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11.发明授权Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics 失效与肺炎链球菌相关的核酸和氨基酸序列用于诊断和治疗公开(公告)号：US07875437B2
公开(公告)日：2011-01-25
申请号：US12001413
申请日：2007-12-11
CPC分类号： C07K14/3156 , A61K31/7052 , A61K39/00 , A61K39/092 , A61K2039/53 , C07H21/02 , C07H21/04 , C07K14/315 , Y02A50/472
摘要： The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.
摘要翻译： 本发明提供了分离的多肽和源自肺炎链球菌的核酸序列，其可用于诊断和治疗病理状况; 针对多肽的抗体; 以及用于制备多肽的方法。 本发明还提供了用于检测，预防和治疗由细菌感染引起的病理状况的方法。
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公开(公告)号：US20110015400A1
公开(公告)日：2011-01-20
申请号：US12895068
申请日：2010-09-30
IPC分类号： C07D405/06
CPC分类号： C07F7/10 , C07D211/26 , C07D211/52 , C07D211/70 , C07D213/38 , C07D213/40 , C07D213/53 , C07D405/06
摘要： This invention is directed to processes for the preparation of a compound of the formula I or salt thereof, that is useful as a tryptase inhibitor, to intermediates useful in the preparation of such a compound, to processes for the preparation of such intermediates, and to the use of such intermediates for the preparation of such a compound.
摘要翻译： 本发明涉及制备式I化合物或其盐的方法，其可用作类胰蛋白酶抑制剂，可用于制备这种化合物的中间体，制备这种中间体的方法，以及 使用这样的中间体制备这种化合物。
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13.发明授权Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics 有权与肺炎链球菌相关的核酸和氨基酸序列用于诊断和治疗公开(公告)号：US07790412B2
公开(公告)日：2010-09-07
申请号：US11803132
申请日：2007-05-11
IPC分类号： C12P21/06
CPC分类号： C07K14/3156 , A61K31/7052 , A61K39/00 , A61K39/092 , A61K2039/53 , C07H21/02 , C07H21/04 , C07K14/315 , Y02A50/472
摘要： The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.
摘要翻译： 本发明提供了分离的多肽和源自肺炎链球菌的核酸序列，其可用于诊断和治疗病理状况; 针对多肽的抗体; 以及用于制备多肽的方法。 本发明还提供了用于检测，预防和治疗由细菌感染引起的病理状况的方法。
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14.发明授权公开(公告)号：US07151171B1
公开(公告)日：2006-12-19
申请号：US11027802
申请日：2004-12-30
CPC分类号： C07K14/3156
摘要： The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.
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15.发明授权公开(公告)号：US07129340B1
公开(公告)日：2006-10-31
申请号：US11028457
申请日：2004-12-30
CPC分类号： C07K14/3156
摘要： The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.
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16.发明授权公开(公告)号：US07115731B1
公开(公告)日：2006-10-03
申请号：US11027399
申请日：2004-12-30
CPC分类号： C07K14/3156
摘要： The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.
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公开(公告)号：US20220133881A1
公开(公告)日：2022-05-05
申请号：US17576021
申请日：2022-01-14
发明人： Stephen ANDERSON , Simon DELAGRAVE , John HAMBERGER , Qinglian LI , Sophia MUNDLE , Nausheen RAHMAN
摘要： The present disclosure relates to liquid and dried compositions comprising a live, attenuated or genetically modified herpesvirus and methods of preparing such compositions, in one aspect, the composition comprises at least two or more pharmaceutically acceptable excepients, at least one of which is histidine and at least one of which is a sugar or sugar alcohol. The compostions retain a sufficiently high infectious titre following storage or large-scale manufacturing steps, such as lyophilization.
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公开(公告)号：US20130344109A1
公开(公告)日：2013-12-26
申请号：US13885485
申请日：2011-11-15
申请人： Scott Gallichan , Ausra Mancevski , Nathalie Reveneau , Jin Su , Francois Dalencon , Jean Haensler
发明人： Scott Gallichan , Ausra Mancevski , Nathalie Reveneau , Jin Su , Francois Dalencon , Jean Haensler
IPC分类号： A61K39/39
CPC分类号： A61K39/39 , A61K9/0019 , A61K9/107 , A61K9/1075 , A61K39/118 , A61K47/44 , A61K2039/55505 , A61K2039/55511 , A61K2039/55561 , A61K2039/55566 , A61K2039/572 , A61K2039/575
摘要： The present invention provides compositions comprising a Chlamydial major outer membrane protein (referenced herein as “MOMP”), from at least one Chlamydial serovar and an adjuvant, characterized in that the adjuvant comprises the product E6020 having CAS Number 287180-63-6. The composition may further comprise at least one carrier system (e.g., emulsion, mineral particle). The MOMP protein may be derived from any species of Chlamydia (e.g., C. trachomatis, C. pneumoniae, C. psittaci, or C. trachomatis MoPn). In preferred embodiments, the composition comprises one or more major outer membrane proteins each derived from different serovars of C. trachomatis. The invention also provides methods of inducing an immune response to a Chlamydia species (e.g., C. trachomatis) in a subject, by administering to the subject a composition of the invention.
摘要翻译： 本发明提供了包含来自至少一种衣原体血清型和佐剂的衣原体主要外膜蛋白（本文称为“MOMP”）的组合物，其特征在于所述佐剂包含具有CAS号287180-63-6的产物E6020。 该组合物还可以包含至少一种载体体系（例如乳液，矿物颗粒）。 MOMP蛋白可以衍生自衣原体（例如沙眼衣原体，沙眼衣原体，肺炎衣原体，鹦鹉热鹦鹉或C.沙眼衣原体MoPn）的任何种类。 在优选的实施方案中，组合物包含一种或多种主要的外膜蛋白，其各自衍生自沙眼衣原体的不同血清型。 本发明还提供了通过向受试者施用本发明的组合物来诱导受试者对衣原体（例如沙眼衣原体）的免疫应答的方法。
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19.发明申请公开(公告)号：US20130078271A1
公开(公告)日：2013-03-28
申请号：US13613827
申请日：2012-09-13
IPC分类号： A61K39/09
CPC分类号： C07K14/3156 , A61K31/7052 , A61K39/00 , A61K39/092 , A61K2039/53 , C07H21/02 , C07H21/04 , C07K14/315 , Y02A50/472
摘要： The invention provides methods of treating subject with polypeptides having at least 80% identity to SEQ ID NO: 5326. The methods stimulate an immune response in the subject and provide methods for prevention and treatment of pathological conditions resulting from bacterial infection.
摘要翻译： 本发明提供了用与SEQ ID NO：5326具有至少80％同一性的多肽治疗受试者的方法。该方法刺激受试者的免疫应答并提供预防和治疗由细菌感染引起的病理状况的方法。
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20.发明授权公开(公告)号：US08293884B2
公开(公告)日：2012-10-23
申请号：US11796731
申请日：2007-04-27
CPC分类号： C07K14/3156 , A61K31/7052 , A61K39/00 , A61K39/092 , A61K2039/53 , C07H21/02 , C07H21/04 , C07K14/315 , Y02A50/472
摘要： The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.
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