公开(公告)号：US20210254093A1

公开(公告)日：2021-08-19

申请号：US17195247

申请日：2021-03-08

申请人： Devgen NV

发明人： Thierry BOGAERT ,  Romaan RAEMAEKERS ,  Yann NAUDET

IPC分类号： C12N15/82 ,  C12N15/113

摘要： The present invention relates to the prevention and/or control of infestation by insect pest species. In particular, the invention relates to down-regulation of expression of target genes in insect pests using interfering ribonucleic acid (RNA) molecules. Also described are transgenic plants that (i) express or are capable of expressing interfering RNAs of the invention and (ii) are resistant to infestation by insect pest species. Compositions containing the interfering RNAs of the invention are also provided.

公开(公告)号：US20210123069A1

公开(公告)日：2021-04-29

申请号：US17051048

申请日：2019-04-17

申请人： DEVGEN NV

发明人： Lien DE SCHRIJVER ,  Kaat CAPPELLE ,  Lies DEGRAVE ,  Yann NAUDET ,  Steffy DENORME

IPC分类号： C12N15/82 ,  A01N63/60

摘要： Disclosed are double stranded RNA molecules that are toxic to flea beetles, particularly the flea beetle species Psylliodes chrysocephala, Phyllotreta nemorum, Phyllotreta striolata, Phyllotreta armoraciae, and Phyllotreta cruciferae. In particular, interfering RNA molecules capable of interfering with pest target genes and that are toxic to the target pest are provided. Further, methods of making and using the interfering RNA, for example in transgenic plants or as the active ingredient in a composition, to confer protection from insect damage are disclosed.

公开(公告)号：US09982258B2

公开(公告)日：2018-05-29

申请号：US14485103

申请日：2014-09-12

申请人： Romaan Raemaekers ,  Pascale Feldmann ,  Geert Plaetinck ,  Irene Nooren ,  Frederic Pecqueur ,  Laurent Kubler ,  Nicole Damme ,  Lies Degrave ,  Isabel Remory ,  Thierry Bogaert

发明人： Romaan Raemaekers ,  Pascale Feldmann ,  Geert Plaetinck ,  Irene Nooren ,  Els Van Bleu ,  Frederic Pecqueur ,  Laurent Kubler ,  Nicole Damme ,  Lies Degrave ,  Isabel Remory ,  Thierry Bogaert

IPC分类号： C12N15/11 ,  C12N15/113 ,  A01N63/02 ,  C12N15/82

CPC分类号： C12N15/113 ,  A01N63/02 ,  C12N15/8286 ,  C12N2310/14 ,  Y02A40/162

摘要： The present invention relates to methods for controlling pest infestation using double stranded RNA molecules. The invention provides methods for producing transgenic cells expressing the double stranded RNA molecules, as well as compositions and commodity products containing or treated with such molecules.

公开(公告)号：US09206438B2

公开(公告)日：2015-12-08

申请号：US13462636

申请日：2012-05-02

申请人： Myriam Beghyn ,  Thierry Andre Olivier Eddy Bogaert ,  Pascale Feldmann ,  Romaan Raemaekers

发明人： Myriam Beghyn ,  Thierry Andre Olivier Eddy Bogaert ,  Pascale Feldmann ,  Romaan Raemaekers

IPC分类号： C12N15/82 ,  C07K14/435

CPC分类号： C12N15/113 ,  A01N57/16 ,  A01N63/00 ,  C07K14/43563 ,  C12N15/8218 ,  C12N15/8286 ,  C12N2310/14 ,  Y02A40/162

摘要： The present invention relates to genetic control of infestation by insect pest species, particularly prevention and/or control of pest infestation of plants, using interfering ribonucleic acid (RNA) molecules. Compositions and combinations containing the interfering RNA molecules of the invention for use in topical applications, for example in the form of insecticides.

摘要翻译： 本发明涉及使用干扰核糖核酸（RNA）分子的昆虫害虫侵染的遗传控制，特别是预防和/或控制植物害虫侵染。 含有用于局部应用的本发明的干扰RNA分子的组合物和组合，例如以杀虫剂的形式。

公开(公告)号：US20140109258A1

公开(公告)日：2014-04-17

申请号：US14022278

申请日：2013-09-10

申请人： Devgen NV

发明人： Marc Van De Craen ,  Geert Karel Maria Plaetinck ,  Isabel Vercauteren ,  Marc Georges Logghe ,  Thierry Andre Olivier Eddy Bogaert ,  Richard Zwaal

IPC分类号： C12N15/113 ,  C12N15/82

CPC分类号： C12N15/8285 ,  C12N15/111 ,  C12N15/113 ,  C12N15/8279 ,  C12N2310/14 ,  C12N2310/3519 ,  C12N2330/30

摘要： The present invention concerns concatemer and/or stabilized RNA constructs capable of forming dsRNA, optionally comprising a sequence capable of protecting the dsRNA against RNA processing in a host cell. The invention also relates to methods of producing these constructs and to methods for using these constructs. The constructs according to the present invention are particularly useful in plant pest control.

摘要翻译： 本发明涉及能够形成dsRNA的并联和/或稳定的RNA构建体，任选地包含能够保护dsRNA的宿主免受宿主细胞中RNA加工的序列。 本发明还涉及生产这些构建体的方法和使用这些构建体的方法。 根据本发明的构建体在植物害虫防治中特别有用。

公开(公告)号：US20090233960A1

公开(公告)日：2009-09-17

申请号：US12083408

申请日：2006-10-13

申请人： Philippe Van Rompaey ,  Philippe Arzel ,  Olivier Raynald Defert ,  Dirk Casimir Maria Leysen

发明人： Philippe Van Rompaey ,  Philippe Arzel ,  Olivier Raynald Defert ,  Dirk Casimir Maria Leysen

IPC分类号： A61K31/437 ,  A61K31/44 ,  C07D471/04 ,  C07D213/02

CPC分类号： C07D213/40 ,  C07D401/12 ,  C07D407/12 ,  C07D409/12 ,  C07D471/04

摘要： The present invention relates to new AGC kinase inhibitors, in particular to compounds of Formula I, II, or III or a stereoisomer, tautomer, racemic, metabolite, pro- or predrug, salt, hydrate, or solvate thereof, I II III wherein X, R1, R2, R3, R31, n, and m have the meaning defined in the claims. In particular, the present invention relates more specifically to ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease.

摘要翻译： 本发明涉及新的AGC激酶抑制剂，特别是涉及式I，II或III的化合物或其立体异构体，互变异构体，外消旋，代谢物，前体或前药，盐，水合物或溶剂合物，其中X ，R1，R2，R3，R31，n和m具有权利要求中限定的含义。 特别地，本发明更具体地涉及包含这种抑制剂的ROCK抑制剂，组合物，特别是药物，以及这些抑制剂在治疗和预防疾病中的用途。

公开(公告)号：US20090118283A1

公开(公告)日：2009-05-07

申请号：US11988699

申请日：2006-07-11

申请人： Olivier Raynald Defert ,  Gert De Wilde ,  Petra Blom ,  Dirk Casimir Maria Leysen ,  Thomas Brown ,  Nadzeya Kaval

发明人： Olivier Raynald Defert ,  Gert De Wilde ,  Petra Blom ,  Dirk Casimir Maria Leysen ,  Thomas Brown ,  Nadzeya Kaval

IPC分类号： A61K31/4409 ,  C07D211/72 ,  C07D239/38 ,  A61K31/505 ,  A61K31/5377 ,  A61P25/08 ,  A61P9/00 ,  A61P3/10 ,  A61K31/501 ,  C07D405/12 ,  C07D413/12

CPC分类号： C07D213/75 ,  C07D213/81 ,  C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00

摘要： The present invention relates to new AGC kinase inhibitors, in particular to compounds of Formula (I) or (II) or a stereoisomer tautomer, racemic, metabolite, pro- or predrug, salt, hydrate, or solvate thereof, wherein Ar1, Ar2, R1, R3, p and n have the meaning defined in the claims In particular, the present invention relates to more specifically AGC kinases inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease.

摘要翻译： 本发明涉及新的AGC激酶抑制剂，特别是涉及式（I）或（II）的化合物或立体异构体互变异构体，外消旋，代谢产物，前体或前药，盐，水合物或溶剂合物，其中Ar1，Ar2， R1，R3，p和n具有权利要求中限定的含义。特别地，本发明更具体地涉及AGC激酶抑制剂，组合物，特别是药物，包含这种抑制剂，以及这些抑制剂在治疗和预防 疾病。

公开(公告)号：US20080039442A1

公开(公告)日：2008-02-14

申请号：US11793559

申请日：2005-12-20

申请人： Petra Blom ,  Jan de Kerpel ,  Eric Fourmaintraux ,  Titus Kaletta ,  Dirk Leysen

发明人： Petra Blom ,  Jan de Kerpel ,  Eric Fourmaintraux ,  Titus Kaletta ,  Dirk Leysen

IPC分类号： A61K31/343 ,  A61K31/357 ,  A61K31/381 ,  A61K31/404 ,  A61K31/4155 ,  A61K31/423 ,  A61K31/433 ,  A61K31/4525 ,  A61K31/47 ,  A61K31/4965 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/55 ,  A61P25/00 ,  A61P9/00 ,  C07D209/42 ,  C07D215/48 ,  C07D231/10 ,  C07D233/18 ,  C07D241/02 ,  C07D263/58 ,  C07D265/30 ,  C07D285/06 ,  C07D307/82 ,  C07D307/85 ,  C07D307/87 ,  C07D319/16 ,  C07D333/56 ,  C07D333/70 ,  C07D405/02 ,  C07D409/12 ,  C07D413/02 ,  C07D493/00

CPC分类号： C07D307/82 ,  C07D209/42 ,  C07D215/48 ,  C07D307/85 ,  C07D333/70 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12

摘要： The present invention relates to compounds that interact with ion channels. In particular, the invention relates to compounds having the structural Formula (I), (II), (III) or (IV), stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or a pharmaceutically acceptable salt and/or solvate thereof, Formula (I), (II), (III), (IV), wherein X1, X2, Y, Z, W, R1, R8, R9, R10, L, A, z, and n have the meaning defined in claim 1. The invention also relates to methods for preparing said compounds, to pharmaceutical compositions comprising said compounds, and to the use of said compounds in methods for treatment of the human and animal body.

摘要翻译： 本发明涉及与离子通道相互作用的化合物。 特别地，本发明涉及具有结构式（I），（II），（III）或（IV），其立体异构体，互变异构体，外消旋学，前药，代谢物或其药学上可接受的盐和/或溶剂合物的化合物， 式（I），（II），（III），（IV）其中X 1，X 2，Y，Z，W，R 1， R 8，R 9，R 10，L，A，Z和n具有权利要求1中所定义的含义。 本发明还涉及制备所述化合物的方法，包含所述化合物的药物组合物以及所述化合物在治疗人和动物体的方法中的用途。

公开(公告)号：US20070092910A1

公开(公告)日：2007-04-26

申请号：US10561098

申请日：2004-06-17

申请人： Gert De Wilde ,  Michael Saunders ,  Marc Logghe

发明人： Gert De Wilde ,  Michael Saunders ,  Marc Logghe

IPC分类号： C40B30/06 ,  C07H21/04 ,  C12P21/06 ,  C07K16/28 ,  C07K14/705

CPC分类号： C12N9/0006

摘要： The present invention relates to nucleotide sequences, particularly those of SEQ ID NO's 2, 7 and 9 that encode and may be used to express amino acid sequences that are useful in the identification and development of compounds for the prevention and treatment of metabolic diseases such as diabetes and obesity. The invention also relates to the amino acid sequences—such as proteins and/or polypeptides—that are encoded by, and that may be obtained by suitable expression of, the nucleotide sequences of the invention, particularly those set out in SEQ ID NO's 1, 6 and 8. The invention further relates to genetic constructs, host cells and organisms that have been transformed with the nucleotide sequences of the invention and that can express the amino acid sequences of the invention and methods and compositions which utilize the nucleotide and amino acid sequences of the invention.

摘要翻译： 本发明涉及编码并可用于表达可用于鉴定和开发用于预防和治疗代谢性疾病的化合物的氨基酸序列的核苷酸序列，特别是SEQ ID NO：2,7和9的核苷​​酸序列， 糖尿病和肥胖。 本发明还涉及由本发明的核苷酸序列，特别是SEQ ID NO：1中列出的那些的核苷酸序列编码并且可以通过适当表达获得的氨基酸序列 - 例如蛋白质和/或多肽 - 本发明还涉及已经用本发明的核苷酸序列转化并可以表达本发明的氨基酸序列的遗传构建体，宿主细胞和生物体，以及利用核苷酸和氨基酸序列的方法和组合物 的本发明。

公开(公告)号：US20200239891A1

公开(公告)日：2020-07-30

申请号：US16756298

申请日：2018-11-06

申请人： DEVGEN NV

发明人： Yann Naudet ,  Myriam Beghyn ,  Lien De Schrijver ,  Isabelle Maillet ,  Annelies Philips

IPC分类号： C12N15/113 ,  C07H21/02 ,  C12N15/63

摘要： Disclosed are double stranded RNA (dsRNA) molecules that are toxic to insect pests. In particular, interfering RNA molecules capable of modulating expression of a pest insect target gene and that are toxic to the insect pest are provided. Further, methods of making and using the interfering RNA, for example as the active ingredient in an insecticidal composition or in a transgenic plant, to confer protection from insect damage are disclosed.