公开(公告)号：US20240290431A1

公开(公告)日：2024-08-29

申请号：US18656302

申请日：2024-05-06

申请人： Hangzhou Calibra Diagnostics Co., Ltd.

发明人： Rongchang CHEN ,  Sheng QUAN ,  Chao ZHANG ,  Ziqing KONG ,  Pengyun LIU ,  Huafen LIU

IPC分类号： G16B40/00 ,  G01N33/53 ,  G01N33/68 ,  G16B5/20 ,  G16C20/70 ,  G16H50/30

CPC分类号： G16B40/00 ,  G01N33/5308 ,  G01N33/6848 ,  G16B5/20 ,  G16C20/70 ,  G16H50/30

摘要： The present disclosure provides a biomarker for detecting colorectal cancer and a use thereof. A metabolomics method is used to analyze metabolites with significant differences in urine of patients with colorectal cancer and normal people, such that a series of biomarkers capable of early predicting an occurrence risk of colorectal cancer are screened out, a group of biomarkers are further screened to construct a diagnostic model for colorectal cancer, and the model can be used for conveniently, non-invasively and effectively predicting whether an individual suffers from colorectal cancer, and meets clinical needs.

公开(公告)号：US20240287573A1

公开(公告)日：2024-08-29

申请号：US18565163

申请日：2022-06-03

申请人： MONTE ROSA THERAPEUTICS, INC.

发明人： Amine SADOK ,  Debora BONENFANT

IPC分类号： C12Q1/48 ,  C07K14/705 ,  G01N33/68

CPC分类号： C12Q1/48 ,  C07K14/705 ,  G01N33/6848

摘要： Described herein are fusion protein(s), e.g., fusion protein(s) comprising: i) a cereblon protein, e.g., a human cereblon protein, and ii) a Proximity Labeling Enzyme. Also described are polynucleotide sequence(s) encoding the fusion protein(s), vector(s) comprising the polynucleotide sequence(s), and cells transformed with the vector(s). Also described herein are methods of using the fusion protein(s), polynucleotide sequence(s), vector(s), and cell(s).

公开(公告)号：US20240280583A1

公开(公告)日：2024-08-22

申请号：US18638970

申请日：2024-04-18

申请人： Immatics Biotechnologies GmbH

发明人： Toni WEINSCHENK ,  Julia LEIBOLD

IPC分类号： G01N33/68 ,  G01N33/569

CPC分类号： G01N33/6848 ,  G01N33/56977 ,  G01N33/6842 ,  G01N33/6878 ,  G01N2333/70539 ,  G01N2458/15 ,  G01N2496/00 ,  G01N2560/00 ,  G01N2570/00

摘要： The present invention relates to a method for the absolute quantification of naturally processed HLA-restricted cancer peptides, i.e. the determination of the copy number of peptide(s) as presented per cell. The present invention can not only be used for the development of antibody therapies or peptide vaccines, but is also highly valuable for a molecularly defined immuno-monitoring, and useful in the processes of identifying of new peptide antigens for immunotherapeutic strategies, such as respective vaccines, antibody-based therapies or adoptive T-cell transfer approaches in cancer, infectious and/or autoimmune diseases.

公开(公告)号：US20240280566A1

公开(公告)日：2024-08-22

申请号：US18644619

申请日：2024-04-24

申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

发明人： Omid Farokhzad ,  Morteza Mahmoudi ,  Claudia Corbo

IPC分类号： G01N33/543 ,  B82Y35/00 ,  C01G49/02 ,  G01N33/574 ,  G01N33/68 ,  G06F18/24 ,  G06N20/20 ,  G16B40/20

CPC分类号： G01N33/5432 ,  C01G49/02 ,  G01N33/54326 ,  G01N33/57488 ,  G01N33/6842 ,  G01N33/6848 ,  G06F18/24 ,  G06N20/20 ,  G16B40/20 ,  B82Y35/00 ,  C01P2004/64 ,  G06F2218/20

摘要： The present disclosure provides a system comprising a communication interface and computer for assigning a label to the biomolecule fingerprint, wherein the label corresponds to a biological state. The present disclosure also provides a sensor arrays for detecting biomolecules and methods of use. In some embodiments, the sensor arrays are capable of determining a disease state in a subject.

公开(公告)号：US20240280558A1

公开(公告)日：2024-08-22

申请号：US18578513

申请日：2022-07-13

申请人： Seer, Inc.

发明人： Theodore Platt ,  Iman Mohtashemi ,  Hugo Kitano ,  Asim Siddiqui

IPC分类号： G01N33/487 ,  G01N30/86 ,  G01N33/68

CPC分类号： G01N33/48792 ,  G01N30/8631 ,  G01N33/6848

摘要： In some aspects, the present disclosure provides a method for normalizing and processing mass spectrometry datasets. In some embodiments, the method comprises loading a plurality of mass spectrometry data obtained from a plurality of samples into a memory of a computing node to generate a cached dataset. In some embodiments, the method comprises transmitting a copy of the cached dataset to a plurality of cache memories of a plurality of computing nodes. In some embodiments, the method comprises determining, using the plurality of computing nodes, a plurality of feature values for the plurality of mass spectrometry data. In some embodiments, the method comprises normalizing, using the plurality of computing nodes, across the plurality of mass spectrometry datasets using the plurality of feature values to generate a plurality of normalized mass spectrometry data.

公开(公告)号：US20240255522A1

公开(公告)日：2024-08-01

申请号：US18589276

申请日：2024-02-27

申请人： GENENTECH, INC.

发明人： Adel Mahmoud ELSOHLY ,  Joshua Gregory GOBER ,  Juan LI

IPC分类号： G01N33/68 ,  G01N33/58

CPC分类号： G01N33/6878 ,  G01N33/582 ,  G01N33/6848 ,  G01N2333/70539

摘要： Described herein are reagents and methods for high-throughput screening of antigen binding to MHCII alleles.

公开(公告)号：US20240255518A1

公开(公告)日：2024-08-01

申请号：US18421538

申请日：2024-01-24

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Yuetian Yan ,  Gaoyuan Liu ,  Shunhai Wang

IPC分类号： G01N33/68 ,  C12Q1/37 ,  G01N30/02 ,  G01N30/06 ,  G01N30/16 ,  G01N30/72

CPC分类号： G01N33/6848 ,  C12Q1/37 ,  G01N30/16 ,  G01N30/7266 ,  G01N33/6857 ,  G01N2030/027 ,  G01N2030/067 ,  G01N2333/96413 ,  G01N2333/96416 ,  G01N2333/96419 ,  G01N2333/976

摘要： The present invention generally pertains to methods of characterizing of a protein of interest. In particular, the present invention pertains to the use of post-column denaturation, size exclusion chromatography and mass spectrometry for detecting, identifying and characterizing crosslinking amino acid residues in a therapeutic antibody.

公开(公告)号：US20240248087A1

公开(公告)日：2024-07-25

申请号：US18564216

申请日：2022-09-23

申请人： CENTRO DE EDUCAÇÃO FÍSICA ALMIRANTE ADALBERTO NUNES ,  UNIVERSIDADE FEDERAL DO RIO DE JANEIRO

发明人： Marcos DIAS PEREIRA ,  Andréia CARNEIRO DA SILVA ,  Giuseppe PALMISANO

IPC分类号： G01N33/573 ,  G01N33/68

CPC分类号： G01N33/573 ,  G01N33/6848 ,  G01N33/6893 ,  G01N2333/7055 ,  G01N2333/78 ,  G01N2333/902 ,  G01N2333/976 ,  G01N2333/99 ,  G01N2570/00 ,  G01N2800/10

摘要： Methods and kits used in the diagnosis of predisposition to the development of rhabdomyolysis. To perform the invention, a biological sample is withdrawn from an investigated individual, such as a blood or urine sample, preferably urine. The investigation is conducted from the detection and quantification of proteins in said sample, proteins selected from a panel that includes: cathepsin H; alpha-1 collagen chain (I); phosphatidylinositol-3-kinase interaction protein 1; beta-defensin 1; integrin beta-1; Brevican core protein; a member of the tumor necrosis factor receptor superfamily 10C; gamma-glutamylcyclotransferase; Glutaredoxin, Flavin reductase; Desmocollin-2; Alpha-1 collagen chain (I); Sodium/nucleoside cotransporter 1; Uteroglobin; Hemoglobin alpha subunit; Hemicentin-1; CCN family member 3; Parkinson's disease protein 7; Intercellular adhesion molecule 2; Secreted Ly-6/uPAR-related protein 1; N-acetylmuramoyl-L-alanine amidase; Cathepsin Z; Fatty acid-binding protein 5; Atractin; Peptidyl-prolyl cis-trans isomerase A and heart fatty acid-binding protein.

公开(公告)号：US20240238341A1

公开(公告)日：2024-07-18

申请号：US18561846

申请日：2022-05-20

申请人： Washington University

发明人： Jonathan Kipnis

IPC分类号： A61K35/17 ,  A61K39/00 ,  A61P25/00 ,  C12N5/0783 ,  C12Q1/6869 ,  G01N33/569 ,  G01N33/68

CPC分类号： A61K35/17 ,  A61K39/4611 ,  A61K39/4632 ,  A61K39/46433 ,  A61P25/00 ,  C12N5/0636 ,  C12Q1/6869 ,  G01N33/56972 ,  G01N33/6848 ,  G01N2333/7051 ,  G01N2333/70539

摘要： The present disclosure is directed to methods and compositions for producing a recombinant cell expressing a T cell receptor (TCR) specific for a peptide of interest, methods and compositions for obtaining a nucleic acid or pair of TCR chain polypeptides and/or nucleic acids encoding a TCR, a cell population comprising the recombinant cell harboring the one or more nucleic acids encoding a TCR or TCR chain obtained by said method, and a method for treating a disorder of the central nervous system comprising administering to the subject said cell population.

公开(公告)号：US12038444B2

公开(公告)日：2024-07-16

申请号：US17828465

申请日：2022-05-31

申请人： Protein Metrics, LLC

发明人： Andrew Nichols ,  Marshall Bern ,  Yong Joo Kil ,  Eric Carlson

IPC分类号： G01N33/68 ,  H01J49/00

CPC分类号： G01N33/6848 ,  H01J49/0036 ,  H01J49/004

摘要： Methods and apparatuses for the identification and/or characterization of properties of a macromolecule based on mass spectrometry data. Specifically, described herein are methods and apparatuses for converting peptide-level data into a pseudo-intact mass spectra. Also described herein are methods and apparatuses for converting peptide-level data into a pseudo-electropherogram. The methods may be well suited for analyzing proteins and protein complexes, including estimating properties of post-translational modifications of the proteins and protein complexes. Methods may include generating a theoretical graph or spectrum based on peptide-level mass spectrometry data. In some embodiments, the theoretical graph may be a theoretical intact mass spectrum or a theoretical charge distribution spectrum.