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公开(公告)号：US20180327735A1
公开(公告)日：2018-11-15
申请号：US16048362
申请日：2018-07-30
发明人： Bing Lou WONG , Wai Hong CHUNG
CPC分类号： C12N9/88 , B01D15/3804 , C12Y402/02004 , C12Y402/0202
摘要： The present invention provides a method for purifying Chondroitinase ABC (ChABC). The present method includes using a heparin-immobilized affinity chromatography column, and through chromatography method obtaining a purified ChABC from a matrix containing said ChABC. The present method is capable of obtaining ChABC in high purity with the advantages of simplicity in preparation and high yield.
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12.发明申请公开(公告)号：US20170356002A1
公开(公告)日：2017-12-14
申请号：US15460468
申请日：2017-03-16
申请人： Spogen Biotech Inc.
发明人： Brian M. Thompson , Jorg Augustin
CPC分类号： C12N15/8249 , A01H5/00 , A01N63/00 , C05B15/00 , C05C9/00 , C05F11/08 , C05G3/02 , C07K14/415 , C12N1/20 , C12N9/78 , C12N15/8237 , C12N15/8279 , C12Y302/01 , C12Y305/99007 , C12Y402/0202 , Y02A40/229 , Y02P60/218
摘要： Methods for stimulating plant growth and/or promoting plant health using free enzymes or recombinant microorganisms that overexpress enzymes are provided. Plant seeds coated with free enzymes or recombinant microorganisms that overexpress enzymes are also provided. Compositions comprising a fertilizer and an enzyme or a recombinant microorganism that overexpresses an enzyme are provided. Modified enzymes having ACC deaminase activity, recombinant microorganisms expressing the modified enzymes, plant seeds treated with the modified enzymes or recombinant microorganisms, and methods for stimulating plant growth and/or promoting plant health using the modified enzymes or recombinant microorganisms are also provided.
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公开(公告)号：US09410141B2
公开(公告)日：2016-08-09
申请号：US14790075
申请日：2015-07-02
IPC分类号： C12N15/64 , C12P19/34 , C12P21/06 , C12N15/00 , C12N9/88 , C12N9/26 , C12N9/24 , C12N9/14 , C07H21/04 , C07K1/00 , A61K38/00
CPC分类号： A61K38/51 , A61K38/00 , C12N9/88 , C12Y402/0202 , C12Y402/02021
摘要： The present disclosure relates to protein and nucleic acid mutants of chondroitinase ABCI. Such nucleic acid mutants encode for chondroitinase ABCI mutant enzymes exhibiting altered chondroitin lyase activity or increased resistance to inactivation from stressors including UV light or heat. Methods of using such nucleic acid mutants encoding chondroitinase ABCI mutant enzymes is also provided.
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公开(公告)号：US09102930B2
公开(公告)日：2015-08-11
申请号：US13849420
申请日：2013-03-22
CPC分类号： A61K38/51 , A61K38/00 , C12N9/88 , C12Y402/0202 , C12Y402/02021
摘要： The present disclosure relates to protein and nucleic acid mutants of chondroitinase ABCI. Such nucleic acid mutants encode for chondroitinase ABCI mutant enzymes exhibiting altered chondroitin lyase activity or increased resistance to inactivation from stressors including UV light or heat. Methods of using such nucleic acid mutants encoding chondroitinase ABCI mutant enzymes is also provided.
摘要翻译： 本公开涉及软骨素酶ABCI的蛋白质和核酸突变体。 这种核酸突变体编码表现出改变的软骨素裂解酶活性的软骨素酶ABCI突变体酶或增强的抗应激物包括UV光或热的对灭活的抗性。 还提供了使用编码软骨素酶ABCI突变酶的核酸突变体的方法。
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15.发明公开公开(公告)号：US20240228395A9
公开(公告)日：2024-07-11
申请号：US18476259
申请日：2023-09-27
申请人： Spogen Biotech Inc.
发明人： Brian M. Thompson , Jorg Augustin
IPC分类号： C05F11/08 , A01N63/50 , C05B15/00 , C05C9/00 , C05F17/20 , C05G3/60 , C07K14/415 , C12N1/20 , C12N9/78 , C12N15/82
CPC分类号： C05F11/08 , A01N63/50 , C05B15/00 , C05C9/00 , C05F17/20 , C05G3/60 , C07K14/415 , C12N1/20 , C12N9/78 , C12N15/8237 , C12N15/8249 , C12N15/8279 , C12Y302/01 , C12Y305/99007 , C12Y402/0202 , Y02A40/22 , Y02P60/21
摘要： Methods for stimulating plant growth and/or promoting plant health using free enzymes or recombinant microorganisms that overexpress enzymes are provided. Plant seeds coated with free enzymes or recombinant microorganisms that overexpress enzymes are also provided. Compositions comprising a fertilizer and an enzyme or a recombinant microorganism that overexpresses an enzyme are provided. Modified enzymes having ACC deaminase activity, recombinant microorganisms expressing the modified enzymes, plant seeds treated with the modified enzymes or recombinant microorganisms, and methods for stimulating plant growth and/or promoting plant health using the modified enzymes or recombinant microorganisms are also provided.
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16.发明公开公开(公告)号：US20240132419A1
公开(公告)日：2024-04-25
申请号：US18476270
申请日：2023-09-26
申请人： Spogen Biotech Inc.
发明人： Brian M. Thompson , Jorg Augustin
IPC分类号： C05F11/08 , A01N63/50 , C05B15/00 , C05C9/00 , C05F17/20 , C05G3/60 , C07K14/415 , C12N1/20 , C12N9/78 , C12N15/82
CPC分类号： C05F11/08 , A01N63/50 , C05B15/00 , C05C9/00 , C05F17/20 , C05G3/60 , C07K14/415 , C12N1/20 , C12N9/78 , C12N15/8237 , C12N15/8249 , C12N15/8279 , C12Y302/01 , C12Y305/99007 , C12Y402/0202 , Y02A40/22 , Y02P60/21
摘要： Methods for stimulating plant growth and/or promoting plant health using free enzymes or recombinant microorganisms that overexpress enzymes are provided. Plant seeds coated with free enzymes or recombinant microorganisms that overexpress enzymes are also provided. Compositions comprising a fertilizer and an enzyme or a recombinant microorganism that overexpresses an enzyme are provided. Modified enzymes having ACC deaminase activity, recombinant microorganisms expressing the modified enzymes, plant seeds treated with the modified enzymes or recombinant microorganisms, and methods for stimulating plant growth and/or promoting plant health using the modified enzymes or recombinant microorganisms are also provided.
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公开(公告)号：US10036004B1
公开(公告)日：2018-07-31
申请号：US15788824
申请日：2017-10-20
发明人： Bing Lou Wong , Wai Hong Chung
CPC分类号： C12N9/88 , B01D15/3804 , B01D15/3828 , C12Y402/02004 , C12Y402/0202
摘要： The present invention provides a method for purifying Chondroitinase ABC (ChABC). The present method includes using a heparin-immobilized affinity chromatography column, and through chromatography method obtaining a purified ChABC from a matrix containing said ChABC. The present method is capable of obtaining ChABC in high purity with the advantages of simplicity in preparation and high yield.
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公开(公告)号：US09463225B2
公开(公告)日：2016-10-11
申请号：US14491792
申请日：2014-09-19
CPC分类号： A61K38/51 , A61K9/0019 , A61K9/0085 , A61K9/19 , A61K38/47 , A61K47/10 , C12Y402/02004 , C12Y402/0202 , C12Y402/02021
摘要： The present invention provides a therapeutic agent for disc herniation, which has extremely few adverse side effects, can achieve a prolonged pain-ameliorating effect when administered in only a single dose, and can exhibit a high therapeutic effect and high safety in clinical applications. The present invention relates to a therapeutic agent for disc herniation, which is characterized by containing chondroitinase ABC as an active ingredient and being administered in such a manner that the ingredient can be administered into a human disk in an amount of 1-8 units per disk.
摘要翻译： 本发明提供了一种椎间盘突出症治疗剂，其具有极少的副作用，仅在单一剂量下施用时可达到延长的疼痛改善效果，并且在临床应用中可表现出高治疗效果和高安全性。 椎间盘突出治疗剂本发明涉及椎间盘突出症治疗剂，其特征在于含有软骨素酶ABC作为活性成分，并且以这样的方式给药，使得该成分可以以每个盘1-8个单位的量施用于人体盘 。
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公开(公告)号：US20130210082A1
公开(公告)日：2013-08-15
申请号：US13849420
申请日：2013-03-22
IPC分类号： C12N9/88
CPC分类号： A61K38/51 , A61K38/00 , C12N9/88 , C12Y402/0202 , C12Y402/02021
摘要： The present disclosure relates to protein and nucleic acid mutants of chondroitinase ABCI. Such nucleic acid mutants encode for chondroitinase ABCI mutant enzymes exhibiting altered chondroitin lyase activity or increased resistance to inactivation from stressors including UV light or heat. Methods of using such nucleic acid mutants encoding chondroitinase ABCI mutant enzymes is also provided.
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20.发明申请COMPOSITIONS AND METHODS OF USING CHONDROITINASE ABCI MUTANTS 有权组合物和使用CHONDROITINASE ABCI MUTANT的方法公开(公告)号：US20110014158A1
公开(公告)日：2011-01-20
申请号：US12781762
申请日：2010-05-17
CPC分类号： A61K38/51 , A61K38/00 , C12N9/88 , C12Y402/0202 , C12Y402/02021
摘要： The present invention relates to protein and nucleic acid mutants of chondroitinase ABCI. Such chondroitinase ABCI mutant enzymes exhibit altered chondroitin lyase activity or increased resistance to inactivation from stressors including UV light or heat. Methods of using chondroitinase ABCI mutant enzymes are also provided.
摘要翻译： 本发明涉及软骨素酶ABCI的蛋白质和核酸突变体。 这种软骨素酶ABCI突变体酶表现出改变的软骨素裂解酶活性或增强的对包括UV光或热量在内的应激物灭活的抗性。 还提供了使用软骨素酶ABCI突变酶的方法。
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