公开(公告)号：US06809317B2

公开(公告)日：2004-10-26

申请号：US10313945

申请日：2002-12-06

Applicant: Wilfried Vandervorst

Inventor： Wilfried Vandervorst

IPC: H01J4910

CPC classification number: H01J49/0463 ,  G01N1/32 ,  G01N19/06 ,  G01N23/2251 ,  G01N27/628

Abstract: The present invention is related to a method and apparatus for performing a surface analysis of a sample by mass spectrometry. According to one aspect of the invention, the ions necessary for the spectrometry are produced by a probe beam, which is preferably an electron beam, in combination with a gas mixture comprising at least a reactive gas component. Due to the interaction of the probe beam with the reactive gas and the surface atoms, reactions take place between the surface atoms and the reactive gas molecules, resulting in volatile compounds being released from the surface. One or more laser beams cause the ionization of these compounds, after which the resulting ions are accelerated towards a mass spectrometer. The method and apparatus allow an accurate depth profiling of a test sample to be performed.

Abstract translation: 本发明涉及通过质谱进行样品的表面分析的方法和装置。 根据本发明的一个方面，用于光谱测定所需的离子通过与优选为电子束的探针光束一起，与至少包含反应性气体组分的气体混合物组合产生。 由于探针与反应气体和表面原子的相互作用，反应发生在表面原子和反应性气体分子之间，导致挥发性化合物从表面释放。 一个或多个激光束引起这些化合物的电离，之后所得到的离子朝向质谱仪加速。 该方法和装置允许执行测试样品的准确的深度分布。

公开(公告)号：US06800850B2

公开(公告)日：2004-10-05

申请号：US10658455

申请日：2003-09-10

Applicant: Yoshiki Hirano ,  Yoshiro Shiokawa

Inventor： Yoshiki Hirano ,  Yoshiro Shiokawa

IPC: H01J4910

CPC classification number: H01J49/145 ,  H01J49/22

Abstract: A reflection type ion attachment mass spectrometry apparatus is provided with a metal ion generation region, an attachment region and a mass spectrometry region. The metal ion generation region and the mass spectrometry region are formed as a common compartment and the attachment region is provided adjoining the common compartment. The attachment region has an electrostatic field generation unit for forming an electrostatic field in order to reflect the metal ions introduced from the metal ion generation region so as to guide them to the mass spectrometry region. Thereby, a trace ingredient can be detected with a high measurement sensitivity, the problems of disturbance of the mass spectrometer, deterioration of the metal ion emitter, the size of the apparatus, direct sampling, etc. are solved, and broad use in industry is possible.

Abstract translation: 反射型离子附着质谱装置具有金属离子产生区域，附着区域和质谱区域。 金属离子产生区域和质谱区域形成为公共隔室，并且附接区域邻接公共隔室设置。 附着区具有用于形成静电场的静电场产生单元，以便反射从金属离子产生区引入的金属离子，以引导它们进入质谱区。 因此，可以以高测量灵敏度检测微量成分，解决质谱仪干扰问题，金属离子发射体劣化，设备尺寸，直接取样等问题，广泛应用于工业领域 可能。

公开(公告)号：US06707040B2

公开(公告)日：2004-03-16

申请号：US10341621

申请日：2003-01-13

Applicant: Alexander A. Makarov ,  Pavel V. Bondarenko

Inventor： Alexander A. Makarov ,  Pavel V. Bondarenko

IPC: H01J4910

CPC classification number: H01J49/067 ,  H01J49/0418 ,  H01J49/164

Abstract: An ionization apparatus for connection to a mass analyzer is provided. The ionization apparatus comprises a sample slide provided with at least two channels having inner surface having samples deposited thereon, means for delivering energy such as a laser to one of the channels to release and ionize the sample to form ions, and an interfacial orifice for collecting the ions formed in the channel.

Abstract translation: 提供了一种用于连接到质量分析器的电离装置。 该离子化装置包括具有至少两个具有沉积有样品的内表面的通道的样品载片，用于将诸如激光的能量传送到通道之一以释放和离子化样品以形成离子的装置，以及用于收集的界面孔 在通道中形成的离子。

公开(公告)号：US06642515B1

公开(公告)日：2003-11-04

申请号：US09936938

申请日：2001-09-20

Applicant: Kentaro Yamaguchi

Inventor： Kentaro Yamaguchi

IPC: H01J4910

CPC classification number: H01J49/165 ,  G01N27/62

Abstract: The invention is provides a method and an apparatus for performing electrospray ionization mass spectrometric analysis, which method can exactly analyze a mass of a molecular ion or a fragment ion of an unstable organometallic complex or a polymeric organic compound. The method includes cooling a sample to be analyzed which contains a solvent and is caused to flow out from a spray small-diameter tube with an inert gas for low temperature vaporization (A), and carrying out ionization and mass spectrometric analysis of the sample to be analyzed while cooling a chamber (7) for removing a solvent or an ion source shield (8) with liquid nitrogen.

Abstract translation: 本发明提供了一种用于进行电喷雾离子化质谱分析的方法和装置，该方法可以精确地分析不稳定的有机金属络合物或聚合有机化合物的分子离子或片段离子的质量。 该方法包括冷却含有溶剂的待分析样品，并用用于低温蒸发的惰性气体（A）从喷雾小径管流出，并进行样品的电离和质谱分析 在冷却用于用液氮除去溶剂或离子源屏蔽（8）的室（7）的同时进行分析。

公开(公告)号：US06617575B1

公开(公告)日：2003-09-09

申请号：US10069597

申请日：2002-02-28

Applicant: Rainer Karl Cramer

Inventor： Rainer Karl Cramer

IPC: H01J4910

CPC classification number: H01J49/0431 ,  H01J49/0418

Abstract: The present invention pertains to modified ion source targets suitable for use with liquid matrices (e.g., glycerol and lactic acid) in liquid matrix-assisted laser desorption/ionisation (MALDI) methods, as used, for example, in infrared (IR) liquid MALDI mass spectrometry (MS), preferably using time of flight (TOF) instruments. The modified targets comprise (a) a target plate (3) adapted for use in an ion source, said plate having an outward facing surface; and (b) a shielded sample cavity comprising: (i) a sample cavity (4) formed in said outward facing surface, said cavity having a sample cavity mouth and a sample cavity volume, and adapted to receive a liquid sample (5); and (ii) a perforated sample cavity shield (1), said shield covering said sample cavity mouth and having one or more exit holes through which ions formed inside the sample cavity may escape or be extracted. The present invention also pertains to ion sources, mass spectrometers, methods of MALDI and methods of mass spectrometry using such modified ion source targets.

Abstract translation: 本发明涉及在液体基质辅助激光解吸/电离（MALDI）方法中适用于液体基质（例如甘油和乳酸）的改性离子源靶，例如用于红外（IR）液体MALDI 质谱（MS），优选使用飞行时间（TOF）仪器。 修饰的靶包括（a）适于在离子源中使用的靶板（3），所述板具有面向外的表面; （b）屏蔽样品腔，包括：（i）形成在所述面向外的表面中的样品腔（4），所述空腔具有样品腔口和样品腔体积，并适于接收液体样品（5）; 和（ii）穿孔样品腔屏蔽件（1），所述屏蔽件覆盖所述样品空腔口并且具有一个或多个出口孔，通过该出口孔形成在样品腔内的离子可以逸出或提取。 本发明还涉及离子源，质谱仪，MALDI的方法和使用这种改性离子源靶的质谱法。

公开(公告)号：US06573494B1

公开(公告)日：2003-06-03

申请号：US10022116

申请日：2001-12-04

Applicant: Bruce A. Andrien, Jr. ,  Michael A. Sansone ,  Allan G. Burt ,  Craig M. Whitehouse

Inventor： Bruce A. Andrien, Jr. ,  Michael A. Sansone ,  Allan G. Burt ,  Craig M. Whitehouse

IPC: H01J4910

CPC classification number: H01J49/167 ,  H01J49/107 ,  H01J49/165

Abstract: A single or multiple layer curved Electrospray sample introduction means has been configured in an Atmospheric Pressure Ion (API) source interfaced to a mass analyzer. Sample solutions introduced through curved or bent sample introduction Electrospray (ES) probes configured in an API source are sprayed from the ES probe tip at an angle which differs from centerline of the ES probe body. Single or multiple curved ES probes can be configured in an Atmospheric Pressure Ion source interfaced to mass analyzers. Curved ES probes can also be configured in an API source which includes Atmospheric Pressure Chemical ionization.

Abstract translation: 单个或多层弯曲的电喷雾样品引入装置已经配置在与质量分析仪接口的大气压离子（API）源中。 通过弯曲或弯曲样品引入引入的样品溶液以API源形式配置的电喷雾（ES）探针以不同于ES探针体中心线的角度从ES探针尖端喷射。 单个或多个弯曲的ES探头可以在与大量分析仪接口的大气压离子源中配置。 弯曲的ES探头也可以在包含大气压化学电离的API源中配置。

公开(公告)号：US06326616B1

公开(公告)日：2001-12-04

申请号：US09173195

申请日：1998-10-15

Applicant: Bruce A. Andrien, Jr. ,  Michael A. Sansone ,  Allan G. Burt ,  Craig M. Whitehouse

Inventor： Bruce A. Andrien, Jr. ,  Michael A. Sansone ,  Allan G. Burt ,  Craig M. Whitehouse

IPC: H01J4910

CPC classification number: H01J49/167 ,  H01J49/107 ,  H01J49/165

Abstract: A single or multiple layer curved Electrospray sample introduction means has been configured in an Atmospheric Pressure Ion (API) source interfaced to a mass analyzer. Sample solutions introduced through curved or bent sample introduction Electrospray (ES) probes configured in an API source are sprayed from the ES probe tip at an angle which differs from centerline of the ES probe body. Single or multiple curved ES probes can be configured in an Atmospheric Pressure Ion source interfaced to mass analyzers. Curved ES probes can also be configured in an API source which includes Atmospheric Pressure Chemical ionization.

Abstract translation: 单个或多层弯曲的电喷雾样品引入装置已经配置在与质量分析仪接口的大气压离子（API）源中。 通过弯曲或弯曲样品引入引入的样品溶液以API源形式配置的电喷雾（ES）探针以不同于ES探针体中心线的角度从ES探针尖端喷射。 单个或多个弯曲的ES探头可以在与大量分析仪接口的大气压离子源中配置。 弯曲的ES探头也可以在包含大气压化学电离的API源中配置。

公开(公告)号：US06822229B2

公开(公告)日：2004-11-23

申请号：US10221915

申请日：2002-12-30

Applicant: Ludger Wilken ,  Volker Hoffmann ,  Peter Geisler ,  Klaus Wetzig

Inventor： Ludger Wilken ,  Volker Hoffmann ,  Peter Geisler ,  Klaus Wetzig

IPC: H01J4910

CPC classification number: H01J49/10

Abstract: A glow discharge source for the elemental analysis of solid samples of material by means of optical glow discharge spectroscopy (GD-OES) or glow discharge mass spectroscopy (GD-MS) or secondary neutral particle mass spectroscopy (SNMS), a glow discharge being produced by means of a connected electrical voltage source on the sample of material between the latter and an anode and evaluated spectrometrically, wherein a current transformer component for detecting the current flowing between the glow discharge and the voltage source is disposed at or in the anode or connected electrically with the anode.

Abstract translation: 通过光辉度放电光谱（GD-OES）或辉光放电质谱（GD-MS）或二次中性粒子质谱（SNMS）对固体样品进行元素分析的辉光放电源，产生辉光放电 通过在后者和阳极之间的材料样品上的连接的电压源进行光谱测量，其中用于检测在辉光放电和电压源之间流动的电流的电流互感器部件设置在阳极或连接 与阳极电气连接。

公开(公告)号：US06734434B1

公开(公告)日：2004-05-11

申请号：US09744205

申请日：2001-01-18

Applicant: Wayne G Sainty

Inventor： Wayne G Sainty

IPC: H01J4910

CPC classification number: H01J27/146 ,  H01J27/022

Abstract: An ion source (10) for producing a beam of ions from a plasma is disclosed. A plasma is created at the center of an annular anode (12) by collisions between energetic electrons and molecules of an ionisable gas. The electrons are sourced from a cathode filament (11) and are accelerated to the anode (12) by an applied electric potential. A magnetic field having an axis aligned with the axis of the anode acts to concentrate the flow of electrons to the center of the anode (12). The ionisable gas is introduced into the ion source (10) at the point of concentrated electron flow. Ions created in the resultant plasma are expelled from the ion source as an ion beam centered on the axis of the magnetic field. The surfaces of the anode are coated with an electrically conductive non-oxidising layer of Titanium Nitride to prevent a build up of an insulating layer on the anode.

Abstract translation: 公开了一种用于从等离子体产生离子束的离子源（10）。 通过能量电子和可离子化气体的分子之间的碰撞，在环形阳极（12）的中心处产生等离子体。 电子源自阴极细丝（11），并通过施加的电势被加速到阳极（12）。 具有与阳极轴对准的轴的磁场用于将电子流集中到阳极（12）的中心。 离子源（10）在浓缩电子流的时候被引入离子源（10）。 在所得到的等离子体中产生的离子作为离子束从离子源排出，作为以磁场轴为中心的离子束。 阳极的表面涂覆有氮化钛的导电非氧化层，以防止在阳极上形成绝缘层。

公开(公告)号：US06734423B2

公开(公告)日：2004-05-11

申请号：US10030396

申请日：2002-01-08

Applicant: Wayne A. Bryden

Inventor： Wayne A. Bryden

IPC: H01J4910

CPC classification number: H01J49/0022 ,  H01J49/161

Abstract: A mass spectrometer system comprising a laser and a mass spectrometer. The mass spectrometer has a vacuum interface that provides entrance of a gaseous sample into an extraction region of the mass spectrometer. The laser is positioned to provide laser light incident on a sample non-gaseous substance positioned adjacent the vacuum interface. The laser light provides vaporization of the sample, which provides a high concentration of gaseous molecules from the sample substance at the vacuum interface.

Abstract translation: 包括激光和质谱仪的质谱仪系统。 质谱仪具有真空界面，其提供气体样品进入质谱仪的提取区域。 激光被定位成提供入射在邻近真空界面定位的样品非气态物质上的激光。 激光提供样品的蒸发，其在真空界面处从样品物质提供高浓度的气体分子。