公开(公告)号：US20180001315A1

公开(公告)日：2018-01-04

申请号：US15540765

申请日：2015-12-22

Applicant: Hitachi Industrial Equipment Systems Co., Ltd.

Inventor： Takeshi KANEKO ,  Hirotoshi SATO ,  Yukio MORI ,  Yukiyasu SANO

IPC: B01L1/02 ,  F24F3/16

CPC classification number: B01L1/02 ,  B01L1/00 ,  B01L2200/143 ,  B01L2300/0627 ,  B01L2300/0858 ,  B01L2300/12 ,  C12M37/00 ,  F24F3/1607

Abstract: In a state where an operator performs operation using a safety cabinet while confirming standard operating procedures and sample data, a display device such as a monitor screen provided in the safety cabinet is arranged at a position that is not subject to effects of deterioration due to diffused reflection of light from a fluorescent lamp or sterilization lamp irradiation, and that does not generate resistance in an airflow path, while also protecting the display device from decontamination operation and preventing dirt from being adhered to a portion related to display. Transparent windows are provided on both a portion of a back wall or a side wall of a work space in the safety cabinet and a portion of a rear wall or a side wall of the body of the safety cabinet separated from the back wall or the side wall of the work space by a circulation flow path, which allow the operator to see through both walls, and the display device is placed on an outer side portion of the transparent window provided at the portion of the rear wall or the side wall of the body of the safety cabinet.

公开(公告)号：US20170275581A1

公开(公告)日：2017-09-28

申请号：US15450344

申请日：2017-03-06

Applicant: SHIBUYA CORPORATION

Inventor： Tetsuya NISHIMURA ,  Katsuki HASHIMOTO ,  Kazuhito TANIMOTO

IPC: C12M1/12 ,  C12M1/00 ,  A61L2/20

CPC classification number: C12M37/00 ,  A61L2/208 ,  A61L2202/121 ,  B01L1/02 ,  C12M23/06 ,  C12M23/58 ,  C12M29/00 ,  C12M37/04 ,  C12M41/14 ,  C12M47/16

Abstract: An isolator system 1 includes: a main isolator 3 in which an aseptic state is maintained and which is for performing an aseptic operation; an incubator 4 in which the aseptic state is maintained and which is connected to the main isolator 3 and is for culturing cells and the like; decontamination means 35 for decontaminating the inside of the main isolator 3; and a decontamination station 9 that decontaminates the inside of the incubator 4. The isolator system 1 further includes a blocking member 30 for sealing a connection port 13 from the outside, the port being provided in the main isolator 3 and being for connection with the incubator 4. When the inside of the main isolator 3 is decontaminated, the connection port 13 is sealed from the outside with the blocking member 30. The isolator system that can efficiently decontaminate the main isolator and the subisolator connected to this main isolator can be provided.

公开(公告)号：US09757866B2

公开(公告)日：2017-09-12

申请号：US13948953

申请日：2013-07-23

Applicant: Daniel R. Dilday, Jr. ,  Roberto Reyes ,  Stanley Weidmeyer

Inventor： Daniel R. Dilday, Jr. ,  Roberto Reyes ,  Stanley Weidmeyer

IPC: F16L39/00 ,  B25J21/02 ,  B01L1/02 ,  G21F7/047

CPC classification number: B25J21/02 ,  B01L1/02 ,  G21F7/047 ,  Y10T29/49826

Abstract: The invention provides a system for preventing fluid exchange between the interior and exterior of containment enclosures such as process-, hazard-, and research-enclosure systems generally, gloveboxes, containment systems, isolation systems, confinement systems, cleanrooms, negative air systems, and positive air system areas while simultaneously providing material transfer into and out of the enclosures. The invention also provides a method for transporting material into or out of a containment structure.

公开(公告)号：US20170107014A1

公开(公告)日：2017-04-20

申请号：US15204271

申请日：2016-07-07

Applicant: Ideal Vacuum Products LLC

Inventor： Tony C. Smith ,  Richard D. Holets

IPC: B65D21/02

CPC classification number: B65D21/0201 ,  B01L1/02 ,  B01L2200/028 ,  B01L2200/0689 ,  B01L2400/049

Abstract: A modular vacuum chamber system provides for tapered surfaces and resilient sealing members, wherein the tapered surfaces are protected from undesired contact with work surfaces, and provide for vacuum-tight engagement of various modules. Modules can include chamber modules, defining shapes for a resultant vacuum chamber. Modules can comprise connecting modules, configured to sealingly engage two chamber modules and form a larger vacuum chamber than either module alone. Modules can comprise wall plate modules, configured to sealingly engage a chamber module and form a surface of a vacuum chamber. Wall plate modules can comprise solid plates, optically transparent plates, and plates accommodating ports for communication between the vacuum chamber and the environment outside the vacuum chamber.

公开(公告)号：US09545628B2

公开(公告)日：2017-01-17

申请号：US13503188

申请日：2010-09-22

Applicant: Stephanie Armau

Inventor： Stephanie Armau

IPC: B01L1/02 ,  B01L3/00

CPC classification number: B01L1/02 ,  B01L3/54 ,  B01L2200/025 ,  B01L2200/141 ,  B01L2300/023 ,  B01L2300/024 ,  B01L2300/041 ,  B01L2300/046

Abstract: The chamber (2) includes a wall (5) having an opening (7) and a connection interface (8), a door (10), joining elements (12), elements for maneuvering the door (10) and actuating elements for control of the maneuvering elements. The container (3) includes a wall (14) having an opening (16), a connection interface (9), a door (18), joining elements (13) and elements for maneuvering the door that are functionally joined to the door, and the system also includes, functionally integrated, marking elements, that rest on the container and that can store data, elements for short-range data reading that are functionally complementary to the marking elements, elements for storing read data, elements for producing an output signal based on read or stored data, and elements for controlling the opening of the first door and thus the second door, that respond to the output signal received from the elements for producing an output signal.

Abstract translation: 室（2）包括具有开口（7）和连接界面（8）的壁（5），门（10），接合元件（12），用于操纵门（10）的元件和用于控制的致动元件 的机动元素。 容器（3）包括具有开口（16），连接接口（9），门（18），接合元件（13）和功能性地连接到门的门的元件的壁（14） 并且系统还包括功能集成的标记元件，其位于容器上并且可以存储数据，与标记元件功能互补的短距离数据读取的元件，用于存储读取数据的元件，用于产生输出的元件 基于读取或存储的数据的信号，以及用于控制第一门和第二门的打开的元件，其响应从元件接收的用于产生输出信号的输出信号。

公开(公告)号：US09314787B2

公开(公告)日：2016-04-19

申请号：US10497952

申请日：2002-12-13

Applicant: Jean-Yves Porret

Inventor： Jean-Yves Porret

IPC: G21F5/018 ,  B01L1/02 ,  G21F7/005 ,  G21F7/047

CPC classification number: B01L1/02 ,  G21F7/005 ,  G21F7/047 ,  Y02E50/30

Abstract: A protective device (20) is provided to equip a sterile enclosure (1) configured to be placed in communication with another sterile enclosure (2) so as to allow objects to be transferred from one enclosure to the other. The protective device (20) covers an interface defined between the sterile enclosures (1, 2).

Abstract translation: 提供保护装置（20）以配备被配置成与另一个无菌外壳（2）连通的无菌外壳（1），以允许物体从一个外壳传送到另一个外壳。 保护装置（20）覆盖限定在无菌外壳（1,2）之间的接口。

公开(公告)号：US20150289500A1

公开(公告)日：2015-10-15

申请号：US14439226

申请日：2013-12-04

Applicant: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

Inventor： Guenter R. Fuhr ,  Heiko Zimmermann

IPC: A01N1/02

CPC classification number: A01N1/0252 ,  A01N1/0257 ,  B01L1/02 ,  B01L7/50 ,  B01L2300/047

Abstract: The invention relates to a cryogenic storage device (100), in particular for storing biological samples (1) in the cryopreserved state, comprising a storage container (cryogenic tank 10) for cooling the samples in a reservoir (12) of liquid nitrogen or in a nitrogen vapour above the reservoir, a hood (21), and a flushing device (30) for introduction of a coolant (preferably cold nitrogen gas) into the hood space (22). The storage container is closed by a lid section (13). The coolant conduit (31) of the flushing device opens in the hood space (22). The storage temperature is adjustable in a locally delimited cooling section (24) by the refrigerant stream (2). The flushing device comprises a coolant vessel (32), which is formed by the storage container (10) with the reservoir of liquid nitrogen and/or an additional container. The invention further relates to a method for operating the cryogenic storage device.

Abstract translation: 本发明涉及一种低温存储装置（100），特别是用于储存处于冷冻保存状态的生物样品（1）的低温存储装置（100），包括用于冷却液氮储存器（12）中的样品的储存容器（低温罐10） 在所述储存器上方的氮蒸气，发动机罩（21）和用于将冷却剂（优选冷氮气）引入所述发动机罩空间（22）的冲洗装置（30）。 储存容器由盖部分（13）封闭。 冲洗装置的冷却剂导管（31）在发动机罩空间（22）中打开。 存储温度可通过制冷剂流（2）在局部限定的冷却段（24）中调节。 冲洗装置包括由存储容器（10）与液氮储存器和/或附加容器形成的冷却剂容器（32）。 本发明还涉及一种用于操作低温储存装置的方法。

公开(公告)号：US20150224506A1

公开(公告)日：2015-08-13

申请号：US14692131

申请日：2015-04-21

Applicant: Argos Therapeutics, Inc.

Inventor： Simon Jonathon Spence ,  Richard Alexander Grant ,  Timothy Doyle Peele ,  William Samuel Hunter ,  Ashraf F. Abdelmoteleb ,  David Thomas Kneen ,  Robert Alister Neil ,  Simon Harris

IPC: B01L9/00 ,  B01L7/00

CPC classification number: G01N35/0099 ,  B01L1/00 ,  B01L1/02 ,  B01L3/021 ,  B01L3/0293 ,  B01L3/5085 ,  B01L7/52 ,  B01L9/06 ,  B01L9/523 ,  B01L2200/02 ,  B01L2200/0642 ,  B01L2200/142 ,  B01L2300/046 ,  B01L2300/06 ,  B01L2300/0838 ,  B01L2300/123 ,  B01L2400/0481 ,  G01L1/00 ,  G01N1/34 ,  G01N35/00732 ,  G01N35/00871 ,  G01N2021/0378 ,  Y10T436/11 ,  Y10T436/2575

Abstract: Processing containers include a first member having a substantially rigid body with a plurality of regions defining spaced apart workstations and a flexible barrier member sealably attached to the first member to define a closed chamber over the plurality of workstations. The flexible barrier is substantially impermeable and includes or is a manipulation tool that is sealably attached to the barrier. The manipulation tool has a first internal interface that resides in the closed chamber under the flexible barrier and a second external interface that resides outside the closed chamber. The processing containers are particularly suitable for automated processing of nucleic acids and other samples. The manipulation tool can cooperate with or include a pipette head. When the barrier is sealed, the barrier separates the contents of the container from a robotic arm or other manipulation device.

Abstract translation: 处理容器包括具有基本上刚性的第一构件，其具有限定间隔开的工作站的多个区域以及密封地附接到第一构件以在多个工作站上限定闭合腔室的柔性阻挡构件。 柔性屏障基本上是不可渗透的，并且包括或者是可密封地附接到屏障的操纵工具。 操纵工具具有位于柔性屏障下方的封闭腔室中的第一内部接口和位于封闭腔室外部的第二外部接口。 处理容器特别适用于核酸和其他样品的自动加工。 操作工具可配合或包括移液管头。 当屏障被密封时，屏障将容器的内容物与机器手臂或其他操纵装置分开。

公开(公告)号：US20150099262A1

公开(公告)日：2015-04-09

申请号：US14505028

申请日：2014-10-02

Applicant: Becton, Dickinson and Company

Inventor： Steven MURDOCH ,  Scott HORTON ,  Gil REININ

IPC: G01N15/14 ,  A61L2/20 ,  B01L1/02

CPC classification number: A61L2/20 ,  B01L1/02 ,  B01L2200/082 ,  B01L2300/0681 ,  G01N15/1459 ,  G01N2015/1006 ,  G01N2035/00306

Abstract: Flow cytometer systems are provided that mitigate aerosols generated during operation of a flow cytometer. A flow cytometer system can include various combinations of: a flow cytometer instrument base, a flow cytometer, and a biosafety hood (BSH). In some embodiments, a subject flow cytometer system includes a flow cytometer instrument base, a flow cytometer, and a BSH. In some embodiments, a subject flow cytometer system includes a flow cytometer instrument base and a flow cytometer. In some cases, a BSH includes an aerosol management system, which provides a redundant air filtration system. Also provided are components of a flow cytometer system (e.g., a BSH configured to attach to a flow cytometer instrument base, a flow cytometer instrument base configured to attach to a BSH, etc.). Also provided are methods, including methods of performing a flow cytometric procedure using a flow cytometer system; and methods of decontaminating a flow cytometer system.

Abstract translation: 提供了流式细胞仪系统，其减轻在流式细胞仪操作期间产生的气溶胶。 流式细胞仪系统可以包括以下各种组合：流式细胞仪器基座，流式细胞仪和生物安全罩（BSH）。 在一些实施方案中，受试者流式细胞仪系统包括流式细胞仪仪器基座，流式细胞仪和BSH。 在一些实施方案中，受试者流式细胞仪系统包括流式细胞仪仪器基座和流式细胞仪。 在某些情况下，BSH包括气溶胶管理系统，其提供冗余的空气过滤系统。 还提供了流式细胞计数器系统的组件（例如，被配置为附着到流式细胞仪器基座的BSH，被配置为附接到BSH的流式细胞仪器基座等）。 还提供了方法，包括使用流式细胞仪系统进行流式细胞术程序的方法; 以及对流式细胞仪系统进行净化的方法。

公开(公告)号：US20140120009A1

公开(公告)日：2014-05-01

申请号：US14149127

申请日：2014-01-07

Applicant: PANASONIC HEALTHCARE CO., LTD.

Inventor： Yasuhiko Yokoi ,  Jiro Ohnishi ,  Akifumi Iwama ,  Masaki Harada ,  Yoshiaki Noguchi

IPC: C12M1/12

CPC classification number: B01L1/02 ,  A61L2/0094 ,  A61L2/025 ,  A61L2/208 ,  A61L2202/11 ,  A61L2202/122 ,  A61L2202/13 ,  A61L2202/14 ,  B01L2300/14 ,  C12M37/00 ,  G01M3/26

Abstract: An isolator includes a work chamber, a sterilizing substance supply unit, a gas flow channel pressure adjustment unit, a work chamber barometer, and a controller. The controller is configured to control execution of a gas flow channel leak test for checking a gas leak in a gas flow channel based on a detection result by the work chamber barometer after making the gas flow channel pressure adjustment unit increase or decrease the pressure in the gas flow channel, and is configured to control supply of the sterilizing substance by the sterilizing substance supply unit. The controller performs heating of a heater, which accompanies the supply of the sterilizing substance, in parallel with the gas flow channel leak test.

Abstract translation: 隔离器包括工作室，灭菌物质供给单元，气体流路压力调节单元，工作室气压计和控制器。 控制器被配置为在使气体流路压力调节单元增加或减小气体流动通道压力调节单元中的压力之后，基于工作室气压计的检测结果来控制用于检查气体流路中的气体泄漏的气体流路泄漏测试的执行 气体流路，被配置为控制由灭菌物质供给部供给灭菌物质。 与气体流路泄漏试验并行地进行伴随灭菌物质的供给的加热器的加热。