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73 条记录 (耗时 0.037 秒)

    Diffusion-controllable coatings on medical device
    12.
    发明授权
    Diffusion-controllable coatings on medical device 有权
    医疗器械上的扩散可控涂层

    公开(公告)号：US06827966B2

    公开(公告)日：2004-12-07

    申请号：US10153063

    申请日：2002-05-22

    申请人： Yongxing Qiu ,  Fiona Patricia Carney ,  Nichola Kotov ,  John Martin Lally ,  Carol Ann Morris ,  Lynn Cook Winterton

    发明人： Yongxing Qiu ,  Fiona Patricia Carney ,  Nichola Kotov ,  John Martin Lally ,  Carol Ann Morris ,  Lynn Cook Winterton

    IPC分类号： B05D300

    CPC分类号： A61L27/34 ,  A61L27/306 ,  A61L31/088 ,  A61L31/10 ,  G02B1/043

    摘要： The present invention provides a method for forming on a medical device, preferably an ophthalmic lens, more preferably a contact lens, a diffusion-controllable coating capable of controlling the out-diffusion or release of guest materials from the medical device. The method of the invention comprises: (1) applying one layer of clay and optionally one or more layers of polyionic materials onto the medical device; or (2) applying alternatively a layer of a first polyionic material and a layer of a second polyionic material having charges opposite of the charges of the first polyionic material onto the medical device and releasing the coated medical device into a releasing medium having a composition capable of imparting a desired permeability to the diffusion-controllable coating on the medical device.

    摘要翻译： 本发明提供了一种用于在医疗装置上形成的方法，优选为眼科镜片，更优选隐形眼镜，能够控制来自医疗装置的客体材料的扩散或释放的扩散控制涂层。 本发明的方法包括：（1）将一层粘土和任选的一层或多层聚离子材料施加到医疗装置上; 或（2）交替地将第一聚离子材料层和具有与第一聚离子材料的电荷相反的电荷的第二聚离子材料层施加到医疗装置上，并将涂覆的医疗装置释放到具有能够 对所述医疗装置上的扩散可控涂层施加期望的渗透性。

    Single-dip process for achieving a layer-by-layer-like coating
    13.
    发明授权
    Single-dip process for achieving a layer-by-layer-like coating 有权
    用于实现逐层状涂层的单浸渍工艺

    公开(公告)号：US06793973B2

    公开(公告)日：2004-09-21

    申请号：US09775104

    申请日：2001-02-01

    申请人： Lynn Cook Winterton ,  John Martin Lally ,  Michael Rubner ,  Yongxing Qiu

    发明人： Lynn Cook Winterton ,  John Martin Lally ,  Michael Rubner ,  Yongxing Qiu

    IPC分类号： B05D134

    CPC分类号： G02B1/043 ,  A61L27/34 ,  B05D1/185 ,  B05D7/52 ,  C08J7/04 ,  C08J2375/04

    摘要： A method of forming a coating of polyionic materials in a layer-by-layer-like manner onto a polymeric material is provided. A polymeric material, such as a contact lens, can be dipped once into a solution of polyionic materials such that layers of polyionic material can be formed thereon. A single dip solution of the present invention typically contains a polyanionic material and a polycationic material in a non-stoichiometric amount and maintained within a certain pH range.

    摘要翻译： 提供了将聚离子材料的涂层以逐层状的方式形成在聚合物材料上的方法。 诸如隐形眼镜的聚合物材料可以浸渍一次到聚离子材料的溶液中，使得可以在其上形成聚离子材料层。 本发明的单浸液通常含有非离子性材料和非化学计量的聚阳离子材料并保持在一定pH范围内。

    Method for applying lubricious coating to a polymeric article
    15.
    发明授权
    Method for applying lubricious coating to a polymeric article 有权
    将润滑涂层施加到聚合物制品上的方法

    公开(公告)号：US07798639B2

    公开(公告)日：2010-09-21

    申请号：US11076391

    申请日：2005-03-09

    申请人： Lynn Cook Winterton ,  Yongxing Qiu ,  John Martin Lally ,  Manal M. Gabriel

    发明人： Lynn Cook Winterton ,  Yongxing Qiu ,  John Martin Lally ,  Manal M. Gabriel

    IPC分类号： G02C7/04

    CPC分类号： G02B1/043 ,  A61L27/34 ,  A61L31/10 ,  A61L2400/10 ,  Y10T428/31667 ,  Y10T428/31884 ,  Y10T428/31891 ,  Y10T428/31935 ,  Y10T428/31971

    摘要： The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a lubricious coating including a capping layer of polyvinylpyrrolidone and/or at least one layer of a lubricious coating material and one layer of a polyionic material having charges opposite of the charges of the lubricious coating material. The lubricious coating on the medical device of the invention has increased lubricity, preferably characterized by an averaged CoF of about 3.0 or less, increased hydrophilicity characterized by an averaged contact angle of about 80 degree or less, and increased bacterial adhesion resistance, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having a lubricious coating thereon.

    摘要翻译： 本发明提供了一种医疗装置，优选眼科装置，更优选隐形眼镜，其包括含有聚乙烯吡咯烷酮的覆盖层和/或至少一层光滑涂层材料和一层聚离子材料的光滑涂层， 电荷与润滑涂层材料的电荷相反。 本发明的医疗装置上的润滑涂层具有增加的润滑性，优选特征在于平均CoF为约3.0或更小，增加的亲水性特征在于平均接触角为约80度或更小，并且增加了细菌粘附性，同时保持 所需的体积特性如透氧性和透镜材料的离子渗透性。 这种透镜可用作延长佩戴的隐形眼镜。 此外，本发明提供了制造其上具有光滑涂层的医疗装置，优选隐形眼镜的方法。

    LbL-coated medical device and method for making the same
    16.
    发明授权
    LbL-coated medical device and method for making the same 有权
    LbL涂层医疗器械及其制造方法

    公开(公告)号：US07582327B2

    公开(公告)日：2009-09-01

    申请号：US11137181

    申请日：2005-05-25

    申请人： Yongxing Qiu ,  Lynn Cook Winterton ,  John Martin Lally

    发明人： Yongxing Qiu ,  Lynn Cook Winterton ,  John Martin Lally

    IPC分类号： A61L33/00

    CPC分类号： A61L31/10 ,  A61L27/34 ,  G02B1/043 ,  Y10T428/31504 ,  Y10T428/31663 ,  Y10T428/31855 ,  C08L39/00

    摘要： The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a core material and a biocompatible LbL coating non-covalently attached to said core material. The biocompatible LbL coating comprises at least one charge/non-charge bilayer, wherein said charge/non-charge bilayer is composed of, in no particular order, one layer of a charged polymeric material and one layer of a non-charged polymeric material which is capable of being non-covalently bond to the charged polymeric material.

    摘要翻译： 本发明提供一种医疗装置，优选为眼科装置，更优选隐形眼镜，其包括非共价连接到所述芯材料的芯材料和生物相容性LbL涂层。 生物相容的LbL涂层包含至少一个电荷/非电荷双层，其中所述电荷/非电荷双层以无特别的顺序由一层带电荷的聚合物材料和一层非带电聚合物材料组成，其中 能够非共价地键合到带电的聚合物材料上。

    Method for modifying a surface
    20.
    发明授权
    Method for modifying a surface 有权
    修改表面的方法

    公开(公告)号：US06719929B2

    公开(公告)日：2004-04-13

    申请号：US09774942

    申请日：2001-01-31

    申请人： Lynn Cook Winterton ,  Yongxing Qiu ,  John Martin Lally ,  Paul Clement Nicolson

    发明人： Lynn Cook Winterton ,  Yongxing Qiu ,  John Martin Lally ,  Paul Clement Nicolson

    IPC分类号： B29D1100

    CPC分类号： B29C37/0032 ,  B29D11/00048 ,  B29K2995/0092 ,  B29L2009/00 ,  B29L2011/0041

    摘要： A method of forming a contact lens within a mold is provided. A coating of a polyionic material(s) is applied to the mold before forming a lens therein. The coating can be applied by spraying or dipping the mold within a solution(s) of polyionic materials. Various other additives can also be applied to the mold. The coating can then be transferred to a contact lens formed within the mold such that the resulting lens has altered surface properties.

    摘要翻译： 提供了一种在模具内形成隐形眼镜的方法。 在其中形成透镜之前，将一种聚离子材料的涂层施加到模具上。 可以通过将模具喷雾或浸入聚离子材料溶液中来施加涂层。 各种其他添加剂也可以应用于模具。 然后可以将涂层转移到形成在模具内的隐形眼镜，使得所得到的镜片具有改变的表面性质。