公开(公告)号：US20040229364A1

公开(公告)日：2004-11-18

申请号：US10365970

申请日：2003-02-13

发明人： Perry G. Caimi ,  Saverio Carl Falco ,  Anthony J. Kinney ,  J. Antoni Rafalski ,  Zude Weng

IPC分类号： C12N015/29 ,  C12P021/00 ,  C12N015/00 ,  C07H021/04 ,  C12N015/82 ,  C12N015/09 ,  C12N015/63 ,  C07K001/00 ,  C07K014/00

CPC分类号： C12Y301/03012 ,  C07H21/04 ,  C12N9/16 ,  C12N15/8273

摘要： This invention relates to isolated nucleic acid fragments encoding trehalose metabolism enzymes, more specifically, alpha, alpha-trehalase, alpha, alpha-trehalose-phosphate synthase or trehalose-6-phosphate phosphatase. The invention also relates to the construction of a recombinant DNA construct encoding all or a portion of the alpha, alpha-trehalase, alpha, alpha-trehalose-phosphate synthase or trehalose-6-phosphate phosphatase, in sense or antisense orientation, wherein expression of the recombinant DNA construct results in production of altered levels of the alpha, alpha-trehalase, alpha, alpha-trehalose-phosphate synthase or trehalose-6-phosphate phosphatase in a transformed host cell.

摘要翻译： 本发明涉及编码海藻糖代谢酶，更具体地，α，α-海藻糖酶，α，α-海藻糖 - 磷酸合成酶或海藻糖-6-磷酸磷酸酶的分离的核酸片段。 本发明还涉及在正义或反义方向上构建编码α，α-海藻糖酶，α，α-海藻糖-6-磷酸磷酸酶的全部或部分的重组DNA构建体，其中表达 重组DNA构建体导致转化的宿主细胞中α，α-海藻糖酶，α，α-海藻糖磷酸合酶或海藻糖-6-磷酸磷酸酶水平的变化。

公开(公告)号：US6133034A

公开(公告)日：2000-10-17

申请号：US274121

申请日：1994-07-12

申请人： Arne Reidar Strom ,  Inga Kaasen ,  Olaf Bay Styrvold ,  John McDougall

发明人： Arne Reidar Strom ,  Inga Kaasen ,  Olaf Bay Styrvold ,  John McDougall

IPC分类号： C12N9/10 ,  C12N9/16 ,  C12N15/31 ,  C12N15/82 ,  C12N5/04 ,  C12N15/63

CPC分类号： C12N9/1051 ,  C12N15/8245 ,  C12N9/16 ,  C12Y204/01015 ,  C12Y301/03012

摘要： This invention relates to genes involved in the biosynthesis of trehalose. The genes encode trehalose-6-phosphate synthase (trehalose synthase) and trehalose-6-phosphate phosphatase (trehalose phosphatase).

摘要翻译： 本发明涉及参与海藻糖生物合成的基因。 该基因编码海藻糖-6-磷酸合成酶（海藻糖合酶）和海藻糖-6-磷酸磷酸酶（海藻糖磷酸酶）。

公开(公告)号：US20240124858A1

公开(公告)日：2024-04-18

申请号：US18399556

申请日：2023-12-28

申请人： Viridos, Inc.

发明人： Eric R. Moellering ,  Saheed Imam ,  Luke Peach ,  Ryan Kalb ,  Sarah Potts

IPC分类号： C12N9/16 ,  C12N1/12 ,  C12N9/10

CPC分类号： C12N9/16 ,  C12N1/12 ,  C12N9/1051 ,  C12Y204/01216 ,  C12Y301/03012

摘要： The invention involves the provision of recombinant algal mutants that have a genetic modification to a nucleic acid sequence encoding a trehalose biosynthetic enzyme, and/or a genetic modification to a nucleic acid encoding an RNA binding domain And in some embodiments either of these algal mutants can further have a genetic mutation to a nucleic acid sequence encoding an SGI1 polypeptide. Attenuation of one, two, or all three of these genes results in a mutant organism with increased lipid productivity. It was also discovered that one, two, three, or more genetic mutations can be accumulated or “stacked” in a particular mutant cell or organism to result in further increases in the production of lipid products. The lipid products of these mutants are useful as biofuels or for other specialty chemical products.

公开(公告)号：US11779639B2

公开(公告)日：2023-10-10

申请号：US17054872

申请日：2019-05-10

申请人： THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH ,  THE UNIVERSITY OF MELBOURNE

发明人： Chris Tonkin ,  Alessandro Uboldi ,  Malcolm McConville ,  Martin Blume

IPC分类号： A61K39/002 ,  A61P33/02 ,  C12N1/10 ,  C12N1/36 ,  C12N9/10 ,  C12N9/12 ,  C12N9/16 ,  A61K39/00

CPC分类号： A61K39/002 ,  A61P33/02 ,  C12N1/10 ,  C12N1/36 ,  C12N9/1051 ,  C12N9/1205 ,  C12N9/16 ,  C12Y204/01015 ,  C12Y207/01001 ,  C12Y301/03012 ,  A61K2039/522 ,  A61K2039/523 ,  A61K2039/552

摘要： The present disclosure provides mutant parasites, in particular protozoan parasites comprising a mutation of the trehalose-6-phosphate synthase/6-phosphate phosphatase (TPS/TPP)-like gene of Toxoplasma gondii (herein referred to as ‘Toxoplasma’) or a homologue thereof as well as vaccines comprising same.

公开(公告)号：US20150361441A1

公开(公告)日：2015-12-17

申请号：US14840256

申请日：2015-08-31

申请人： BASF Plant Science Company GmbH ,  Crop Functional Genomics Center

发明人： Ana Isabel Sanz Molinero ,  Steven Vandenabeele ,  Christophe Reuzeau ,  Yang Do Choi ,  Ju Kon Kim

IPC分类号： C12N15/82 ,  C12N9/16 ,  C07K14/415 ,  C12N9/10

CPC分类号： C12N15/8261 ,  C07K14/415 ,  C12N9/1051 ,  C12N9/16 ,  C12N15/8273 ,  C12Y204/01015 ,  C12Y301/03012 ,  Y02A40/146

摘要： The present invention concerns a method for enhancing yield-related traits in plants by modulating expression in a plant of a nucleic acid encoding a CLC-like (Chloride Channel-like) polypeptide, an OsBURP-like (BURP-domain containing protein) polypeptide, an AP2/ERF polypeptide, or a protein fusion comprising a TPS (trehalose-6-phosphate synthase) and a TPP (trehalose-6-phosphate phosphatase) polypeptide, or modulating one or more nucleic acids encoding a TPS and a TPP enzyme, whether comprised in the same or in separate molecules. The present invention also concerns plants having modulated expression of a nucleic acid encoding a CLC-like polypeptide, an OsBURP-like polypeptide, an AP2/ERF polypeptide, or a TPP polypeptide, which plants have enhanced yield-related traits relative to control plants. Also provided are unknown TPS-encoding and TPP-encoding nucleic acids, and constructs comprising the same, and constructs a CLC-like, OsBURP-like, or AP2/ERF coding nucleic acid useful in performing the methods of the invention.

摘要翻译： 本发明涉及通过调节植物中编码CLC样（氯化物通道样）多肽，含OsBURP样（含BURP结构域的蛋白质）多肽）的核酸的表达来增强植物中产量相关性状的方法， AP2 / ERF多肽或包含TPS（海藻糖-6-磷酸合成酶）和TPP（海藻糖-6-磷酸磷酸酶）多肽的蛋白质融合物，或调节编码TPS和TPP酶的一种或多种核酸，无论是否 包含在相同或分开的分子中。 本发明还涉及已经调节了编码CLC样多肽，OsBURP样多肽，AP2 / ERF多肽或TPP多肽的核酸表达的植物，该植物相对于对照植物具有增强的产量相关性状。 还提供了未知的TPS编码和编码TPP的核酸，以及包含其的构建体，并构建可用于实施本发明方法的CLC样OsBURP样或AP2 / ERF编码核酸。

公开(公告)号：US20140288287A1

公开(公告)日：2014-09-25

申请号：US14301826

申请日：2014-06-11

申请人： Ceres, Inc.

发明人： Nickolai Alexandrov ,  Vyacheslav Brover ,  Kenneth Feldmann

IPC分类号： C12N9/16

CPC分类号： C12N9/16 ,  C07K14/415 ,  C12N15/52 ,  C12Y301/03012

摘要： The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in cells, either as a promoter or as a protein coding sequence or as an UTR or as a 3′ termination sequence, and are also useful in controlling the behavior of a gene in the chromosome, in controlling the expression of a gene or as tools for genetic mapping, recognizing or isolating identical or related DNA fragments, or identification of a particular individual organism, or for clustering of a group of organisms with a common trait.

摘要翻译： 本发明提供构成植物基因组片段的DNA分子，以及由此编码的多肽。 DNA分子可用于指定细胞中的基因产物，作为启动子或蛋白质编码序列或作为UTR或作为3'终止序列，并且还可用于控制染色体中基因的行为， 在控制基因的表达或用于遗传作图，识别或分离相同或相关的DNA片段，或特定个体生物体的鉴定或用于具有共同性状的一组生物体的聚类的工具。

公开(公告)号：US20120301563A1

公开(公告)日：2012-11-29

申请号：US13289950

申请日：2011-11-04

申请人： John Aikens ,  Robert J. Turner

发明人： John Aikens ,  Robert J. Turner

IPC分类号： C12N1/12 ,  C12N1/13 ,  A61K35/74 ,  A61P17/00 ,  A23L1/48 ,  C11B1/00 ,  C08B37/00 ,  C10L1/18 ,  C10L1/19 ,  C12P19/14 ,  A61P19/02

CPC分类号： C12P19/12 ,  C12M21/02 ,  C12M23/24 ,  C12M23/26 ,  C12M25/02 ,  C12M33/00 ,  C12M41/06 ,  C12N1/12 ,  C12N9/1051 ,  C12N9/1066 ,  C12N9/16 ,  C12N15/74 ,  C12N15/80 ,  C12Y204/01014 ,  C12Y204/01015 ,  C12Y204/01036 ,  C12Y204/01064 ,  C12Y204/01213 ,  C12Y301/03012 ,  C12Y301/03024

摘要： Provided herein are methods of producing and processing a feedstock from a photosynthetic microorganism. Also provided are various transgenic photosynthetic microorganism and photobioreactors for use in the methods.

摘要翻译： 本文提供了从光合微生物生产和加工原料的方法。 还提供了用于该方法的各种转基因光合微生物和光生物反应器。

公开(公告)号：US20120266327A1

公开(公告)日：2012-10-18

申请号：US13502643

申请日：2010-10-14

申请人： Ana Isabel Sanz Molinero ,  Steven Vandenabeele ,  Christophe Reuzeau ,  Yang Do Choi ,  Ju Kon Kim

发明人： Ana Isabel Sanz Molinero ,  Steven Vandenabeele ,  Christophe Reuzeau ,  Yang Do Choi ,  Ju Kon Kim

IPC分类号： C12N15/82 ,  C12N5/10 ,  A01H5/10 ,  A01H5/00

CPC分类号： C12N15/8261 ,  C07K14/415 ,  C12N9/1051 ,  C12N9/16 ,  C12N15/8273 ,  C12Y204/01015 ,  C12Y301/03012 ,  Y02A40/146

摘要： The present invention relates generally to the field of molecular biology and concerns a method for enhancing various economically important yield-related traits in plants. More specifically, the present invention concerns a method for enhancing yield-related traits in plants by modulating expression in a plant of a nucleic acid encoding a CLC-like (Chloride Channel-like) polypeptide, or an OsBURP-like (BURP-domain containing protein) polypeptide, or an AP2/ERF polypeptide or a protein fusion comprising a TPS (trehalose-6-phosphate synthase) and a TPP (trehalose-6-phosphate phosphatase) polypeptide or modulating one or more nucleic acid encoding a TPS and a TPP enzyme, whether comprised in the same or in separate molecules. The present invention also concerns plants having modulated expression of a nucleic acids and constructs comprising them, useful in performing the methods of the invention.

摘要翻译： 本发明一般涉及分子生物学领域，涉及增强植物中各种经济上重要的产量相关性状的方法。 更具体地，本发明涉及一种通过调节植物中编码CLC样（氯化物通道样）多肽或OsBURP样（含BURP结构域）的核酸的植物中的表达来增强植物中产量相关性状的方法 蛋白质）多肽或包含TPS（海藻糖-6-磷酸合成酶）和TPP（海藻糖-6-磷酸磷酸酶）多肽的AP2 / ERF多肽或蛋白质融合物，或调节一种或多种编码TPS和TPP的核酸 酶，无论是包含在相同还是分开的分子中。 本发明还涉及具有调节核酸表达的植物和包含它们的构建体的植物，其可用于实施本发明的方法。

公开(公告)号：US20080009066A1

公开(公告)日：2008-01-10

申请号：US11726306

申请日：2007-03-21

申请人： Perry Caimi ,  J. Rafalski ,  Zude Weng ,  Anthony Kinney ,  Saverio Falco

发明人： Perry Caimi ,  J. Rafalski ,  Zude Weng ,  Anthony Kinney ,  Saverio Falco

IPC分类号： C07H21/04 ,  A01H5/00 ,  C07K1/00 ,  C12N15/00 ,  C12N15/82 ,  C12N5/02 ,  C12N5/04 ,  C12N9/00

CPC分类号： C12Y301/03012 ,  C07H21/04 ,  C12N9/16 ,  C12N15/8273

摘要： This invention relates to isolated nucleic acid fragments encoding trehalose metabolism enzymes, more specifically, alpha, alpha-trehalase, alpha, alpha-trehalose-phosphate synthase or trehalose-6-phosphate phosphatase. The invention also relates to the construction of a recombinant DNA construct encoding all or a portion of the alpha, alpha-trehalase, alpha, alpha-trehalose-phosphate synthase or trehalose-6-phosphate phosphatase, in sense or antisense orientation, wherein expression of the recombinant DNA construct results in production of altered levels of the alpha, alpha-trehalase, alpha, alpha-trehalose-phosphate synthase or trehalose-6-phosphate phosphatase in a transformed host cell.

摘要翻译： 本发明涉及编码海藻糖代谢酶，更具体地，α，α-海藻糖酶，α，α-海藻糖 - 磷酸合成酶或海藻糖-6-磷酸磷酸酶的分离的核酸片段。 本发明还涉及在正义或反义方向上构建编码α，α-海藻糖酶，α，α-海藻糖-6-磷酸磷酸酶的全部或部分的重组DNA构建体，其中表达 重组DNA构建体导致转化的宿主细胞中α，α-海藻糖酶，α，α-海藻糖磷酸合酶或海藻糖-6-磷酸磷酸酶水平的变化。

公开(公告)号：US07214858B2

公开(公告)日：2007-05-08

申请号：US10365970

申请日：2003-02-13

申请人： Perry G. Caimi ,  Saverio Carl Falco ,  Zude Weng

发明人： Perry G. Caimi ,  Saverio Carl Falco ,  Zude Weng

IPC分类号： A01H5/00 ,  A01H5/10 ,  C12N15/82 ,  C12N15/55

CPC分类号： C12Y301/03012 ,  C07H21/04 ,  C12N9/16 ,  C12N15/8273

摘要： This invention relates to isolated nucleic acid fragments encoding trehalose metabolism enzymes, more specifically, alpha, alpha-trehalase, alpha, alpha-trehalose-phosphate synthase or trehalose-6-phosphate phosphatase. The invention also relates to the construction of a recombinant DNA construct encoding all or a portion of the alpha, alpha-trehalase, alpha, alpha-trehalose-phosphate synthase or trehalose-6-phosphate phosphatase, in sense or antisense orientation, wherein expression of the recombinant DNA construct results in production of altered levels of the alpha, alpha-trehalase, alpha, alpha-trehalose-phosphate synthase or trehalose-6-phosphate phosphatase in a transformed host cell.

摘要翻译： 本发明涉及编码海藻糖代谢酶，更具体地，α，α-海藻糖酶，α，α-海藻糖 - 磷酸合成酶或海藻糖-6-磷酸磷酸酶的分离的核酸片段。 本发明还涉及在正义或反义方向上构建编码α，α-海藻糖酶，α，α-海藻糖-6-磷酸磷酸酶的全部或部分的重组DNA构建体，其中表达 重组DNA构建体导致转化的宿主细胞中α，α-海藻糖酶，α，α-海藻糖磷酸合酶或海藻糖-6-磷酸磷酸酶水平的变化。