公开(公告)号：US20110166159A1

公开(公告)日：2011-07-07

申请号：US13050356

申请日：2011-03-17

申请人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

发明人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

IPC分类号： A61K31/497 ,  C07D409/04 ,  A61K31/381 ,  C07D401/04 ,  A61K31/4436 ,  C07D403/04 ,  A61K31/506 ,  A61K31/405 ,  A61K31/4184 ,  C07D417/14 ,  A61K31/428 ,  C07D401/14 ,  A61K31/4709 ,  A61K31/4155 ,  A61K31/4535 ,  A61P1/00 ,  A61P19/02 ,  A61P3/10 ,  A61P25/28 ,  A61P17/06 ,  A61P37/06 ,  A61P7/06

CPC分类号： C07D409/04 ,  C07D333/38 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

公开(公告)号：US07906553B2

公开(公告)日：2011-03-15

申请号：US12548189

申请日：2009-08-26

申请人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

发明人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

IPC分类号： A61K31/38

CPC分类号： C07D409/04 ,  C07D333/38 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04

摘要： Described herein are compounds of Formula (I) having the structure: where A, J, R1, R4, Z and X are described herein; and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

摘要翻译： 本文描述了具有以下结构的式（I）的化合物：其中A，J，R 1，R 4，Z和X在本文中描述; 和含有这种化合物的药物组合物，其调节储存操作的钙（SOC）通道的活性。 本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。

公开(公告)号：US10967314B2

公开(公告)日：2021-04-06

申请号：US16655243

申请日：2019-10-17

申请人： Zhijun Wang

发明人： Zhijun Wang ,  Jinmei Zhang

IPC分类号： B01D35/26 ,  B01D35/157 ,  C02F1/00 ,  B01D29/64

摘要： The present disclosure provides a water floating object treatment device for sewage treatment, including water pump, motor, round box, butt joint hole, liquid inlet pipe, electric adjusting valve, pneumatic controller, round frame, slurry pump, round tube, three-blade long plate, fan-shaped scraping plate, fine screw rod, guide sliding rod, wire brush bristle, assembling hole, fine-hole filter plate, strip hole, round plate, air cylinder, rubber round block, fan-shaped hole, threaded hole, and sliding hole. The present disclosure is reasonable in design, and function of filtering water in a treatment tank is realized. By replacing and installing the fine-hole filter plates with different sizes of holes, different degrees of filter effects are achieved. Meanwhile, the filtered water can be injected into corresponding treatment tank.

公开(公告)号：US20150065676A1

公开(公告)日：2015-03-05

申请号：US14394741

申请日：2012-10-08

申请人： Zhijun WANG

发明人： Zhijun Wang

IPC分类号： C08G18/78 ,  C08G18/42 ,  C08G18/48 ,  C08G18/79

CPC分类号： C08G18/283 ,  B01F17/005 ,  C08G18/284 ,  C08G18/285 ,  C08G18/2865 ,  C08G18/2875 ,  C08G18/4277 ,  C08G18/4833 ,  C08G18/7887 ,  C08G18/79 ,  C08G18/792 ,  C08G18/795 ,  C09D5/4461 ,  C09D5/4488 ,  C09D7/40 ,  C09D11/037 ,  C09D11/102 ,  C09D17/003 ,  C09D17/004

摘要： The present invention is related to a polyurethane dispersant and a preparation method thereof. The polyurethane dispersant is terminated by a nitrogen-containing heterocyclic compound during synthesis. The nitrogen-containing heterocyclic compound is prepared by subjecting anhydride and a compound containing a primary amine and a secondary amine or a hydroxyl or mercapto group to dehydration condensation. The condensed product is the nitrogen-containing heterocyclic compound, containing a reactive hydrogen. The structural formula of the compound containing the primary amine and the secondary amine or hydroxyl or mercapto group is shown as follows: wherein n=1 to 5, and preferably 2 to 4, R1 and R2 are respectively alkyls containing 1 to 8 carbons, R1 and R2 are independent of each other or connected by a chemical bond to form one or more saturated or unsaturated 4-member to 8-member rings, and X represents N, O, or S.

摘要翻译： 本发明涉及一种聚氨酯分散剂及其制备方法。 在合成过程中，聚氨酯分散剂被含氮杂环化合物封端。 含氮杂环化合物通过使酸酐和含有伯胺和仲胺或羟基或巯基的化合物进行脱水缩合来制备。 缩合产物是含有反应性氢的含氮杂环化合物。 包含伯胺和仲胺或羟基或巯基的化合物的结构式如下：其中n = 1至5，优选2至4，R1和R2分别为含有1至8个碳的烷基，R1 并且R2彼此独立或通过化学键连接以形成一个或多个饱和或不饱和的4元件至8元环，X表示N，O或S.

公开(公告)号：US08754219B2

公开(公告)日：2014-06-17

申请号：US13643537

申请日：2011-04-27

申请人： Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

发明人： Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

IPC分类号： A61K31/44 ,  C07D221/02

CPC分类号： C07D417/12 ,  C07C233/75 ,  C07C233/80 ,  C07C233/92 ,  C07C255/60 ,  C07C2601/02 ,  C07D213/81 ,  C07D231/12 ,  C07D231/14 ,  C07D231/16 ,  C07D231/18 ,  C07D231/56 ,  C07D263/57 ,  C07D277/34 ,  C07D277/56 ,  C07D317/62 ,  C07D333/38 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

摘要翻译： 本文描述了含有这种化合物的化合物和药物组合物，其调节储存操作的钙（SOC）通道的活性。 本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。

公开(公告)号：US08618307B2

公开(公告)日：2013-12-31

申请号：US12883014

申请日：2010-09-15

申请人： Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers

发明人： Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers

IPC分类号： C07D263/58

CPC分类号： C07D409/12 ,  C07D333/38 ,  C07D409/14 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

公开(公告)号：US08372991B2

公开(公告)日：2013-02-12

申请号：US13050356

申请日：2011-03-17

申请人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

发明人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

IPC分类号： C07D409/00

CPC分类号： C07D409/04 ,  C07D333/38 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04

摘要： Described herein are compounds of Formula (I): wherein A, J, Z, X, R1 and R4 are defined herein, and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

摘要翻译： 本文描述的是式（I）的化合物：其中A，J，Z，X，R 1和R 4在本文中定义，以及含有这种化合物的药物组合物，其调节储存操作的钙（SOC）通道的活性。 本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。

公开(公告)号：US20110136816A1

公开(公告)日：2011-06-09

申请号：US13006701

申请日：2011-01-14

申请人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

发明人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

IPC分类号： A61K31/498 ,  A61K31/433 ,  A61K31/423 ,  A61K31/381 ,  A61K31/428 ,  A61K31/437 ,  A61K31/4436 ,  A61K31/502 ,  A61P37/06 ,  A61P37/08 ,  A61P29/00 ,  A61P11/06 ,  A61P21/00 ,  A61P17/00 ,  A61P1/16

CPC分类号： C07D409/04 ,  C07D333/38 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

摘要翻译： 本文描述了含有这种化合物的化合物和药物组合物，其调节储存操作的钙（SOC）通道的活性。 本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。

公开(公告)号：US20110065724A1

公开(公告)日：2011-03-17

申请号：US12883014

申请日：2010-09-15

申请人： Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers

发明人： Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers

IPC分类号： A61K31/497 ,  C07D409/12 ,  A61K31/381 ,  C07D495/04 ,  C07D333/38 ,  C07D403/14 ,  C07D403/12 ,  A61K31/416 ,  C07D417/12 ,  A61K31/428 ,  A61P1/00 ,  A61P19/00 ,  A61P3/10 ,  A61P17/06

CPC分类号： C07D409/12 ,  C07D333/38 ,  C07D409/14 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

公开(公告)号：US20100273797A1

公开(公告)日：2010-10-28

申请号：US12829701

申请日：2010-07-02

申请人： Erik Boman ,  Susana Conde Ceide ,  Russell Dahl ,  Nancy G. J. Delaet ,  Justin Ernst ,  Antonio Garrido Montalban ,  Jeffrey Kahl ,  Christopher Larson ,  Stephen Miller ,  Hiroshi Nakanishi ,  Edward Roberts ,  Eddine Saiah ,  Robert Sullivan ,  Zhijun Wang

发明人： Erik Boman ,  Susana Conde Ceide ,  Russell Dahl ,  Nancy G. J. Delaet ,  Justin Ernst ,  Antonio Garrido Montalban ,  Jeffrey Kahl ,  Christopher Larson ,  Stephen Miller ,  Hiroshi Nakanishi ,  Edward Roberts ,  Eddine Saiah ,  Robert Sullivan ,  Zhijun Wang

IPC分类号： A61K31/5377 ,  A61K31/5375 ,  A61K31/437 ,  A61P9/00 ,  A61P19/02 ,  A61P1/00 ,  A61P29/00 ,  A61P37/06 ,  A61P25/00 ,  A61P25/28 ,  A61P3/04 ,  A61P17/00

CPC分类号： A61K31/416 ,  C07D207/40 ,  C07D231/12 ,  C07D231/40 ,  C07D239/47 ,  C07D249/12 ,  C07D253/075 ,  C07D295/088 ,  C07D403/12 ,  C07D471/04 ,  C07D487/04 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/411

摘要： The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions medicated by cytokines such as arthritis.

摘要翻译： 本发明提供可用作细胞因子抑制剂的低分子量化合物及其组合物。 特别地，本发明的化合物可用作抗炎剂。 还提供了用于制备这些药剂的方法及其在预防或治疗由诸如关节炎的细胞因子药物治疗的病症中的用途。