公开(公告)号：US07157477B2

公开(公告)日：2007-01-02

申请号：US10415249

申请日：2001-10-24

Applicant: Manhua Zhang ,  Shangjie Xu ,  Tao Wu ,  Shen Chen ,  Tao Shen

Inventor： Manhua Zhang ,  Shangjie Xu ,  Tao Wu ,  Shen Chen ,  Tao Shen

IPC: C07D213/38 ,  C07C225/32 ,  A61K31/135 ,  A61K31/44

CPC classification number: A61K41/0057 ,  C07C225/32 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2603/54 ,  C07D213/38

Abstract: The invention involves a methods and compositions for use in photodynamic therapy. Novel perylenequinone derivatives, conjugates comprising perylenequinone derivatives and a binding agent, and methods of treatment using these compositions are disclosed. The present invention relates to the field of photosensitizers possessing photodynamic activities. They possess high photodynamic activities and low dark toxicities, which makes them as more potent photodynamic agents than HPD against cancer and AIDS virus.

Abstract translation: 本发明涉及用于光动力疗法的方法和组合物。 公开了新型苝醌衍生物，包含苝醌衍生物和结合剂的共轭物，以及使用这些组合物的处理方法。 本发明涉及具有光动力学活性的光敏剂领域。 它们具有高光动力学活性和低暗毒性，这使得它们比HPD对抗癌症和艾滋病病毒更有效的光动力学剂。

公开(公告)号：US07128983B2

公开(公告)日：2006-10-31

申请号：US10643041

申请日：2003-08-18

Applicant: Tien-yau Luh ,  Lingzhi Zhang ,  Chin-Fa Lee ,  Chung-Chih Wu ,  Cheih-Wei Chen

Inventor： Tien-yau Luh ,  Lingzhi Zhang ,  Chin-Fa Lee ,  Chung-Chih Wu ,  Cheih-Wei Chen

IPC: H05B33/12 ,  C07D307/02 ,  H01L27/32 ,  H01L51/50

CPC classification number: C07D307/36 ,  C07D307/42 ,  H01L51/0037 ,  H01L51/0065 ,  H01L51/0081 ,  H01L51/5048 ,  H01L2251/308 ,  Y10S428/917

Abstract: A furan-containing compound of formula (I): Ar is aryl, heteroaryl, or oligoaryl; A is furyl; B is aryl or heteroaryl; R1 is hydrogen, alkenyl, alkynyl, aryl, heteroaryl, cyclyl, heterocyclyl, or oligoaryl; and R2 is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cyclyl, or heterocyclyl. The compound is useful as a hole transporting material in an organic light emitting diode device.

Abstract translation: 含呋喃的式（I）化合物：Ar是芳基，杂芳基或低聚芳基; A是furyl; B是芳基或杂芳基; R 1是氢，烯基，炔基，芳基，杂芳基，环基，杂环基或低聚芳基; R 2是氢，烷基，烯基，炔基，芳基，杂芳基，环基或杂环基。 该化合物可用作有机发光二极管装置中的空穴传输材料。

公开(公告)号：US07122621B2

公开(公告)日：2006-10-17

申请号：US10463998

申请日：2003-06-17

Applicant: Hueih Min Chen

Inventor： Hueih Min Chen

IPC: A61K38/00

CPC classification number: C07K14/001 ,  A61K38/00 ,  A61K48/00 ,  C07H21/04

Abstract: Disclosed is a cell lytic polypeptide that has a region capable of forming an amphipathic alpha helix and a net charge of +12 or more, or that contains 3 regions, each capable of forming an amphipathic alpha helix. A nucleic acid encoding the polypeptide is also disclosed. Also within the scope of this invention are a pharmaceutical composition containing the polypeptide or nucleic acid and a pharmaceutically acceptable carrier, and a method for treating a cellular proliferative disorder.

Abstract translation: 公开了一种细胞裂解多肽，其具有能够形成两亲性α螺旋的区域和+12以上的净电荷，或者包含3个区域，每个能够形成两亲性α螺旋。 还公开了编码该多肽的核酸。 也在本发明的范围内的是含有多肽或核酸和药学上可接受的载体的药物组合物，以及治疗细胞增殖性疾病的方法。

公开(公告)号：US07115762B2

公开(公告)日：2006-10-03

申请号：US10884844

申请日：2004-07-02

Applicant: Fen-Tair Luo

Inventor： Fen-Tair Luo

IPC: C07F15/00 ,  B01J31/00 ,  C07C253/00

CPC classification number: B01J31/1658 ,  B01J31/2239 ,  B01J31/2404 ,  B01J2231/4211 ,  B01J2231/4261 ,  B01J2231/4266 ,  B01J2531/0205 ,  B01J2531/824 ,  C07B2200/11 ,  C07C17/35 ,  C07C45/63 ,  C07C45/68 ,  C07C67/343 ,  C07F15/006 ,  Y02P20/584 ,  C07C25/28 ,  C07C49/807 ,  C07C49/796 ,  C07C49/782 ,  C07C69/618

Abstract: This invention relates to a recyclable palladacycle catalyst of formula in which each is a single bond or a double bond, provided that if one is a double bond, its neighboring is not a double bond; each of X and Z, independently, is —P(R′)—, —S—, —N(R′)—, or —N═, in which R′ is alkyl, aryl, cyclyl, heteroaryl, or heterocyclyl; each of Y1 and Y2, independently, is an anion of an organic or inorganic acid; each of X1, X2, X3, Z1, Z2, and Z3, independently, is —C═, —CR″—, in which R″ is H, alkyl, aryl, cyclyl, heteroaryl, or heterocyclyl; and each of R1, R2, R3, R4, R5, R6, R7, and R8, independently, is H, alkyl, aryl, cyclyl, heteroaryl, or heterocyclyl, or R1, X, X1, and R2, together form a 3–8 membered ring, or R2, X1, X2, and R3, together form a 3–8 membered ring, or R3, X2, X3, and R4, together form a 3–8 membered ring, or R5, Z, Z1, and R6, together form a 3–8 membered ring, or R6, Z1, Z2, and R7, together form a 3–8 membered ring, or R7, Z2, Z3, and R8, together form a 3–8 membered ring; provided that one of R1, R2, R3, R4, R5, R6, R7, and R8, or the ring formed from R1, X, X1, and R2, or the ring formed from R2, X1, X2, and R3, or the ring formed from R3, X2, X3, and R4, or the ring formed from R5, Z, Z1, and R6, or the ring formed from R1, Z1, Z2, and R7, or the ring formed from R7, Z2, Z3, and R8 is connected to a first polymer. Also included in this invention are a method of promoting a coupling reaction using the above-described palladacycle compound and a method of making it.

公开(公告)号：US07109015B2

公开(公告)日：2006-09-19

申请号：US10813549

申请日：2004-03-29

Applicant: You-Di Liao

Inventor： You-Di Liao

IPC: C12N9/52 ,  C12N15/57 ,  C12N15/70 ,  C12P21/06

CPC classification number: C12N9/48 ,  C12P21/06

Abstract: The present invention provides methionine aminopeptidases (MetAPs) with a broad substrate range, particularly those capable of removing the N-terminal Met from bulky or acidic penultimate residues. In preferred embodiments, these MetAPs have mutations at the 233, 206 and/or 168 positions of SEQ ID NO:1. Preferably, amino acids at these residues are substituted with glycine or threonine. Also provided are cells comprising the MetAPs, DNA encoding the MetAPs, and methods of using the MetAPs.

Abstract translation: 本发明提供了具有宽底物范围的甲硫氨酸氨基肽酶（MetAP），特别是那些能够从大体积或酸性倒数第二残基中除去N末端Met的那些。 在优选的实施方案中，这些MetAP在SEQ ID NO：1的233,206和/或168位具有突变。 优选地，这些残基处的氨基酸被甘氨酸或苏氨酸取代。 还提供了包含MetAP的细胞，编码MetAP的DNA以及使用MetAP的方法。

公开(公告)号：US07099870B2

公开(公告)日：2006-08-29

申请号：US10045616

申请日：2001-11-09

Applicant: Wen-Lian Hsu ,  Yi-Shiou Chen

Inventor： Wen-Lian Hsu ,  Yi-Shiou Chen

IPC: G06F7/00 ,  G06F17/30 ,  G06F17/00 ,  G06F12/00 ,  G06F15/173

CPC classification number: G06F17/30899

Abstract: Updating a personalized web page by identifying characteristic features and an information sample from an input, in which the input specifies a web site that provides the information sample. When an update is required by a user-specified frequency, corresponding contents of the web site are determined based on the characteristic features. If the corresponding contents are highly relevant to the information sample, the corresponding contents are extracted, and the personalized web page is updated with the corresponding contents.

Abstract translation: 通过从输入中识别特征特征和信息样本来更新个性化网页，其中输入指定提供信息样本的网站。 当用户指定的频率需要更新时，基于特征特征确定网站的相应内容。 如果相应的内容与信息样本高度相关，则提取相应的内容，并用相应的内容更新个性化网页。

公开(公告)号：US20060186346A1

公开(公告)日：2006-08-24

申请号：US11061672

申请日：2005-02-18

Applicant: Pei-Kuen Wei

Inventor： Pei-Kuen Wei

IPC: G01N21/64

CPC classification number: G01N21/6452 ,  G01N21/648 ,  G01N2021/6484

Abstract: The present invention is a method for providing light onto a thin light transparent substrate comprising the steps of passing noncoherent light through a fiber optic line light guide to produce line light; and impinging the line light onto the edge of the substrate to produce an evanescent planar wave on the surface of the substrate. This method is specifically useful in reading fluorescent signals from microarrays placed on a light transparent substrate.

Abstract translation: 本发明是一种在薄光透明基板上提供光的方法，包括以下步骤：使非相干光通过光纤线光导以产生线光; 并且将线光照射到衬底的边缘上，以在衬底的表面上产生消逝的平面波。 该方法特别适用于从放置在透光性基板上的微阵列读取荧光信号。

公开(公告)号：US20060179506A1

公开(公告)日：2006-08-10

申请号：US11327263

申请日：2006-01-06

Applicant: Chih-Ming Chou ,  I-Ching Lu ,  Gen-Der Chen ,  Chioh-Yueh Chen ,  Chang-Jen Huang

Inventor： Chih-Ming Chou ,  I-Ching Lu ,  Gen-Der Chen ,  Chioh-Yueh Chen ,  Chang-Jen Huang

IPC: A01K67/027

CPC classification number: A01K67/0275 ,  A01K2217/05 ,  A01K2227/40 ,  A01K2267/03 ,  A01K2267/035 ,  C12N15/8509

Abstract: A genetically modified zebrafish embryo, comprising a HBNF cDNA or a NGF cDNA or a GDNF cDNA together with a cDNA encoding green fluorescent protein (GFP) so as to induce neurite outgrowth during said zebrafish embryonic development, and a method of using such genetically modified zebrafish embryo to identify a therapeutic agent are disclosed.

Abstract translation: 一种经遗传修饰的斑马鱼胚胎，其包含HBNF cDNA或NGF cDNA或GDNF cDNA以及编码绿色荧光蛋白（GFP）的cDNA，以便在所述斑马鱼胚胎发育过程中诱导神经突生长，以及使用这种转基因斑马鱼 公开了确定治疗剂的胚胎。

公开(公告)号：US20060144821A1

公开(公告)日：2006-07-06

申请号：US11029191

申请日：2005-01-04

Applicant: Yuh-Lin Wang

Inventor： Yuh-Lin Wang

IPC: C23F1/00

CPC classification number: A44C17/005 ,  A44C27/00 ,  H01J2237/31737

Abstract: The present invention provides a method for engraving desired irreproducible patterns on the surface of gemstones including diamond by the use of an energetic ion beam. The pattern has a characteristic topological texture, which is irreproducible even using the same ion beam to engrave onto the same location of the same diamond.

Abstract translation: 本发明提供了一种通过使用能量离子束在包括金刚石的宝石表面上雕刻期望的不可再现图案的方法。 该图案具有特征拓扑结构，即使使用相同的离子束雕刻到相同钻石的相同位置上也是不可再现的。

公开(公告)号：US07037696B1

公开(公告)日：2006-05-02

申请号：US09654652

申请日：2000-09-05

Applicant: Lie-Fen Shyur ,  Jui-Lin Chen ,  Ning-Sun Yang

Inventor： Lie-Fen Shyur ,  Jui-Lin Chen ,  Ning-Sun Yang

IPC: C12N9/02

CPC classification number: C12Y302/01073 ,  C12N9/244 ,  C12Y302/01006

Abstract: A truncated glucanase with an improved thermal stability and a higher specific enzymatic activity than the wild-type enzyme. The truncated glucanase is obtained by removing a number of amino acid residues from the C-terminal of the wild-type 1,3-1,4-β-D-glucanase of Fibrobacter succinogenes. The removal of the C-terminal amino acid residues can be conducted at the genetic level by modifying the gene encoding for the wild type enzyme using, for example, a PCR-based method. Or, it can also be conducted at the protein level by first producing the wild-type enzyme protein and then subjecting the wild-type protein to certain protease action to remove a portion of its C-terminal.

Abstract translation: 具有比野生型酶更高的热稳定性和更高的特异性酶活性的截短的葡聚糖酶。 截短的葡聚糖酶是通过从富含纤维杆菌的野生型1,3-1,4-β-D-葡聚糖酶的C末端除去多个氨基酸残基获得的。 通过使用例如基于PCR的方法修饰编码野生型酶的基因，可以在遗传水平上进行C-末端氨基酸残基的去除。 或者也可以在蛋白质水平上进行，首先制造野生型酶蛋白质，然后使野生型蛋白质进行某些蛋白酶作用去除其C末端的一部分。