johann Greschner ,  Yves Martin ,  Helga Weiss ,  Hemantha K. Wickramasinghe ,  Olaf Wolter

IPC: G01B7/34 ,  G01B21/30 ,  G01N27/00 ,  G01Q10/04 ,  G01Q60/04 ,  G01Q60/16 ,  G01Q60/38 ,  G01Q70/10 ,  H01J37/28 ,  H01L21/00 ,  H01L21/66

CPC classification number: G01Q60/38 ,  B82Y35/00 ,  G01Q60/04 ,  G01Q60/16 ,  G01Q70/10 ,  Y10S977/878

Abstract: An ultrafine tip for AFM and STM profilometry of trenches having sidewalls. The tip includes a lateral circumferential edge protrusion to allow profilometry of the sidewalls of a trench located in a semiconductor or insulator substrate.

Abstract translation: 具有侧壁的沟槽的AFM和STM轮廓测量法的超细尖端。 尖端包括侧向周向边缘突起，以允许位于半导体或绝缘体衬底中的沟槽的侧壁的轮廓测量。

公开(公告)号：US5284754A

公开(公告)日：1994-02-08

申请号：US754000

申请日：1991-09-03

Applicant: Thomas Bayer ,  Klaus Sauber

Inventor： Thomas Bayer ,  Klaus Sauber

IPC: C07D501/20 ,  C12N9/06 ,  C12N11/08 ,  C12N11/10 ,  C12P35/00 ,  C12P35/06

CPC classification number: C12N9/0024 ,  C12N11/08 ,  C12N11/10 ,  C12P35/06 ,  Y10S435/911

Abstract: A process for the continuous conversion of cephalosporin derivatives into glutaryl-7-aminocephalosporanic acid derivativesA process for the continuous conversion of cephalosporin derivatives into the corresponding glutaryl-7-aminocephalosporanic acid derivatives in the presence of a catalyst containing D-amino-acid oxidase is described. The product yield can be increased, where appropriate, by addition of hydrogen peroxide.

Abstract translation: 将头孢菌素衍生物连续转化为戊二酰-7-氨基头孢烷酸衍生物的方法在含有D-氨基酸氧化酶的催化剂存在下，将头孢菌素衍生物连续转化成相应的戊二酰-7-氨基头孢烷酸衍生物的方法是 描述。 通过加入过氧化氢可以适当地增加产物的产率。

公开(公告)号：US5051379A

公开(公告)日：1991-09-24

申请号：US568306

申请日：1990-08-16

Applicant: Thomas Bayer ,  Johann Greschner ,  Georg Kraus ,  Helga Weiss ,  Olaf Wolter

Inventor： Thomas Bayer ,  Johann Greschner ,  Georg Kraus ,  Helga Weiss ,  Olaf Wolter

IPC: G01B7/34 ,  B81C1/00 ,  C23F1/00 ,  G01N27/00 ,  G01Q60/16 ,  G01Q60/38 ,  G01Q70/02 ,  G02B21/00 ,  H01J37/28 ,  H01L21/302 ,  H01L41/09

CPC classification number: G01Q60/16 ,  B82Y35/00 ,  G01Q60/04 ,  G01Q60/38

Abstract: A method and apparatus is described for a micromechanical sensor for the AFM/STM profilometry, which consist of a cantilever beam with a tip at its end and a mounting block at the opposite end. The method incorporated the steps of coating a wafer substrate; producing a mask for the desired cantilever beam pattern on the top side of the wafer; and a mask on the bottom side of the wafer; planarizing said cantilever beam pattern with photoresist; producing a mask for the desired tip in the area of the cantilever beam pattern producing the desired tip using an etching step, and simultaneously transferring the cantilever beam pattern from the upper to the lower part of the layer; and removing the supporting wafer material by etching through the bottom side mask. A mask for the desired cantilever beam pattern and the tip pattern contains all relevant information for a subsequent substrate etching process is described for etching step by step into a silicon substrate.

公开(公告)号：US4969415A

公开(公告)日：1990-11-13

申请号：US458006

申请日：1989-12-28

Applicant: Johann W. Bartha ,  Thomas Bayer ,  Johann Greschner ,  Georg Kraus ,  Gerhard Schmid

Inventor： Johann W. Bartha ,  Thomas Bayer ,  Johann Greschner ,  Georg Kraus ,  Gerhard Schmid

IPC: C23C16/08 ,  C23C16/30 ,  C23C16/448 ,  C23C16/50 ,  H01L21/28 ,  H01L21/285

CPC classification number: C23C16/4488 ,  C23C16/08 ,  H01L21/28556 ,  Y10S148/147

Abstract: The apparatus comprises a plasma deposition chamber having a port through which a fluoro compound etch gas is introduced into the chamber and a port through which the chamber is evacuated, refractory metal cathode configuration within the chamber, an anode within the chamber, and energy impression means for ionizing the etch gas in the chamber, whereby the etch gas reacts with the refractory metal cathode configuration to convert the metal to gaseous refractory metal fluorides which decompose to form a deposited layer on a semiconductor substrate positioned on the anode.

公开(公告)号：US09204623B2

公开(公告)日：2015-12-08

申请号：US13702390

申请日：2010-06-08

Applicant: Thomas Bayer ,  Oliver Wirths

Inventor： Thomas Bayer ,  Oliver Wirths

IPC: A01K67/00 ,  G01N33/00 ,  A01K67/027 ,  C07K14/47 ,  C12N15/85

CPC classification number: A01K67/0278 ,  A01K67/0275 ,  A01K2217/052 ,  A01K2227/105 ,  A01K2267/0312 ,  C07K14/4711 ,  C12N15/8509

Abstract: The present invention describes a novel transgenic mouse model for the common sporadic form of Alzheimer's disease. More particularly, the invention relates to a nucleotide sequence encoding Aβ 4-42 in functional linkage with at least a promoter, signal peptide sequence and a polyadenylation signal sequence, a cell and a transgenic non-human animal comprising said nucleotide sequence, and their respective use in screening methods.

Abstract translation: 本发明描述了用于常见散发形式的阿尔茨海默氏病的新型转基因小鼠模型。 更具体地，本发明涉及编码A＆bgr的核苷酸序列; 4-42，其与至少一种启动子，信号肽序列和多聚腺苷酸化信号序列功能连接，包含所述核苷酸序列的细胞和转基因非人动物，以及它们在筛选方法中的各自用途。

公开(公告)号：US08823227B2

公开(公告)日：2014-09-02

申请号：US12745571

申请日：2008-11-27

Applicant: Thomas Bayer

Inventor： Thomas Bayer

IPC: H02K7/116 ,  F16H49/00 ,  F16H25/06

CPC classification number: F16H25/06 ,  H02K7/116

Abstract: In a drive unit having at least one transmission stage (Ü) and one drive element (4) for driving with high power density, having a drive element (4), and element (8), and an output element (14), wherein a translation and transmission of a drive torque occurs between the drive element (4) and the output element (14) via a plurality of radially movable toothed segments (10), the drive element (4) is to be embodied as an electrical drive for the transmission stage (Ü).

Abstract translation: 在具有至少一个传动级（Ü）和用于以高功率密度驱动的驱动元件（4）的驱动单元中，具有驱动元件（4）和元件（8）以及输出元件（14），其中 通过多个可径向移动的齿形段（10）在驱动元件（4）和输出元件（14）之间发生驱动扭矩的平移和传递，驱动元件（4）将被实施为电驱动 传输阶段（Ü）。

公开(公告)号：US08795664B2

公开(公告)日：2014-08-05

申请号：US13701758

申请日：2011-06-03

Applicant: Thomas Bayer ,  Oliver Wirths ,  Henrik Martens ,  Christian Erck

Inventor： Thomas Bayer ,  Oliver Wirths ,  Henrik Martens ,  Christian Erck

IPC: A61K39/395 ,  C07K16/18 ,  C12N5/20

CPC classification number: C07K16/18 ,  A61K2039/505 ,  C07K2317/32 ,  C07K2317/33 ,  C07K2317/76

Abstract: The invention relates to binding molecules capable of specifically recognizing soluble oligomers of N-terminal truncated Aβ starting with pyroglutamate (AβρE), pharmaceutical compositions comprising same, and their respective therapeutic uses. Particularly, the invention relates to an antibody molecule capable of specifically recognizing Aβ oligomers, wherein said antibody binds and/or detects an epitope as bound and/or detected by antibody PG3-38 9D5H6 as deposited under DSM AC-C3056. Further, the invention provides a method of inhibiting the formation or the seeding effect of said AβρE oligomers, and a method for identifying agents useful in the treatment and/or prevention of an amyloid-related disorder as well as methods of diagnosing a subject suspected of suffering from a disease associated with amyloidogenesis and/or amyloid plaque formation and to methods of monitoring the efficacy of a treatment of a disease associated with amyloidogenesis and/or amyloid-plaque formation characterized by the presence of Aβ oligomers in a subject.

Abstract translation: 本发明涉及能够特异性识别N-末端截短的A和Bgr的可溶性低聚物的结合分子; 由焦谷氨酸（A＆Bgr; E）开始，包含其的药物组合物及其各自的治疗用途。 特别地，本发明涉及能够特异性识别A＆bgr的抗体分子; 寡聚体，其中所述抗体结合和/或检测由DSM AC-C3056沉积的抗体PG3-38 9D5H6结合和/或检测的表位。 此外，本发明提供了抑制所述Aβ和β-寡聚体的形成或播种作用的方法，以及用于鉴定可用于治疗和/或预防淀粉样蛋白相关病症的药剂的方法以及诊断方法 怀疑患有与淀粉样变性和/或淀粉样蛋白斑形成相关的疾病的受试者以及监测与淀粉样变性和/或淀粉样蛋白斑形成有关的疾病的治疗功效的方法，其特征在于存在Aβ和B淀粉样蛋白。 受试者中的寡聚体。

公开(公告)号：US08258926B2

公开(公告)日：2012-09-04

申请号：US12469999

申请日：2009-05-21

Applicant: Thomas Bayer ,  Balthazar-Simon Ten Berge ,  Wolf-Stephan Wilke

Inventor： Thomas Bayer ,  Balthazar-Simon Ten Berge ,  Wolf-Stephan Wilke

IPC: H04Q5/22

CPC classification number: G07C9/00111 ,  B64F1/366 ,  G06Q10/08 ,  G06Q50/30

Abstract: A method for automatically checking in passengers and their luggage by an electronic input of the passenger data or travel data by the passenger himself into an automatic check-in terminal is provided. In the automatic check-in terminal, possibly following selection of various criteria, the boarding pass and one or more information media for attachment to the luggage are created and output. The information medium created is a luggage tag which is easy to affix to the luggage item and which contains, in machine-readable form, at least all the data and information which are required for a later generation of an internationally standardized, preferably self-adhesive luggage band which is affixed to the luggage item within a conveying and sorting system in addition to the luggage tag.

Abstract translation: 提供了一种通过乘客自身的电子输入或乘客自身的旅行数据自动检查乘客及其行李的方法，该自动登机终端。 在自动登机终端中，可能在选择各种标准之后，建立并输出登机牌和用于附着到行李的一个或多个信息介质。 所创建的信息介质是容易粘贴到行李件的行李标签，并且以机器可读形式包含至少所有数据和信息，这些数据和信息为后来产生国际标准化，优选自粘性所需的所有数据和信息 行李带除了行李标签之外，还贴在行李箱内的运输和分拣系统内。

公开(公告)号：US20110259144A1

公开(公告)日：2011-10-27

申请号：US13073572

申请日：2011-03-28

Applicant: Frank Michel ,  Michael Schmidt ,  Thomas Bayer ,  Heiko Schreiber ,  Lars Estermann

Inventor： Frank Michel ,  Michael Schmidt ,  Thomas Bayer ,  Heiko Schreiber ,  Lars Estermann

IPC: F16H35/00

CPC classification number: F16H25/06

Abstract: Gearing (1), in particular single-stage gearing having a transmission ratio of greater than 1 to 10, having an internal gear (2) with an internal toothing (5), a first toothed ring with radially movable first teeth (6) for engaging into the internal toothing (5), a second toothed ring with radially movable second teeth (7) for engaging into the internal toothing (5), an inner shaft (21) on which is fastened a first cam disk (16) for the radial drive of the first teeth (6) and a second cam disk (17) for the radial drive of the second teeth (7), and a load dividing device for dividing a torque transmitted via the toothed rings between the toothed rings.

Abstract translation: 齿轮（1），特别是具有大于1至10的传动比的单级传动装置，具有带内齿轮（5）的内齿轮（2），具有可径向移动的第一齿（6）的第一齿环，用于 接合到所述内齿（5）中的第二齿环，具有用于接合到所述内齿（5）中的径向可移动的第二齿（7）的第二齿环，内轴（21），紧固在所述内齿轮（21）上的第一凸轮盘 第一齿（6）的径向驱动和用于第二齿（7）的径向驱动的第二凸轮盘（17），以及负载分配装置，用于分割通过齿环之间的齿环传递的扭矩。