公开(公告)号：US09554738B1

公开(公告)日：2017-01-31

申请号：US15234449

申请日：2016-08-11

Applicant: Zyomed Corp.

Inventor： Sandeep Gulati ,  Timothy L. Ruchti ,  John L. Smith ,  William Van Antwerp

IPC: G01J5/02 ,  A61B5/1455 ,  G01N21/359 ,  G01N21/3563 ,  A61B5/145 ,  A61B5/00

CPC classification number: A61B5/1455 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/6801 ,  A61B2562/0238 ,  A61B2562/046 ,  A61B2576/00 ,  G01N21/3563 ,  G01N21/359 ,  G01N2201/12

Abstract: In a noninvasive system for detection/measurement of analytes in tissue, spectra from the medium are deconstructed into features. Conditioned features, which contain frequency components specific to the analytes, are derived from one or more features after modulating a carrier kernel with the feature. The conditioned features are computationally collided with one or more Zyotons that are co-dependent with the conditioned features. One or more collisions amplify the energy absorbed by the analyte from radiation directed to the tissue. The value of the amplified energy is transformed into an accurate estimate of the concentration of the analyte. Depending on the analyte type, a particular tissue region is targeted and/or one or more parameters of the computational collision are selected.

Abstract translation: 在用于检测/测量组织中分析物的非侵入性系统中，来自培养基的光谱被解构为特征。 包含特定于分析物的频率分量的条件特征在调制具有特征的载体核心之后从一个或多个特征导出。 条件特征与一个或多个与条件特征相关的Zyotons计算相撞。 一个或多个碰撞放大被分析物从被引导到组织的辐射所吸收的能量。 扩增能量的值被转化为准确估计分析物的浓度。 根据分析物类型，特定组织区域是目标的，和/或选择计算碰撞的一个或多个参数。

公开(公告)号：US09459202B2

公开(公告)日：2016-10-04

申请号：US14993830

申请日：2016-01-12

Applicant: Zyomed Corp.

Inventor： Sandeep Gulati ,  Timothy L. Ruchti ,  William Van Antwerp ,  John L. Smith

IPC: G01J5/02 ,  G01N21/3577 ,  A61B5/024 ,  G01N21/359 ,  G01N21/47 ,  G01N21/49 ,  G01N33/49 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1495

CPC classification number: A61B5/14532 ,  A61B5/0075 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/02433 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/4833 ,  G01N33/49 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/067 ,  G01N2201/12 ,  G01N2201/129

Abstract: A collision-computing system detects and amplifies the energy associated with a feature signal to determine occurrences or absence of events, such as ultrasonic and/or geophysical events, or to determine presence and/or concentrations of substances such as blood glucose, toxic chemicals, etc., in a noisy, high-clutter environment or sample. To this end, a conditioned feature, obtained by modulating a carrier kernel with a feature signal, is collided with a Zyoton—a waveform that without a collision can travel substantially unperturbed in a propagation medium over a specified distance. The conditioned feature and the Zyoton are particularly constructed to be co-dependent in terms of their respective dispersion velocities and the divergence of a waveform resulting from the collision. The collision operation can transfer at least a portion of the feature energy to the resulting waveform, and the transferred energy can be amplified in successive collisions for detecting/measuring events/substances.

Abstract translation: 碰撞计算系统检测和放大与特征信号相关联的能量，以确定诸如超声波和/或地球物理事件之类的事件的出现或不存在，或者确定物质的存在和/或浓度，例如血糖，有毒化学物质， 等等，在嘈杂，高杂乱的环境或样品中。 为此，通过调制具有特征信号的载体核获得的调节特征与Zyoton-a波形相撞，其中没有碰撞可以在传播介质中在特定距离上基本上不受干扰地行进。 调节特征和Zyoton特别构造为在它们各自的分散速度和由碰撞产生的波形的发散度方面是共同依赖的。 碰撞操作可以将特征能量的至少一部分转移到所得到的波形，并且传送的能量可以在连续的碰撞中被放大以用于检测/测量事件/物质。

公开(公告)号：US20170035308A1

公开(公告)日：2017-02-09

申请号：US15233474

申请日：2016-08-10

Applicant: Zyomed Corp.

Inventor： Sandeep Gulati ,  Timothy L. Ruchti ,  William Van Antwerp ,  John L. Smith

IPC: A61B5/024 ,  G01N21/359 ,  G01N21/49 ,  A61B5/00 ,  G01N33/49 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1495 ,  G01N21/3577 ,  G01N33/483

CPC classification number: A61B5/14532 ,  A61B5/0075 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/02433 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/4833 ,  G01N33/49 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/067 ,  G01N2201/12 ,  G01N2201/129

Abstract: In a noninvasive system for measurement of heart rate and other heart-related characteristics a photoplethysmogram (PPG) obtained from a tissue is divided into several feature waveforms, each corresponding to a PPG window of a particular length. Conditioned features, containing frequency components specific to heart-related events, are derived from the features by modulating a carrier kernel with such features. The conditioned features are computationally collided with one or more Zyotons that are co-dependent with the conditioned features. For each conditioned feature, one or more collisions selectively amplify frequency components in features sourced from PPG, and respective energy change values are obtained from such amplified energy portions. The resulting energy change values are analyzed to determine a smallest time-window likely containing heart rate and other heart-related events in the PPG data stream. Over time, the detected events are grouped and analyzed to determine heart rate and other heart-related characteristics.

Abstract translation: 在用于测量心率和其他心脏相关特征的非侵入性系统中，从组织获得的光谱体积图（PPG）被分成几个特征波形，每个特征波形对应于特定长度的PPG窗口。 包含与心脏相关事件特定的频率分量的条件特征是通过使用这些特征调制载体内核从特征得出的。 条件特征与一个或多个与条件特征相关的Zyotons计算相撞。 对于每个调节特征，一个或多个碰撞选择性地放大来自PPG的特征中的频率分量，并且从这种经放大的能量部分获得各自的能量变化值。 分析所得到的能量变化值以确定可能包含PPG数据流中的心率和其他心脏相关事件的最小时间窗口。 随着时间的推移，检测到的事件被分组和分析，以确定心率和其他心脏相关特征。

公开(公告)号：US09448165B2

公开(公告)日：2016-09-20

申请号：US15081465

申请日：2016-03-25

Applicant: Zyomed Corp.

Inventor： Sandeep Gulati ,  Timothy L. Ruchti ,  John L. Smith ,  William Van Antwerp

IPC: G01J5/02 ,  G01N21/359 ,  A61B5/145 ,  A61B5/1455 ,  G01N33/483

CPC classification number: A61B5/14532 ,  A61B5/0075 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/02433 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/4833 ,  G01N33/49 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/067 ,  G01N2201/12 ,  G01N2201/129

Abstract: In a noninvasive system for detection/measurement of glucose and other analytes in a medium such as tissue, illumination is directed to the medium and corresponding radiation from the medium is collected. Spectral energy changes associated with fragment(s)/feature(s) obtained from the collected radiation are determined using collision computing. Such spectral energy changes generally represent analyte concentration. The collection of radiation and/or illumination is controlled either to target a particular volume of the medium or such that the spectral energy changes become directionally monotonic with respect to analyte concentration, or both. The collection parameters include: duration of collection, location and/or a size of a collection spot on the medium surface, and angle of a collector relative to the medium surface. The illuminated and/or collection spots may be treated to improve accuracy of analyte measurement.

Abstract translation: 在用于在诸如组织的培养基中检测/测量葡萄糖和其它分析物的非侵入性系统中，照射被引导到介质并收集来自培养基的相应辐射。 使用碰撞计算确定与从收集的辐射获得的片段/特征相关联的光谱能量变化。 这种光谱能量变化通常表示分析物浓度。 控制辐射和/或照明的收集以靶向介质的特定体积，或者使得光谱能量变化相对于分析物浓度变得朝向单调，或两者。 收集参数包括：介质表面上的收集点的持续时间，位置和/或收集点的大小以及收集器相对于介质表面的角度。 可以处理照明和/或收集点以提高分析物测量的准确度。

公开(公告)号：US20160231236A1

公开(公告)日：2016-08-11

申请号：US15081465

申请日：2016-03-25

Applicant: Zyomed Corp.

Inventor： Sandeep Gulati ,  Timothy L. Ruchti ,  John L. Smith ,  William Van Antwerp

IPC: G01N21/359 ,  A61B5/1455 ,  G01N33/483 ,  A61B5/145

CPC classification number: A61B5/14532 ,  A61B5/0075 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/02433 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/4833 ,  G01N33/49 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/067 ,  G01N2201/12 ,  G01N2201/129

Abstract: In a noninvasive system for detection/measurement of glucose and other analytes in a medium such as tissue, illumination is directed to the medium and corresponding radiation from the medium is collected. Spectral energy changes associated with fragment(s)/feature(s) obtained from the collected radiation are determined using collision computing. Such spectral energy changes generally represent analyte concentration. The collection of radiation and/or illumination is controlled either to target a particular volume of the medium or such that the spectral energy changes become directionally monotonic with respect to analyte concentration, or both. The collection parameters include: duration of collection, location and/or a size of a collection spot on the medium surface, and angle of a collector relative to the medium surface. The illuminated and/or collection spots may be treated to improve accuracy of analyte measurement.

Abstract translation: 在用于在诸如组织的培养基中检测/测量葡萄糖和其它分析物的非侵入性系统中，照射被引导到介质并收集来自培养基的相应辐射。 使用碰撞计算确定与从收集的辐射获得的片段/特征相关联的光谱能量变化。 这种光谱能量变化通常表示分析物浓度。 控制辐射和/或照明的收集以靶向介质的特定体积，或者使得光谱能量变化相对于分析物浓度变得朝向单调，或两者。 收集参数包括：介质表面上的收集点的持续时间，位置和/或收集点的大小以及收集器相对于介质表面的角度。 可以处理照明和/或收集点以提高分析物测量的准确度。

公开(公告)号：US20160139043A1

公开(公告)日：2016-05-19

申请号：US14993905

申请日：2016-01-12

Applicant: Zyomed Corp.

Inventor： Sandeep Gulati ,  Timothy L. Ruchti ,  William Van Antwerp ,  John L. Smith

IPC: G01N21/3577 ,  G01N33/49 ,  G01N21/359

CPC classification number: A61B5/14532 ,  A61B5/0075 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/02433 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/4833 ,  G01N33/49 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/067 ,  G01N2201/12 ,  G01N2201/129

Abstract: A synthetic projection system determines analyte concentration, such as blood glucose concentration, from a spectral-energy change associated with an uncharacterized instance of a medium in which the analyte is likely present. The projection system is factory calibrated for different instances of the medium, without needing instance-specific training or calibration. The projection system includes a set of projector curves, each relating spectral-energy change values obtained by analyzing reference medium samples to analyte concentrations in those samples. Each projector curve also corresponds to a respective range of energy-change gradients, determined using a group of surrogate media characterized according to analyte concentrations measured using a reference system. A spectral-energy-change gradient for the uncharacterized medium may be computed to select one of the projectors curves. Analyte concentration in the uncharacterized medium can be reliably computed at a specified high level of accuracy using the spectral-energy change associated therewith and the selected curve.

Abstract translation: 合成投影系统从与可能存在分析物的介质的非特征实例相关联的光谱能量变化来确定分析物浓度，例如血糖浓度。 投影系统在不同实例的介质下进行出厂校准，无需实例特定的训练或校准。 投影系统包括一组投影仪曲线，每个投影仪曲线都将通过分析参考介质样品获得的光谱能量变化值与这些样品中的分析物浓度相关联。 每个投影仪曲线也对应于能量变化梯度的相应范围，使用一组代用介质，其特征在于使用参考系统测量的分析物浓度。 可以计算未表征介质的光谱能量变化梯度以选择投影仪曲线之一。 使用与其相关联的光谱能量变化和所选择的曲线，可以以指定的高精确度可靠地计算未表征介质中的分析物浓度。

公开(公告)号：US20160139042A1

公开(公告)日：2016-05-19

申请号：US14993885

申请日：2016-01-12

Applicant: Zyomed Corp.

Inventor： Sandeep Gulati ,  Timothy L. Ruchti

IPC: G01N21/3577 ,  G01N33/49 ,  G01N21/359

CPC classification number: A61B5/14532 ,  A61B5/0075 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/02433 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/4833 ,  G01N33/49 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/067 ,  G01N2201/12 ,  G01N2201/129

Abstract: A synthesizer synthesizes Zyotons, waveforms that without a collision can travel substantially unperturbed in a propagation medium over a specified distance, for extracting via collision computing properties of interest of signals, such as the occurrence/absence of events and presence or concentrations of substances such as blood glucose, toxic chemicals, etc., obtained from high noise/clutter environments. The Zyotons are synthesized using base waveform families/generator functions unrelated to the signal environment. The Zyotons and corresponding carrier kernels include component(s) adapted to correspond to a signal property of interest and other component(s) adapted to correspond to other properties, such as noise and clutter. The number of each type of component(s) may be determined using a representative signal obtained from the environment that is optionally transformed via derivitization, addition of noise and/or another representative signal, etc. A base waveform family/generator function can be selected according to the representative signal morphology.

Abstract translation: 合成器合成Zyotons，没有碰撞的波形可以在传播介质中在特定距离内基本上不受干扰地传播，用于通过诸如事件的发生/不存在以及物质的存在或浓度（例如， 血糖，有毒化学物质等，从高噪声/杂波环境中获得。 Zyotons使用与信号环境无关的基本波形族/发生器功能合成。 Zyotons和相应的载体内核包括适于对应于感兴趣的信号特性的组件和适于对应于诸如噪声和杂波的其他性质的其它组件的组件。 可以使用从环境获得的代表信号来确定每种类型的组件的数量，所述代表性信号可选地通过衍生化，噪声的添加和/或其他代表性信号进行变换。可以选择基本波形族/发生器功能 根据代表信号的形态。

公开(公告)号：US20160139041A1

公开(公告)日：2016-05-19

申请号：US14993830

申请日：2016-01-12

Applicant: Zyomed Corp.

Inventor： Sandeep Gulati ,  Timothy L. Ruchti ,  William Van Antwerp ,  John L. Smith

IPC: G01N21/3577 ,  G01N33/49 ,  G01N21/359

CPC classification number: A61B5/14532 ,  A61B5/0075 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/02433 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/4833 ,  G01N33/49 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/067 ,  G01N2201/12 ,  G01N2201/129

Abstract: A collision-computing system detects and amplifies the energy associated with a feature signal to determine occurrences or absence of events, such as ultrasonic and/or geophysical events, or to determine presence and/or concentrations of substances such as blood glucose, toxic chemicals, etc., in a noisy, high-clutter environment or sample. To this end, a conditioned feature, obtained by modulating a carrier kernel with a feature signal, is collided with a Zyoton—a waveform that without a collision can travel substantially unperturbed in a propagation medium over a specified distance. The conditioned feature and the Zyoton are particularly constructed to be co-dependent in terms of their respective dispersion velocities and the divergence of a waveform resulting from the collision. The collision operation can transfer at least a portion of the feature energy to the resulting waveform, and the transferred energy can be amplified in successive collisions for detecting/measuring events/substances.

Abstract translation: 碰撞计算系统检测和放大与特征信号相关联的能量，以确定诸如超声波和/或地球物理事件之类的事件的出现或不存在，或者确定物质的存在和/或浓度，例如血糖，有毒化学物质， 等等，在嘈杂，高杂乱的环境或样品中。 为此，通过调制具有特征信号的载体核获得的调节特征与Zyoton-a波形相撞，其中没有碰撞可以在传播介质中在特定距离上基本上不受干扰地行进。 调节特征和Zyoton特别构造为在它们各自的分散速度和由碰撞产生的波形的发散度方面是共同依赖的。 碰撞操作可以将特征能量的至少一部分转移到所得到的波形，并且传送的能量可以在连续的碰撞中被放大以用于检测/测量事件/物质。

公开(公告)号：US20160097716A1

公开(公告)日：2016-04-07

申请号：US14869550

申请日：2015-09-29

Applicant: Zyomed Corp.

Inventor： Sandeep Gulati ,  Timothy L. Ruchti ,  William V. Antwerp ,  John L. Smith

IPC: G01N21/47 ,  A61B5/024 ,  G01N33/49 ,  G01N21/49 ,  G01N21/359

CPC classification number: A61B5/14532 ,  A61B5/0075 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/02433 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/4833 ,  G01N33/49 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/067 ,  G01N2201/12 ,  G01N2201/129

Abstract: In a noninvasive system for detection/measurement of glucose and other analytes in a medium such as tissue, spectra from the medium are deconstructed into features. Conditioned features, which contain frequency components specific to glucose or the other analytes, are derived from one or more features by modulating a carrier kernel with the feature. The conditioned features are computationally collided with one or more Zyotons that are co-dependent with the conditioned features. One or more collisions amplify a property of the analyte e.g., energy absorbed by glucose in tissue from radiation directed to the skin. A gradient of several values of the amplified property, each value corresponding to a particular radiation pattern according to a spectroscopic tomographic sequence, is used to select a suitable projector curve, with which a representative amplified value is projected to an accurate estimate of the concentration of glucose or the other analytes, without needing personalized calibration.

Abstract translation: 在用于在诸如组织的培养基中检测/测量葡萄糖和其它分析物的非侵入性系统中，来自培养基的光谱被解构为特征。 包含特定于葡萄糖或其他分析物的频率分量的条件特征通过调制具有该特征的载体核心从一个或多个特征导出。 条件特征与一个或多个与条件特征相关的Zyotons计算相撞。 一个或多个碰撞放大分析物的性质，例如组织中由葡萄糖吸收的能量，辐射被引导到皮肤。 使用放大性能的几个值的梯度，每个值对应于根据光谱断层扫描序列的特定辐射图，其值被选择合适的投影仪曲线，其中代表性的放大值被预测为准确地估计浓度 葡萄糖或其他分析物，不需要个性化校准。