公开(公告)号：US20050210957A1

公开(公告)日：2005-09-29

申请号：US11072371

申请日：2005-03-04

申请人： Andrew Tipler ,  Neil Plant

发明人： Andrew Tipler ,  Neil Plant

IPC分类号： B01D46/46 ,  G01B13/00 ,  G01B13/08 ,  G01N15/08 ,  G01N30/08 ,  G01N30/32 ,  G01N30/52 ,  G01N30/54 ,  G01N30/60 ,  G01N30/62 ,  G01N30/86 ,  G01N30/89

CPC分类号： G01N30/89 ,  G01N15/0826 ,  G01N30/32 ,  G01N30/60 ,  G01N2030/324 ,  G01N2030/524 ,  G01N2030/626 ,  G01N2030/525

摘要： Disclosed are systems and methods that include providing a vessel having an adsorbent disposed therein, the vessel having an inlet and an outlet for communicating a carrier gas through the vessel; determining a differential pressure between the inlet and the outlet for a known flow rate at the outlet; and, determining a geometric measure for the vessel based on a ratio of the known flow rate and the differential pressure. In some embodiments, the methods and systems can include a viscosity in the ratio, determining a flow rate at ambient pressure using a factor based on a ratio of a gas pressure at the output and ambient pressure, and/or, determining a flow rate at ambient temperature using a factor based on a ratio of a temperature at the output and ambient temperature.

公开(公告)号：US6139735A

公开(公告)日：2000-10-31

申请号：US255881

申请日：1999-02-23

申请人： Irving Wainer ,  Yanxiao Zhang

发明人： Irving Wainer ,  Yanxiao Zhang

IPC分类号： B01J20/281 ,  B01D15/08 ,  B01J20/28 ,  B01J20/32 ,  C12Q1/02 ,  G01N30/02 ,  G01N30/52 ,  G01N30/72 ,  G01N30/88 ,  G01N30/89

CPC分类号： B01D15/3804 ,  B01J20/28033 ,  B01J20/286 ,  B01J20/3204 ,  B01J20/3242 ,  B01J20/3246 ,  B01J20/3251 ,  B01J20/3274 ,  G01N30/48 ,  B01J2220/54 ,  B01J2220/58 ,  G01N2030/527 ,  G01N30/02 ,  G01N30/7233 ,  G01N30/89

摘要： This invention provides a immobilized receptors on supports in liquid chromatographic systems. The method of the invention provides means of evaluating the attachment of agents to receptors comprising the steps of:(a) immobilizing receptors on artificial membrane supports in a column,(b) exposing the supports with the receptors to test agents at varying concentrations in a liquid chromatographic system,(c) eluting the test agent from the column, and(d) evaluating the elution profile of the test materials from the column.Using this method, it is possible to evaluate the interaction of the test agent with the receptor. Following elution, it is possible to directly determine molecular structure by passing the elute through other testing devices such as a mass spectrometer.

公开(公告)号：US5057224A

公开(公告)日：1991-10-15

申请号：US507455

申请日：1990-04-11

申请人： Ming-Shi Shiao ,  Lee-Julian Lin

发明人： Ming-Shi Shiao ,  Lee-Julian Lin

IPC分类号： C07J9/00 ,  G01N30/62 ,  G01N30/74 ,  G01N30/89

CPC分类号： G01N30/62 ,  C07J9/005 ,  G01N2030/626 ,  G01N30/74 ,  G01N30/89

摘要： The present invention provides a composition for evaluating the performance of reverse phase high performance liquid chromatographic columns, especially in the aspect of separating a mixture having stereo- and positional isomers, which comprises oxygenated triterpenoids obtained from the cultured mycelia of Ganoderma lucidum (Fr.) Karat.

摘要翻译： 本发明提供了用于评价反相高效液相色谱柱的性能的组合物，特别是在分离具有立体异构体和位置异构体的混合物的方面，其包含由培养的灵芝菌丝体（Fr.）获得的含氧三萜类化合物， 卡拉特

公开(公告)号：US11467142B2

公开(公告)日：2022-10-11

申请号：US16072065

申请日：2017-01-20

申请人： Sweden Development Research Pharma (SDR) AB

发明人： Mohammad Amin Mohammad

IPC分类号： B01L3/00 ,  G01N30/02 ,  G01N30/04 ,  B01D15/32 ,  G01N30/06 ,  G01N30/89

摘要： The invention relates to a standard solution for inverse gas chromatography and/or surface energy analysis; a volumetric container for preparing such a standard solution; a method of preparing such a standard solution for inverse gas chromatography and/or a surface energy analysis and a method of probing a solid sample. The standard solution comprises a series of three or more compounds of increasing carbon chain length of general formula (I): R—X wherein: for the three or more compounds R is a series of alkyl, a series of alkenyl or a series of alkynyl groups of increasing carbon chain length; and for all three or more compounds X is H, OH, CO2H, C(O)H, C(O)CH3, NH2, SH or halogen; and the relationship between carbon chain length and volume of the compounds of increasing carbon chain length of general formula (I) is determined by the following formula.

公开(公告)号：US20180164275A1

公开(公告)日：2018-06-14

申请号：US15570030

申请日：2016-04-29

申请人： Avraham Arthur KOMILOSH ,  Dalia PINKERT

发明人： Avraham Arthur KOMILOSH ,  Dalia PINKERT

IPC分类号： G01N33/44 ,  C08G69/10 ,  G01N21/47 ,  G01N30/89 ,  G01N30/06 ,  C08G69/46

CPC分类号： G01N33/442 ,  C08G69/10 ,  C08G69/46 ,  G01N21/47 ,  G01N30/06 ,  G01N30/74 ,  G01N30/89 ,  G01N33/68 ,  G01N2021/4711

摘要： The present invention provides a process for characterizing a glatiramer acetate, related drug substance (GARDS) or a glatiramer acetate related drug product (GARDP) comprising separating a batch of a GARDS or GARDP according to hydrophobicity and determining the molar mass of the separated material, thereby characterizing the GARDS or GARDP by molar mass as a function of hydrophobicity.

公开(公告)号：US20160349273A1

公开(公告)日：2016-12-01

申请号：US14902754

申请日：2014-06-25

申请人： FORSCHUNGSZENTRUM JÜLICH GMBH

发明人： Luitgard NAGEL_STEGER ,  Oleksandr BRENER ,  Lothar GREMER ,  Dieter WILLBOLD

IPC分类号： G01N33/68 ,  B01D15/32 ,  G01N30/89

CPC分类号： G01N33/6896 ,  B01D15/325 ,  G01N30/89 ,  G01N33/6845 ,  G01N2333/4709 ,  G01N2500/00 ,  G01N2500/20 ,  G01N2800/2821

摘要： A method for the quantitative characterization of amyloid and/or aggregated peptides and/or proteins in a sample, comprising: providing a sample, wherein the sample includes an amyloid and/or aggregated peptide and/or protein having at least one aggregate size and shape; adding an active ingredient to be analyzed to the sample solution; separating the amyloid and/or aggregated peptides and/or proteins are from one another according to their aggregate size and shape; optionally completely denaturing the amyloid and/or aggregated peptides and/or proteins of a particular fraction into monomer building blocks; determining the change in concentration of the peptide and/or protein building blocks in at least one fraction by comparison against control values without the active ingredient.

摘要翻译： 一种用于定量表征样品中淀粉样蛋白和/或聚集的肽和/或蛋白质的方法，包括：提供样品，其中所述样品包括具有至少一个聚集体尺寸和形状的淀粉样蛋白和/或聚集的肽和/或蛋白质 ; 将待分析的活性成分加入到样品溶液中; 淀粉样蛋白和/或聚集的肽和/或蛋白质的分离根据它们的聚集体大小和形状彼此分离; 任选地使特定级分的淀粉样蛋白和/或聚集的肽和/或蛋白质完全变性成单体结构单元; 通过与没有活性成分的对照值进行比较，确定至少一个馏分中肽和/或蛋白质结构单元的浓度变化。

公开(公告)号：US20050014280A1

公开(公告)日：2005-01-20

申请号：US10840469

申请日：2004-05-05

申请人： Junan Guo ,  Ping He ,  Anthony Qu ,  Steve Yang ,  Shabbir Anik

发明人： Junan Guo ,  Ping He ,  Anthony Qu ,  Steve Yang ,  Shabbir Anik

IPC分类号： G01N15/08 ,  G01N30/52 ,  G01N30/86 ,  G01N30/89 ,  G01N31/16

CPC分类号： G01N30/8693 ,  G01N15/08 ,  G01N30/89 ,  G01N2030/527

摘要： The present invention provides a method for determining drug permeability, wherein the method comprises, for each reference drug of at least two reference drugs having (i) the same ionization state at a given pH and (ii) a known drug permeability determined by the same drug permeability testing technique, the calculation of a metric related to retention time of each reference compound eluted from a liquid chromatography column having an immobilized artificial membrane functional group. Then, based on each metric and each known drug permeability, drug permeability is expressed as a function of the metric. The method may further comprise the calculation of the metric related to retention time for a further drug eluted from the liquid chromatography column, the further drug having the same ionization state at the given pH and an unknown drug permeability, and an assessment of drug permeability for the further drug, based on the metric for the further drug and the function.

摘要翻译： 本发明提供了一种用于测定药物渗透性的方法，其中所述方法包括至少两种参考药物的每种参考药物，所述参考药物具有（i）在给定pH下具有相同的电离状态，以及（ii）由相同的 药物渗透性测试技术，计算与具有固定的人造膜官能团的液相色谱柱洗脱的每个参考化合物的保留时间相关的度量。 然后，基于每个度量和每个已知的药物渗透性，药物渗透性被表示为度量的函数。 该方法还可以包括与从液相色谱柱洗脱的另外药物的保留时间相关的度量的计算，所述另外的药物在给定pH下具有相同的电离状态和未知的药物通透性，以及药物通透性的评估 进一步的药物，基于进一步药物和功能的指标。

公开(公告)号：US5627329A

公开(公告)日：1997-05-06

申请号：US527609

申请日：1995-09-13

申请人： Chandrasekhar Krishnan ,  Jian S. Qi ,  Joseph A. Incavo ,  William L. Reuter ,  Vivek Jain

发明人： Chandrasekhar Krishnan ,  Jian S. Qi ,  Joseph A. Incavo ,  William L. Reuter ,  Vivek Jain

IPC分类号： G01N13/00 ,  G01N30/00 ,  G01N30/02 ,  G01N30/89 ,  G01N15/00

CPC分类号： G01N30/00 ,  G01N13/00 ,  G01N2030/025 ,  G01N30/89

摘要： Disclosed is a method of determining a diffusion coefficient for a diffusant in a particulate. An inert gas is passed through a particulate containing the diffusant. A parameter that is proportional to the concentration of the diffusant in the inert gas is measured over a period of time and the slope of the linear portion of that relationship is determined and is multiplied by a constant.

摘要翻译： 公开了一种确定微粒中扩散剂的扩散系数的方法。 惰性气体通过含有扩散剂的颗粒。 在一段时间内测量与惰性气体中的扩散剂的浓度成比例的参数，并确定该关系的线性部分的斜率并乘以常数。

公开(公告)号：US10386285B2

公开(公告)日：2019-08-20

申请号：US15032220

申请日：2014-09-03

申请人： Sartorius Stedim Biotech GmbH

发明人： Rebecca Petersen ,  Axel Thiefes ,  Katrin Köhler ,  Wolfgang Demmer ,  Sven Dankenbrink

IPC分类号： G01N15/08 ,  G01N30/88 ,  G01N30/89

摘要： The present invention relates to a method for determining the functionality and integrity of depth filter sheets and depth filter sheet systems comprising inorganic layered double hydroxide for contaminant removal in biotechnological processes.

公开(公告)号：US20190033272A1

公开(公告)日：2019-01-31

申请号：US16072065

申请日：2017-01-20

申请人： Sweden Development Research Pharma (SDR) AB

发明人： Mohammad Amin MOHAMMAD

IPC分类号： G01N30/89 ,  G01N30/06

摘要： The invention relates to a standard solution for inverse gas chromatography and/or surface energy analysis; a volumetric container for preparing such a standard solution; a method of preparing such a standard solution for inverse gas chromatography and/or a surface energy analysis and a method of probing a solid sample. The standard solution comprises a series of three or more compounds of increasing carbon chain length of general formula (I): R—X wherein: for the three or more compounds R is a series of alkyl, a series of alkenyl or a series of alkynyl groups of increasing carbon chain length; and for all three or more compounds X is H, OH, CO2H, C(O)H, C(O)CH3, NH2, SH or halogen; and the relationship between carbon chain length and volume of the compounds of increasing carbon chain length of general formula (I) is determined by the following formula.