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公开(公告)号：USD411581S
公开(公告)日：1999-06-29
申请号：US88419
申请日：1998-05-22
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12.发明授权Stem and progenitor cell compositions recovered from bone marrow or cord blood; system and method for preparation thereof 有权从骨髓或脐带血中回收的干细胞和祖细胞组成; 系统及其制备方法公开(公告)号：US08167139B2
公开(公告)日：2012-05-01
申请号：US11825542
申请日：2007-07-06
申请人： Philip H. Coelho , Bruce A. Baker , John R. Chapman , Junzhi Li , Prince Emmanuel , Robert S. Childers
发明人： Philip H. Coelho , Bruce A. Baker , John R. Chapman , Junzhi Li , Prince Emmanuel , Robert S. Childers
CPC分类号： A61M1/3693 , A61B5/15003 , A61B5/150038 , A61B5/150045 , A61B5/150366 , A61B5/150389 , A61B5/150503 , A61B5/153 , A61M1/0209 , A61M1/0231 , A61M1/029 , A61M2202/0462 , B01D21/262 , B01D21/34 , B01D2221/10 , B04B5/0428
摘要： The invention includes compositions of stem and progenitor cells recovered from bone marrow or cord blood containing most of the viable CD34+ cells and substantially depleted of red blood cells resident in the original sample, without any xenobiotic additives to aid cell separation. The invention also includes a system and method for preparing the compositions. The system includes a bag set and a processing device, which utilizes an optical sensor, microcontroller, servo motor, accelerometer, load cell, and battery. The system and method utilize centrifugation to stratify the cells into layers and then separate and transfer the stem cells into a stem cell bag. The processing device's microcontroller receives input from the device's accelerometer, load cell and optical sensor to direct the metering valve in the bag set to open and close to permit the transfer of as many stems cells as possible with as few red cells as possible.
摘要翻译： 本发明包括从含有大多数活的CD34 +细胞的骨髓或脐血回收的干细胞和祖细胞的组合物，并且基本上不存在驻留在原始样品中的红细胞，而没有任何异生生物添加剂来辅助细胞分离。 本发明还包括用于制备组合物的系统和方法。 该系统包括一个采用光学传感器，微控制器，伺服电机，加速度计，称重传感器和电池的行李箱和处理装置。 该系统和方法利用离心将细胞分层，然后分离并将干细胞转移到干细胞袋中。 处理设备的微控制器接收来自设备的加速度计，称重传感器和光学传感器的输入，以将计量阀引导到袋组中打开和关闭，以允许尽可能少的红细胞转移尽可能多的茎细胞。
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公开(公告)号：US07211191B2
公开(公告)日：2007-05-01
申请号：US10957095
申请日：2004-09-30
申请人： Philip H. Coelho , Eric Sommer , Richard Klosinski , Jim Hobbs
发明人： Philip H. Coelho , Eric Sommer , Richard Klosinski , Jim Hobbs
CPC分类号： A61M1/3693 , A61M1/0231 , A61M1/0272 , A61M1/0281 , B04B5/0428 , B04B2005/0435
摘要： An apparatus and method for collecting whole blood and then separating it into components for subsequent use or storage. A self-contained bag set is used to collect the sample, which may then be placed into a device adapted to fit into a centrifuge for separation of components. Each component is then sequentially extracted according to density, with a sensor present in the device to control the operation of valves directing the collection of each component. Each component may then be separated into its own storage container.
摘要翻译： 一种用于收集全血，然后将其分离成组件以供随后使用或储存的装置和方法。 使用独立的袋组来收集样品，然后可以将样品放置在适于装配到离心机中用于分离组分的装置中。 然后根据密度依次提取每个组分，传感器存在于装置中以控制导向各组分收集的阀的操作。 然后可以将每个组件分离成其自己的存储容器。
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公开(公告)号：US07182107B2
公开(公告)日：2007-02-27
申请号：US10737066
申请日：2003-12-15
申请人： Eric Sommer , Philip Henry Coelho , Phil Kingsley
发明人： Eric Sommer , Philip Henry Coelho , Phil Kingsley
IPC分类号： B65B1/04
CPC分类号： A61B17/00491 , A61B2017/00495
摘要： A loading station having a dispensing manifold for loading syringe pairs with thrombin and adhesive and clotting proteins for use as a biological adhesive. The resulting loaded syringe pairs are compatible with a variety of biological adhesive dispensers and may be used in a surgical setting.
摘要翻译： 具有用于将注射器对与凝血酶和粘合剂一起加载并用于生物粘合剂的凝血蛋白的分配歧管的装载站。 所得到的装载的注射器对与各种生物粘合剂分配器兼容，并且可以用于手术设置。
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公开(公告)号：US6123696A
公开(公告)日：2000-09-26
申请号：US118688
申请日：1998-07-16
CPC分类号： A61J1/10 , A61M1/0209 , A61M1/3693
摘要： A method and apparatus for the sequestration of components of a fluid by forcing heavier fractions of the fluid to pass beyond a yieldable partition integrally formed within a bag. Fluid fractions remain sequestered within bag compartments when forces driving the heavier fraction have been removed.
摘要翻译： 一种用于通过迫使较重部分的流体超过在袋内整体形成的可屈服隔板的方法和装置来隔离流体的组分。 当驱动较重部分的力已经被去除时，流体部分保留在袋隔室内。
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公开(公告)号：US6077447A
公开(公告)日：2000-06-20
申请号：US235234
申请日：1999-01-22
CPC分类号： B01L7/00
摘要： A device for producing fibrinogen includes a platen having a surface configured for heat exchange with a container, which is adhered to the platen by device of a vacuum and heat exchange allowing both cooling and heating to occur along the boundary between the container and the platen. The platen is operatively coupled to a device of rocking the platen about a horizontal axis and the container allows scavenging of a cryoprecipitate fibrinogen from the blood product for subsequent utilization. A method for fabricating fibrinogen is also disclosed, including the steps of receiving blood product in a container having a heat transfer surface thereon, adhering a container to a heat transfer platen, rocking the container and coating the interior of the container with blood product, transferring heat and thereby altering the temperature of the platen, sensing the temperature of the platen and monitoring the platen temperature, and coupling the heat transfer to the temperature sensor and cycling the blood product through a phase change.
摘要翻译： 用于生产纤维蛋白原的装置包括具有被配置为与容器进行热交换的表面的压板，该容器通过真空和热交换的装置粘附到压板上，从而允许冷却和加热沿容器和压板之间的边界发生。 压盘可操作地联接到围绕水平轴线摇摆压板的装置，并且容器允许来自血液制品的低温沉淀纤维蛋白原的清除用于随后的使用。 还公开了一种用于制造纤维蛋白原的方法，包括以下步骤：在具有传热表面的容器中接收血液制品，将容器粘附到传热台板上，摇动容器并用血液制品涂覆容器的内部 热量，从而改变压板的温度，感测压板的温度和监测压板温度，以及将热传递耦合到温度传感器并使血液产品循环通过相变。
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公开(公告)号：US5939023A
公开(公告)日：1999-08-17
申请号：US653359
申请日：1996-05-24
申请人： Philip H. Coelho , Terry Wolf
发明人： Philip H. Coelho , Terry Wolf
IPC分类号： A61J1/05 , A61J1/00 , A61J1/14 , A61K35/14 , A61K38/17 , A61L26/00 , A61L31/00 , A61M1/02 , B01D9/00 , B05D1/18 , C07K1/30 , C07K14/745 , C07K14/75 , B01L3/00
CPC分类号： A61J1/1412 , A61J1/1462 , A61J1/1487 , A61M1/0272 , A61M1/0277 , B01D9/0013 , C07K14/75 , A61J1/10 , A61J2205/30 , A61M1/0281 , A61M2202/0449
摘要： An instrumentality for promulgating the cryoprecipitation of fibrinogen from a blood product. The instrumentality contemplates a container for the blood product, an apparatus for creating the fibrinogen within the container and a method of manipulating the container within the apparatus and subsequently after fibrinogen has been formed. The apparatus includes a receiver within which the container is supported, a motion transfer device for the receiver to impart motion to the container while simultaneously subjecting the container to a temperature differential to cause heat transfer. The motion imparted to the container results in a thin coating of the blood product being disposed on an interior surface of the container which, in turn, is exposed to a heat transfer fluid through the wall of the container. Successive coatings placed on an interior of the container are timed such that each coating is placed on a previous coating that has changed phase. Flexure of the container after the contents of the container have been frozen can occur by providing a vacuum within the container causing an implosion of frozen material. Subsequent phase change back to a liquid and then a second freeze/thaw followed by centrifugation causes a cryo-fraction to be precipitated therefrom. The container within which the blood product is housed includes an opening for admission of the blood product therewithin, an outlet for extraction of fibrinogen and access to a source which can provide a pressure differential vis a vis the interior and exterior of the container. Information of the temperature profile within the container may also be provided.
摘要翻译： 从血液制品中颁发纤维蛋白原的冷沉淀的手段。 仪器考虑了用于血液制品的容器，用于在容器内产生纤维蛋白原的装置，以及在装置内操作容器并且随后在形成纤维蛋白原之后的方法。 该装置包括容器被支撑在其中的接收器，用于接收器的运动传递装置，以向容器施加运动，同时使容器经受温差以引起热传递。 赋予容器的运动导致血液制品的薄涂层被设置在容器的内表面上，而这又暴露于通过容器壁的传热流体。 放置在容器内部的连续涂层被定时，使得每个涂层被放置在改变阶段的先前涂层上。 在容器内容物已被冷冻之后容器的弯曲可以通过在容器内提供真空而导致冻结材料的内爆而发生。 随后的相变回液体，然后第二次冷冻/解冻，然后离心导致冷冻馏分从其中沉淀。 容纳血液制品的容器包括用于容纳血液制品的开口，用于提取纤维蛋白原的出口和进入能够相对于容器的内部和外部提供压差的源。 还可以提供容器内的温度曲线的信息。
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公开(公告)号：US10045526B2
公开(公告)日：2018-08-14
申请号：US14917872
申请日：2014-09-09
申请人： SynGen Inc.
发明人： Philip H. Coelho
摘要： An apparatus and related method for the optimization of the cryopreservation of various types of cells, including but not limited to hematopoietic and mesenchymal stem and progenitor cells, and endothelial progenitor cells found in normal blood, placental/cord blood, bone marrow or the stromal vascular fraction of adipose tissue. The apparatus for cryopreservation of biological materials in a sterile environment comprises a cryopreservation workstation, a rigid disposable cartridge, and a freezing bag assembly. The apparatus and related method provide for the precise, temperature controlled, homogenously distributed introduction of a cryoprotectant containing dimethyl sulfoxide (DMSO) into a solution containing nucleated cells in a manner that provides a safe increase in osmotic pressure and a controlled release of exothermic heat within the cells as the DMSO penetrates the cell membrane and replaces water molecules prior to the freezing of the cells.
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公开(公告)号：US08511480B2
公开(公告)日：2013-08-20
申请号：US13506145
申请日：2012-03-30
IPC分类号： B01D21/26
CPC分类号： B01D21/26 , A61M1/029 , A61M2202/0413 , A61M2202/0464 , A61M2202/10 , B01D21/262 , B01D21/307 , B01D21/34 , B01D2221/10 , B01L3/50215 , B01L2300/048 , B01L2300/049 , B01L2300/0681 , B01L2400/0605 , B01L2400/0611 , G01N2035/00495
摘要： A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.
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20.发明授权Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby 有权从其形成的血浆和凝血酶制备稳定的长期凝血酶的装置和方法公开(公告)号：US07056722B1
公开(公告)日：2006-06-06
申请号：US09709237
申请日：2000-11-10
申请人： Philip Henry Coelho , Phil Kingsley , Jim Brausch , James H. Godsey , Gail Rock
发明人： Philip Henry Coelho , Phil Kingsley , Jim Brausch , James H. Godsey , Gail Rock
CPC分类号： G01N33/86 , A61J3/002 , A61K35/16 , A61L24/108 , C12N9/6429 , C12Y304/21005 , G01N33/4905 , G01N2333/974
摘要： A sterile method for preparing stable thrombin component from a single donor's plasma in which the thrombin component is harvested simultaneously from the clotting and adhesive proteins component from the same donor plasma in less than one hour. The combined components provide an improved biological hemostatic agent and tissue sealant by virtue of its freedom from the risk of contaminating viruses or bacteria from allogenic human or bovine blood sources. The thrombin provides polymerization of the clotting and adhesive proteins in less than five seconds, and is sufficiently stable to provide that fast clotting over a six hour period. Further, the clotting times can be predictably lengthened by diluting the thrombin with saline.
摘要翻译： 一种用于从单个供体血浆中制备稳定的凝血酶组分的无菌方法，其中凝血酶组分在不到一小时的时间内从同一供体血浆的凝血和粘附蛋白组分同时收获。 组合的组分由于其免于污染来自同种异体人或牛血源的病毒或细菌的风险而提供改进的生物止血剂和组织密封剂。 凝血酶在不到5秒内提供凝血和粘附蛋白的聚合，并且足够稳定，以便在6小时内提供快速凝血。 此外，通过用盐水稀释凝血酶可以可预测地延长凝血时间。
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