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25 条记录 (耗时 0.013 秒)

    Retardation of metalloproteinase incidental to HIV and/or AIDS
    11.
    再颁专利
    Retardation of metalloproteinase incidental to HIV and/or AIDS 失效
    与HIV和/或艾滋病有关的金属蛋白酶的延迟

    公开(公告)号：USRE38386E1

    公开(公告)日：2004-01-13

    申请号：US09973331

    申请日：2001-10-09

    申请人： Charles L. Berman

    发明人： Charles L. Berman

    IPC分类号： A61K3165

    CPC分类号： A61K31/65

    摘要： The instant invention provides a product of manufacture for retarding the biochemical formation of metalloproteinase, including gelatinase, elastase, collaginase, and the like, within the tissues of the body of a patient who has been inflicted with the HIV virus and/or the HIV virus which has advance to the AIDS virus, through the administration of an effective amount of a non-antimicrobial/non-antibiotic/non-antibacterial, chemically modified tetracycline (CMT) analog, its salts, cojugates and/or derivatives, and combinations thereof.

    4-fluoro-N-indan-2-yl benzamide and its use as a pharmaceutical
    15.
    发明授权
    4-fluoro-N-indan-2-yl benzamide and its use as a pharmaceutical 有权
    4-氟-N-茚满-2-基苯甲酰胺及其作为药物的用途

    公开(公告)号：US06617359B2

    公开(公告)日：2003-09-09

    申请号：US10073330

    申请日：2002-02-13

    申请人： Paulus Wohlfart ,  Teri Suzuki ,  Ramalinga M. Dharanipragada ,  Alena Safarova ,  Armin Walser ,  Hartmut Strobel

    发明人： Paulus Wohlfart ,  Teri Suzuki ,  Ramalinga M. Dharanipragada ,  Alena Safarova ,  Armin Walser ,  Hartmut Strobel

    IPC分类号： A61K3165

    CPC分类号： C07C233/65 ,  A61K31/166 ,  C07C2602/08

    摘要： The present invention relates to the method of stimulating the expression of endothelial NO-synthase in a mammal, which method comprises administering a physiologically active amount of 4-fluoro-N-indan-2-yl benzamide according to the formula (I) to the said mammal. The compound (I) can be used for the therapy and prophylaxis of cardiovascular diseases like stable and unstable angina pectoris, Prinzmetal angina (spasm), acute coronary syndrome, heart failure, myocardial infarction, stroke, thrombosis, peripheral artery occlusive disease PAOD, atherosclerosis, restenosis, endothelial damage after PTCA, essential hypertension, pulmonary hypertension, secondary hypertension, renovascular chronic glomerulonephritis, erectile dysfunction, ventricular arrhythmia, and the lowering of cardiovascular risk of postmenopausal women or after intake of contraceptives, the therapy and prophylaxis of diabetes and diabetes complications (nephropathy, retinopathy), angiogenesis, asthma bronchiale, chronic renal failure, cirrhosis of the liver, restricted memory performance or a restricted ability to learn.

    摘要翻译： 本发明涉及刺激哺乳动物内皮细胞NO合成酶表达的方法，该方法包括将生理活性量的式（I）的4-氟-N-茚满-2-基苯甲酰胺给予 哺乳动物说 化合物（I）可用于治疗和预防心血管疾病如稳定和不稳定型心绞痛，Prinzmetal心绞痛（痉挛），急性冠状动脉综合征，心力衰竭，心肌梗死，中风，血栓形成，外周动脉闭塞性疾病PAOD，动脉粥样硬化 ，PTCA后再狭窄，内皮损伤，原发性高血压，肺动脉高压，继发性高血压，肾血管性慢性肾小球肾炎，勃起功能障碍，室性心律失常，绝经后妇女心血管危险降低或避孕药物摄入后，糖尿病和糖尿病的治疗和预防 并发症（肾病，视网膜病变），血管生成，哮喘支气管炎，慢性肾功能衰竭，肝硬化，限制性记忆能力或受限的学习能力。

    Pharmaceutical compositions, mainly vaginal suppository, containing many different active ingredients
    18.
    发明授权
    Pharmaceutical compositions, mainly vaginal suppository, containing many different active ingredients 失效
    药物组合物，主要是阴道栓剂，含有许多不同的活性成分

    公开(公告)号：US06432935B1

    公开(公告)日：2002-08-13

    申请号：US08776273

    申请日：1997-01-22

    申请人： Márton Milánkovits

    发明人： Márton Milánkovits

    IPC分类号： A61K3165

    CPC分类号： A61K45/06 ,  A61K9/0034 ,  A61K31/415 ,  Y10S514/966 ,  Y10S514/967 ,  A61K31/165 ,  A61K31/135 ,  A61K2300/00

    摘要： Compositions comprising an antibiotic, sulphonamide, at least one an antiquagul agent, e.g., clotrimazol (bis-phenyl-(2-chlorophenyl)-1-imidazolyl-methane), natamycin, or nystatin,and 5-nitro-metronidazol (5-nitro-inidazoles) e.g., (metronidazol or tinidazol or nimorazol) and a pharmaceutically acceptable carrier. The compositions are useful mainly as vaginal suppositories.

    摘要翻译： 包含抗生素，磺酰胺，至少一种抗凝血剂（例如克立咪唑（双 - 苯基 - （2-氯苯基）-1-咪唑基甲烷）），游霉素或制霉菌素和5-硝基甲硝唑（5-硝基 - 咪唑），例如（甲硝唑或替硝唑或尼莫拉唑）和药学上可接受的载体。 该组合物主要用作阴道栓剂。

    Methods and compositions for topical treatment of eye surface inflammation and related dry eye disease
    19.
    发明授权
    Methods and compositions for topical treatment of eye surface inflammation and related dry eye disease 失效
    用于局部治疗眼表炎症和相关干眼病的方法和组合物

    公开(公告)号：US06432934B1

    公开(公告)日：2002-08-13

    申请号：US09130638

    申请日：1998-08-06

    申请人： Jeffrey P. Gilbard

    发明人： Jeffrey P. Gilbard

    IPC分类号： A61K3165

    CPC分类号： A61K31/65 ,  A61K33/14 ,  Y10S514/912 ,  A61K33/10 ,  A61K2300/00

    摘要： Ophthalmic compositions and methods of using the same to simultaneously treat eye surface inflammation and dry eye are disclosed. The ophthalmic preparation contains a tetracycline compound in aqueous solution. The preparation preferably further includes a balance of electrolytes sufficient to maintain or restore essentially normal levels of conjunctival mucus-containing goblet cells and corneal glycogen. These electrolytes can include potassium, chloride, bicarbonate, sodium, calcium, magnesium and phosphate.

    摘要翻译： 公开了眼用组合物及其使用方法以同时治疗眼表炎症和干眼症。 眼用制剂在水溶液中含有四环素化合物。 该制剂优选还包括足以维持或恢复基本上正常水平的含结膜粘液的杯状细胞和角膜糖原的电解质的平衡。 这些电解质可以包括钾，氯化物，碳酸氢钠，钠，钙，镁和磷酸盐。

    Methods and compositions for treatment of inflammatory disease
    20.
    发明授权
    Methods and compositions for treatment of inflammatory disease 失效
    用于治疗炎性疾病的方法和组合物

    公开(公告)号：US06677321B1

    公开(公告)日：2004-01-13

    申请号：US09724645

    申请日：2000-11-28

    申请人： Bruce Levin

    发明人： Bruce Levin

    IPC分类号： A61K3165

    CPC分类号： A61K45/06 ,  A61K9/0014 ,  A61K31/23 ,  A61K31/24 ,  A61K31/56 ,  A61K31/65 ,  A61K2300/00

    摘要： Compositions useful for treating inflammatory diseases including arthritis are disclosed which comprise cetyl myristoleate compounds or related compounds and at least one compound useful for treatment of inflammatory disease, such as tetracycline compounds, Cox-2 inhibitors, non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, local anaesthetics, chelating agents, matrix metalloprotease inhibitors, inhibitors of inflammatory cytokines, glucosamine, chondroitin sulfate and collagen hydrolysate. Also disclosed are pharmaceutical compositions and methods of treatment for inflammatory disease and local inflammation and dermal irritation. Also disclosed are compositions including tetracycline and at least one compound useful for treatment of inflammatory disease.

    摘要翻译： 公开了用于治疗包括关节炎在内的炎性疾病的组合物，其包含十六烷基肉豆蔻酸酯化合物或相关化合物和至少一种可用于治疗炎性疾病的化合物，例如四环素化合物，Cox-2抑制剂，非甾体抗炎药（NSAID） ，皮质类固醇，局部麻醉剂，螯合剂，基质金属蛋白酶抑制剂，炎性细胞因子抑制剂，葡糖胺，硫酸软骨素和胶原蛋白水解产物。 还公开了药物组合物和治疗炎性疾病和局部炎症和皮肤刺激的方法。 还公开了包含四环素和至少一种可用于治疗炎性疾病的化合物的组合物。