Process for Synthesis of Lactams
    208.
    发明申请
    Process for Synthesis of Lactams 审中-公开
    内酰胺合成方法

    公开(公告)号:US20160257688A1

    公开(公告)日:2016-09-08

    申请号:US15031326

    申请日:2014-10-22

    Abstract: Methods for the synthesis of lactams are presented whereby a carboxylic acid of the formula HOOC—OR—NH-LG, wherein OR is an organic moiety and LG is a leaving group, is reacted with an acid, such as an organic acid, in particular a strong acid, and a dehydrating agent, which may be one in the same such as a strong acid anhydride, such that the amount of acid added allows for the desired transformation to take place without the loss of the leaving group (LG) before the cyclization, and recovering the lactam such as that of the formula (a), provided herein, wherein G represents the atom(s) needed to form a closed ring.

    Abstract translation: 提出了合成内酰胺的方法,其中式HOOC-OR-NH-LG的羧酸(其中OR为有机部分,LG为离去基团)与酸例如有机酸反应 强酸和脱水剂,其可以是相同的酸,例如强酸酐,使得添加的酸的量允许进行所需的转化而不会在离开基团(LG)之前损失, 环化和回收如本文所提供的式(a)的内酰胺,其中G表示形成封闭环所需的原子。

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