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    Diffusion-controllable coatings on medical device
    1.
    发明授权
    Diffusion-controllable coatings on medical device 有权
    医疗器械上的扩散可控涂层

    公开(公告)号：US06827966B2

    公开(公告)日：2004-12-07

    申请号：US10153063

    申请日：2002-05-22

    申请人： Yongxing Qiu ,  Fiona Patricia Carney ,  Nichola Kotov ,  John Martin Lally ,  Carol Ann Morris ,  Lynn Cook Winterton

    发明人： Yongxing Qiu ,  Fiona Patricia Carney ,  Nichola Kotov ,  John Martin Lally ,  Carol Ann Morris ,  Lynn Cook Winterton

    IPC分类号： B05D300

    CPC分类号： A61L27/34 ,  A61L27/306 ,  A61L31/088 ,  A61L31/10 ,  G02B1/043

    摘要： The present invention provides a method for forming on a medical device, preferably an ophthalmic lens, more preferably a contact lens, a diffusion-controllable coating capable of controlling the out-diffusion or release of guest materials from the medical device. The method of the invention comprises: (1) applying one layer of clay and optionally one or more layers of polyionic materials onto the medical device; or (2) applying alternatively a layer of a first polyionic material and a layer of a second polyionic material having charges opposite of the charges of the first polyionic material onto the medical device and releasing the coated medical device into a releasing medium having a composition capable of imparting a desired permeability to the diffusion-controllable coating on the medical device.

    摘要翻译： 本发明提供了一种用于在医疗装置上形成的方法，优选为眼科镜片，更优选隐形眼镜，能够控制来自医疗装置的客体材料的扩散或释放的扩散控制涂层。 本发明的方法包括：（1）将一层粘土和任选的一层或多层聚离子材料施加到医疗装置上; 或（2）交替地将第一聚离子材料层和具有与第一聚离子材料的电荷相反的电荷的第二聚离子材料层施加到医疗装置上，并将涂覆的医疗装置释放到具有能够 对所述医疗装置上的扩散可控涂层施加期望的渗透性。

    Polymeric articles having a lubricious coating and method for making the same
    5.
    发明授权
    Polymeric articles having a lubricious coating and method for making the same 有权
    具有光滑涂层的聚合物及其制造方法

    公开(公告)号：US06940580B2

    公开(公告)日：2005-09-06

    申请号：US10338631

    申请日：2003-01-08

    申请人： Lynn Cook Winterton ,  Yongxing Qiu ,  John Martin Lally ,  Manal M. Gabriel

    发明人： Lynn Cook Winterton ,  Yongxing Qiu ,  John Martin Lally ,  Manal M. Gabriel

    IPC分类号： A61L27/34 ,  A61L31/10 ,  G02B1/04 ,  G02C7/04

    CPC分类号： G02B1/043 ,  A61L27/34 ,  A61L31/10 ,  A61L2400/10 ,  Y10T428/31667 ,  Y10T428/31884 ,  Y10T428/31891 ,  Y10T428/31935 ,  Y10T428/31971

    摘要： The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a lubricious coating including a capping layer of polyvinylpyrrolidone and/or at least one layer of a lubricious coating material and one layer of a polyionic material having charges opposite of the charges of the lubricious coating material. The lubricious coating on the medical device of the invention has increased lubricity, preferably characterized by an averaged CoF of about 3.0 or less, increased hydrophilicity characterized by an averaged contact angle of about 80 degree or less, and increased bacterial adhesion resistance, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having a lubricious coating thereon.

    摘要翻译： 本发明提供了一种医疗装置，优选眼科装置，更优选隐形眼镜，其包括含有聚乙烯吡咯烷酮的覆盖层和/或至少一层光滑涂层材料和一层聚离子材料的光滑涂层， 电荷与润滑涂层材料的电荷相反。 本发明的医疗装置上的润滑涂层具有增加的润滑性，优选特征在于平均CoF为约3.0或更小，增加的亲水性特征在于平均接触角为约80度或更小，并且增加了细菌粘附性，同时保持 所需的体积特性如透氧性和透镜材料的离子渗透性。 这种透镜可用作延长佩戴的隐形眼镜。 此外，本发明提供了制造其上具有光滑涂层的医疗装置，优选隐形眼镜的方法。

    Method for applying a coating to a medical device
    6.
    发明授权
    Method for applying a coating to a medical device 有权
    将涂层施加到医疗装置的方法

    公开(公告)号：US06858248B2

    公开(公告)日：2005-02-22

    申请号：US10153007

    申请日：2002-05-22

    申请人： Yongxing Qiu ,  Lynn Cook Winterton ,  John Martin Lally ,  Yasuo Matsuzawa ,  Rafael Victor Andino ,  Allen Gilliard

    发明人： Yongxing Qiu ,  Lynn Cook Winterton ,  John Martin Lally ,  Yasuo Matsuzawa ,  Rafael Victor Andino ,  Allen Gilliard

    IPC分类号： A61L27/34 ,  B05D1/18 ,  G02B1/10 ,  B05C3/05 ,  B05C3/09 ,  G02C7/04

    CPC分类号： G02B1/10 ,  A61L27/34 ,  B05D1/18 ,  B29D11/00865 ,  Y10S134/901

    摘要： This invention provides a method for efficiently applying a coating to each of a plurality of objects selected from the group consisting of ophthalmic lenses, molds for making ophthalmic lenses, and other medical devices, the method comprising dipping the plurality of objects into a coating bath containing a coating solution having a coating material; and creating with a means a convective current flow and thereby forcing a coating solution flowing over and under each of the plurality of ophthalmic lenses. In a preferred embodiment, the plurality of objects are held in baskets which are pre-conditioned to have a first layer of polyelectrolytes and a second layer of aqueous solution or have a mixed layer of polyelectrolytes and aqueous solution on the surfaces of the baskets.

    摘要翻译： 本发明提供了一种有效地将涂层施加到从由眼科镜片，用于制造眼镜片的模具和其他医疗装置组成的组中的多个物体中的每一个上的方法，所述方法包括将多个物体浸入含有 具有涂料的涂布溶液; 并且以手段产生对流电流，从而迫使在多个眼科镜片中的每一个上流动的涂覆溶液。 在优选实施例中，多个物体被保持在篮子中，篮子被预处理成具有第一层聚电解质和第二层水溶液，或者在篮子的表面上具有聚电解质和水溶液的混合层。

    Polymeric materials for making contact lenses
    7.
    发明授权
    Polymeric materials for making contact lenses 有权
    用于制作隐形眼镜的聚合材料

    公开(公告)号：US06815074B2

    公开(公告)日：2004-11-09

    申请号：US10153040

    申请日：2002-05-22

    申请人： Celeste Aguado ,  Paul Clement Nicolson ,  Lynn Cook Winterton ,  Yongxing Qiu ,  John Martin Lally ,  Jacalyn Mary Schremmer

    发明人： Celeste Aguado ,  Paul Clement Nicolson ,  Lynn Cook Winterton ,  Yongxing Qiu ,  John Martin Lally ,  Jacalyn Mary Schremmer

    IPC分类号： B32B904

    CPC分类号： G02B1/043 ,  A61L27/18 ,  A61L27/26 ,  A61L27/34 ,  A61L2430/16 ,  Y10T428/31663 ,  C08L51/085

    摘要： An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

    摘要翻译： 一种适用于眼睛延长磨损期至少一天的眼科镜片，没有临床显着量的角膜肿胀，并且没有实质的佩戴者不适。 透镜具有透氧性和离子或水渗透性的平衡，离子或水渗透性足以提供良好的眼内运动，使得透镜和眼睛之间发生良好的泪液交换。 优选的透镜是含氧大分子单体和离子单体单体的共聚产物。 本发明包括长期佩戴的隐形眼镜，其包括具有从内表面延伸到外表面的氧透过和离子传播途径的核心。