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11.发明授权Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases 失效可用于抑制G蛋白功能和治疗增殖性疾病的三环酰胺和尿素化合物公开(公告)号：US06365588B1
公开(公告)日：2002-04-02
申请号：US09350870
申请日：1999-07-09
申请人： Robert W. Bishop , Ronald J. Doll , Alan K. Mallams , F. George Njoroge , Joanne M. Petrin , John J. Piwinski , Ronald L. Wolin , Arthur G. Taveras , Stacy W. Remiszewski
发明人： Robert W. Bishop , Ronald J. Doll , Alan K. Mallams , F. George Njoroge , Joanne M. Petrin , John J. Piwinski , Ronald L. Wolin , Arthur G. Taveras , Stacy W. Remiszewski
IPC分类号： A61K3154
CPC分类号： C07D231/12 , A61K31/444 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/50 , A61K31/505 , C07D221/16 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： A method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells is disclosed. The method comprises the administration of a compound of Formula 1.0: to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being. Novel compounds of the formulas 5.0, 5.1 and 5.2, wherein R is —C(R20)(R21)(R46), and 5.3, 5.3A and 5.3B, wherein R is —N(R25)(R48), are disclosed. Also disclosed are processes for making 3-substituted compounds of Formulas 5.0, 5.1, 5.2 and 5.3. Further disclosed are novel compounds which are intermediates in the process for making 3-substituted compounds of Formulas 5.0, 5.1, 5.2 and 5.3.
摘要翻译： 公开了抑制Ras功能并因此抑制细胞异常生长的方法。 该方法包括向生物系统施用式1.0化合物。 特别地，该方法抑制哺乳动物如人的细胞的异常生长。式5.0,5.1和5.2的新型化合物，其中R是-C（R 20）（R 21）（R 46）和5.3,5.3 A和5.3B，其中R是-N（R25）（R48）。还公开了制备式5.0,5.1,5.2和5.3的3-取代的化合物的方法。进一步公开的是新化合物，其是 制备式5.0,5.1,5.2和5.3的3-取代的化合物的方法。
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公开(公告)号：US5977128A
公开(公告)日：1999-11-02
申请号：US971099
申请日：1997-11-14
申请人： Robert W. Bishop , Ronald J. Doll , Alan K. Mallams , F. George Njoroge , Joanne M. Petrin , John J. Piwinski , Ronald L. Wolin , Arthur G. Taveras , Stacy W. Remiszewski
发明人： Robert W. Bishop , Ronald J. Doll , Alan K. Mallams , F. George Njoroge , Joanne M. Petrin , John J. Piwinski , Ronald L. Wolin , Arthur G. Taveras , Stacy W. Remiszewski
IPC分类号： A61K31/435 , A61K31/4375 , A61K31/4545 , A61K31/495 , A61K31/496 , A61P35/00 , C07D221/06 , C07D221/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04
CPC分类号： C07D401/12 , A61K31/4545 , A61K31/496 , C07D221/16 , C07D401/04 , C07D401/14
摘要： A method of inhibiting Ras function and therefore inhibiting cellular growth is disclosed. The method comprises the administration of a compound of Formula 1.0 ##STR1## Also disclosed are novel compounds of the formulas: ##STR2## Also disclosed are processes for making 3-substituted compounds of the Formulas 1.1, 1.2 and 1.3.Further disclosed are novel compounds which are intermediates in the processes for making the 3-substituted compounds of Formulas 1.1, 1.2, and 1.3.
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13.发明授权Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease 失效用于抑制G蛋白功能和治疗增殖性疾病的三环酰胺
公开(公告)号：US5874442A
公开(公告)日：1999-02-23
申请号：US766601
申请日：1996-12-12
申请人： Ronald J. Doll , Joseph M. Kelly , Alan K. Mallams , F. George Njoroge , Stacy W. Remiszewski , Arthur G. Taveras
发明人： Ronald J. Doll , Joseph M. Kelly , Alan K. Mallams , F. George Njoroge , Stacy W. Remiszewski , Arthur G. Taveras
IPC分类号： A61P35/00 , C07D401/14 , A61K31/44 , C07D221/16
CPC分类号： C07D401/14
摘要： "Novel compounds, such as: ##STR1## are disclosed. Also disclosed are methods for inhibiting the abnormal growth of cells, for inhibiting farnesyl protein transferase and for treating cancers using the novel compounds."
摘要翻译： （图）（IMAGE）（27.0）
（27.0） （32.0） （39.0） 用于抑制细胞的异常生长，用于抑制法呢基蛋白转移酶和使用新化合物治疗癌症。 -
14.发明授权Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases 失效可用于抑制G蛋白功能和治疗增殖性疾病的三环化合物
公开(公告)号：US5712280A
公开(公告)日：1998-01-27
申请号：US418973
申请日：1995-04-07
申请人： Ronald J. Doll , Alan K. Mallams , Adriano Afonso , Dinanath F. Rane , Randall R. Rossman , F. George Njoroge
发明人： Ronald J. Doll , Alan K. Mallams , Adriano Afonso , Dinanath F. Rane , Randall R. Rossman , F. George Njoroge
IPC分类号： A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/47 , A61K31/473 , A61K31/495 , A61P35/00 , A61P43/00 , C07D211/32 , C07D213/28 , C07D221/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D409/12 , C07D491/04 , C07D491/044
CPC分类号： C07D401/12 , C07D211/32 , C07D221/16 , C07D401/14 , C07D409/12 , C07D491/04
摘要： Novel compounds of Formula ##STR1## are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the Formula 1.0 to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.
摘要翻译： 公开了新颖的式（IMAGE）化合物。 还公开了抑制Ras功能并因此抑制细胞异常生长的方法。 该方法包括向生物系统施用式1.0的化合物。 特别地，该方法抑制哺乳动物例如人的细胞的异常生长。
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15.发明授权Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases 失效可用于抑制G蛋白功能和治疗增殖性疾病的三环化合物
公开(公告)号：US5672611A
公开(公告)日：1997-09-30
申请号：US446265
申请日：1995-05-22
申请人： Ronald J. Doll , Alan K. Mallams , Adriano Afonso , Dinanath F. Rane , Randall R. Rossman , F. George Njoroge
发明人： Ronald J. Doll , Alan K. Mallams , Adriano Afonso , Dinanath F. Rane , Randall R. Rossman , F. George Njoroge
IPC分类号： A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/47 , A61K31/473 , A61K31/495 , A61P35/00 , A61P43/00 , C07D211/32 , C07D213/28 , C07D221/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D409/12 , C07D491/04 , C07D491/044 , C07D211/06
CPC分类号： C07D401/12 , C07D211/32 , C07D221/16 , C07D401/14 , C07D409/12 , C07D491/04
摘要： Novel compounds of Formula ##STR1## are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the Formula 1.0 to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.
摘要翻译： 公开了新颖的式（IMAGE）化合物。 还公开了抑制Ras功能并因此抑制细胞异常生长的方法。 该方法包括向生物系统施用式1.0的化合物。 特别地，该方法抑制哺乳动物例如人的细胞的异常生长。
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公开(公告)号：US06576639B1
公开(公告)日：2003-06-10
申请号：US09520449
申请日：2000-03-08
申请人： Ronald J. Doll , Joseph M. Kelly , Alan K. Mallams , F. George Njoroge , Stacy W. Remiszewski , Arthur G. Taveras
发明人： Ronald J. Doll , Joseph M. Kelly , Alan K. Mallams , F. George Njoroge , Stacy W. Remiszewski , Arthur G. Taveras
IPC分类号： A61K3144
CPC分类号： C07D401/14
摘要： Novel compounds, such as: are disclosed. Also disclosed are methods for inhibiting the abnormal growth of cells, for inhibiting farnesyl protein transferase and for treating cancers using the novel compounds.
摘要翻译： 还公开了新的化合物，例如：。还公开了抑制细胞异常生长，抑制法呢基蛋白转移酶和使用新化合物治疗癌症的方法。
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17.发明授权Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease 有权用于抑制G蛋白功能和治疗增殖性疾病的三环酰胺公开(公告)号：US06214828B1
公开(公告)日：2001-04-10
申请号：US09190362
申请日：1998-11-12
申请人： Ronald J. Doll , Joseph M. Kelly , Alan K. Mallams , F. George Njoroge , Stacy W. Remiszewski , Arthur G. Taveras
发明人： Ronald J. Doll , Joseph M. Kelly , Alan K. Mallams , F. George Njoroge , Stacy W. Remiszewski , Arthur G. Taveras
IPC分类号： A61K31496
CPC分类号： C07D401/14
摘要： Novel compounds, such as: are disclosed. Also disclosed are methods for inhibiting the abnormal growth of cells, for inhibiting farnesyl protein transferase and for treating cancers using the novel compounds.
摘要翻译： 公开了新的化合物，如：。 还公开了抑制细胞异常生长，抑制法呢基蛋白转移酶和使用新化合物治疗癌症的方法。
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18.发明授权Tricyclic piperidinyl compounds useful as inhibitors of farnesyl-protein transferase 失效可用作法呢基蛋白转移酶抑制剂的三环哌啶基化合物
公开(公告)号：US5965570A
公开(公告)日：1999-10-12
申请号：US927729
申请日：1997-09-11
申请人： Alan B. Cooper , Alan K. Mallams , Viyyoor M. Girijavallabhan , Ronald J. Doll , Arthur G. Taveras , F. George Njoroge , John J. Baldwin , John C. Reader
发明人： Alan B. Cooper , Alan K. Mallams , Viyyoor M. Girijavallabhan , Ronald J. Doll , Arthur G. Taveras , F. George Njoroge , John J. Baldwin , John C. Reader
IPC分类号： C07D221/06 , C07D401/14 , A61K31/44
CPC分类号： C07D401/14 , C07D221/06
摘要： Novel tricyclic compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel tricyclic compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human.
摘要翻译： 公开了新的三环化合物和药物组合物，其是酶的抑制剂，法呢基蛋白转移酶。 还公开了抑制Ras功能并因此抑制细胞异常生长的方法。 该方法包括将新型三环化合物施用于生物系统。 特别地，该方法抑制哺乳动物（例如人）中细胞的异常生长。
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19.发明授权
公开(公告)号：US5958940A
公开(公告)日：1999-09-28
申请号：US927728
申请日：1997-09-11
申请人： Dinanath F. Rane , Alan B. Cooper , Alan K. Mallams , Ronald J. Doll , F. George Njoroge , Arthur G. Taveras
发明人： Dinanath F. Rane , Alan B. Cooper , Alan K. Mallams , Ronald J. Doll , F. George Njoroge , Arthur G. Taveras
IPC分类号： C07D401/14 , A61K31/44
CPC分类号： C07D401/14
摘要： Novel tricyclic compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel tricyclic compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.
摘要翻译： 公开了新的三环化合物和药物组合物，其是酶的抑制剂，法呢基蛋白转移酶。 还公开了抑制Ras功能并因此抑制细胞异常生长的方法。 该方法包括将新型三环化合物施用于生物系统。 特别地，该方法抑制哺乳动物如人的细胞的异常生长。
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20.发明授权Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases 失效用于抑制G蛋白功能和治疗增殖性疾病的三环化合物
公开(公告)号：US5801175A
公开(公告)日：1998-09-01
申请号：US713324
申请日：1996-09-13
申请人： Adriano Afonso , John J. Baldwin , Ronald J. Doll , Ge Li , Alan K. Mallams , F. George Njoroge , Dinanath F. Rane , John C. Reader , Randall R. Rossman
发明人： Adriano Afonso , John J. Baldwin , Ronald J. Doll , Ge Li , Alan K. Mallams , F. George Njoroge , Dinanath F. Rane , John C. Reader , Randall R. Rossman
IPC分类号： A61P35/00 , C07D221/16 , C07D401/04 , C07D401/12 , C07D491/04 , A61K31/495 , A61K31/505 , C07D401/14 , C07D403/14
CPC分类号： C07D401/04 , C07D221/16 , C07D401/12 , C07D491/04
摘要： Novel compounds of Formula ##STR1## are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the above formula to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.
摘要翻译： 公开了新颖的式（IMAGE）化合物。 还公开了抑制Ras功能并因此抑制细胞异常生长的方法。 该方法包括将上述式的化合物施用于生物系统。 特别地，该方法抑制哺乳动物例如人的细胞的异常生长。
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