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公开(公告)号：US06630574B1
公开(公告)日：2003-10-07
申请号：US09614124
申请日：2000-07-11
申请人： Tongtong Wang , Chaitanya S. Bangur , Michael J. Lodes , Gary R. Fanger , Thomas S. Vedvick , Darrick Carter , Marc W. Retter , Jane Mannion , Liqun Fan
发明人： Tongtong Wang , Chaitanya S. Bangur , Michael J. Lodes , Gary R. Fanger , Thomas S. Vedvick , Darrick Carter , Marc W. Retter , Jane Mannion , Liqun Fan
IPC分类号： A61K3816
CPC分类号： C07K14/47 , A61K38/00 , C12Q1/6886 , C12Q2600/158
摘要： Compositions comprising isolated cancer-associated L552S polypeptides are disclosed. Such compositions can comprise, for example, portions of said cancer-associated L552S polypeptides and/or the corresponding polynucleotides encoding such portions. Illustrative uses of the compositions, for example in cancer diagnostic methods, are also provided.
摘要翻译： 公开了包含分离的癌相关L552S多肽的组合物。 这样的组合物可以包括例如所述癌相关L552S多肽的部分和/或编码这些部分的相应多核苷酸。 还提供了组合物的说明性用途，例如癌症诊断方法。
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公开(公告)号：US06746846B1
公开(公告)日：2004-06-08
申请号：US09658824
申请日：2000-09-08
申请人： Tongtong Wang , Chaitanya S. Bangur , Michael J. Lodes , Gary R. Fanger , Thomas S. Vedvick , Darrick Carter , Marc W. Retter , Jane Mannion , Liqun Fan
发明人： Tongtong Wang , Chaitanya S. Bangur , Michael J. Lodes , Gary R. Fanger , Thomas S. Vedvick , Darrick Carter , Marc W. Retter , Jane Mannion , Liqun Fan
IPC分类号： G01N33574
CPC分类号： C07K14/47 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C07K2319/00 , C12Q1/6886 , C12Q2600/158
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a lung tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as lung cancer. Diagnostic methods based on detecting a lung tumor protein, or mRNA encoding such a protein, in a sample are also provide.
摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如肺癌。 组合物可以包含一种或多种肺肿瘤蛋白，其免疫原性部分，或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达肺肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可以用于例如预防和治疗诸如肺癌的疾病。 还提供了基于在样品中检测肺肿瘤蛋白或编码这种蛋白的mRNA的诊断方法。
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公开(公告)号：US20090062194A1
公开(公告)日：2009-03-05
申请号：US11929772
申请日：2007-10-30
申请人： Tongtong Wang , Robert A. Henderson , Teresa M. Foy , Patricia D. McNeill , Yoshihiro Watanabe , Michael D. Kalos , Gary R. Fanger , Chaitanya S. Bangur
发明人： Tongtong Wang , Robert A. Henderson , Teresa M. Foy , Patricia D. McNeill , Yoshihiro Watanabe , Michael D. Kalos , Gary R. Fanger , Chaitanya S. Bangur
CPC分类号： G01N33/57411 , A61K39/00 , A61K39/0011 , A61K2039/5154 , A61K2039/5158 , A61K2039/53 , A61K2039/545 , C07K14/47 , C07K14/4748 , C07K16/3023 , C07K2317/21 , C07K2317/34 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/40 , C12N15/86 , C12N2710/10343 , C12N2710/10371 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , G01N33/5088 , G01N33/57423
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
摘要翻译： 公开了用于治疗和诊断癌症，特别是肺癌的组合物和方法。 说明性组合物包含一种或多种肺肿瘤多肽，其免疫原性部分，编码这种多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是肺癌的诊断，预防和/或治疗。
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公开(公告)号：US20080171690A1
公开(公告)日：2008-07-17
申请号：US11929579
申请日：2007-10-30
申请人： Robert A. Henderson , Tongtong Wang , Yoshihiro Watanabe , Michael D. Kalos , Paul R. Sleath , Jeffrey C. Johnson , Marc W. Retter , Margarita Durham , Darrick Carter , Gary R. Fanger , Thomas S. Vedvick , Chaitanya S. Bangur , Andria McNabb
发明人： Robert A. Henderson , Tongtong Wang , Yoshihiro Watanabe , Michael D. Kalos , Paul R. Sleath , Jeffrey C. Johnson , Marc W. Retter , Margarita Durham , Darrick Carter , Gary R. Fanger , Thomas S. Vedvick , Chaitanya S. Bangur , Andria McNabb
CPC分类号： C07K14/4748 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C07K14/47 , C07K16/3023 , C07K2317/34 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C12Q1/6886 , C12Q2600/158 , G01N33/57423
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
摘要翻译： 公开了用于治疗和诊断癌症，特别是肺癌的组合物和方法。 说明性组合物包含一种或多种肺肿瘤多肽，其免疫原性部分，编码这种多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是肺癌的诊断，预防和/或治疗。
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公开(公告)号：US06858204B2
公开(公告)日：2005-02-22
申请号：US10017754
申请日：2001-10-29
申请人： Robert A. Henderson , Tongtong Wang , Yoshihiro Watanabe , Jeffrey C. Johnson , Marc W. Retter , Margarita Durham , Darrick Carter , Gary R. Fanger , Thomas S. Vedvick , Chaitanya S. Bangur , Andria McNabb
发明人： Robert A. Henderson , Tongtong Wang , Yoshihiro Watanabe , Jeffrey C. Johnson , Marc W. Retter , Margarita Durham , Darrick Carter , Gary R. Fanger , Thomas S. Vedvick , Chaitanya S. Bangur , Andria McNabb
CPC分类号： C07K14/47 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C07K2319/00 , C12Q1/6886 , C12Q2600/158
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
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16.发明申请公开(公告)号：US20110177082A1
公开(公告)日：2011-07-21
申请号：US13009413
申请日：2011-01-19
申请人： Chaitanya S. Bangur , Marc W. Retter , Gary R. Fanger , Paul Hill
发明人： Chaitanya S. Bangur , Marc W. Retter , Gary R. Fanger , Paul Hill
IPC分类号： A61K39/395 , C07H21/00 , C07K14/00 , C07K7/00 , C07K16/00 , A61K31/7088 , A61K38/00 , A61K35/12 , A61K39/00 , A61P35/00 , C12N15/63 , G01N33/68 , C12N5/0783 , G01N33/53 , G01N33/566 , C12N1/00 , C12N5/10
CPC分类号： C07K16/3069 , A61K38/00 , A61K39/00 , C07K14/47 , C07K14/4748 , C07K2317/34 , C07K2317/77 , C07K2319/00
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.
摘要翻译： 公开了用于治疗和诊断癌症，特别是卵巢癌的组合物和方法。 说明性组合物包含一个或多个卵巢肿瘤多肽，其免疫原性部分，编码此类多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达此类多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是卵巢癌的诊断，预防和/或治疗。
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17.发明授权公开(公告)号：US06858710B2
公开(公告)日：2005-02-22
申请号：US10198053
申请日：2002-07-17
申请人： Chaitanya S. Bangur , Marc W. Retter , Gary R. Fanger , Paul Hill
发明人： Chaitanya S. Bangur , Marc W. Retter , Gary R. Fanger , Paul Hill
IPC分类号： A61K38/00 , A61K39/00 , C07K14/47 , C07K16/30 , A61K35/14 , A61K39/395 , A61K51/00 , C07K1/00 , C07K16/00
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K14/4748 , C07K16/3069 , C07K2317/34 , C07K2317/77 , C07K2319/00
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.
摘要翻译： 公开了用于治疗和诊断癌症，特别是卵巢癌的组合物和方法。 说明性组合物包含一个或多个卵巢肿瘤多肽，其免疫原性部分，编码此类多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达此类多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是卵巢癌的诊断，预防和/或治疗。
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公开(公告)号：US06933363B1
公开(公告)日：2005-08-23
申请号：US09519642
申请日：2000-03-06
申请人： Tongtong Wang , Chaitanya S. Bangur
发明人： Tongtong Wang , Chaitanya S. Bangur
CPC分类号： C07K14/47 , A61K38/00 , C12Q1/6886 , C12Q2600/158
摘要： Compositions for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise cancer-associated L552S polypeptides, for example, as set forth illustratively in SEQ ID NO:786, or portions or variants thereof. Such compositions may be used, for example, in the diagnosis, prevention, and treatment of diseases such as lung cancer.
摘要翻译： 公开了用于治疗和诊断癌症的组合物，例如肺癌。 组合物可以包含与癌症相关的L552S多肽，例如，如SEQ ID NO：786所示，或其部分或变体。 这样的组合物可以用于例如诊断，预防和治疗诸如肺癌的疾病。
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公开(公告)号：US07579160B2
公开(公告)日：2009-08-25
申请号：US10922124
申请日：2004-08-19
CPC分类号： G01N33/57411 , A61K39/00 , A61K39/0011 , A61K2039/5154 , A61K2039/5158 , A61K2039/53 , A61K2039/545 , C07K14/47 , C07K14/4748 , C07K16/3023 , C07K2317/21 , C07K2317/34 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/40 , C12N15/86 , C12N2710/10343 , C12N2710/10371 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , G01N33/5088 , G01N33/57423
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
摘要翻译： 公开了用于治疗和诊断癌症，特别是肺癌的组合物和方法。 说明性组合物包含一种或多种肺肿瘤多肽，其免疫原性部分，编码这种多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是肺癌的诊断，预防和/或治疗。
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