利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

93 条记录 (耗时 0.033 秒)

    MONOCLONAL ANTIBODIES TARGETING AMYLOID BETA OLIGOMERS
    1.
    发明申请
    MONOCLONAL ANTIBODIES TARGETING AMYLOID BETA OLIGOMERS 有权
    单克隆抗体靶向AMYLOID BETA寡聚体

    公开(公告)号：US20130295095A1

    公开(公告)日：2013-11-07

    申请号：US13701758

    申请日：2011-06-03

    申请人： Thomas Bayer ,  Oliver Wirths ,  Henrik Martens ,  Christian Erck

    发明人： Thomas Bayer ,  Oliver Wirths ,  Henrik Martens ,  Christian Erck

    IPC分类号： C07K16/18

    CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K2317/32 ,  C07K2317/33 ,  C07K2317/76

    摘要： The invention relates to binding molecules capable of specifically recognizing soluble oligomers of N-terminal truncated Aβ starting with pyroglutamate (AβρE), pharmaceutical compositions comprising same, and their respective therapeutic uses. Particularly, the invention relates to an antibody molecule capable of specifically recognizing Aβ oligomers, wherein said antibody binds and/or detects an epitope as bound and/or detected by antibody PG3-38 9D5H6 as deposited under DSM AC-C3056. Further, the invention provides a method of inhibiting the formation or the seeding effect of said AβρE oligomers, and a method for identifying agents useful in the treatment and/or prevention of an amyloid-related disorder as well as methods of diagnosing a subject suspected of suffering from a disease associated with amyloidogenesis and/or amyloid plaque formation and to methods of monitoring the efficacy of a treatment of a disease associated with amyloidogenesis and/or amyloid-plaque formation characterized by the presence of Aβ oligomers in a subject.

    摘要翻译： 本发明涉及能够特异性识别由焦谷氨酸（AbetarhoE）开始的N-末端截短的Abeta的可溶性低聚物，包含其的药物组合物及其各自的治疗用途的结合分子。 特别地，本发明涉及能够特异性识别Aβ寡聚体的抗体分子，其中所述抗体结合和/或检测由DSM AC-C3056沉积的抗体PG3-38 9D5H6结合和/或检测的表位。 此外，本发明提供抑制所述AbetarhoE寡聚体的形成或播种作用的方法，以及用于鉴定可用于治疗和/或预防淀粉样蛋白相关病症的药剂的方法以及诊断疑似患者的方法 患有与淀粉样变性和/或淀粉样蛋白斑形成相关的疾病，以及监测治疗与淀粉样变性和/或淀粉样蛋白斑形成有关的疾病的功效的方法，其特征在于受试者中存在Aβ寡聚体。

    Transgenic mouse model expressing amyloid β 4-42 peptide
    2.
    发明授权
    Transgenic mouse model expressing amyloid β 4-42 peptide 有权
    表达淀粉样蛋白的转基因小鼠模型 4-42肽

    公开(公告)号：US09204623B2

    公开(公告)日：2015-12-08

    申请号：US13702390

    申请日：2010-06-08

    申请人： Thomas Bayer ,  Oliver Wirths

    发明人： Thomas Bayer ,  Oliver Wirths

    IPC分类号： A01K67/00 ,  G01N33/00 ,  A01K67/027 ,  C07K14/47 ,  C12N15/85

    CPC分类号： A01K67/0278 ,  A01K67/0275 ,  A01K2217/052 ,  A01K2227/105 ,  A01K2267/0312 ,  C07K14/4711 ,  C12N15/8509

    摘要： The present invention describes a novel transgenic mouse model for the common sporadic form of Alzheimer's disease. More particularly, the invention relates to a nucleotide sequence encoding Aβ 4-42 in functional linkage with at least a promoter, signal peptide sequence and a polyadenylation signal sequence, a cell and a transgenic non-human animal comprising said nucleotide sequence, and their respective use in screening methods.

    摘要翻译： 本发明描述了用于常见散发形式的阿尔茨海默氏病的新型转基因小鼠模型。 更具体地，本发明涉及编码A＆bgr的核苷酸序列; 4-42，其与至少一种启动子，信号肽序列和多聚腺苷酸化信号序列功能连接，包含所述核苷酸序列的细胞和转基因非人动物，以及它们在筛选方法中的各自用途。

    Monoclonal antibodies targeting amyloid beta oligomers
    3.
    发明授权
    Monoclonal antibodies targeting amyloid beta oligomers 有权
    针对淀粉样β寡聚体的单克隆抗体

    公开(公告)号：US08795664B2

    公开(公告)日：2014-08-05

    申请号：US13701758

    申请日：2011-06-03

    申请人： Thomas Bayer ,  Oliver Wirths ,  Henrik Martens ,  Christian Erck

    发明人： Thomas Bayer ,  Oliver Wirths ,  Henrik Martens ,  Christian Erck

    IPC分类号： A61K39/395 ,  C07K16/18 ,  C12N5/20

    CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K2317/32 ,  C07K2317/33 ,  C07K2317/76

    摘要： The invention relates to binding molecules capable of specifically recognizing soluble oligomers of N-terminal truncated Aβ starting with pyroglutamate (AβρE), pharmaceutical compositions comprising same, and their respective therapeutic uses. Particularly, the invention relates to an antibody molecule capable of specifically recognizing Aβ oligomers, wherein said antibody binds and/or detects an epitope as bound and/or detected by antibody PG3-38 9D5H6 as deposited under DSM AC-C3056. Further, the invention provides a method of inhibiting the formation or the seeding effect of said AβρE oligomers, and a method for identifying agents useful in the treatment and/or prevention of an amyloid-related disorder as well as methods of diagnosing a subject suspected of suffering from a disease associated with amyloidogenesis and/or amyloid plaque formation and to methods of monitoring the efficacy of a treatment of a disease associated with amyloidogenesis and/or amyloid-plaque formation characterized by the presence of Aβ oligomers in a subject.

    摘要翻译： 本发明涉及能够特异性识别N-末端截短的A和Bgr的可溶性低聚物的结合分子; 由焦谷氨酸（A＆Bgr; E）开始，包含其的药物组合物及其各自的治疗用途。 特别地，本发明涉及能够特异性识别A＆bgr的抗体分子; 寡聚体，其中所述抗体结合和/或检测由DSM AC-C3056沉积的抗体PG3-38 9D5H6结合和/或检测的表位。 此外，本发明提供了抑制所述Aβ和β-寡聚体的形成或播种作用的方法，以及用于鉴定可用于治疗和/或预防淀粉样蛋白相关病症的药剂的方法以及诊断方法 怀疑患有与淀粉样变性和/或淀粉样蛋白斑形成相关的疾病的受试者以及监测与淀粉样变性和/或淀粉样蛋白斑形成有关的疾病的治疗功效的方法，其特征在于存在Aβ和B淀粉样蛋白。 受试者中的寡聚体。

    TRANSGENIC MOUSE MODEL EXPRESSING AMYLOID BETA 4-42 PEPTIDE
    4.
    发明申请
    TRANSGENIC MOUSE MODEL EXPRESSING AMYLOID BETA 4-42 PEPTIDE 有权
    转基因鼠模型表达4-42肽的淀粉样蛋白

    公开(公告)号：US20130179998A1

    公开(公告)日：2013-07-11

    申请号：US13702390

    申请日：2010-06-08

    申请人： Thomas Bayer ,  Oliver Wirths

    发明人： Thomas Bayer ,  Oliver Wirths

    IPC分类号： A01K67/027

    CPC分类号： A01K67/0278 ,  A01K67/0275 ,  A01K2217/052 ,  A01K2227/105 ,  A01K2267/0312 ,  C07K14/4711 ,  C12N15/8509

    摘要： The present invention describes a novel transgenic mouse model for the common sporadic form of Alzheimer's disease. More particularly, the invention relates to a nucleotide sequence encoding Aβ 4-42 in functional linkage with at least a promoter, signal peptide sequence and a polyadenylation signal sequence, a cell and a transgenic non-human animal comprising said nucleotide sequence, and their respective use in screening methods.

    摘要翻译： 本发明描述了用于常见散发形式的阿尔茨海默氏病的新型转基因小鼠模型。 更具体地，本发明涉及编码与至少启动子，信号肽序列和多聚腺苷酸化信号序列，细胞和包含所述核苷酸序列的细胞和转基因非人动物的功能性连接的Aβ4-42的核苷酸序列，以及它们各自的 用于筛选方法。

    METHOD FOR OPTIMALLY OPERATING TRANSMISSIONS
    7.
    发明申请
    METHOD FOR OPTIMALLY OPERATING TRANSMISSIONS 有权
    最佳运行方式

    公开(公告)号：US20100089163A1

    公开(公告)日：2010-04-15

    申请号：US12595277

    申请日：2008-04-02

    申请人： Michael Engelbreit ,  Thomas Bayer

    发明人： Michael Engelbreit ,  Thomas Bayer

    IPC分类号： G01M13/02

    CPC分类号： G01M13/021

    摘要： A method for optimally operating mechanically loaded, moved, particularly rotating components, such as gearboxes, wherein in the operating stage damage accumulation is used to evaluate the influence of a collective load on the lifespan of the loaded rotating components, the moving components (1) being divided into a plurality of segments (5-10) for determining individual collective loads (6; 18).

    摘要翻译： 用于最佳地操作机械负载的，移动的，特别是旋转的部件（例如齿轮箱）的方法，其中在操作阶段损伤积累用于评估集合载荷对所加载的旋转部件的寿命的影响，移动部件（1） 被分成多个段（5-10），用于确定各个集体负荷（6; 18）。

    Linear drive, in particular a rack and pinion drive
    8.
    发明申请
    Linear drive, in particular a rack and pinion drive 审中-公开
    线性驱动，特别是齿条齿轮传动

    公开(公告)号：US20090320630A1

    公开(公告)日：2009-12-31

    申请号：US10588747

    申请日：2004-11-23

    申请人： Thomas Bayer ,  Frank Michel

    发明人： Thomas Bayer ,  Frank Michel

    IPC分类号： F16H55/28

    CPC分类号： F16H55/28 ,  B23Q5/385 ,  B23Q5/56 ,  F16H2057/123 ,  Y10T74/19623

    摘要： The invention relates to a linear drive, in particular a rack and pinion drive, comprising at least one motor element (2) which is mounted on or in a retaining element (1.1, 1.2). The motor element (2) drives, directly or indirectly, a pinion (4), optionally, via an integrated drive (3), said pinion co-operating with a linear guide (5). According to the invention, the retaining element (1.1, 1.2) can be displaced by at least one actuator (12.1 to 12.3) in relation to a receiving element (6).

    摘要翻译： 本发明涉及线性驱动器，特别是齿条和小齿轮驱动器，其包括安装在保持元件（1.1,1.2）上或其中的至少一个马达元件（2）。 马达元件（2）直接或间接地驱动小齿轮（4），可选地通过集成驱动器（3）驱动，所述小齿轮与直线导轨（5）配合。 根据本发明，保持元件（1.1,1.2）可以相对于接收元件（6）由至少一个致动器（12.1至12.3）移位。