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11.发明授权公开(公告)号：US10694972B2
公开(公告)日：2020-06-30
申请号：US15536333
申请日：2015-12-15
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Rafael V. Davalos , Mohammad Bonakdar , Eduardo L. Latouche , Roop L. Mahajan , John L. Robertson , Christopher B. Arena , Michael B. Sano
IPC: A61B5/053 , A61B5/01 , G01N33/543
Abstract: Provided herein are devices, systems, and methods for monitoring lesion or treated area in a tissue during focal ablation or cell membrane disruption therapy. Provided herein are embodiments of an electrical conductivity sensor having an impedance sensor, where the impedance sensor can be configured to measure a low-frequency and a high-frequency impedance and a substrate, where the impedance sensor is coupled to the substrate. The substrate can be flexible. In embodiments, the impedance sensor can contain two or more electrical conductors. The electrical conductors can be in a bipolar configuration. The electrical conductors can be in a tetrapolar configuration. In embodiments, the electrical conductivity sensor can have two impedance sensors that can be coupled to the substrate such that they are orthogonal to each other.
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公开(公告)号：US20190351224A1
公开(公告)日：2019-11-21
申请号：US16520901
申请日：2019-07-24
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Michael B. Sano , Christopher B. Arena , Scott S. Verbridge , Rafeal V. Davalos
Abstract: A system and method for selectively treating aberrant cells such as cancer cells through administration of a train of electrical pulses is described. The pulse length and delay between successive pulses is optimized to produce effects on intracellular membrane potentials. Therapies based on the system and method produce two treatment zones: an ablation zone surrounding the electrodes within which aberrant cells are non-selectively killed and a selective treatment zone surrounding the ablation zone within which target cells are selectively killed through effects on intracellular membrane potentials. As a result, infiltrating tumor cells within a tumor margin can be effectively treated while sparing healthy tissue. The system and method are useful for treating various cancers in which solid tumors form and have a chance of recurrence from microscopic disease surrounding the tumor.
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公开(公告)号：US10292755B2
公开(公告)日：2019-05-21
申请号：US15186653
申请日：2016-06-20
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Christopher B. Arena , Rafael V. Davalos , Michael B. Sano
Abstract: The present invention relates to the field of biomedical engineering and medical treatment of diseases and disorders. Methods, devices, and systems for in vivo treatment of cell proliferative disorders are provided. In embodiments, the methods comprise the delivery of high-frequency bursts of bipolar pulses to achieve the desired modality of cell death. More specifically, embodiments of the invention relate to a device and method for destroying aberrant cells, including tumor tissues, using high-frequency, bipolar electrical pulses having a burst width on the order of microseconds and duration of single polarity on the microsecond to nanosecond scale. In embodiments, the methods rely on conventional electroporation with adjuvant drugs or irreversible electroporation to cause cell death in treated tumors. The invention can be used to treat solid tumors, such as brain tumors.
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公开(公告)号：US20170266438A1
公开(公告)日：2017-09-21
申请号：US15310114
申请日：2015-05-12
Applicant: Michael B. SANO , Christopher B. ARENA , Scott S. VERBRIDGE , Rafael V. DAVALOS , Virginia Tech Intellectual Properties, Inc.
Inventor： Michael B. Sano , Christopher B. Arena , Scott S. Verbridge , Rafeal V. Davalos
Abstract: A system and method for selectively treating aberrant cells such as cancer cells through administration of a train of electrical pulses is described. The pulse length and delay between successive pulses is optimized to produce effects on intracellular membrane potentials. Therapies based on the system and method produce two treatment zones: an ablation zone surrounding the electrodes within which aberrant cells are non-selectively killed and a selective treatment zone surrounding the ablation zone within which target cells are selectively killed through effects on intracellular membrane potentials. As a result, infiltrating tumor cells within a tumor margin can be effectively treated while sparing healthy tissue. The system and method are useful for treating various cancers in which solid tumors form and have a chance of recurrence from microscopic disease surrounding the tumor.
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15.发明申请TREATMENT PLANNING FOR ELECTRICAL-ENERGY BASED THERAPIES BASED ON CELL CHARACTERISTICS 审中-公开基于细胞特征的基于电能的治疗方案治疗计划公开(公告)号：US20150289923A1
公开(公告)日：2015-10-15
申请号：US14686380
申请日：2015-04-14
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Rafael V. Davalos , Christopher B. Arena
IPC: A61B18/12
CPC classification number: A61B18/1206 , A61B2018/00613 , A61B2018/00666 , A61B2018/00702 , A61B2018/00988 , A61B2018/143
Abstract: A method for treating a target tissue in a patient in need thereof is provided. The method includes the steps of identifying one or more characteristics of one or more cells of a target tissue; calculating a threshold electric field for inducing IRE in the target tissue based on the one or more characteristics; constructing a treatment protocol of one or more pulse parameters, wherein the treatment protocol is capable of inducing IRE in the target tissue; and delivering the treatment protocol to the target tissue. Systems for treatment planning for medical therapies involving administering electrical treatment energy are also provided.
Abstract translation: 提供了一种用于治疗有需要的患者中的靶组织的方法。 该方法包括识别目标组织的一个或多个细胞的一个或多个特征的步骤; 基于所述一个或多个特征，计算用于在目标组织中诱导IRE的阈值电场; 构建一个或多个脉冲参数的治疗方案，其中所述治疗方案能够在靶组织中诱导IRE; 并将治疗方案递送至靶组织。 还提供了涉及电疗治疗能量的医疗治疗计划的系统。
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Patent Agency Ranking
16.发明公开公开(公告)号：US20240277245A1
公开(公告)日：2024-08-22
申请号：US18404473
申请日：2024-01-04
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Rafael V. Davalos , Mohammad Bonakdar , Eduardo L. Latouche , Roop L. Mahajan , John L. Robertson , Christopher B. Arena , Michael B. Sano
IPC: A61B5/0538 , A61B5/01 , G01N33/543
CPC classification number: A61B5/0538 , A61B5/01 , G01N33/5438
Abstract: Provided herein are devices, systems, and methods for monitoring lesion or treated area in a tissue during focal ablation or cell membrane disruption therapy.
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公开(公告)号：US11638603B2
公开(公告)日：2023-05-02
申请号：US16443351
申请日：2019-06-17
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Michael B. Sano , Christopher B. Arena , Scott S. Verbridge , Rafael V. Davalos
Abstract: The present invention relates to the field of biomedical engineering and medical treatment of diseases and disorders. Methods, devices, and systems for in vivo treatment of cell proliferative disorders are provided. In embodiments, the methods comprise the delivery of high-frequency bursts of bipolar pulses to achieve the desired modality of cell death. More specifically, embodiments of the invention relate to a device and method for destroying aberrant cells, including tumor tissues, using high-frequency, bipolar electrical pulses having a burst width on the order of microseconds and duration of single polarity on the microsecond to nanosecond scale. In embodiments, the methods rely on conventional electroporation with adjuvant drugs or irreversible electroporation to cause cell death in treated tumors. The invention can be used to treat solid tumors, such as brain tumors.
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18.发明授权公开(公告)号：US11382681B2
公开(公告)日：2022-07-12
申请号：US16372520
申请日：2019-04-02
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Christopher B. Arena , Rafael V. Davalos , Michael B. Sano
Abstract: The present invention relates to the field of biomedical engineering and medical treatment of diseases and disorders. Methods, devices, and systems for in vivo treatment of cell proliferative disorders are provided. In embodiments, the methods comprise the delivery of high-frequency bursts of bipolar pulses to achieve the desired modality of cell death. More specifically, embodiments of the invention relate to a device and method for destroying aberrant cells, including tumor tissues, using high-frequency, bipolar electrical pulses having a burst width on the order of microseconds and duration of single polarity on the microsecond to nanosecond scale. In embodiments, the methods rely on conventional electroporation with adjuvant drugs or irreversible electroporation to cause cell death in treated tumors. The invention can be used to treat solid tumors, such as brain tumors.
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公开(公告)号：US20220151688A1
公开(公告)日：2022-05-19
申请号：US17591992
申请日：2022-02-03
Applicant: Virginia Tech Intellectual Properties Inc.
Inventor： Paulo A. Garcia , Christopher B. Arena , Michael B. Sano , Rafael V. Davalos
Abstract: Systems and methods are provided for modeling and for providing a graphical representation of tissue heating and electric field distributions for medical treatment devices that apply electrical treatment energy through one or a plurality of electrodes. In embodiments, methods comprise: providing one or more parameters of a treatment protocol for delivering one or more electrical pulses to tissue through a plurality of electrodes; modeling electric and heat distribution in the tissue based on the parameters; and displaying a graphical representation of the modeled electric and heat distribution. In another embodiment, a treatment planning module is adapted to generate an estimated target ablation zone based on a combination of one or more parameters for an irreversible electroporation protocol and one or more tissue-specific conductivity parameters.
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公开(公告)号：US20210023362A1
公开(公告)日：2021-01-28
申请号：US16938778
申请日：2020-07-24
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Melvin F. Lorenzo , Christopher B. Arena , Suyashree Bhonsle , Natalie White , Lucy Epshteyn , Rafael V. Davalos
Abstract: Electroporation-based therapies (EBTs) employ high voltage pulsed electric fields (PEFs) to permeabilize tumor tissue, resulting in changes in passive electrical properties detectable using electrical impedance spectroscopy (EIS). Currently, commercial potentiostats for EIS are limited by impedance spectrum acquisition time (˜10 s); this timeframe is much larger than pulse periods used with EBTs (˜1 s). Fourier Analysis SpecTroscopy (FAST) is introduced as a methodology for monitoring tissue inter-burst impedance (diagnostic FAST) and intra-burst impedance (therapeutic FAST) during EBTs. FAST is a rapid-capture (
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