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    TIME-RESOLVED AND WAVELENGTH-RESOLVED SPECTROSCOPY FOR CHARACTERIZING BIOLOGICAL MATERIALS
    11.
    发明申请
    TIME-RESOLVED AND WAVELENGTH-RESOLVED SPECTROSCOPY FOR CHARACTERIZING BIOLOGICAL MATERIALS 失效
    用于表征生物材料的时间分辨率和波长分辨光谱

    公开(公告)号：US20100067003A1

    公开(公告)日：2010-03-18

    申请号：US12516341

    申请日：2007-11-26

    Applicant: Laura Marcu ,  Javier A. Jo ,  Daniel Elson

    Inventor： Laura Marcu ,  Javier A. Jo ,  Daniel Elson

    IPC: G01J3/30

    CPC classification number: G01N21/6408 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0294 ,  G01J3/2889 ,  G01J3/4406 ,  G01N21/6402 ,  G01N21/6486 ,  G01N2021/6421 ,  G01N2021/6484

    Abstract: One embodiment of the present invention provides a system that characterizes a biological sample by analyzing light emissions from the biological sample in response to an excitation. The system first radiates the biological sample with a laser impulse to cause the biological sample to produce a responsive light emission. Next, the system uses a wavelength splitting device to split the responsive light emission into a set of spectral bands of different central wavelengths. The system applies temporal delays to the set of spectral bands so that each spectral band arrives at an optical detector at a different time, thereby allowing the optical detector to temporally resolve the responsive light emission for each spectral band separately. Next, the system captures the delayed spectral bands within a single detection window of the optical detector. The system then processes the captured spectral bands.

    Abstract translation: 本发明的一个实施方案提供了一种通过响应于激发分析来自生物样品的光发射来表征生物样品的系统。 系统首先用激光脉冲辐射生物样品，使生物样品产生响应性发光。 接下来，系统使用波长分离装置将响应光发射分成不同中心波长的一组光谱带。 该系统将时间延迟应用于频谱带集合，使得每个频谱带在不同时间到达光学检测器，从而允许光学检测器分别时间地分辨每个频谱带的响应光发射。 接下来，系统捕获在光学检测器的单个检测窗口内的延迟的光谱带。 然后系统处理捕获的光谱带。

    HIGH-SPEED, RUGGED, TIME-RESOLVED, RAMAN SPECTROMETER FOR SENSING MULTIPLE COMPONENTS OF A SAMPLE AND FOR DIAGNOSTICS OF PATHOLOGICAL SKIN CONDITIONS SUCH AS CANCER
    12.
    发明申请
    HIGH-SPEED, RUGGED, TIME-RESOLVED, RAMAN SPECTROMETER FOR SENSING MULTIPLE COMPONENTS OF A SAMPLE AND FOR DIAGNOSTICS OF PATHOLOGICAL SKIN CONDITIONS SUCH AS CANCER 有权
    用于感应样品的多个组分和用于诊断病理学皮肤病症如癌症的高分辨率，有声，时间分辨率的拉曼光谱仪

    公开(公告)号：US20100027002A1

    公开(公告)日：2010-02-04

    申请号：US12551404

    申请日：2009-08-31

    Applicant: Ricardo CLAPS

    Inventor： Ricardo CLAPS

    IPC: G01J3/44

    CPC classification number: G01J3/44 ,  G01J3/0218 ,  G01J3/0227 ,  G01J3/1895 ,  G01J3/26 ,  G01J3/2889 ,  G01J3/32 ,  G01J2003/123 ,  G01N21/65

    Abstract: A new architecture for implementing a time-resolved Raman spectrometer is 2-3 orders of magnitude faster than current systems. In one embodiment, the invention employs a rotating optical switch to time multiplex an input signal through multiple band-pass filters and into a single optical detector which is electrically activated only when the filtered input light pulse is about to impact it.Time-multiplexing the input signal through multiple optical filters and time-sequencing the optical detector enables the device to detect and analyze 2-3 orders of magnitude faster than current designs. In one embodiment, the system may be employed for the diagnostics of a pathological condition of skin tissue in patients, such as malignant melanoma or other types of skin cancers and abnormal conditions.

    Abstract translation: 实现时间分辨拉曼光谱仪的新架构比现有系统快2-3个数量级。 在一个实施例中，本发明采用旋转光开关，通过多个带通滤波器对输入信号进行时间复用，并将其转换成仅在滤波后的输入光脉冲即将影响时才被电激活的单个光检测器。 通过多个光学滤波器对输入信号进行时分复用，并对光学检测器进行时间排序，使器件能够比目前的设计更快地检测和分析2-3个数量级。 在一个实施方案中，该系统可用于诊断患者皮肤组织的病理状况，例如恶性黑素瘤或其他类型的皮肤癌症和异常状况。

    Apparatus for registering and analyzing the spectral signature of a dynamic event
    13.
    发明申请
    Apparatus for registering and analyzing the spectral signature of a dynamic event 有权
    用于记录和分析动态事件的光谱特征的装置

    公开(公告)号：US20100004887A1

    公开(公告)日：2010-01-07

    申请号：US12380674

    申请日：2009-03-02

    Applicant: Johnathan Martin Mooney

    Inventor： Johnathan Martin Mooney

    IPC: G01J3/40 ,  G06F19/00

    CPC classification number: G01J3/02 ,  G01J3/0237 ,  G01J3/0289 ,  G01J3/14 ,  G01J3/2803 ,  G01J3/2823 ,  G01J3/2889

    Abstract: Apparatus for registering the spectral signature of a dynamic source event include an imaging-sensor array configured to register electromagnetic energy over a predetermined range of electromagnetic wavelengths and an optical system configured for imaging onto the imaging-sensor array a dispersion pattern of electromagnetic energy emitted from a source event external to the optical system. The optical system includes (i) a focusing element and (ii) a selected set of optical dispersion apparatus. Among the optical dispersion apparatus are at least a first optically dispersive element that disperses a first selected set of wavelengths within the sensitivity range of the imaging-sensor array and at least a second optically dispersive element that disperses a second selected set of wavelengths within the sensitivity range of the imaging-sensor array such that wavelengths emitted from a source event that are within the first and second selected sets of wavelengths impinge simultaneously upon the imaging-sensor array along, respectively, a first extrapolated axis and a second extrapolated axis that is non-parallel to the first extrapolated axis.

    Abstract translation: 用于记录动态源事件的光谱特征的装置包括被配置为在电磁波长的预定范围内记录电磁能量的成像传感器阵列和被配置用于在成像传感器阵列上成像的电磁能量的散射图案 光学系统外部的源事件。 光学系统包括（i）聚​​焦元件和（ii）所选择的一组光学分散设备。 在光学分散装置中，至少是第一光学色散元件，其将成像传感器阵列的灵敏度范围内的第一选定组的波长分散，并且将至少第二光学色散元件分散在灵敏度范围内的第二选定组合 成像传感器阵列的范围使得从源事件发射的波长在第一和第二选定组合波长内同时在成像传感器阵列上分别沿着第一外插轴和第二外推轴非对称 平行于第一外推轴。

    High-speed, rugged, time-resolved, raman spectrometer for sensing multiple components of a sample
    16.
    发明授权
    High-speed, rugged, time-resolved, raman spectrometer for sensing multiple components of a sample 有权
    高速，坚固，时间分辨的拉曼光谱仪，用于感测样品的多个组分

    公开(公告)号：US07602488B2

    公开(公告)日：2009-10-13

    申请号：US11452129

    申请日：2006-06-12

    Applicant: Ricardo Claps ,  Bradley A. Smith

    Inventor： Ricardo Claps ,  Bradley A. Smith

    IPC: G01J3/44

    CPC classification number: G01J3/44 ,  G01J3/0218 ,  G01J3/0227 ,  G01J3/1895 ,  G01J3/26 ,  G01J3/2889 ,  G01J3/32 ,  G01J2003/123 ,  G01N21/65

    Abstract: A new architecture for implementing a time-resolved Raman spectrometer is 2-3 orders of magnitude faster than current systems. The system additionally is compact, environmentally rugged, low cost and can detect multiple components of a sample simultaneously. In one embodiment, the invention employs a rotating optical switch to time multiplex an input signal through multiple bandpass filters and into a single optical detector which is electrically activated only when the filtered input light pulse is about to impact it.The combination of time-multiplexing the input signal through multiple optical filters and time-sequencing the optical detector enables the device to detect and analyze 2-3 orders of magnitude faster than current designs, processing spectra within milliseconds instead of seconds. The system can process multiple material samples (25+) simultaneously, instead of sequentially, and its mechanical ruggedness and simplicity enables using the system in harsh physical environments when traditional spectrometers can not be used reliably.

    Abstract translation: 实现时间分辨拉曼光谱仪的新架构比现有系统快2-3个数量级。 该系统还具有结构紧凑，环境坚固，成本低，可同时检测样品的多个成分。 在一个实施例中，本发明采用旋转光学开关来将输入信号经过多个带通滤波器进行时间复用，并进入单个光学检测器，只有当滤波后的输入光脉冲即将影响时才能电激活。 通过多个光学滤波器对输入信号进行时间复用和对光学检测器进行时间排序的组合使得该器件能够比目前的设计更快地检测和分析2-3个数量级，在几毫秒而不是几秒内处理光谱。 该系统可以同时处理多个材料样品（25+），而不是依次加工，并且其机械坚固性和简单性使得在传统光谱仪不能可靠地使用恶劣的物理环境中使用该系统。

    System, method and apparatus for the detection of patient-borne fluorescing nanocrystals
    19.
    发明申请
    System, method and apparatus for the detection of patient-borne fluorescing nanocrystals 失效
    用于检测病人携带的荧光纳米晶体的系统，方法和装置

    公开(公告)号：US20080281172A1

    公开(公告)日：2008-11-13

    申请号：US11801549

    申请日：2007-05-10

    Applicant: Marlin O. Thurston ,  Karl W. Olson

    Inventor： Marlin O. Thurston ,  Karl W. Olson

    IPC: G01J5/28 ,  A61B6/00

    CPC classification number: G01J3/4406 ,  A61B5/0059 ,  A61B5/415 ,  A61B5/418 ,  G01J3/02 ,  G01J3/027 ,  G01J3/28 ,  G01J3/2889 ,  G01N21/6408 ,  G01N21/6428

    Abstract: System, method and apparatus wherein a probe employing non-imagining optics is utilized in conjunction with a fluorescing nanocrystal tracer at the body of a patient. Excitation components within the probe working end are utilized to excite the nanocrystals to fluoresce at wavelengths in the near infrared region, such fluorescent energy is homogenized by interacting with involved tissue to provide a uniform fluorescing intensity over the surface of a photo-detector. Initialization and background determination procedures are described along with a technique for determining statistically significant levels of fluorescing activity.

    Abstract translation: 系统，方法和装置，其中使用非想象光学元件的探针与患者体内的荧光纳米晶体示踪剂结合使用。 探针工作端内的激发元件用于激发纳米晶体以在近红外区域的波长发荧光，通过与所涉及的组织相互作用使荧光能量均匀化，以在光检测器的表面上提供均匀的荧光强度。 描述初始化和背景确定程序以及用于确定统计学显着水平的荧光活性的技术。

    ARRANGEMENT FOR AN OPTICAL SYSTEM FOR POLARIZATION-DEPENDENT, TIME-RESOLVED OPTICAL SPECTROSCOPY, OPTICAL MEASUREMENT SYSTEMS AND METHOD FOR THE POLARIZATION-DEPENDENT SPECTROSCOPIC ANALYSIS OF MEASUREMENT LIGHT
    20.
    发明申请
    ARRANGEMENT FOR AN OPTICAL SYSTEM FOR POLARIZATION-DEPENDENT, TIME-RESOLVED OPTICAL SPECTROSCOPY, OPTICAL MEASUREMENT SYSTEMS AND METHOD FOR THE POLARIZATION-DEPENDENT SPECTROSCOPIC ANALYSIS OF MEASUREMENT LIGHT 失效
    用于偏光相关的光学系统的装置，时间分辨光学光谱，光学测量系统和测量光的偏光度分光光度法

    公开(公告)号：US20080239313A1

    公开(公告)日：2008-10-02

    申请号：US11843546

    申请日：2007-08-22

    Applicant: Nikolaus Ernsting

    Inventor： Nikolaus Ernsting

    IPC: G01J3/447

    CPC classification number: G01J3/2889 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/44

    Abstract: The invention is directed to an arrangement for an optical system for polarizalion-dependent, time-resolved optical spectroscopy, in particular a spectrometer that includes a polarization device which has a crystal polarizer and includes a light entry area which is arranged upstream of the polarization device and which is formed in such a way as to enclose a spatial acceptance angle of the crystal polarizer, and also that includes a light exit area which is arranged downstream of the polarization device, wherein an intermediate area which connects the light entry area and the light exit area is formed in the polarization device with a path length of at most approximately 4 mm which is traversed in the crystal polarizer by light impinging within the spatial acceptance angle. The invention also is directed to an optical measurement system comprising an arrangement, and also to a method for the polarization-dependent spectroscopic analysis of measurement light, in particular in time-resolved optical spectroscopy.

    Abstract translation: 本发明涉及一种用于偏振相关时间分辨光谱的光学系统的装置，特别是包括具有晶体偏振器的偏振装置的光谱仪，该偏振装置包括布置在偏振装置上游的光入射区域 并且其以包围晶体偏振器的空间接受角的方式形成，并且还包括布置在偏振装置的下游的光出射区域，其中连接光入射区域和光线的中间区域 出射区域形成在极化装置中，其路径长度至多约4mm，其通过在空间接受角度内的光照射而在晶体偏振器中穿过。 本发明还涉及一种光学测量系统，其特别是在时间分辨的光谱中，包括一种装置，以及用于测量光的偏振相关光谱分析的方法。

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