公开(公告)号：US06827966B2

公开(公告)日：2004-12-07

申请号：US10153063

申请日：2002-05-22

申请人： Yongxing Qiu ,  Fiona Patricia Carney ,  Nichola Kotov ,  John Martin Lally ,  Carol Ann Morris ,  Lynn Cook Winterton

发明人： Yongxing Qiu ,  Fiona Patricia Carney ,  Nichola Kotov ,  John Martin Lally ,  Carol Ann Morris ,  Lynn Cook Winterton

IPC分类号： B05D300

CPC分类号： A61L27/34 ,  A61L27/306 ,  A61L31/088 ,  A61L31/10 ,  G02B1/043

摘要： The present invention provides a method for forming on a medical device, preferably an ophthalmic lens, more preferably a contact lens, a diffusion-controllable coating capable of controlling the out-diffusion or release of guest materials from the medical device. The method of the invention comprises: (1) applying one layer of clay and optionally one or more layers of polyionic materials onto the medical device; or (2) applying alternatively a layer of a first polyionic material and a layer of a second polyionic material having charges opposite of the charges of the first polyionic material onto the medical device and releasing the coated medical device into a releasing medium having a composition capable of imparting a desired permeability to the diffusion-controllable coating on the medical device.

摘要翻译： 本发明提供了一种用于在医疗装置上形成的方法，优选为眼科镜片，更优选隐形眼镜，能够控制来自医疗装置的客体材料的扩散或释放的扩散控制涂层。 本发明的方法包括：（1）将一层粘土和任选的一层或多层聚离子材料施加到医疗装置上; 或（2）交替地将第一聚离子材料层和具有与第一聚离子材料的电荷相反的电荷的第二聚离子材料层施加到医疗装置上，并将涂覆的医疗装置释放到具有能够 对所述医疗装置上的扩散可控涂层施加期望的渗透性。

公开(公告)号：US20080260804A1

公开(公告)日：2008-10-23

申请号：US12214321

申请日：2008-06-18

申请人： Carol Ann Morris ,  Manal M. Gabriel ,  Yongxing Qiu ,  Lynn Cook Winterton ,  John Martin Lally ,  Marcia Kay Ash ,  Fiona Patricia Carney ,  Courtney Flem Morgan

发明人： Carol Ann Morris ,  Manal M. Gabriel ,  Yongxing Qiu ,  Lynn Cook Winterton ,  John Martin Lally ,  Marcia Kay Ash ,  Fiona Patricia Carney ,  Courtney Flem Morgan

IPC分类号： A01N25/34 ,  A01N33/12 ,  A61K38/40 ,  G01N19/02

CPC分类号： G02B1/043 ,  A61L27/34 ,  A61L31/10

摘要： The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial coating including at least one layer of polyquat of formula (I) or (II). The antimicrobial coating on the medical device of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial, a low toxicity, low coefficient of friction, and increased hydrophilicity while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial coating thereon.

摘要翻译： 本发明提供一种医疗装置，优选隐形眼镜，其包括抗微生物涂层，其包含至少一层式（I）或（II）的聚四氢叶酸。 本发明的医疗装置上的抗微生物涂层对微生物具有高抗微生物效果，包括革兰氏阳性和革兰氏阴性细菌，低毒性，低摩擦系数和增加的亲水性，同时保持所需的体积特性如氧气渗透性和 透镜材料的离子透过率。 这种透镜可用作延长佩戴的隐形眼镜。 此外，本发明提供了制造其上具有抗微生物涂层的医疗装置，优选隐形眼镜的方法。

公开(公告)号：US07402318B2

公开(公告)日：2008-07-22

申请号：US10287091

申请日：2002-11-04

申请人： Carol Ann Morris ,  Manal M. Gabriel ,  Yongxing Qiu ,  Lynn Cook Winterton ,  John Martin Lally ,  Marcia Kay Ash ,  Fiona Patricia Carney ,  Courtney Flem Morgan

发明人： Carol Ann Morris ,  Manal M. Gabriel ,  Yongxing Qiu ,  Lynn Cook Winterton ,  John Martin Lally ,  Marcia Kay Ash ,  Fiona Patricia Carney ,  Courtney Flem Morgan

IPC分类号： A61F13/00

CPC分类号： G02B1/043 ,  A61L27/34 ,  A61L31/10

摘要： The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial coating including at least one layer of polyquat of formula (I) or (II). The antimicrobial coating on the medical device of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial, a low toxicity, low coefficient of friction, and increased hydrophilicity while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial coating thereon.

公开(公告)号：US07666461B2

公开(公告)日：2010-02-23

申请号：US10969280

申请日：2004-10-20

申请人： Yongxing Qiu ,  Fiona Patricia Carney ,  Nichola Kotov ,  John Martin Lally ,  Carol Ann Morris

发明人： Yongxing Qiu ,  Fiona Patricia Carney ,  Nichola Kotov ,  John Martin Lally ,  Carol Ann Morris

IPC分类号： B05D3/00 ,  G02C7/04 ,  A61F2/14

CPC分类号： A61L27/34 ,  A61L27/306 ,  A61L31/088 ,  A61L31/10 ,  G02B1/043

摘要： The present invention provides a method for forming on a medical device, preferably an ophthalmic lens, more preferably a contact lens, a diffusion-controllable coating capable of controlling the out-diffusion or release of guest materials from the medical device. The method of the invention comprises: (1) applying one layer of clay and optionally one or more layers of polyionic materials onto the medical device; or (2) applying alternatively a layer of a first polyionic material and a layer of a second polyionic material having charges opposite of the charges of the first polyionic material onto the medical device and releasing the coated medical device into a releasing medium having a composition capable of imparting a desired permeability to the diffusion-controllable coating on the medical device.

摘要翻译： 本发明提供了一种用于在医疗装置上形成的方法，优选为眼科镜片，更优选隐形眼镜，能够控制来自医疗装置的客体材料的扩散或释放的扩散控制涂层。 本发明的方法包括：（1）将一层粘土和任选的一层或多层聚离子材料施加到医疗装置上; 或（2）交替地将第一聚离子材料层和具有与第一聚离子材料的电荷相反的电荷的第二聚离子材料层施加到医疗装置上，并将涂覆的医疗装置释放到具有能够 对所述医疗装置上的扩散可控涂层施加期望的渗透性。

公开(公告)号：US20080139963A1

公开(公告)日：2008-06-12

申请号：US12008312

申请日：2008-01-10

申请人： Fiona Patricia Carney ,  Carol Ann Morris ,  Yongxing Qiu

发明人： Fiona Patricia Carney ,  Carol Ann Morris ,  Yongxing Qiu

IPC分类号： A61B5/00

CPC分类号： A61B5/42 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/411 ,  A61B5/4306 ,  A61B10/0045 ,  A61B2010/0067

摘要： The present invention provides a contact lens, preferably a daily disposable contact lens, which can be used to collect one or more analytes of interest in a tear fluid, and in turn, determine the physiological state or health of an individual.

摘要翻译： 本发明提供一种隐形眼镜，优选为每日一次性隐形眼镜，其可用于在泪液中收集一种或多种感兴趣的分析物，并且进而确定个体的生理状况或健康状况。

公开(公告)号：US06926965B2

公开(公告)日：2005-08-09

申请号：US10654566

申请日：2003-09-03

申请人： Yongxing Qiu ,  Lynn Cook Winterton ,  John Martin Lally

发明人： Yongxing Qiu ,  Lynn Cook Winterton ,  John Martin Lally

IPC分类号： G02C7/04 ,  A61F9/00 ,  A61L27/00 ,  A61L27/34 ,  A61L31/10 ,  G02B1/04 ,  B32B25/20 ,  B32B27/08 ,  B32B27/30

CPC分类号： A61L31/10 ,  A61L27/34 ,  G02B1/043 ,  Y10T428/31504 ,  Y10T428/31663 ,  Y10T428/31855 ,  C08L39/00

摘要： The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a core material and a biocompatible LbL coating non-covalently attached to said core material. The biocompatible LbL coating comprises at least one charge/non-charge bilayer, wherein said charge/non-charge bilayer is composed of, in no particular order, one layer of a charged polymeric material and one layer of a non-charged polymeric material which is capable of being non-covalently bond to the charged polymeric material.

公开(公告)号：US06896926B2

公开(公告)日：2005-05-24

申请号：US10654340

申请日：2003-09-03

申请人： Yongxing Qiu ,  Lynn Cook Winterton ,  John Martin Lally ,  Yasuo Matsuzawa

发明人： Yongxing Qiu ,  Lynn Cook Winterton ,  John Martin Lally ,  Yasuo Matsuzawa

IPC分类号： G02C7/04 ,  A61L27/00 ,  A61L27/34 ,  A61L29/00 ,  A61L31/00 ,  B05D1/18 ,  G02B1/04 ,  G02C13/00 ,  B05D1/36 ,  B05D1/38

CPC分类号： A61L27/34 ,  B05D1/185 ,  G02B1/043

摘要： The present invention provides an improved LbL-coating process for modifying the surface of a medical device, preferably an ophthalmic device, more preferably a contact lens. An LbL coating on a contact lens, which is prepared according to the process of the invention, can have increased hydrophilicity characterized by an averaged contact angle of about 80 degree or less, preferably about 50 degrees or less, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material.

摘要翻译： 本发明提供改进的LbL涂覆方法，用于改变医疗装置的表面，优选眼科装置，更优选隐形眼镜。 根据本发明的方法制备的隐形眼镜上的LbL涂层可以具有增强的亲水性，其特征在于约80度或更小，优选约50度或更小的平均接触角，同时保持所需的松散性 作为透镜材料的透氧性和离子透过性。

公开(公告)号：US06852353B2

公开(公告)日：2005-02-08

申请号：US09911218

申请日：2001-07-23

申请人： Yongxing Qiu ,  Lynn Cook Winterton ,  John Martin Lally

发明人： Yongxing Qiu ,  Lynn Cook Winterton ,  John Martin Lally

IPC分类号： A61L27/34 ,  C08J7/16 ,  G02B1/04 ,  A61L27/00 ,  B05D1/02 ,  B05D1/18 ,  B05D1/36 ,  B05D1/38

CPC分类号： C08J7/16 ,  A61L27/34 ,  G02B1/043

摘要： The present invention generally relates to a method of modifying the surface of substrates such as contact lenses and other biomedical articles by at least partially coating the surfaces of such substrates with a polymeric tie layer having reactive sites. Various other moieties may then be chemically attached to the article surface by reaction of the other moieties with the reactive sites through classical chemical attachment mechanisms.

摘要翻译： 本发明总体上涉及一种通过用具有反应性位点的聚合物连接层至少部分地涂覆这些基底的表面来改性基底例如隐形眼镜和其它生物医学制品的表面的方法。 然后可以通过经典的化学附着机制将其它部分与反应性位点反应，将各种其它部分化学连接到制品表面。

公开(公告)号：US08309117B2

公开(公告)日：2012-11-13

申请号：US10732543

申请日：2003-12-10

申请人： Michael F. Rubner ,  Sung Yun Yang ,  Yongxing Qiu ,  Lynn Cook Winterton ,  John Martin Lally

发明人： Michael F. Rubner ,  Sung Yun Yang ,  Yongxing Qiu ,  Lynn Cook Winterton ,  John Martin Lally

IPC分类号： A61K9/00

CPC分类号： A61K9/5015 ,  A61K31/14 ,  A61L27/34 ,  A61L27/54 ,  A61L29/106 ,  A61L29/16 ,  A61L31/088 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/45 ,  A61L2300/608 ,  A61L2300/61 ,  A61L2300/624 ,  G02B1/043 ,  Y10T428/31678 ,  Y10T428/31681 ,  Y10T428/31692

摘要： The present invention provides a method for preparing a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating on a medical device, wherein the antimicrobial metal-containing LbL coating comprises at least one layer of a negatively charged polyionic material having —COOAg groups and/or silver nanoparticles formed by reducing Ag+ ions associated with the —COO− groups of the negatively charged polyionic material. In addition, the present invention provides a medical device prepared according to a method of the invention.

摘要翻译： 本发明提供了一种在医疗装置上制备具有抗微生物金属的LbL涂层的医疗装置，优选隐形眼镜的方法，其中所述含抗微生物金属的LbL涂层包括至少一层带负电荷的聚离子材料层， 通过还原与带负电荷的聚离子材料的-COO-基团相关联的Ag +离子形成的-COOAg基团和/或银纳米颗粒。 此外，本发明提供了根据本发明的方法制备的医疗装置。

公开(公告)号：US06940580B2

公开(公告)日：2005-09-06

申请号：US10338631

申请日：2003-01-08

申请人： Lynn Cook Winterton ,  Yongxing Qiu ,  John Martin Lally ,  Manal M. Gabriel

发明人： Lynn Cook Winterton ,  Yongxing Qiu ,  John Martin Lally ,  Manal M. Gabriel

IPC分类号： A61L27/34 ,  A61L31/10 ,  G02B1/04 ,  G02C7/04

CPC分类号： G02B1/043 ,  A61L27/34 ,  A61L31/10 ,  A61L2400/10 ,  Y10T428/31667 ,  Y10T428/31884 ,  Y10T428/31891 ,  Y10T428/31935 ,  Y10T428/31971

摘要： The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a lubricious coating including a capping layer of polyvinylpyrrolidone and/or at least one layer of a lubricious coating material and one layer of a polyionic material having charges opposite of the charges of the lubricious coating material. The lubricious coating on the medical device of the invention has increased lubricity, preferably characterized by an averaged CoF of about 3.0 or less, increased hydrophilicity characterized by an averaged contact angle of about 80 degree or less, and increased bacterial adhesion resistance, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having a lubricious coating thereon.

摘要翻译： 本发明提供了一种医疗装置，优选眼科装置，更优选隐形眼镜，其包括含有聚乙烯吡咯烷酮的覆盖层和/或至少一层光滑涂层材料和一层聚离子材料的光滑涂层， 电荷与润滑涂层材料的电荷相反。 本发明的医疗装置上的润滑涂层具有增加的润滑性，优选特征在于平均CoF为约3.0或更小，增加的亲水性特征在于平均接触角为约80度或更小，并且增加了细菌粘附性，同时保持 所需的体积特性如透氧性和透镜材料的离子渗透性。 这种透镜可用作延长佩戴的隐形眼镜。 此外，本发明提供了制造其上具有光滑涂层的医疗装置，优选隐形眼镜的方法。