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公开(公告)号:US07595309B2
公开(公告)日:2009-09-29
申请号:US10853635
申请日:2004-05-24
申请人: Mark L. Nelson , Roger Frechette , Peter Viski , Beena Bhatia , David Messersmith , Mohamed Y. Ismail , Todd Bowser , Laura McIntyre , Darrell J. Koza , Glen Rennie , Paul Sheahan , Paul Hawkins , Atul K. Verma , Tadeusz Warchol , Upul Bandarage
发明人: Mark L. Nelson , Roger Frechette , Peter Viski , Beena Bhatia , David Messersmith , Mohamed Y. Ismail , Todd Bowser , Laura McIntyre , Darrell J. Koza , Glen Rennie , Paul Sheahan , Paul Hawkins , Atul K. Verma , Tadeusz Warchol , Upul Bandarage
IPC分类号: A61K31/65 , C07C43/00 , C07D221/18
CPC分类号: C07D213/64 , C07C237/26 , C07C251/24 , C07C251/48 , C07C271/22 , C07C271/28 , C07C271/58 , C07C275/24 , C07C311/06 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2603/46 , C07D207/22 , C07D213/50 , C07D213/56 , C07D239/36 , C07D261/18 , C07D277/30 , C07D277/42 , C07D295/096 , C07D295/135 , C07D295/155 , C07D307/54 , C07D307/68 , C07D307/79 , C07D317/60 , C07D333/24 , C07D333/28 , C07D333/60 , C07F9/2475
摘要: The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译: 本发明至少部分地涉及新的7-取代四环素化合物。 这些四环素化合物可用于治疗多种四环素化合物反应状态,例如细菌感染和肿瘤,以及其他已知的米诺环素和四环素化合物的一般应用,例如阻断四环素外排和调节基因表达。
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公开(公告)号:US20090325908A1
公开(公告)日:2009-12-31
申请号:US12351405
申请日:2009-01-09
申请人: Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Y. Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell J. Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhatia , Atul K. Verma , Laura Honeyman , Tadeusz Warchol , David Messersmith
发明人: Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Y. Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell J. Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhatia , Atul K. Verma , Laura Honeyman , Tadeusz Warchol , David Messersmith
IPC分类号: A61K31/65 , C07C237/26
CPC分类号: A61K31/65 , C07C237/26 , C07C255/59 , C07C271/22 , C07C271/28 , C07C271/30 , C07C271/58 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C275/42 , C07C275/50 , C07C275/54 , C07C311/06 , C07C311/21 , C07C333/08 , C07C335/22 , C07C381/10 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2603/46 , C07D295/155 , C07F9/4006 , C07F9/4056 , Y02A50/473 , Y02A50/481
摘要: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译: 本发明至少部分地涉及新的9-取代的米诺环素化合物。 这些米诺环素化合物可用于治疗多种四环素化合物反应状态,例如细菌感染和肿瘤,以及其他已知的米诺环素和四环素化合物的一般应用,例如阻断四环素外排和调节基因表达。
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公开(公告)号:US06818635B2
公开(公告)日:2004-11-16
申请号:US09895812
申请日:2001-06-29
IPC分类号: A61K3165
CPC分类号: C07D213/64 , C07C237/26 , C07C251/24 , C07C251/48 , C07C271/22 , C07C271/28 , C07C271/58 , C07C275/24 , C07C311/06 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2603/46 , C07D207/22 , C07D213/50 , C07D213/56 , C07D239/36 , C07D261/18 , C07D277/30 , C07D277/42 , C07D295/096 , C07D295/135 , C07D295/155 , C07D307/54 , C07D307/68 , C07D307/79 , C07D317/60 , C07D333/24 , C07D333/28 , C07D333/60 , C07F9/2475
摘要: The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译: 本发明至少部分地涉及新的7-取代四环素化合物。 这些四环素化合物可用于治疗多种四环素化合物反应状态,例如细菌感染和肿瘤,以及其他已知的米诺环素和四环素化合物的一般应用,例如阻断四环素外排和调节基因表达。
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公开(公告)号:US08492365B2
公开(公告)日:2013-07-23
申请号:US12481368
申请日:2009-06-09
申请人: Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Ismail , Todd Bowser , Beena Bhatia , David Messersmith , Laura McIntyre , Darrell Koza , Glen Rennie , Paul Sheahan , Paul Hawkins , Atul Verma , Tadeusz Warchol , Upul Bandarage
发明人: Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Ismail , Todd Bowser , Beena Bhatia , David Messersmith , Laura McIntyre , Darrell Koza , Glen Rennie , Paul Sheahan , Paul Hawkins , Atul Verma , Tadeusz Warchol , Upul Bandarage
IPC分类号: A61K31/65 , A61K31/42 , A61K31/426 , A61K31/4402 , A61K31/505 , A61K31/5375 , C07C237/26 , C07D239/26 , C07D295/104 , C07D261/08 , C07D277/42
CPC分类号: C07D213/64 , C07C237/26 , C07C251/24 , C07C251/48 , C07C271/22 , C07C271/28 , C07C271/58 , C07C275/24 , C07C311/06 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2603/46 , C07D207/22 , C07D213/50 , C07D213/56 , C07D239/36 , C07D261/18 , C07D277/30 , C07D277/42 , C07D295/096 , C07D295/135 , C07D295/155 , C07D307/54 , C07D307/68 , C07D307/79 , C07D317/60 , C07D333/24 , C07D333/28 , C07D333/60 , C07F9/2475
摘要: The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
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公开(公告)号:US08048867B2
公开(公告)日:2011-11-01
申请号:US10839023
申请日:2004-05-04
申请人: Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Y. Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell J. Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhatia , Atul K. Verma , Laura McIntyre , Tadeusz Warchol , David Messersmith
发明人: Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Y. Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell J. Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhatia , Atul K. Verma , Laura McIntyre , Tadeusz Warchol , David Messersmith
IPC分类号: A61K31/59 , C07C401/00
CPC分类号: A61K31/65 , C07C237/26 , C07C255/59 , C07C271/22 , C07C271/28 , C07C271/30 , C07C271/58 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C275/42 , C07C275/50 , C07C275/54 , C07C311/06 , C07C311/21 , C07C333/08 , C07C335/22 , C07C381/10 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2603/46 , C07D295/155 , C07F9/4006 , C07F9/4056 , Y02A50/473 , Y02A50/481
摘要: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译: 本发明至少部分地涉及新的9-取代的米诺环素化合物。 这些米诺环素化合物可用于治疗多种四环素化合物反应状态,例如细菌感染和肿瘤,以及其他已知的米诺环素和四环素化合物的一般应用,例如阻断四环素外排和调节基因表达。
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公开(公告)号:US20090306022A1
公开(公告)日:2009-12-10
申请号:US12481368
申请日:2009-06-09
申请人: Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Ismail , Todd Bowser , Beena Bhatia , David Messersmith , Laura McIntyre , Darrell Koza , Glen Rennie , Paul Sheahan , Paul Hawkins , Atul Verma , Tadeusz Warchol , Upul Bandarage
发明人: Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Ismail , Todd Bowser , Beena Bhatia , David Messersmith , Laura McIntyre , Darrell Koza , Glen Rennie , Paul Sheahan , Paul Hawkins , Atul Verma , Tadeusz Warchol , Upul Bandarage
IPC分类号: A61K31/65 , C07C237/26 , C07D277/38 , C07D333/24 , C07D213/56 , C07D307/54 , C07D239/52 , C07D413/06 , C07D239/34
CPC分类号: C07D213/64 , C07C237/26 , C07C251/24 , C07C251/48 , C07C271/22 , C07C271/28 , C07C271/58 , C07C275/24 , C07C311/06 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2603/46 , C07D207/22 , C07D213/50 , C07D213/56 , C07D239/36 , C07D261/18 , C07D277/30 , C07D277/42 , C07D295/096 , C07D295/135 , C07D295/155 , C07D307/54 , C07D307/68 , C07D307/79 , C07D317/60 , C07D333/24 , C07D333/28 , C07D333/60 , C07F9/2475
摘要: The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译: 本发明至少部分地涉及新的7-取代四环素化合物。 这些四环素化合物可用于治疗多种四环素化合物反应状态,例如细菌感染和肿瘤,以及其他已知的米诺环素和四环素化合物的一般应用,例如阻断四环素外排和调节基因表达。
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公开(公告)号:US20120283201A1
公开(公告)日:2012-11-08
申请号:US13547870
申请日:2012-07-12
申请人: Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Y. Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell J. Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhalie , Atul K. Verma , Laura Honeyman , Tadeusz Warchol , David Messersmith
发明人: Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Y. Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell J. Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhalie , Atul K. Verma , Laura Honeyman , Tadeusz Warchol , David Messersmith
IPC分类号: A61K31/65 , C07C275/40 , C07C271/30 , C07D307/81 , C07D333/24 , C07D317/60 , C07F9/40 , A61K31/662 , C07C311/21 , C07C255/60 , C07F7/10 , A61K31/695 , C07D295/155 , C07C275/54 , C07C335/20 , C07C311/05 , C07D213/56 , C07C279/18 , C07H15/203 , A61K31/7034 , A61P31/04 , A61P35/00 , C07D213/64 , C07C237/26
CPC分类号: A61K31/65 , C07C237/26 , C07C255/59 , C07C271/22 , C07C271/28 , C07C271/30 , C07C271/58 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C275/42 , C07C275/50 , C07C275/54 , C07C311/06 , C07C311/21 , C07C333/08 , C07C335/22 , C07C381/10 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2603/46 , C07D295/155 , C07F9/4006 , C07F9/4056 , Y02A50/473 , Y02A50/481
摘要: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译: 本发明至少部分地涉及新的9-取代的米诺环素化合物。 这些米诺环素化合物可用于治疗多种四环素化合物反应状态,例如细菌感染和肿瘤,以及其他已知的米诺环素和四环素化合物的一般应用,例如阻断四环素外排和调节基因表达。
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公开(公告)号:US09090541B2
公开(公告)日:2015-07-28
申请号:US13547870
申请日:2012-07-12
申请人: Peter Viski , Beena Bhatia , Tadeusz Warchol , David Messersmith
发明人: Peter Viski , Beena Bhatia , Tadeusz Warchol , David Messersmith
IPC分类号: A61K31/65 , A61K31/64 , A61K31/695 , C07D213/56 , C07C237/26 , C07C275/30 , C07C255/59 , C07C271/22 , C07C271/28 , C07C271/30 , C07C271/58 , C07C275/34 , C07C275/38 , C07C275/40 , C07C275/42 , C07C275/50 , C07C275/54 , C07C311/06 , C07C311/21 , C07C333/08 , C07C335/22 , C07C381/10 , C07D295/155 , C07F9/40
CPC分类号: A61K31/65 , C07C237/26 , C07C255/59 , C07C271/22 , C07C271/28 , C07C271/30 , C07C271/58 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C275/42 , C07C275/50 , C07C275/54 , C07C311/06 , C07C311/21 , C07C333/08 , C07C335/22 , C07C381/10 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2603/46 , C07D295/155 , C07F9/4006 , C07F9/4056 , Y02A50/473 , Y02A50/481
摘要: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
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公开(公告)号:US08344153B2
公开(公告)日:2013-01-01
申请号:US12796825
申请日:2010-06-09
申请人: Kevin Michael Cottrell , Alex Aronov , Robert J. Davies , Jon H. Come , David Messersmith , Jinwang Xu , Upul Keerthi Bandarage , Jingrong Cao
发明人: Kevin Michael Cottrell , Alex Aronov , Robert J. Davies , Jon H. Come , David Messersmith , Jinwang Xu , Upul Keerthi Bandarage , Jingrong Cao
IPC分类号: A61K31/425 , C07D277/00
CPC分类号: C07D417/06
摘要: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译: 本发明涉及可用作PI3K抑制剂,特别是PI3Kγ的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病,病症或病症的方法。
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10.
公开(公告)号:US07598245B2
公开(公告)日:2009-10-06
申请号:US11787165
申请日:2007-04-13
申请人: Michael J. Arnost , Guy W. Bemis , Robert J. Davies , Cornelia J. Forster , Ronald Grey, Jr. , Mark W. Ledeboer , Brian Ledford , Craig Marhefka , David Messersmith , Albert C. Pierce , Francesco G. Salituro , Jian Wang
发明人: Michael J. Arnost , Guy W. Bemis , Robert J. Davies , Cornelia J. Forster , Ronald Grey, Jr. , Mark W. Ledeboer , Brian Ledford , Craig Marhefka , David Messersmith , Albert C. Pierce , Francesco G. Salituro , Jian Wang
IPC分类号: A61K31/427 , A61K31/5377 , C07D413/12 , C07D263/32 , C07D249/08
CPC分类号: C07D401/04 , C07D249/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/04
摘要: The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及蛋白激酶抑制剂。 本发明还提供包含本发明化合物的药物组合物,制备化合物的方法和使用该组合物治疗各种疾病的方法。
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