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    Axillary androstenol and dehydroepiandrosterone as fertile period onset indicators
    12.
    发明授权
    Axillary androstenol and dehydroepiandrosterone as fertile period onset indicators 失效
    脯氨酸和脱水表雄酮作为生育期发病指标

    公开(公告)号：US4931403A

    公开(公告)日：1990-06-05

    申请号：US390156

    申请日：1989-08-07

    申请人： Winnifred B. Cutler ,  George Preti ,  George R. Huggins

    发明人： Winnifred B. Cutler ,  George Preti ,  George R. Huggins

    IPC分类号： G01N33/74

    CPC分类号： G01N33/743 ,  Y10S436/906 ,  Y10T436/146666

    摘要： A novel method of determining the onset of the fertile period of a human female is disclosed comprising the step of monitoring the axillary secretions of said female during the course of her menstrual cycle to determine variations in the concentration of androstenol or dehydroepiandrosterone sulfate. A first significant increase in the concentration of either of those compounds following the cessation of menses is indicative of the onset of the fertile period. In each case, a follicular phase peak occurs which exceeds by at least twice the concentration of those compounds present at any other time during the menstrual cycle. As a result, the monitoring of these compounds may act as reliable indicators predicting the occurrence of ovulation in five to seven days, and/or indicating the onset of the fertile period at a time when appropriate contraceptive measures can still be taken to avoid pregnancy or sexual intercourse can promote fertility.

    摘要翻译： 公开了一种确定人类雌性可育期发病的新方法，包括在月经周期中监测所述雌性腋窝分泌物的步骤，以确定硫氨酸或脱氢表雄酮硫酸盐浓度的变化。 月经停止后，这些化合物中的任一种的浓度首次显着增加，表明可育期的开始。 在每种情况下，发生卵泡相峰，其超过在月经周期期间的任何其他时间存在的那些化合物的浓度的至少两倍。 因此，这些化合物的监测可以作为预测五至七天排卵发生的可靠指标，和/或表示在仍然可以采取适当的避孕措施避免怀孕或/或 性交可以促进生育。

    Fertility indicator system containing anthocyanin pigment
    13.
    发明授权
    Fertility indicator system containing anthocyanin pigment 失效
    含花青素色素的生育指标体系

    公开(公告)号：US4358288A

    公开(公告)日：1982-11-09

    申请号：US302848

    申请日：1981-09-16

    申请人： Dorothee F. E. Goldman

    发明人： Dorothee F. E. Goldman

    IPC分类号： G01N33/50 ,  A61B10/00 ,  G01N33/52

    CPC分类号： G01N33/52 ,  Y10S436/906

    摘要： Fertility in females, especially human females, is evaluated by contacting a mucin-containing body fluid such as saliva with a fertility evaluation medium comprising an anthocyanin pigment and a substrate which facilitates generation of a color response in the pigment, in the presence of vaginal fluid or substances similar to those found in the vaginal fluid, especially ascorbic acid and sugars. A resulting color change in the fertility evaluation medium can be used to determine whether the female is not fertile at that time, whether fertility is imminent in the female, or whether the female actually is fertile.

    摘要翻译： 通过使含有粘蛋白的体液如唾液与包含花青素颜料的生育力评估培养基和在阴道液存在下促进色素反应的基质接触来评估女性尤其是人类女性的生育能力 或类似于在阴道液中发现的物质，特别是抗坏血酸和糖。 生育力评估介质中的颜色变化可以用于确定当时女性是否不能肥沃，女性的生育率是否即将到来，还是女性是否实际上是肥沃的。

    Assays
    14.
    发明授权
    Assays 失效
    测定

    公开(公告)号：US07109042B2

    公开(公告)日：2006-09-19

    申请号：US09780351

    申请日：2001-02-12

    申请人： Keith May ,  Michael Evans Prior ,  Ian Richards

    发明人： Keith May ,  Michael Evans Prior ,  Ian Richards

    IPC分类号： G01N33/558

    CPC分类号： G01N33/54366 ,  G01N30/90 ,  G01N33/54386 ,  G01N33/548 ,  G01N33/549 ,  G01N33/558 ,  G01N33/58 ,  G01N33/689 ,  G01N33/76 ,  G01N2800/368 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/962 ,  Y10S435/969 ,  Y10S435/97 ,  Y10S435/975 ,  Y10S436/805 ,  Y10S436/81 ,  Y10S436/814 ,  Y10S436/817 ,  Y10S436/818 ,  Y10S436/906

    摘要： An analytical test device useful for example in pregnancy testing, comprises a hollow casing (500) constructed of moisture-impervious solid material, such as plastics materials, containing a dry porous carrier (510) which communicates indirectly with the exterior of the casing via a bibulous sample receiving member (506) which protrudes from the casing such that a liquid test sample can be applied to the receiving member and permeate therefrom to the porous carrier, the carrier containing in a first zone a labelled specific binding reagent is freely mobile within the porous carrier when in the moist state, and in a second zone spatially distinct from the first zone unlabelled specific binding reagent for the same analyte which unlabelled reagent is permanently immobilised on the carrier material and is therefore not mobile in the moist state, the two zones being arranged such that liquid sample applied to the porous carrier can permeate via the first zone into the second zone, and the device incorporating means, such as an aperture (508) in the casing, enabling the extent (if any) to which the labelled reagent becomes bound in the second zone to be observed. Preferably the device includes a removable cap for the protruding bibulous member.

    摘要翻译： 可用于例如妊娠试验的分析测试装置包括由不透水的固体材料（例如塑料材料）构成的中空壳体（500），其包含干燥多孔载体（510），所述干燥多孔载体（510）经由壳体的外部经由 吸收样品接收构件（506），其从壳体突出，使得液体测试样品可以施加到接收构件并从其渗透到多孔载体上，在第一区域中包含标记的特异性结合剂的载体可在 多孔载体在处于潮湿状态时，在与第一区空间不同的第二区中，未标记的特异性结合试剂用于相同分析物，未标记的试剂永久地固定在载体材料上，因此在潮湿状态下不能移动， 被布置成使得施加到多孔载体的液体样品可以经由第一区域渗透到第二区域中 装置结合的装置，例如壳体中的孔（508），使得能够观察标记的试剂在第二区域中结合的程度（如果有的话）。 优选地，该装置包括用于突出的吸水构件的可移除盖。

    Assays
    16.
    发明申请
    Assays 审中-公开
    测定

    公开(公告)号：US20050244986A1

    公开(公告)日：2005-11-03

    申请号：US10990946

    申请日：2004-11-16

    申请人： Keith May ,  Michael Prior ,  Ian Richards

    发明人： Keith May ,  Michael Prior ,  Ian Richards

    IPC分类号： G01N33/53 ,  G01N30/90 ,  G01N33/543 ,  G01N33/548 ,  G01N33/549 ,  G01N33/558 ,  G01N33/58 ,  G01N33/68 ,  G01N33/76 ,  G01N37/00

    CPC分类号： G01N33/54366 ,  G01N30/90 ,  G01N33/54386 ,  G01N33/548 ,  G01N33/549 ,  G01N33/558 ,  G01N33/58 ,  G01N33/689 ,  G01N33/76 ,  G01N2800/368 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/962 ,  Y10S435/969 ,  Y10S435/97 ,  Y10S435/975 ,  Y10S436/805 ,  Y10S436/81 ,  Y10S436/814 ,  Y10S436/817 ,  Y10S436/818 ,  Y10S436/906

    摘要： An analytical test device useful for example in pregnancy testing, comprises a hollow casing (500) constructed of moisture-impervious solid material, such as plastics materials, containing a dry porous carrier (510) which communicates indirectly with the exterior of the casing via a bibulous sample receiving member (506) which protrudes from the casing such that a liquid test sample can be applied to the receiving member and permeate therefrom to the porous carrier, the carrier containing in a first zone a labelled specific binding reagent is freely mobile within the porous carrier when in the moist state, and in a second zone spatially distinct from the first zone unlabelled specific binding reagent for the same analyte which unlabelled reagent is permanently immobilised on the carrier material and is therefore not mobile in the moist state, the two zones being arranged such that liquid sample applied to the porous carrier can permeate via the first zone into the second zone, and the device incorporating means, such as an aperture (508) in the casing, enabling the extent (if any) to which the labelled reagent becomes bound in the second zone to be observed. Preferably the device includes a removable cap for the protruding bibulous member.

    摘要翻译： 可用于例如妊娠试验的分析测试装置包括由不透水的固体材料（例如塑料材料）构成的中空壳体（500），其包含干燥多孔载体（510），所述干燥多孔载体（510）经由壳体的外部经由 吸收样品接收构件（506），其从壳体突出，使得液体测试样品可以施加到接收构件并从其渗透到多孔载体上，在第一区域中包含标记的特异性结合剂的载体可在 多孔载体在处于潮湿状态时，在与第一区空间不同的第二区中，未标记的特异性结合试剂用于相同分析物，未标记的试剂永久地固定在载体材料上，因此在潮湿状态下不能移动， 被布置成使得施加到多孔载体的液体样品可以经由第一区域渗透到第二区域中 装置结合的装置，例如壳体中的孔（508），使得能够观察标记的试剂在第二区域中结合的程度（如果有的话）。 优选地，该装置包括用于突出的吸水构件的可移除盖。

    Assays
    18.
    发明申请
    Assays 失效
    测定

    公开(公告)号：US20010008774A1

    公开(公告)日：2001-07-19

    申请号：US09780351

    申请日：2001-02-12

    申请人： Conopco Inc.

    发明人： Keith May ,  Michael Evans Prior ,  Ian Richards

    IPC分类号： G01N033/558

    CPC分类号： G01N33/54366 ,  G01N30/90 ,  G01N33/54386 ,  G01N33/548 ,  G01N33/549 ,  G01N33/558 ,  G01N33/58 ,  G01N33/689 ,  G01N33/76 ,  G01N2800/368 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/962 ,  Y10S435/969 ,  Y10S435/97 ,  Y10S435/975 ,  Y10S436/805 ,  Y10S436/81 ,  Y10S436/814 ,  Y10S436/817 ,  Y10S436/818 ,  Y10S436/906

    摘要： An analytical test device useful for example in pregnancy testing, comprises a hollow casing (500) constructed of moisture-impervious solid material, such as plastics materials, containing a dry porous carrier (510) which communicates indirectly with the exterior of the casing via a bibulous sample receiving member (506) which protrudes from the casing such that a liquid test sample can be applied to the receiving member and permeate therefrom to the porous carrier, the carrier containing in a first zone a labelled specific binding reagent is freely mobile within the porous carrier when in the moist state, and in a second zone spatially distinct from the first zone unlabelled specific binding reagent for the same analyte which unlabelled reagent is permanently immobilised on the carrier material and is therefore not mobile in the moist state, the two zones being arranged such that liquid sample applied to the porous carrier can permeate via the first zone into the second zone, and the device incorporating means, such as an aperture (508) in the casing, enabling the extent (if any) to which the labelled reagent becomes bound in the second zone to be observed. Preferably the device includes a removable cap for the protruding bibulous member.

    摘要翻译： 可用于例如妊娠试验的分析测试装置包括由不透水的固体材料（例如塑料材料）构成的中空壳体（500），其包含干燥多孔载体（510），所述干燥多孔载体（510）经由壳体的外部经由 吸收样品接收构件（506），其从壳体突出，使得液体测试样品可以施加到接收构件并从其渗透到多孔载体上，在第一区域中包含标记的特异性结合剂的载体可在 多孔载体在处于潮湿状态时，在与第一区空间不同的第二区中，未标记的特异性结合试剂用于相同分析物，未标记的试剂永久地固定在载体材料上，因此在潮湿状态下不能移动， 被布置成使得施加到多孔载体的液体样品可以经由第一区域渗透到第二区域中 装置结合的装置，例如壳体中的孔（508），使得能够观察标记的试剂在第二区域中结合的程度（如果有的话）。 优选地，该装置包括用于突出的吸水构件的可移除盖。

    Apparatus and method for monitoring ovulation
    19.
    发明授权
    Apparatus and method for monitoring ovulation 失效
    监测排卵的装置和方法

    公开(公告)号：US6159159A

    公开(公告)日：2000-12-12

    申请号：US224182

    申请日：1998-12-31

    申请人： Joseph M. Canter ,  Yongwu Yang ,  Wanglong Zhou ,  Victor S. Sapirstein ,  Melvin P. Ehrlich ,  James S. Harrison ,  Eugene Katsman ,  Omanand Koul ,  Michael Y. Lu ,  Michael A. Greenwald

    发明人： Joseph M. Canter ,  Yongwu Yang ,  Wanglong Zhou ,  Victor S. Sapirstein ,  Melvin P. Ehrlich ,  James S. Harrison ,  Eugene Katsman ,  Omanand Koul ,  Michael Y. Lu ,  Michael A. Greenwald

    IPC分类号： A61B10/00

    CPC分类号： A61B10/0012 ,  A61B2010/0025 ,  Y10S436/906

    摘要： A quantitative process for monitoring female fertility cycle wherein the process involves directing a laser beam, preferably generated by a diode laser, onto an area of a slide containing an air-dried sample of a female body fluid. The diffraction pattern resulting from the sample is detected by a two-dimensional photo diode array and analyzed by a microprocessor. If a ferning pattern exists, such pattern will generate a characteristic structure in the diffraction pattern which is then detected by the photo diode array. If no ferning occurs, the corresponding diffraction pattern will be structureless. The microprocessor is programmed with an algorithm to produce a quantitative index of ferning indicating quantitatively the ferning level. Preferably, a plurality of spots on the sample are measured to determine the ferning level at each spot, and the microprocessor then makes a final determination as to final ferning level on the basis of the test results of all of the spots. This significantly increases the reliability of the final test result, since a defect at one test spot or anomaly of one test result will not be fatal to the final result.

    摘要翻译： 一种用于监测雌性生育周期的定量过程，其中该方法包括将优选由二极管激光产生的激光束引导到含有女性体液的空气干燥样品的载玻片的区域上。 由样品产生的衍射图由二维光电二极管阵列检测并由微处理器分析。 如果存在镀层图案，则这种图案将产生衍射图案中的特征结构，然后由光电二极管阵列检测。 如果没有发生发光，相应的衍射图将是无结构的。 微处理器用一种算法进行编程，以产生定量指定的定量指标。 优选地，测量样品上的多个点以确定每个点处的熨烫水平，然后微处理器基于所有点的测试结果对最终熨烫水平进行最终确定。 这显着增加了最终测试结果的可靠性，因为一个测试点的缺陷或一个测试结果的异常对最终结果不会是致命的。

    Method of screening for endometriosis
    20.
    发明授权
    Method of screening for endometriosis 失效
    筛查子宫内膜异位症的方法

    公开(公告)号：US5843673A

    公开(公告)日：1998-12-01

    申请号：US474696

    申请日：1995-06-07

    申请人： Kathy Lynn Sharpe-Timms

    发明人： Kathy Lynn Sharpe-Timms

    IPC分类号： G01N33/573 ,  G01N33/68 ,  G01N33/53 ,  G01N33/558

    CPC分类号： G01N33/573 ,  G01N33/6893 ,  G01N2333/8146 ,  G01N2800/364 ,  Y10S435/806 ,  Y10S436/814 ,  Y10S436/906

    摘要： A glycoprotein having a molecular weight of 28,000 to 32,000 and an isoelectric point of 7.0 to 9.0, both as determined by two-dimensional SDS polyacrylamide gel electrophoresis, is synthesized and secreted specifically by stromal cells of endometriotic origin. Amino acid residues in the region of the N-terminus of the glycoprotein share amino acid sequence identity with a region of tissue inhibitor of metalloproteinases-1 (TIMP-1). A method of screening for endometriosis is disclosed by detection of lower levels of the protein or TIMP-1 in peritoneal fluid or serum samples of women.

    摘要翻译： 通过二维SDS聚丙烯酰胺凝胶电泳测定的分子量为28,000〜32,000，等电点为7.0〜9.0的糖蛋白由子宫内膜异位症的基质细胞合成并分泌。 糖蛋白N末端区域中的氨基酸残基与金属蛋白酶-1（TIMP-1）组织抑制剂的区域具有氨基酸序列同一性。 通过检测腹膜液或妇女血清样品中较低水平的蛋白质或TIMP-1来揭示子宫内膜异位症筛查的方法。