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11.发明申请OPTICAL IMAGING PROBES, OPTICAL IMAGING SYSTEMS, METHODS OF OPTICAL IMAGING, AND METHODS OF USING OPTICAL IMAGING PROBES 审中-公开光学成像探针，光学成像系统，光学成像方法和使用光学成像探针的方法公开(公告)号：US20120220870A1
公开(公告)日：2012-08-30
申请号：US13406891
申请日：2012-02-28
CPC分类号： A61K49/0013 , A61B5/0075 , A61B6/037 , A61B6/508 , A61K51/00 , A61K51/0491 , B82Y30/00
摘要： Embodiments of the present disclosure provide for radionuclide probes, methods of using the radionuclide probes, methods of detecting an optical signal from radionuclides, methods of detecting an optical signal from a quantum dot(s) that receives optical energy from a radionuclide(s), system for analyzing optical energy emitted by a radionuclide(s), system for imaging a target within a living subject or a sample, methods of imaging a disease or condition, and the like.
摘要翻译： 本公开的实施例提供放射性核素探针，使用放射性核素探针的方法，从放射性核素检测光信号的方法，从从放射性核素接收光能的量子点检测光信号的方法， 用于分析由放射性核素发射的光能的系统，用于对活体或样品内的靶进行成像的系统，成像疾病或病症的方法等。
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公开(公告)号：USD1038873S1
公开(公告)日：2024-08-13
申请号：US29935634
申请日：2024-04-03
申请人： Zhen Cheng
设计人： Zhen Cheng
摘要： FIG. 1 is a front, right, top perspective view of a charging stand, showing my new design;
FIG. 2 is a rear, left, bottom perspective view thereof;
FIG. 3 is a front elevational view of the enlarged scale thereof;
FIG. 4 is a rear elevational view of the enlarged scale thereof;
FIG. 5 is a left side view of the enlarged scale thereof;
FIG. 6 is a right side view of the enlarged scale thereof;
FIG. 7 is a top plan view thereof; and,
FIG. 8 is a bottom plan view thereof.
The dashed broken lines in the figures illustrate portions of the charging stand that form no part of the claimed design.-
13.发明申请公开(公告)号：US20150202335A1
公开(公告)日：2015-07-23
申请号：US14353111
申请日：2012-07-30
申请人： Baozhong Shen , Zhen Cheng , Lihong Bu
发明人： Baozhong Shen , Zhen Cheng , Lihong Bu
CPC分类号： A61K51/088 , A61K49/0002 , A61K49/0032 , A61K49/0056 , A61K49/223
摘要： Disclosed is a targeted molecular imaging probe consisting of a signal component, a component with a targeted affinity to Cx43 and a linker. The biochemical variation characteristic of connexin43 (Cx43) associated with cardiovascular diseases (especially arrhythmia) and neoplastic diseases can be reflected in the form of an image by using the targeted molecular imaging probe capable of being detected by an imaging device, to achieve in vivo molecular imaging.
摘要翻译： 公开了由信号组分，与Cx43具有靶亲和力的组分和连接体组成的靶向分子成像探针。 与心血管疾病（特别是心律失常）和肿瘤疾病相关的连接蛋白43（Cx43）的生物化学变化特征可以通过使用能够由成像装置检测的靶向分子成像探针以图像的形式反映，以实现体内分子 成像。
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14.发明授权公开(公告)号：US08753605B2
公开(公告)日：2014-06-17
申请号：US13199428
申请日：2011-08-30
申请人： Zhen Cheng , Sanjiv Sam Gambhir , Zheng Miao , Hongguang Liu , Gang Ren
发明人： Zhen Cheng , Sanjiv Sam Gambhir , Zheng Miao , Hongguang Liu , Gang Ren
CPC分类号： A61K49/0004 , A61K38/16 , A61K49/0008 , A61K49/14 , A61K51/08 , A61K51/088 , G01N33/574 , G01N33/74 , G01N2333/71
摘要： In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to methods of detecting the over-expression of epidermal growth factor receptor (EGFR) in a subject or sample, methods of diagnosing the presence of one or more angiogenesis related diseases or related biological events in a subject or sample, method of monitoring the progress of one or more angiogenesis related diseases or related biological events in a subject or sample, a 18F-FBEM-CYS-ZEGFR:1907 probe, compositions including a 18F-FBEM-CYS-ZEGFR:1907 probe, and pharmaceutical compositions including a 18F-FBEM-CYS-ZEGFR:1907 probe and the like.
摘要翻译： 根据本公开的目的，如本文所体现和广泛描述的，本公开的实施方案在一方面涉及检测受试者中表皮生长因子受体（EGFR）的过度表达的方法 或样品，诊断受试者或样品中一种或多种血管生成相关疾病或相关生物事件的存在的方法，监测受试者或样品中一种或多种血管生成相关疾病或相关生物学事件进展的方法，18F- FBEM-CYS-ZEGFR：1907探针，包含18F-FBEM-CYS-ZEGFR：1907探针的组合物和包含18F-FBEM-CYS-ZEGFR：1907探针等的药物组合物。
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公开(公告)号：US20130015943A1
公开(公告)日：2013-01-17
申请号：US13519990
申请日：2010-03-10
申请人： Zhengping Liu , Yutang Liu , Jun Wang , Jinhua Yang , Daohua Gao , Zhen Cheng , Quantao Li , Tianju Sun
发明人： Zhengping Liu , Yutang Liu , Jun Wang , Jinhua Yang , Daohua Gao , Zhen Cheng , Quantao Li , Tianju Sun
CPC分类号： H01C7/02 , H01C1/1406 , H01C17/28
摘要： A surface-mount type over-current protection element includes two single-layer composite chips, wherein one chip is made of a first core material and a first and a second metallic foil layer attached on the two surfaces of the first core material, the other chip is made of a second core material and a third and a fourth metallic foil layer attached to the two surfaces of the second core material. The protection element also has an insulating layer arranged between the two chips to electrically insulate and bond to the second and third metallic layers to form a bi-layer composite chip. Part of the first metallic foil layer and the corresponding part of the fourth metallic foil layer are etched to expose part of the first core material and correspond part of the second core material. One or more through-holes are made on the bi-layer composite chip for mounting.
摘要翻译： 表面安装型过电流保护元件包括两个单层复合芯片，其中一个芯片由第一芯材料和附接在第一芯材料的两个表面上的第一和第二金属箔层制成，另一个 芯片由第二芯材料和附接到第二芯材的两个表面的第三和第四金属箔层制成。 保护元件还具有布置在两个芯片之间的绝缘层，以电绝缘并结合到第二和第三金属层以形成双层复合芯片。 第一金属箔层的一部分和第四金属箔层的对应部分被蚀刻以暴露第一芯材料的一部分并对应于第二芯材料的一部分。 在双层复合材料芯片上形成一个或多个通孔用于安装。
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16.发明申请Small technetium-99m and rhenium labeled agents and methods for imaging tissues, organs and tumors 审中-公开小锝-99m和铼标记的试剂和成像组织，器官和肿瘤的方法公开(公告)号：US20060159617A1
公开(公告)日：2006-07-20
申请号：US10534225
申请日：2003-11-08
申请人： Ashfaq Mahmood , Zhen Cheng , Alun Jones , Alan Davison
发明人： Ashfaq Mahmood , Zhen Cheng , Alun Jones , Alan Davison
IPC分类号： A61K51/00 , C07F13/00 , C07F5/00 , C07D211/26
CPC分类号： C07C323/41 , A61K51/0455 , A61K51/0478 , C07C323/25 , C07D211/14 , C07D211/52 , C07D211/58 , C07F13/005
摘要： The present invention relates to compounds and related technetium and rhenium complexes thereof which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors. In another embodiment, the invention relates the methods of imaging tissues, organs or tumors using radiolabeled metal complexes, particularly tissues, organs, or tumors which express certain receptors to which the compounds or complexes of the invention have an affinity. The present invention also relates to methods of treating cancer, particularly those cancer lines which express certain receptors to which the compounds or complexes of the invention have an affinity. In yet another embodiment, the present invention provides methods of imaging and/or inhibiting receptors or neuroreceptors using compounds or complexes of the invention which have an affinity for the receptor or neuroreceptor to be imaged and/or inhibited.
摘要翻译： 本发明涉及适用于组织，器官或肿瘤的成像或治疗性治疗的化合物及其相关锝和铼络合物。 在另一个实施方案中，本发明涉及使用放射性标记的金属络合物，特别是表达本发明的化合物或复合物具有亲和力的某些受体的组织，器官或肿瘤来成像组织，器官或肿瘤的方法。 本发明还涉及治疗癌症的方法，特别是那些表达本发明化合物或复合物具有亲和力的某些受体的那些癌症系。 在另一个实施方案中，本发明提供使用对受体或神经受体成像和/或抑制的亲和力的本发明化合物或复合物成像和/或抑制受体或神经受体的方法。
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公开(公告)号：US09764048B2
公开(公告)日：2017-09-19
申请号：US14353111
申请日：2012-07-30
申请人： Baozhong Shen , Zhen Cheng , Lihong Bu
发明人： Baozhong Shen , Zhen Cheng , Lihong Bu
CPC分类号： A61K51/088 , A61K49/0002 , A61K49/0032 , A61K49/0056 , A61K49/223
摘要： Disclosed is a targeted molecular imaging probe consisting of a signal component, a component with a targeted affinity to Cx43 and a linker. The biochemical variation characteristic of connexin43 (Cx43) associated with cardiovascular diseases (especially arrhythmia) and neoplastic diseases can be reflected in the form of an image by using the targeted molecular imaging probe capable of being detected by an imaging device, to achieve in vivo molecular imaging.
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公开(公告)号：US20120107240A1
公开(公告)日：2012-05-03
申请号：US13373072
申请日：2011-11-03
申请人： Shuanglong Liu , Hongguang Liu , Zhen Cheng
发明人： Shuanglong Liu , Hongguang Liu , Zhen Cheng
IPC分类号： A61K51/00 , C07D211/78 , C12Q1/02
CPC分类号： A61K51/0459 , C07D213/81 , G01N33/5011 , G01N33/5088 , G01N33/5743 , G01N33/60 , G01N2800/52
摘要： Embodiments of the present disclosure provide for labeled probes such as a 3-18F-fluoropicolinamide probe, methods of making labeled probes, pharmaceutical compositions including labeled probes, methods of using labeled probes, methods of diagnosing, localizing, monitoring, and/or assessing melanin related diseases, cancers, tumors, precancerous cells, and related biological events (e.g., malignant melanoma), using labeled probes, kits for diagnosing, localizing, monitoring, and/or assessing melanin related diseases, cancers, tumors, precancerous cells, and related biological events, using labeled probes, and the like.
摘要翻译： 本公开的实施方案提供了标记的探针，例如3-18F-氟吡啶酰胺探针，制备标记探针的方法，包括标记探针的药物组合物，使用标记探针的方法，诊断，定位，监测和/或评估黑色素的方法 使用标记的探针，用于诊断，定位，监测和/或评估黑色素相关疾病，癌症，肿瘤，癌前期细胞和相关的试剂盒的相关疾病，癌症，肿瘤，癌前期细胞和相关生物学事件（例如，恶性黑素瘤） 生物学事件，使用标记探针等。
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19.发明申请Molecular imaging of matrix metalloproteinase expression using labeled chlorotoxin 审中-公开使用标记蝎氯毒素的基质金属蛋白酶表达的分子成像公开(公告)号：US20090004105A1
公开(公告)日：2009-01-01
申请号：US12215136
申请日：2008-06-25
申请人： Zhen Cheng , Sanjiv S. Gambhir
发明人： Zhen Cheng , Sanjiv S. Gambhir
CPC分类号： A61K51/1096 , G01N1/30
摘要： Embodiments of the present disclosure provide for: methods for imaging MMP-2 positive tissue; methods of diagnosing the presence of one or more of MMP-2 positive precancerous cells, MMP-2 positive cancerous cells, MMP-2 positive tumor cells, and MMP-2 positive diseases in a tissue; method of monitoring the progress of one or more of MMP-2 positive precancerous cells, MMP-2 positive cancerous cells, MMP-2 positive tumor cells, and MMP-2 positive diseases in a tissue; pharmaceutical compositions for imaging one or more of MMP-2 positive precancerous cells, MMP-2 positive cancerous cells, MMP-2 positive tumor cells, and MMP-2 positive diseases; compositions; kits; and the like.
摘要翻译： 本公开的实施方案提供：用于成像MMP-2阳性组织的方法; 在组织中诊断MMP-2阳性癌前细胞，MMP-2阳性癌细胞，MMP-2阳性肿瘤细胞和MMP-2阳性疾病的存在的方法; 监测组织中MMP-2阳性癌前细胞，MMP-2阳性癌细胞，MMP-2阳性肿瘤细胞和MMP-2阳性疾病中一种或多种的进展的方法; 用于成像MMP-2阳性癌前细胞，MMP-2阳性癌细胞，MMP-2阳性肿瘤细胞和MMP-2阳性疾病中的一种或多种的药物组合物; 组成; 工具包 等等。
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20.发明申请Novel agents for preventing and treating disorders involving modulation of the RyR receptors 有权用于预防和治疗涉及RyR受体调节的疾病的新型药剂公开(公告)号：US20070049572A1
公开(公告)日：2007-03-01
申请号：US11212413
申请日：2005-08-25
申请人： Andrew Marks , Donald Landry , Shixian Deng , Zhen Cheng , Stephan Lehnart
发明人： Andrew Marks , Donald Landry , Shixian Deng , Zhen Cheng , Stephan Lehnart
IPC分类号： C07D291/08 , A61K31/554
CPC分类号： C07D281/10 , C07D417/12 , C07D417/14
摘要： The present invention provides novel compounds of Formula I and salts, hydrates, solvates, complexes, and prodrugs thereof. The present invention further provides methods for synthesizing compounds of Formula I. The invention additionally provides pharmaceutical compositions comprising the compounds of Formula I and methods of using the pharmaceutical compositions of Formula I to treat and prevent disorders and diseases associated with the RyR receptors that regulate calcium channel functioning in cells. Such disorders and diseases include, by way of example only, cardiac disorders and diseases, skeletal muscular disorders and diseases, cognitive disorders and diseases, malignant hyperthermia, diabetes, and sudden infant death syndrome. Cardiac disorder and diseases include, but are not limited to, irregular heartbeat disorders and diseases; exercise-induced irregular heartbeat disorders and diseases; sudden cardiac death; exercise-induced sudden cardiac death; congestive heart failure; chronic obstructive pulmonary disease; and high blood pressure. Irregular heartbeat disorders and diseases include and exercise-induced irregular heartbeat disorders and diseases include, but are not limited to, atrial and ventricular arrhythmia; atrial and ventricular fibrillation; atrial and ventricular tachyarrhythmia; atrial and ventricular tachycardia; catecholaminergic polymorphic ventricular tachycardia (CPVT); and exercise-induced variants thereof. Skeletal muscular disorder and diseases include, but are not limited to, skeletal muscle fatigue, exercise-induced skeletal muscle fatigue, muscular dystrophy, bladder disorders, and incontinence. Cognitive disorders and diseases include, but are not limited to, Alzheimer's Disease, forms of memory loss, and age-dependent memory loss.
摘要翻译： 本发明提供新的式I化合物及其盐，水合物，溶剂合物，络合物和前药。 本发明还提供了合成式I化合物的方法。本发明另外提供包含式I化合物的药物组合物和使用式I药物组合物的方法，以治疗和预防与调节钙的RyR受体相关的疾病和疾病 通道在单元格中起作用。 这样的疾病和疾病仅包括心脏病和疾病，骨骼肌障碍和疾病，认知障碍和疾病，恶性高热，糖尿病和婴儿猝死综合征。 心脏疾病和疾病包括但不限于不规则的心跳障碍和疾病; 运动引起的心律失常和疾病不规律; 心脏猝死; 运动性心源性猝死; 充血性心力衰竭; 慢性阻塞性肺疾病; 和高血压。 不规律的心跳疾病和疾病包括运动诱发的心律失常和疾病的疾病包括但不限于心房和室性心律失常; 心房和心室颤动; 心房和心室快速性心律失常; 心房和室性心动过速; 儿茶酚胺能多态性室性心动过速（CPVT）; 和运动诱发的变体。 骨骼肌障碍和疾病包括但不限于骨骼肌疲劳，运动引起的骨骼肌疲劳，肌营养不良，膀胱障碍和失禁。 认知障碍和疾病包括但不限于阿尔茨海默病，记忆丧失的形式和年龄依赖性记忆丧失。
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