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    OIL-IN-WATER EMULSION INFLUENZA VACCINE
    192.
    发明申请
    OIL-IN-WATER EMULSION INFLUENZA VACCINE 审中-公开

    公开(公告)号：US20180339037A1

    公开(公告)日：2018-11-29

    申请号：US16018292

    申请日：2018-06-26

    Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

    Inventor： William Ripley Ballou ,  Emmanuel Jules Hanon

    IPC: A61K39/145 ,  A61K39/12 ,  A61K39/39 ,  C12N7/00 ,  A61K39/00

    Abstract: The present invention provides an immunogenic influenza composition in a dose volume suitable for human use, comprising an influenza virus antigen or antigenic preparation thereof and an adjuvant composition comprising an oil-in-water emulsion, wherein said oil-in-water emulsion comprises a metabolisable oil at a level of below 11 mg and an emulsifying agent at a level of below 5 mg and optionally a tocol or a sterol at a level of below 12 mg. Suitably the amount of influenza antigen per strain per dose is 15 μg HA or a low amount such as less than 15 μg HA.

    Methods for making saccharide-protein glycoconjugates
    193.
    发明授权
    Methods for making saccharide-protein glycoconjugates 有权

    公开(公告)号：US10113009B2

    公开(公告)日：2018-10-30

    申请号：US15150302

    申请日：2016-05-09

    Applicant: GlaxoSmithKline Biologicals SA

    Inventor： Allan James Saul ,  Francesca Micoli

    IPC: C08B37/00 ,  C07K16/12 ,  C07K16/44 ,  A61K39/112 ,  A61K39/095 ,  A61K39/02 ,  A61K39/385 ,  C07K14/34 ,  A61K47/64 ,  A61K39/00

    Abstract: The invention provides a process for the reductive amination of a carbonyl group at the reducing terminus of a polysaccharide, wherein the reductive amination is carried out at a pH between 4 and 5. The invention also provides a process for preparing a conjugate of a polysaccharide and a carrier molecule, comprising the steps of: (a) coupling the polysaccharide to a linker, to form a polysaccharide-linker compound in which the free terminus of the linker is an ester group; and (b) reacting the ester group with a primary amine group in the carrier molecule, to form a polysaccharide-linker-carrier molecule conjugate in which the linker is coupled to the carrier molecule via an amide linkage. The invention also provides a process for reducing contamination of a polysaccharide-linker compound with unreacted linker, comprising a step of precipitating unreacted linker under aqueous conditions at a pH of less than 5. The invention also provides polysaccharide-linker-carrier molecule conjugates and intermediate compounds obtained or obtainable by these processes.

    Escherichia coli vaccine combination
    194.
    发明授权
    Escherichia coli vaccine combination 有权

    公开(公告)号：US10105429B2

    公开(公告)日：2018-10-23

    申请号：US15369405

    申请日：2016-12-05

    Applicant: GlaxoSmithKline Biologicals SA

    Inventor： Laura Serino ,  Mariagrazia Pizza

    IPC: A61K39/108 ,  C07K14/245 ,  A61K39/00

    Abstract: The invention provides an immunogenic composition comprising a combination of (i) bacterial Ig-like domain protein fragment (orf405B) having the amino acid sequence set forth in SEQ ID NO:2 or a protein having at least 80% similarity thereto, and (ii) putative Lipoprotein (orf3526) having the amino acid sequence set forth in SEQ ID NO:8 or a protein having at least 80% similarity thereto.

    CONJUGATION OF STAPHYLOCOCCUS AUREUS TYPE 5 AND TYPE 8 CAPSULAR POLYSACCHARIDES
    200.
    发明申请
    CONJUGATION OF STAPHYLOCOCCUS AUREUS TYPE 5 AND TYPE 8 CAPSULAR POLYSACCHARIDES 审中-公开

    公开(公告)号：US20180153983A1

    公开(公告)日：2018-06-07

    申请号：US15809524

    申请日：2017-11-10

    Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

    Inventor： Francesco BERTI ,  Paolo COSTANTINO ,  Maria Rosaria ROMANO

    IPC: A61K39/385 ,  A61K47/64 ,  A61K39/085 ,  A61K39/00

    Abstract: The invention provides a process for preparing a conjugate of a S.aureus type 5 or type 8 capsular polysaccharide and a carrier molecule, comprising the steps of: (a) depolymerising the capsular polysaccharide, to give a polysaccharide fragment; (b) oxidising the fragment in order to introduce an aldehyde group into at least one saccharide residue in the fragment, to give an oxidised saccharide residue; and (c) coupling the oxidised saccharide residue to a carrier molecule via the aldehyde group, thereby giving the conjugate. The coupling in step (c) may be direct, or may be via a linker molecule. The invention also provides a conjugate obtained or obtainable by this process.

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