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公开(公告)号：US20100028866A1
公开(公告)日：2010-02-04
申请号：US12064018
申请日：2006-08-18
CPC分类号： C07K16/18 , C07K14/47 , C12Q1/6881 , C12Q2600/158 , G01N33/5073
摘要： The present invention is a probe, a primer, and an antibody, for detecting a dopaminergic neuron proliferative progenitor cell. According to the present invention, there is provided a polynucleotide probe and a polynucleotide primer for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell, which can hybridize with a polynucleotide consisting of a nucleotide sequence of a Nato3 gene, or a complementary sequence thereto, and an antibody against a Nato3 protein, or a part thereof for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell.
摘要翻译： 本发明是用于检测多巴胺能神经元增殖祖细胞的探针，引物和抗体。 根据本发明，提供了用于检测或选择多巴胺能神经元增殖祖细胞的多核苷酸探针和多核苷酸引物，其可与由Nato3基因的核苷酸序列或互补的多核苷酸组成的多核苷酸杂交 序列，以及针对Nato3蛋白或其部分的抗体用于检测或选择多巴胺能神经元增殖祖细胞。
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公开(公告)号：US07622270B2
公开(公告)日：2009-11-24
申请号：US10532264
申请日：2003-10-21
申请人： Yasuko Nakagawa , Yuichi Ono , Yoshimasa Sakamoto , Eri Mizuhara , Tomoya Nakatani , Yoshimi Takai
发明人： Yasuko Nakagawa , Yuichi Ono , Yoshimasa Sakamoto , Eri Mizuhara , Tomoya Nakatani , Yoshimi Takai
IPC分类号： G01N33/567 , C07K16/28
CPC分类号： G01N33/6896 , C07K14/47
摘要： A novel gene 65B13 expressed specifically and transiently in dopaminergic neuron precursor cells immediately after cell cycle exit was obtained by the present invention. The cellular expression of 65B13 can be used as an index to select cells that are suitable in terms of their safety, survival rate, and network formation ability, for transplant therapy of neurodegenerative diseases such as Parkinson's disease.
摘要翻译： 通过本发明获得在细胞周期出口后立即在多巴胺能神经元前体细胞中特异性和瞬时表达的新基因65B13。 65B13的细胞表达可用作选择适合于其安全性，存活率和网络形成能力的细胞的指标，用于神经变性疾病如帕金森病的移植治疗。
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13.发明申请Methods of Distinguishing Types of Spinal Neurons Using Corl1 Gene as an Indicator 审中-公开使用Corl1基因作为指标区分脊髓神经元类型的方法公开(公告)号：US20080213757A1
公开(公告)日：2008-09-04
申请号：US11574115
申请日：2005-08-23
申请人： Yuichi Ono , Yasuko Nakagawa , Tomoya Nakatani
发明人： Yuichi Ono , Yasuko Nakagawa , Tomoya Nakatani
IPC分类号： C12Q1/68 , G01N33/567
CPC分类号： C12Q1/6876 , C12Q2600/158 , G01N33/5026 , G01N33/5058 , G01N33/5073
摘要： As a result of screening for genes that are selectively expressed in fetal mouse brain region by subtraction method, the present inventors obtained a cDNA fragment encoding Corl1. The expression of Corl1 was examined by RT-PCR, in situ hybridization, and immunostaining using polyclonal antibodies. The results demonstrated that Corl1 was especially expressed at a high level of selectively in the central nervous system during embryonic stages. The expression patterns of Corl1 determined using various markers in embryonic spinal cord were compared to identify types of neurons expressing Corl1. The results revealed that Corl1 was specifically expressed in spinal cord interneurons dI4, dI5, dILA, and dILB. Accordingly, the present invention provides for discrimination between dI4 and dI6, neurons which previously could only be discriminated based on developmental location, using the expression of Corl1 as an indicator.
摘要翻译： 作为筛选通过减法法在胎儿小鼠脑区域中选择性表达的基因的结果，本发明人获得了编码Corl1的cDNA片段。 通过RT-PCR，原位杂交和使用多克隆抗体的免疫染色检测Corl1的表达。 结果表明，Corl1在胚胎期期间在中枢神经系统的高水平选择性表达。 比较使用胚胎脊髓中各种标记物测定的Corl1的表达模式，以鉴定表达Corl1的神经元的类型。 结果表明，Corl1在脊髓中间神经元dI4，dI5，dILA和dILB中特异性表达。 因此，本发明提供了使用Corl1的表达作为指标的dI4和dI6之间的区别，以前仅可以基于发育位置鉴别神经元。
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公开(公告)号：US08187804B2
公开(公告)日：2012-05-29
申请号：US10580989
申请日：2004-11-26
申请人： Yuichi Ono , Yasuko Nakagawa , Tomoya Nakatani
发明人： Yuichi Ono , Yasuko Nakagawa , Tomoya Nakatani
CPC分类号： C12Q1/6881 , C12Q1/6883 , C12Q2600/158 , G01N33/6896 , G01N33/9413 , G01N2800/2835
摘要： The present invention identified Lmx1a genes, which are expressed in dopaminergic neurons at all differentiation stages, from proliferating dopaminergic neuron progenitor cells before cell cycle exit to cells after cell cycle exit. Lmx1a expression in cells can be used as an indicator when selecting cells suitable for transplantation therapy for neurodegenerative diseases such as Parkinson's disease, and is useful as a marker for screening agents involved in the induction of dopaminergic neuron differentiation.
摘要翻译： 本发明鉴定了在细胞周期退出至细胞周期后出现的细胞周期性增殖的多巴胺能神经元祖细胞中，在所有分化阶段的多巴胺能神经元中表达的Lmx1a基因。 当选择适合于帕金森病等神经变性疾病的移植治疗的细胞时，细胞中的Lmx1a表达可用作指示剂，并且可用作参与多巴胺能神经元分化诱导的筛选剂的标记。
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15.发明申请公开(公告)号：US20110229889A1
公开(公告)日：2011-09-22
申请号：US13071450
申请日：2011-03-24
CPC分类号： G01N33/56966 , C07K16/18 , C12Q1/6881 , C12Q2600/158
摘要： The present invention is a probe, a primer, and an antibody, for detecting a dopaminergic neuron proliferative progenitor cell. According to the present invention, there is provided a polynucleotide probe and a polynucleotide primer for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell, which can hybridize with a polynucleotide consisting of a nucleotide sequence of an Msx1 gene or an Msx2 gene, or a complementary sequence thereto, and an antibody against an Msx1 protein or an Msx2 protein, or a part thereof for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell.
摘要翻译： 本发明是用于检测多巴胺能神经元增殖祖细胞的探针，引物和抗体。 根据本发明，提供了用于检测或选择多巴胺能神经元增殖祖细胞的多核苷酸探针和多核苷酸引物，其可以与由Msx1基因或Msx2基因的核苷酸序列组成的多核苷酸杂交 ，或其互补序列，以及针对用于检测或选择多巴胺能神经元增殖祖细胞的Msx1蛋白或Msx2蛋白或其一部分的抗体。
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公开(公告)号：US20120178083A1
公开(公告)日：2012-07-12
申请号：US13352241
申请日：2012-01-17
申请人： Yuichi Ono , Yasuko Nakagawa , Tomoya Nakatani
发明人： Yuichi Ono , Yasuko Nakagawa , Tomoya Nakatani
IPC分类号： C12Q1/68 , C07K16/18 , G01N33/566
CPC分类号： C12Q1/6881 , C12Q1/6883 , C12Q2600/158 , G01N33/6896 , G01N33/9413 , G01N2800/2835
摘要： The present invention identified Lmx1a genes, which are expressed in dopaminergic neurons at all differentiation stages, from proliferating dopaminergic neuron progenitor cells before cell cycle exit to cells after cell cycle exit. Lmx1a expression in cells can be used as an indicator when selecting cells suitable for transplantation therapy for neurodegenerative diseases such as Parkinson's disease, and is useful as a marker for screening agents involved in the induction of dopaminergic neuron differentiation.
摘要翻译： 本发明鉴定了在细胞周期退出至细胞周期后出现的细胞周期性增殖的多巴胺能神经元祖细胞中，在所有分化阶段的多巴胺能神经元中表达的Lmx1a基因。 当选择适合于帕金森病等神经变性疾病的移植治疗的细胞时，细胞中的Lmx1a表达可用作指示剂，并且可用作参与多巴胺能神经元分化诱导的筛选剂的标记。
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17.发明申请GENE SPECIFICALLY EXPRESSED IN POSTMITOTIC DOPAMINERGIC NEURON PRECURSOR CELLS 审中-公开基因在POSTMITOTIC DOPAMINERGIC神经元前体细胞中明确表达公开(公告)号：US20070122882A1
公开(公告)日：2007-05-31
申请号：US11622312
申请日：2007-01-11
申请人： Yasuko Nakagawa , Yuichi Ono , Yoshimasa Sakamoto , Eri Mizuhara , Tomoya Nakatani , Yoshimi Takai
发明人： Yasuko Nakagawa , Yuichi Ono , Yoshimasa Sakamoto , Eri Mizuhara , Tomoya Nakatani , Yoshimi Takai
IPC分类号： C07K14/705 , C07K16/28 , C07H21/04 , C12P21/06
CPC分类号： G01N33/6896 , C07K14/47
摘要： A novel gene 65B13 expressed specifically and transiently in dopaminergic neuron precursor cells immediately after cell cycle exit was obtained by the present invention. The cellular expression of 65B13 can be used as an index to select cells that are suitable in terms of their safety, survival rate, and network formation ability, for transplant therapy of neurodegenerative diseases such as Parkinson's disease.
摘要翻译： 通过本发明获得在细胞周期出口后立即在多巴胺能神经元前体细胞中特异性和瞬时表达的新基因65B13。 65B13的细胞表达可用作选择适合于其安全性，存活率和网络形成能力的细胞的指标，用于神经变性疾病如帕金森病的移植治疗。
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18.发明申请Gene expressed specifically in dopamine-producing neuron precursor cells after termination of division 失效在分裂终止后，特异性表达多巴胺产生神经元前体细胞的基因公开(公告)号：US20060239978A1
公开(公告)日：2006-10-26
申请号：US10532264
申请日：2003-10-21
申请人： Yasuko Nakagawa , Yuichi Ono , Yoshima Sakamoto , Eri Mizuhara , Tomoya Nakatani , Yoshimi Takai
发明人： Yasuko Nakagawa , Yuichi Ono , Yoshima Sakamoto , Eri Mizuhara , Tomoya Nakatani , Yoshimi Takai
IPC分类号： A61K35/30 , C12Q1/68 , G01N33/567 , C07H21/04 , C12N5/08 , C07K14/705 , C07K16/28
CPC分类号： G01N33/6896 , C07K14/47
摘要： A novel gene 65B13 expressed specifically and transiently in dopaminergic neuron precursor cells immediately after cell cycle exit was obtained by the present invention. The cellular expression of 65B13 can be used as an index to select cells that are suitable in terms of their safety, survival rate, and network formation ability, for transplant therapy of neurodegenerative diseases such as Parkinson's disease.
摘要翻译： 通过本发明获得在细胞周期出口后立即在多巴胺能神经元前体细胞中特异性和瞬时表达的新基因65B13。 65B13的细胞表达可用作选择适合于其安全性，存活率和网络形成能力的细胞的指标，用于神经变性疾病如帕金森病的移植治疗。
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19.发明授权Polymer compound comprising aryl repeating units with crosslinking pendent groups and light-emitting element using same 有权包含具有交联侧基的芳基重复单元和使用其的发光元件的高分子化合物公开(公告)号：US08993124B2
公开(公告)日：2015-03-31
申请号：US13056227
申请日：2009-07-29
申请人： Tomoya Nakatani , Keiko Kawaguchi
发明人： Tomoya Nakatani , Keiko Kawaguchi
IPC分类号： H01L51/54 , C08G73/02 , C08L39/00 , C07C25/22 , C07C17/275 , C07C17/23 , H01L51/00 , C07C25/24 , C07C309/65 , C08G61/02 , C08G61/12 , C08L65/00 , C09K11/06 , H01L51/50
CPC分类号： H01L51/0036 , C07C25/22 , C07C25/24 , C07C309/65 , C07C2602/06 , C07C2603/18 , C08G61/02 , C08G61/12 , C08G61/124 , C08G2261/124 , C08G2261/135 , C08G2261/148 , C08G2261/3142 , C08G2261/316 , C08G2261/3241 , C08G2261/411 , C08G2261/76 , C08G2261/92 , C08L65/00 , C09K11/06 , C09K2211/1416 , C09K2211/1425 , C09K2211/145 , C09K2211/1458 , C09K2211/1466 , H01L51/0035 , H01L51/0039 , H01L51/5048 , Y02E10/549 , Y02P70/521 , Y10S428/917
摘要： A polymer compound including: the repeating unit shown in the following formula (I) (wherein: Ar1 represents an arylene group, a divalent heterocyclic group, or a divalent aromatic amine; J1 and J2 each represent a direct bond, an alkylene group, or a phenylene group, and X1 represents an oxygen atom or a sulfur atom; i is an integer from 0 to 3; j is 0 or 1; m is 1 or 2; and R1 represents a hydrogen atom, an alkyl group, an alkoxy group, or the like) and the repeating unit shown in the following formula (II) (wherein: Ar2 represents a fluorene-diyl group; J3 and J4 each represent a direct bond, an alkylene group, or a phenylene group; X2 represents an oxygen atom or a sulfur atom; k is an integer from 0 to 3; l is 0 or 1; and n is 1 or 2).
摘要翻译： 一种高分子化合物，包括：下式（I）所示的重复单元（其中：Ar 1表示亚芳基，二价杂环基或二价芳香族胺; J 1和J 2各自表示直接键合，亚烷基或 亚苯基，X1表示氧原子或硫原子，i表示0〜3的整数，j表示0或1，m表示1或2，R1表示氢原子，烷基，烷氧基 等）和下式（II）所示的重复单元（其中：Ar2表示芴二基; J3和J4各自表示直接键合，亚烷基或亚苯基; X2表示氧 原子或硫原子; k为0至3的整数; l为0或1; n为1或2）。
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20.发明授权Polymer light-emitting material comprising a conjugated polymer and compound exhibiting light emission from the triplet excited state and polymer light-emitting device using the same 失效包含共轭聚合物的聚合物发光材料和表现出来自三线态激发态的光发射的化合物和使用其的聚合物发光器件公开(公告)号：US08142908B2
公开(公告)日：2012-03-27
申请号：US10573839
申请日：2004-09-28
CPC分类号： H01L51/0088 , C08G61/12 , C09K11/06 , C09K2211/1029 , C09K2211/1092 , C09K2211/1425 , C09K2211/185 , H01L51/0035 , H01L51/0036 , H01L51/0038 , H01L51/0043 , H01L51/0084 , H01L51/0085 , H01L51/0087 , H01L51/0089 , H01L51/5016 , H05B33/14 , Y10S428/917
摘要： A polymer light emitting material which contains a polymer compound comprising a repeating unit of the following formula (1) or (2) and having a polystyrene-reduced number-average molecular weight of 103 to 108, and which exhibits light emission from the triplet excited state. [wherein Ar1 and Ar2 each independently represent a trivalent aromatic hydrocarbon group or a trivalent heterocyclic group. X1 and X2 each independently represent O, S, C(═O), S(═O), SO2, C(R1)(R2), Si(R3)(R4), N(R5), B(R6), P(R7) or P(═O)(R8). X1 and Ar2 bond to adjacent carbon atoms in the aromatic ring of Ar1; and X2 and Ar1 bond to adjacent carbon atoms in the aromatic ring of Ar2]; [wherein Ar3 and Ar4 each independently represent a trivalent aromatic hydrocarbon group or a trivalent heterocyclic group. X3 and X4 each independently represent N, B, P, C(R9) or Si(R10). X3 and Ar4 bond to adjacent carbon atoms in the aromatic ring of Ar3; and X4 and Ar3 bond to adjacent carbon atoms in the aromatic ring of Ar4].
摘要翻译： 一种聚合物发光材料，其含有包含下式（1）或（2）的重复单元，聚苯乙烯换算的数均分子量为103〜108的高分子化合物，其表现出来自三重态激发的发光 州。 [其中Ar1和Ar2各自独立地表示三价芳族烃基或三价杂环基。 X1和X2各自独立地表示O，S，C（= O），S（= O），SO2，C（R1）（R2），Si（R3）（R4），N（R5） P（R7）或P（= O）（R8）。 X1和Ar2与Ar1芳环中的相邻碳原子键合; 并且X2和Ar1键合到Ar2的芳环中的相邻碳原子上]; [其中Ar 3和Ar 4各自独立地表示三价芳族烃基或三价杂环基。 X3和X4各自独立地表示N，B，P，C（R9）或Si（R10）。 X3和Ar4与Ar3芳环中的相邻碳原子键合; 并且X 4和Ar 3键合到Ar 4的芳环中的相邻碳原子上]。
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