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公开(公告)号：US6015892A
公开(公告)日：2000-01-18
申请号：US578615
申请日：1996-01-11
IPC分类号： C12N15/09 , A61K31/7088 , A61K31/711 , A61K31/712 , A61K31/7125 , A61K38/00 , A61K48/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07H21/00 , C07H21/04 , C07K14/705 , C12N5/10 , C12N9/12 , C12N15/113 , C12Q1/48 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/573 , G01N33/68 , C07H21/02 , C12N15/85
CPC分类号： C12N15/1137 , A61K48/00 , C07H21/00 , C07K14/70564 , C12N9/12 , C12Q1/6876 , C12Q1/6883 , C12Y207/11013 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/341 , C12N2310/346 , C12N2310/3521 , C12N2310/3527 , C12N2310/3533 , C12Q2600/158
摘要： Compositions and methods are provided for the treatment and diagnosis of diseases associated with protein kinase C. Oligonucleotides are provided which are specifically hybridizable with a PKC gene or mRNA. Oligonucleotides specifically hybridizable with a particular PKC isozyme, set of isozymes or mRNA transcript are provided. Methods of treating conditions amenable to therapeutic intervention by modulating protein kinase C expression with an oligonucleotide specifically hybridizable with a PKC gene or mRNA are disclosed. Compositions and methods are provided for the treatment, detection and diagnosis of diseases associated with protein kinase C alpha and specific transcripts thereof. New nucleic acid sequences are provided which encode 3' untranslated regions of human protein kinase C alpha polynucleotide probes for PKC alpha are also disclosed.
摘要翻译： PCT No.PCT / US94 / 07770 Sec。 371日期1996年1月11日 102（e）日期1996年1月11日PCT提交1994年7月8日PCT公布。 出版物WO95 / 02069 日期1995年1月19日提供了用于治疗和诊断与蛋白激酶C相关的疾病的组合物和方法。提供与PKC基因或mRNA特异性杂交的寡核苷酸。 提供了与特定的PKC同功酶特异性杂交的寡核苷酸，一组同功酶或mRNA转录物。 公开了通过用与PKC基因或mRNA特异性杂交的寡核苷酸调节蛋白激酶C表达来治疗适于治疗干预的病症的方法。 提供组合物和方法用于治疗，检测和诊断与蛋白激酶Cα相关的疾病及其特异性转录物。 提供了新的核酸序列，其编码编码PKCα的人蛋白激酶C 3多核苷酸探针的3'非翻译区。
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12.发明授权Antisense oligonucleotides to human serine/threonine protein phosphatase genes 失效人类丝氨酸/苏氨酸蛋白磷酸酶基因的反义寡核苷酸
公开(公告)号：US5948902A
公开(公告)日：1999-09-07
申请号：US975211
申请日：1997-11-20
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K48/00 , A61P35/00 , A61P43/00 , C12N15/113 , C07H21/04 , C12Q1/68
CPC分类号： C12N15/1137 , C12Y301/03016 , A61K38/00 , C12N2310/321 , C12N2310/322 , C12N2310/334 , C12N2310/335 , C12N2310/341 , C12N2310/345
摘要： Oligonucleotides are provided which are targeted to nucleic acids encoding human serine/threonine protein phosphatases and which are capable of inhibiting protein phosphatase expression. Methods of inhibiting the expression of human protein serine/threonine phosphatases using oligonucleotides of the invention are also provided. The present invention further comprises methods of preventing or inhibiting hyperproliferation of cells and methods of treating abnormal conditions, including cancer, using oligonucleotides of the invention.
摘要翻译： 提供寡核苷酸，其靶向编码人丝氨酸/苏氨酸蛋白磷酸酶的核酸，并且其能够抑制蛋白质磷酸酶表达。 还提供了使用本发明的寡核苷酸抑制人蛋白质丝氨酸/苏氨酸磷酸酶表达的方法。 本发明还包括使用本发明的寡核苷酸来预防或抑制细胞过度增殖的方法和治疗包括癌症在内的异常病症的方法。
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13.发明授权Antisense oligonucleotide modulation of multidrug resistance-associated protein 失效多药耐药相关蛋白的反义寡核苷酸调控
公开(公告)号：US5801154A
公开(公告)日：1998-09-01
申请号：US835770
申请日：1997-04-08
CPC分类号： C12N15/1138 , C07H21/00 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3517
摘要： Compositions and methods are provided for the treatment and diagnosis of diseases or conditions amenable to treatment through modulation of the synthesis or metabolism of multidrug resistance-associated protein (MRP). In accordance with referred embodiments, oligonucleotides are provided which are specifically hybridizable with nucleic acids encoding MRP. In a preferred embodiment, the oligonucleotide has at least one 2'-methoxyethoxy modification. Methods of preventing the development of multidrug resistance and of improving the efficacy of chemotherapy are also disclosed.
摘要翻译： 提供组合物和方法用于治疗和诊断适于通过调节多药耐药相关蛋白（MRP）的合成或代谢来治疗的疾病或病症。 根据所提及的实施方案，提供了与编码MRP的核酸特异性杂交的寡核苷酸。 在优选的实施方案中，寡核苷酸具有至少一个2'-甲氧基乙氧基修饰。 还公开了预防多药耐药性发展和提高化学疗效的方法。
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公开(公告)号：US5744460A
公开(公告)日：1998-04-28
申请号：US612775
申请日：1996-03-07
申请人： Marcel Muller , Thomas Geiger , Karl-Heinz Altmann , Doriano Fabbro , Nicholas M. Dean , Brett Monia , Clarence Frank Bennett
发明人： Marcel Muller , Thomas Geiger , Karl-Heinz Altmann , Doriano Fabbro , Nicholas M. Dean , Brett Monia , Clarence Frank Bennett
IPC分类号： A61K45/06 , A61K31/44 , A61K31/445 , A61K31/505 , A61K31/53 , A61K31/70 , A61K48/00 , C07H21/04
摘要： The invention relates to combinations of PKC-targeted (especially PKC-.alpha.-targeted) deoxyribo- and ribo-oligonucleotides and derivatives thereof with other chemotherapeutic compounds, as well as to pharmaceutical preparations and/or therapies, in relation to disease states which respond to such oligonucleotides or oligonucleotide derivatives, especially to to modulation of the activity of a regulatory protein. In particular, the invention relates to products or combinations comprising antisense oligonucleotides or oligonucleotide derivatives targeted to nucleic acids encoding human PKC and other (preferably standard) chemotherapeutics, either in fixed combination or for chronologically staggered or simultaneous administration, and the combined use of both classes of compounds, either in fixed combination or for chronologically staggered or simultaneous administration, for the treatment of proliferative diseases, especially tumor diseases, that can be treated by inhibition of PKC activity, that is, where the antisense oligonucleotides or oligonucleotide derivatives are targeted to nucleic acids encoding the regulatory protein PKC or active mutated derivatives thereof.
摘要翻译： 本发明涉及PKC靶向（特别是PKC-α靶向的）脱氧核糖核苷酸和核糖寡核苷酸及其衍生物与其它化学治疗化合物的组合，以及关于响应于所述药物的疾病状态的药物制剂和/或治疗 这样的寡核苷酸或寡核苷酸衍生物，特别是调节调节蛋白的活性。 特别地，本发明涉及包含针对编码人PKC的核酸的反义寡核苷酸或寡核苷酸衍生物或其它（优选标准的）化学治疗剂的产品或组合，其以固定组合或按时间顺序交错或同时施用，以及两类的组合使用 的化合物，以固定组合或按时间顺序交错或同时给药，用于治疗可通过抑制PKC活性治疗的增殖性疾病，特别是肿瘤疾病，即反义寡核苷酸或寡核苷酸衍生物靶向核酸 编码调节蛋白PKC的酸或其活性突变衍生物。
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公开(公告)号：US20090270491A1
公开(公告)日：2009-10-29
申请号：US12488394
申请日：2009-06-19
CPC分类号： C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of Tudor-SN. The compositions comprise oligonucleotides, targeted to nucleic acid encoding Tudor-SN. Methods of using these compounds for modulation of Tudor-SN expression and for diagnosis and treatment of diseases and conditions associated with expression of Tudor-SN are provided.
摘要翻译： 提供化合物，组合物和方法用于调节Tudor-SN的表达。 组合物包含靶向编码Tudor-SN的核酸的寡核苷酸。 提供了使用这些化合物调节Tudor-SN表达和诊断和治疗与Tudor-SN表达相关的疾病和病症的方法。
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公开(公告)号：US06653133B1
公开(公告)日：2003-11-25
申请号：US09665615
申请日：2000-09-18
IPC分类号： C07H2104
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for inhibiting Fas mediated signaling. The compositions comprise antisense compounds targeted to nucleic acids encoding Fas, FasL and Fap-1. Methods of using these antisense compounds for inhibition of Fas, FasL and Fap-1 expression and for treatment of diseases, particularly autoimmune and inflammatory diseases and cancers, associated with overexpression or constitutive activation of Fas, FasL or Fap-1 are provided.
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17.发明授权公开(公告)号：US06599742B2
公开(公告)日：2003-07-29
申请号：US09825497
申请日：2001-04-03
IPC分类号： C07H2104
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/321 , C12N2310/322 , C12N2310/334 , C12N2310/335 , C12N2310/341 , C12N2310/345 , C12Y301/03016 , C12N2310/3527 , C12N2310/3521 , C12N2310/3525
摘要： Oligonucleotides are provided which are targeted to nucleic acids encoding human serine/threonine protein phosphatases and which are capable of inhibiting protein phosphatase expression. Methods of inhibiting the expression of human protein serine/threonine phosphatases using oligonucleotides of the invention are also provided. The present invention further comprises methods of preventing or inhibiting hyperproliferation of cells and methods of treating abnormal conditions, including cancer, using oligonucleotides of the invention.
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公开(公告)号：US06537973B1
公开(公告)日：2003-03-25
申请号：US10025139
申请日：2001-12-18
IPC分类号： C07H2104
CPC分类号： C12Q1/6883 , A61K38/00 , C07H21/00 , C12N9/12 , C12N15/1137 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/341 , C12N2310/346 , C12N2310/3521 , C12N2310/3527 , C12N2310/3533 , C12Q1/6876 , C12Q2600/158 , C12Y207/11013
摘要： Compositions and methods are provided for the treatment and diagnosis of diseases associated with protein kinase C. Oligonucleotides are provided which are targeted to nucleic acids encoding PKC. In preferred embodiments, the oligonucleotides contain one or more chemical modifications. Methods of modulating PKC expression and of treating animals suffering from disease amenable to therapeutic intervention by modulating protein kinase C expression using oligonucleotides targeted to PKC are disclosed.
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公开(公告)号：US06136603A
公开(公告)日：2000-10-24
申请号：US280799
申请日：1999-03-26
申请人： Nicholas M. Dean , James G. Karras , Robert McKay
发明人： Nicholas M. Dean , James G. Karras , Robert McKay
IPC分类号： C12N15/09 , A61K31/711 , A61K38/00 , A61K48/00 , A61P11/06 , A61P29/00 , A61P35/00 , A61P43/00 , C12N5/02 , C12N15/113 , C07H21/04 , C12N15/85 , C12Q1/68
CPC分类号： C12N15/1136 , C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346
摘要： Compositions and methods are provided for antisense modulation of interleukin-5 signal transduction. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding interleukin-5 and interleukin-5 receptor.alpha. are preferred. Methods of using these compounds for modulation of interleukin-5 signal transduction and for treatment of diseases associated with interleukin-5 signal transduction are also provided.
摘要翻译： 提供组合物和方法用于白细胞介素-5信号转导的反义调节。 针对编码白细胞介素-5和白细胞介素-5受体α的核酸的反义化合物，特别是反义寡核苷酸是优选的。 还提供了使用这些化合物调节白细胞介素-5信号转导和治疗与白细胞介素-5信号转导相关疾病的方法。
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20.发明授权
公开(公告)号：US6087489A
公开(公告)日：2000-07-11
申请号：US89195
申请日：1998-06-02
申请人： Nicholas M. Dean
发明人： Nicholas M. Dean
IPC分类号： A61K38/00 , A61K45/06 , C12N15/113 , C07H21/04 , C12Q1/68
CPC分类号： C12N15/1137 , A61K45/06 , C12Y201/01045 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/334 , C12N2310/341 , C12N2310/346
摘要： Compounds, compositions and methods are provided for modulating the expression of human thymidylate synthase. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding thymidylate synthase. Methods of using these oligonucleotides for modulation of thymidylate synthase expression and for treatment of diseases such as cancers believed to be responsive to modulation of thymidylate synthase expression are provided.
摘要翻译： 提供化合物，组合物和方法用于调节人胸苷酸合酶的表达。 组合物包含靶向编码胸苷酸合酶的核酸的反义寡核苷酸。 提供了使用这些寡核苷酸调节胸苷酸合酶表达和治疗被认为对胸苷酸合酶表达的调节有反应的疾病的疾病的方法。
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