公开(公告)号：US20110300385A1

公开(公告)日：2011-12-08

申请号：US13214317

申请日：2011-08-22

申请人： Marina Yakovleva ,  Yuan Gao ,  Yangxing Li

发明人： Marina Yakovleva ,  Yuan Gao ,  Yangxing Li

IPC分类号： B32B15/04 ,  B32B15/02 ,  B32B5/16

CPC分类号： B22F1/0062 ,  B22F1/02 ,  B22F9/06 ,  H01M4/382 ,  Y10T428/2991

摘要： The present invention provides a stabilized lithium metal powder having a substantially continuous protective layer of lithium phosphate on the lithium metal powder.

摘要翻译： 本发明提供在锂金属粉末上具有基本上连续的磷酸锂保护层的稳定的锂金属粉末。

公开(公告)号：US20110218145A1

公开(公告)日：2011-09-08

申请号：US13128335

申请日：2009-11-10

申请人： Mara Fornaro ,  John Xu ,  Yuan Gao ,  Rainer Hillenbrand ,  Francois Legay ,  Daniela Stoellner

发明人： Mara Fornaro ,  John Xu ,  Yuan Gao ,  Rainer Hillenbrand ,  Francois Legay ,  Daniela Stoellner

IPC分类号： A61K38/30 ,  C07K16/00 ,  C12N5/16 ,  C07K7/06 ,  C07H21/00 ,  C12N15/63 ,  G01N33/53 ,  C07K14/575 ,  C12N5/10 ,  A61P21/00

CPC分类号： G01N33/54306 ,  C07K14/65 ,  C07K16/22 ,  C07K2317/33 ,  C07K2317/34 ,  G01N2333/65

摘要： High-specificity antibodies can distinguish between modified (e.g, hIGF-1/Ea 3mut) and endogenous wild-type human IGF-1 proteins. These antibodies have little or no cross-reactivity with hIGF-1 or hIGF-2. They also have little or no cross-reactivity with rodent IGF-1 or IGF-2. The antibodies can be used in pharmacokinetic (PK)/pharamcodynamic (PD) assessments of IGF-1/E peptides that have been administered to humans or animals. A sandwich ELISA assay, using the antibody of the invention as a capture antibody, can quantify the mutant IGF-1/E proteins in samples.

摘要翻译： 高特异性抗体可以区分修饰的（例如hIGF-1 / Ea 3mut）和内源性野生型人IGF-1蛋白。 这些抗体与hIGF-1或hIGF-2几乎没有或没有交叉反应性。 它们也与啮齿动物IGF-1或IGF-2几乎没有或没有交叉反应。 该抗体可以用于向人或动物施用的IGF-1 / E肽的药代动力学（PK）/药物动力学（PD）评估。 使用本发明的抗体作为捕获抗体的夹心ELISA测定可以定量样品中的突变型IGF-1 / E蛋白质。

公开(公告)号：US20110093211A1

公开(公告)日：2011-04-21

申请号：US12997441

申请日：2009-06-10

申请人： Andre' Xavier de Carvalho Negrão Valente ,  Yuan Gao ,  Gregory A. Buck ,  Seth Roberts

发明人： Andre' Xavier de Carvalho Negrão Valente ,  Yuan Gao ,  Gregory A. Buck ,  Seth Roberts

IPC分类号： G06F19/00 ,  G01N33/68

CPC分类号： G16B5/00

摘要： A method of generating data indicating whether a set of proteins is a protein complex. The method comprises receiving as input experimental data indicating experimentally observed relationships, each experimentally observed relationship being between a first protein and zero or more second proteins and generating data indicating whether the set of proteins is a protein complex. The experimental data is processed to determine a first data value indicating a number of proteins having a relationship with one or more second proteins and a second data value indicating a number of proteins having a relationship with a selected protein.

摘要翻译： 产生指示蛋白质是否是蛋白质复合物的数据的方法。 该方法包括接收表示实验观察到的关系的输入实验数据，每个实验观察到的关系在第一蛋白质和零个或更多个第二蛋白质之间，并产生指示蛋白质组是否是蛋白质复合物的数据。 处理实验数据以确定指示与一个或多个第二蛋白质具有关系的蛋白质数量的第一数据值和指示与所选蛋白质具有关系的蛋白质数量的第二数据值。

公开(公告)号：US07786037B2

公开(公告)日：2010-08-31

申请号：US11653004

申请日：2007-01-11

申请人： Hsing-Lin Wang ,  Wenguang Li ,  James A. Bailey ,  Yuan Gao

发明人： Hsing-Lin Wang ,  Wenguang Li ,  James A. Bailey ,  Yuan Gao

IPC分类号： B01J23/40 ,  B01J23/42 ,  H01B1/02 ,  H01B1/22 ,  G01J3/44

CPC分类号： G01N21/658 ,  B01J23/42 ,  B01J23/44 ,  B01J23/50 ,  B01J23/52 ,  B01J31/069 ,  B01J35/002 ,  B01J35/006 ,  B01J35/065 ,  B01J37/0203 ,  B01J2231/645 ,  B01J2531/17 ,  B01J2531/18 ,  B01J2531/824 ,  B01J2531/828 ,  C07C67/303 ,  C07C69/618 ,  C07C69/612

摘要： Metal-polyaniline (PANI) composites are provided together with a process of preparing such composites by an electrodeless process. The metal of the composite can have nanoscale structural features and the composites can be used in applications such as catalysis for hydrogenation reactions and for analytical detection methods employing SERS.

摘要翻译： 金属 - 聚苯胺（PANI）复合材料与通过无电极工艺制备这种复合材料的方法一起提供。 复合材料的金属可以具有纳米尺度的结构特征，并且该复合材料可用于氢化反应的催化和使用SERS的分析检测方法。

公开(公告)号：US20100060894A1

公开(公告)日：2010-03-11

申请号：US12619328

申请日：2009-11-16

申请人： Hsing-Lin Wang ,  Wenguang Li ,  James A. Bailey ,  Yuan Gao

发明人： Hsing-Lin Wang ,  Wenguang Li ,  James A. Bailey ,  Yuan Gao

IPC分类号： G01J3/44 ,  C07C5/03 ,  C07F7/10 ,  C07C51/36 ,  B01J35/00

CPC分类号： G01N21/658 ,  B01J23/42 ,  B01J23/44 ,  B01J23/50 ,  B01J23/52 ,  B01J31/069 ,  B01J35/002 ,  B01J35/006 ,  B01J35/065 ,  B01J37/0203 ,  B01J2231/645 ,  B01J2531/17 ,  B01J2531/18 ,  B01J2531/824 ,  B01J2531/828 ,  C07C67/303 ,  C07C69/618 ,  C07C69/612

摘要： Metal-polyaniline (PANI) composites are provided together with a process of preparing such composites by an electrodeless process. The metal of the composite can have nanoscale structural features and the composites can be used in applications such as catalysis for hydrogenation reactions and for analytical detection methods employing SERS.

摘要翻译： 金属 - 聚苯胺（PANI）复合材料与通过无电极工艺制备这种复合材料的方法一起提供。 复合材料的金属可以具有纳米尺度的结构特征，并且该复合材料可用于氢化反应的催化和使用SERS的分析检测方法。

公开(公告)号：US20090023954A1

公开(公告)日：2009-01-22

申请号：US11918859

申请日：2006-04-28

申请人： Kumiko Sueto ,  Osamu Omae ,  Yuan Gao

发明人： Kumiko Sueto ,  Osamu Omae ,  Yuan Gao

IPC分类号： C07F9/02

CPC分类号： H01M10/0569 ,  C07C305/06 ,  C07C311/48 ,  C07F9/06 ,  C07F9/5463 ,  H01G9/2004 ,  H01M8/1016 ,  H01M10/052 ,  H01M14/005 ,  H01M2300/0025 ,  Y02E10/542 ,  Y02E60/122 ,  Y02E60/13 ,  Y02P70/521 ,  Y02P70/54

摘要： An ionic liquid of the present invention is “an ionic liquid comprising an organic substance represented by the following general formula (1) as a cation component” and “an ionic liquid comprising a cation component and an anion component, and the cation component is one or plural kinds selected from the group consisting of cation components represented by the following formula (1)”.

摘要翻译： 本发明的离子液体是“含有作为阳离子成分的下述通式（1）表示的有机物的离子液体”和“含有阳离子成分和阴离子成分的离子液体，阳离子成分为一 或选自由下式（1）表示的阳离子组分组成的组中的多种“）。

公开(公告)号：US20080015789A1

公开(公告)日：2008-01-17

申请号：US11766256

申请日：2007-06-21

申请人： Isidore Rigoutsos ,  Yuan Gao ,  Aristidis Floratos

发明人： Isidore Rigoutsos ,  Yuan Gao ,  Aristidis Floratos

IPC分类号： G01N33/48

CPC分类号： G16B40/00 ,  G16B30/00

摘要： Generally, the present invention provides a way of determining in an unsupervised manner additional members for a family that is defined initially through exemplar sequences. The present invention is unsupervised in that it proceeds without any information related to the exemplar sequences defining the family, without aligning the sequences, without prior knowledge of any patterns in the exemplar sequences, and without knowledge of the cardinality or characteristics of any features that may be present in the exemplar sequences. In one aspect of the invention, a method is used to take a set of unaligned sequences and discover several of many patterns common to some or all of the sequences. These patterns can then be used to determine if candidate sequences are members of the family. In another aspect of the invention, a method is used to take a set of sequences and to determine a set of maximal patterns common to a number of sequences The maximal patterns are determined without any previous knowledge about any properties of features that may be present in the processed sequences.

摘要翻译： 通常，本发明提供以无监督方式确定最初通过示范序列定义的家庭的附加成员的方式。 本发明是无监督的，因为它没有任何与定义家族的示例性序列有关的信息，而不对齐序列，而不具有样本序列中的任何模式的先验知识，并且不知道可能的任何特征的基数或特征 存在于示例序列中。 在本发明的一个方面，使用一种方法来获取一组未对齐的序列，并发现一些或所有序列共有的许多模式中的几种。 然后可以使用这些模式来确定候选序列是否是家族的成员。 在本发明的另一方面中，使用一种方法来获取一组序列并确定一系列序列共有的最大模式集。最大模式是在没有任何关于可能存在于 处理的序列。

公开(公告)号：US07276314B2

公开(公告)日：2007-10-02

申请号：US10760007

申请日：2004-01-16

申请人： Yuan Gao ,  John L. Burba, III

发明人： Yuan Gao ,  John L. Burba, III

IPC分类号： H01M4/58

CPC分类号： H01M4/13 ,  H01M4/02 ,  H01M4/133 ,  H01M4/386 ,  H01M4/387 ,  H01M4/40 ,  H01M4/405 ,  H01M10/0525 ,  H01M10/44 ,  H01M2004/021

摘要： The present invention is a secondary battery having a high specific capacity and good cycleability, and that can be used safely. The secondary battery is manufactured to include an anode formed from a host material capable of absorbing and desorbing lithium in an electrochemical system such as a carbonaceous material, and lithium metal dispersed in the host material. The freshly prepared anodes of the invention are combined with a positive electrode including an active material, a separator that a separates the positive electrode and the negative electrode, and an electrolyte in communication with the positive electrode and the negative electrode. The present invention also includes a method of preparing a freshly prepared anode and a method of operating a secondary battery including the anode of the invention.

摘要翻译： 本发明是具有高比容量和良好循环性的二次电池，可以安全使用。 二次电池被制造为包括由能够在诸如碳质材料的电化学系统中吸收和解吸锂的主体材料形成的阳极和分散在主体材料中的锂金属。 本发明的新鲜制备的阳极与包括活性材料的正极，分离正极和负极的隔板以及与正极和负极连通的电解质组合。 本发明还包括制备新制备的阳极的方法和操作包括本发明的阳极的二次电池的方法。

公开(公告)号：US20060228468A1

公开(公告)日：2006-10-12

申请号：US10568067

申请日：2004-08-09

申请人： Jonathan Lain ,  Ian McDonald ,  David Blackmore ,  Vijay Dass ,  Yuan Gao

发明人： Jonathan Lain ,  Ian McDonald ,  David Blackmore ,  Vijay Dass ,  Yuan Gao

IPC分类号： B05D5/12 ,  B05D3/00

CPC分类号： H01M4/13 ,  H01M2/145 ,  H01M2/16 ,  H01M2/166 ,  H01M4/04 ,  H01M4/0402 ,  H01M4/0404 ,  H01M4/0435 ,  H01M4/139 ,  H01M4/366 ,  H01M4/587 ,  H01M2004/8684

摘要： A process for producing an electrode which comprises forming an electrode precursor comprising a layer comprising an intercalation material, and then applying stabilised lithium metal particles to the surface of the electrode precursor.

摘要翻译： 一种电极的制造方法，其特征在于，包括形成包括层间材料的层的电极前体，然后将稳定的锂金属粒子施加到所述电极前体的表面。

公开(公告)号：US06932922B2

公开(公告)日：2005-08-23

申请号：US10424056

申请日：2003-04-25

申请人： Yuan Gao ,  Marina Yakovleva ,  John L. Burba, III ,  John F. Engel

发明人： Yuan Gao ,  Marina Yakovleva ,  John L. Burba, III ,  John F. Engel

IPC分类号： C01G45/00 ,  C01G51/00 ,  H01M4/02 ,  H01M4/50 ,  H01M4/505 ,  H01M4/52 ,  H01M4/525 ,  H01M10/052 ,  H01M10/0525 ,  H01M10/36 ,  C01G51/04 ,  C01D15/00 ,  C04B35/64

CPC分类号： C01G51/42 ,  C01P2002/20 ,  C01P2002/52 ,  C01P2002/54 ,  C01P2002/72 ,  C01P2002/74 ,  C01P2006/40 ,  H01M4/505 ,  H01M4/525 ,  H01M10/052 ,  H01M10/0525 ,  H01M2004/021

摘要： The present invention includes lithium cobalt oxides having hexagonal layered crystal structures and methods of making same. The lithium cobalt oxides of the invention have the formula LiwCo1−xAxO2+y wherein 0.96≦w≦1.05, 0≦x≦0.05, −0.02≦y≦0.02 and A is one or more dopants. The lithium cobalt oxides of the invention preferably have a position within the principal component space defined by the relationship axi+byi≦c, wherein xi={right arrow over (S)}i•{right arrow over (P)}c1; yi={right arrow over (S)}i•{right arrow over (P)}c2; the vector {right arrow over (S)}i is the x-ray spectrum for the LiwCo1−xAxO2+y compound; the vectors {right arrow over (P)}c1 and {right arrow over (P)}c2 defining the principal component space are determined by measuring the x-ray powder diffraction values {right arrow over (S)}i between 15° and 120° using a 0.02° step size and CuKα rays for a large sample set of lithium cobalt oxides and using the regression of {right arrow over (S)}i of the sample set against the capacity fade after 50 cycles of a lithium coin cell that includes a lithium negative electrode and the lithium cobalt oxide as the positive electrode material and that is cycled between 3.0 and 4.3V at a constant current of C/3 during both charge and discharge cycles; and the values a, b and c are determined by using only the xi and yi values for LiwCo1−xAxO2+y compounds in the sample set that have a capacity fade after 50 cycles of less than or equal to 15%.