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63 条记录 (耗时 0.024 秒)

    Method and apparatus for preparing novel liposome
    12.
    发明授权
    Method and apparatus for preparing novel liposome 有权
    制备新型脂质体的方法和装置

    公开(公告)号：US09579261B2

    公开(公告)日：2017-02-28

    申请号：US13580236

    申请日：2011-02-24

    申请人： Sung Joo Hwang ,  Hee Jun Park ,  Wonkyung Cho ,  Kwang-Ho Cha ,  Junsung Park ,  Chanhyuk Park ,  Donggeon Gu

    发明人： Sung Joo Hwang ,  Hee Jun Park ,  Wonkyung Cho ,  Kwang-Ho Cha ,  Junsung Park ,  Chanhyuk Park ,  Donggeon Gu

    IPC分类号： A61J3/07 ,  A61K9/127 ,  A61K9/19 ,  A61K31/70 ,  B01D11/04

    CPC分类号： A61J3/07 ,  A61K9/127 ,  A61K9/1277 ,  A61K9/19 ,  A61K31/70 ,  B01D11/0411

    摘要： Disclosed is a method for preparing a liposome formulation. In the disclosed method, a lipid fraction is dissolved in an organic solvent. The solution including a bioactive component and the lipid fraction, together with a carrier, is put in a reaction vessel, and a supercritical fluid is introduced thereto, so as to prepare particles coated with the bioactive component-lipid. The supercritical fluid is discharged by compression to obtain proliposome particles, and then the proliposome particles are hydrated by an aqueous solution including water so as to form a liposome solution. Preferably, the formulation may include one or more bioactive components. As required, the liposome formulation may be further processed by methods such as particle size reduction, removal of organic solvent, and freeze-drying. The preparation method can be easily carried out at a laboratory scale. Furthermore, the same method can be employed in liposome formulation preparation in mass production, or at a commercial scale.

    摘要翻译： 公开了一种制备脂质体制剂的方法。 在所公开的方法中，将脂质部分溶解在有机溶剂中。 将包含生物活性成分和脂质部分的溶液与载体一起放入反应容器中，并向其中引入超临界流体，以制备涂覆有生物活性成分 - 脂质的颗粒。 通过压缩将超临界流体排出以获得催乳素体颗粒，然后通过包含水的水溶液使前体脂质颗粒水合以形成脂质体溶液。 优选地，制剂可以包括一种或多种生物活性成分。 根据需要，脂质体制剂可以通过诸如粒径减小，去除有机溶剂和冷冻干燥的方法进一步加工。 该制备方法可以在实验室规模下轻松进行。 此外，相同的方法可以在批量生产或商业规模的脂质体制剂制备中使用。

    Method For Producing Solid-Lipid Composite Drug Particles
    14.
    发明申请
    Method For Producing Solid-Lipid Composite Drug Particles 有权
    生产固体脂质复合药物颗粒的方法

    公开(公告)号：US20080286365A1

    公开(公告)日：2008-11-20

    申请号：US12124518

    申请日：2008-05-21

    申请人： Boris Y. Shekunov ,  Pratibhash Chattopadhyay ,  Robert W. Huff

    发明人： Boris Y. Shekunov ,  Pratibhash Chattopadhyay ,  Robert W. Huff

    IPC分类号： A61K9/14 ,  A61K47/00 ,  A61P43/00

    CPC分类号： A61K9/167 ,  A61K9/5123 ,  B01D11/0403 ,  B01D11/0407 ,  B01D11/0411 ,  B01D11/0484 ,  B01J13/02

    摘要： A method of producing solid composite lipid/drug nanoparticles that includes the steps of: (1) dissolving a lipid and a drug in a suitable organic solvent to form a solution; (2) emulsifying the solution in a liquid to form an emulsion having a discontinuous phase of micelles comprising the organic solvent, the drug and the lipid, and a continuous phase comprising the liquid; and (3) contacting the emulsion with a supercritical fluid under conditions suitable to keep the supercritical fluid in a supercritical state, whereby the supercritical fluid extracts the organic solvent from the micelles, causing them to precipitate as organic-solvent free solid composite lipid/drug nanoparticles suspended or dispersed in the liquid.

    摘要翻译： 一种生产固体复合脂质/药物纳米颗粒的方法，其包括以下步骤：（1）将脂质和药物溶解在合适的有机溶剂中以形成溶液; （2）将溶液乳化在液体中以形成具有包含有机溶剂，药物和脂质的胶束不连续相的乳液和包含液体的连续相; 和（3）在适合于使超临界流体处于超临界状态的条件下使乳液与超临界流体接触，由此超临界流体从胶束中提取有机溶剂，导致它们作为无机溶剂固体复合脂质/药物沉淀 悬浮或分散在液体中的纳米颗粒。

    Particles from supercritical fluid extraction of emulsion
    15.
    发明授权
    Particles from supercritical fluid extraction of emulsion 有权
    超临界流体萃取乳液颗粒

    公开(公告)号：US06998051B2

    公开(公告)日：2006-02-14

    申请号：US10423492

    申请日：2003-04-25

    申请人： Pratibhash Chattopadhyay ,  Boris Y. Shekunov ,  Jeffrey S. Seitzinger ,  Robert W. Huff

    发明人： Pratibhash Chattopadhyay ,  Boris Y. Shekunov ,  Jeffrey S. Seitzinger ,  Robert W. Huff

    IPC分类号： B01D11/00 ,  B29B9/00 ,  A61K9/14

    CPC分类号： B01D11/0411 ,  B01J13/02

    摘要： A method of producing microparticles and nanoparticles of a solute via the extraction of solvent, having the solute dissolved therein, from an emulsion using a supercritical fluid. The solute to be precipitated is dissolved in the solvent to form a solution, and the solution is dispersed in an immiscible or partially miscible liquid to form an emulsion. The particles are produced via the extraction of the solvent from the emulsion using the supercritical fluid. The process can produce an aqueous suspension of particles that are substantially insoluble in water, and the solvents used in the process to form the emulsion initially can be recovered and recycled.

    摘要翻译： 通过使用超临界流体从乳液中提取溶质溶解溶剂的方法来生产溶质的微粒和纳米颗粒。 待沉淀的溶质溶解在溶剂中以形成溶液，并将溶液分散在不混溶或部分混溶的液体中以形成乳液。 通过使用超临界流体从乳液中提取溶剂来生产颗粒。 该方法可以产生基本上不溶于水的颗粒的水性悬浮液，并且可以回收和再循环用于形成乳液的方法中使用的溶剂。

    Composite particles and method for preparing
    16.
    发明授权
    Composite particles and method for preparing 有权
    复合颗粒及其制备方法

    公开(公告)号：US06966990B2

    公开(公告)日：2005-11-22

    申请号：US10441137

    申请日：2003-05-19

    申请人： Pratibhash Chattopadhyay ,  Boris Y. Shekunov ,  Jeffrey S. Seitzinger ,  Robert W. Huff

    发明人： Pratibhash Chattopadhyay ,  Boris Y. Shekunov ,  Jeffrey S. Seitzinger ,  Robert W. Huff

    IPC分类号： B01D11/04 ,  B01J2/02 ,  B01J13/02 ,  B01D11/02

    CPC分类号： B01D11/0411 ,  B01J13/02

    摘要： A method for producing composite particles using a supercritical fluid extraction technique on an emulsion. First and second materials (for example; a polymer and a biologically active material) are dissolved or suspended in a preferably solvent to form a solution or dispersion. The solution or dispersion is emulsified in a polar solvent to form an oil-in-water or water-in-oil-in-water emulsion. The emulsion is contacted with a supercritical fluid to extract the solvent. Removal of the solvent by the supercritical fluid from the emulsion supersaturates at least the first material in the solution causing the first material to precipitate out of the solution as composite particles that include both the first and second materials.

    摘要翻译： 一种使用超临界流体萃取技术在乳液上制备复合颗粒的方法。 将第一和第二材料（例如，聚合物和生物活性材料）溶解或悬浮在优选溶剂中以形成溶液或分散体。 将溶液或分散体在极性溶剂中乳化以形成水包油或水包油包水乳液。 将乳液与超临界流体接触以萃取溶剂。 由超临界流体从乳液中除去溶剂至少使溶液中的第一种材料过饱和，导致第一种材料沉淀出溶液，作为包括第一和第二种材料的复合颗粒。

    Particle formation
    17.
    发明申请
    Particle formation 审中-公开
    颗粒形成

    公开(公告)号：US20050085409A1

    公开(公告)日：2005-04-21

    申请号：US10753757

    申请日：2004-01-07

    申请人： Andreas Kordikowski ,  Darren Gilbert

    发明人： Andreas Kordikowski ,  Darren Gilbert

    IPC分类号： B01D11/04 ,  B01J2/04 ,  A61K38/00 ,  B29B9/00

    CPC分类号： B01J2/04 ,  B01D11/0403 ,  B01D11/0407 ,  B01D11/0411 ,  B01D11/0473 ,  B01D11/0484

    摘要： Method for preparing a target substance in particulate form, by introducing into a particle formation vessel, through separate first and second fluid inlets respectively, (a) a solution or suspension of the target substance in a fluid vehicle (the “target solution/suspension”) and (b) a compressed fluid anti-solvent for the substance, and allowing the anti-solvent to extract the vehicle from the target solution/suspension so as to form particles of the target substance, wherein the target solution/suspension enters the vessel downstream of the point of entry of the anti-solvent and at a point which lies on or close to the main axis of anti-solvent flow, and wherein the anti-solvent has a sub-sonic velocity as it enters the particle formation vessel.

    摘要翻译： 通过分别通过分开的第一和第二流体入口引入颗粒形成容器，（a）目标物质在流体载体中的溶液或悬浮液（“目标溶液/悬浮液”）的制备方法， ）和（b）用于该物质的压缩流体抗溶剂，并且允许反溶剂从目标溶液/悬浮液中提取载体以形成目标物质的颗粒，其中目标溶液/悬浮液进入容器 在反溶剂进入点的下游，位于或接近反溶剂流动主轴线的点处，并且其中反溶剂在其进入颗粒形成容器时具有次声速度。

    Method and apparatus for enhanced size reduction of particles using supercritical fluid liquefaction of materials
    18.
    发明申请
    Method and apparatus for enhanced size reduction of particles using supercritical fluid liquefaction of materials 有权
    使用超临界流体物质液化来增强颗粒尺寸减小的方法和装置

    公开(公告)号：US20050082701A1

    公开(公告)日：2005-04-21

    申请号：US10932559

    申请日：2004-09-02

    申请人： Boris Shekunov ,  Pratibhash Chattopadhyay ,  Jeffrey Seitzinger

    发明人： Boris Shekunov ,  Pratibhash Chattopadhyay ,  Jeffrey Seitzinger

    IPC分类号： B01D11/00 ,  B01D11/04 ,  B01F20060101 ,  B29B9/00 ,  B65D1/00 ,  B65D85/48 ,  H01L20060101 ,  H05B6/00

    CPC分类号： B01J2/02 ,  A61K9/1647 ,  A61K9/1694 ,  B01D11/0411

    摘要： The present invention provides a method and an apparatus for forming particles using supercritical fluid. The method includes the steps of mixing a load material with a first flow of a supercritical fluid in a first mixing chamber having a primary mixing device disposed therein to form a melt, transferring the melt from the first mixing chamber to a second mixing chamber having a secondary mixing device disposed therein, mixing the melt with a second flow of the supercritical fluid in the second mixing chamber to form a lower viscosity melt, expanding the lower viscosity melt across a pressure drop into an expansion chamber that is at a pressure below the critical pressure of the supercritical fluid to convert the supercritical fluid to a gas and thereby precipitate the load material in the form of particles.

    摘要翻译： 本发明提供使用超临界流体形成颗粒的方法和装置。 该方法包括以下步骤：在第一混合室中混合负载材料与超临界流体的第一流，其中设置有初级混合装置以形成熔体，将熔体从第一混合室转移到具有 二次混合装置设置在其中，将熔体与第二混合室中的超临界流体的第二流混合，以形成较低粘度的熔体，将较低粘度的熔体在压降范围内膨胀到膨胀室内，该膨胀室的压力低于临界值 超临界流体的压力将超临界流体转化为气体，从而使负载材料以颗粒的形式沉淀。

    Process for preparing particles
    19.
    发明申请
    Process for preparing particles 失效
    制备颗粒的方法

    公开(公告)号：US20040058007A1

    公开(公告)日：2004-03-25

    申请号：US10250868

    申请日：2003-07-08

    发明人： Goran Eric Sundholm ,  Mustafa Demirbuker ,  Saeed Moshashaee

    IPC分类号： A61K009/16 ,  A61K009/50 ,  B01J013/02 ,  B01J013/04

    CPC分类号： A61K38/28 ,  A61K9/1688 ,  A61K31/167 ,  A61K31/575 ,  A61K31/58 ,  B01D11/0411 ,  Y10S977/773 ,  A61K2300/00

    摘要： A process for preparing particles of a substance, such as a protein or polypeptide, comprising: (a) preparing a first liquid comprising water, the substance and a modulator, wherein the modulator has a solubility in water which decreases with increasing temperature; and (b) contacting the first liquid with a second liquid comprising a fluid gas and an organic solvent using an anti-solvent fluid gas technique under conditions of temperature and pressure which result in the precipitation of particles comprising the substance, wherein the temperature of the first liquid is at or above the cloud point temperature of the first liquid when the first liquid contacts the second liquid. Also claimed are particles obtained according to the process and compositions containing the particles.

    摘要翻译： 一种制备物质如蛋白质或多肽的颗粒的方法，包括：（a）制备包含水，所述物质和调节剂的第一液体，其中所述调节剂在水中具有随温度升高而降低的溶解度; 和（b）使用反溶剂流体气体技术在温度和压力的条件下使第一液体与包含流体气体和有机溶剂的第二液体接触，导致包含物质的颗粒的沉淀，其中 当第一液体接触第二液体时，第一液体处于或高于第一液体的浊点温度。 还要求保护的是根据该方法获得的颗粒和含有颗粒的组合物。