公开(公告)号：US20240076260A1

公开(公告)日：2024-03-07

申请号：US18269654

申请日：2021-09-22

Applicant: ORGANO CORPORATION

Inventor： Shinji NAKAMURA ,  Hitoshi TAKADA ,  Hironao SAJIKI ,  Tsuyoshi YAMADA ,  Kwihwan PARK

IPC: C07C45/65 ,  B01J31/08 ,  B01J31/28 ,  B01J35/10 ,  B01J37/02 ,  C07C253/30

CPC classification number: C07C45/65 ,  B01J31/08 ,  B01J31/28 ,  B01J35/1042 ,  B01J35/1047 ,  B01J35/1071 ,  B01J35/1076 ,  B01J37/0201 ,  C07C253/30 ,  B01J2231/4211 ,  B01J2231/4266

Abstract: A platinum group metal ion-supported catalyst in which platinum group metal ions or platinum group metal complex ions are supported on a non-particulate organic porous ion exchanger, wherein the non-particulate organic porous ion exchanger is formed of a continuous framework phase and a continuous pore phase; has a thickness of a continuous framework of 1 to 100 μm, an average diameter of continuous pores of 1 to 1000 μm, and a total pore volume of 0.5 to 50 ml/g; has an ion exchange capacity per weight in a dry state of 1 to 9 mg equivalent/g; and has ion exchange groups wherein the ion exchange groups are uniformly distributed in the organic porous ion exchanger.

公开(公告)号：US20170173569A1

公开(公告)日：2017-06-22

申请号：US15379986

申请日：2016-12-15

Applicant: Bruce H. Lipshutz ,  Sachin Handa

Inventor： Bruce H. Lipshutz ,  Sachin Handa

IPC: B01J23/89 ,  C07B31/00 ,  B01J37/00 ,  B01J23/745 ,  B01J35/00

CPC classification number: B01J23/8906 ,  B01J23/72 ,  B01J23/745 ,  B01J23/755 ,  B01J31/0202 ,  B01J31/0209 ,  B01J31/0225 ,  B01J31/04 ,  B01J31/068 ,  B01J31/2404 ,  B01J35/0013 ,  B01J37/009 ,  B01J37/16 ,  B01J2231/327 ,  B01J2231/4211 ,  B01J2231/4266 ,  B01J2231/64 ,  B01J2531/824 ,  B01J2531/842 ,  B01J2531/96 ,  C07B31/00 ,  C07B37/04 ,  C07C209/325 ,  C07C213/02 ,  C07C221/00 ,  C07C227/04 ,  C07C231/12 ,  C07C253/30 ,  C07C319/20 ,  C07C2601/14 ,  C07D209/12 ,  C07D211/90 ,  C07D213/30 ,  C07D213/61 ,  C07D215/40 ,  C07D235/18 ,  C07D249/04 ,  C07D249/06 ,  C07D277/48 ,  C07D295/192 ,  C07D401/04 ,  C07D405/04 ,  C07D405/14 ,  C07D409/12 ,  C07D471/04 ,  C07J41/0055 ,  C07C211/52 ,  C07C229/60 ,  C07C233/55 ,  C07C217/84 ,  C07C211/58 ,  C07C217/86 ,  C07C215/76 ,  C07C211/45 ,  C07C237/30 ,  C07C237/36 ,  C07C215/70 ,  C07C217/60 ,  C07C229/42 ,  C07C229/08 ,  C07C255/58 ,  C07C255/59 ,  C07C223/06 ,  C07C225/22 ,  C07C323/36

Abstract: In one embodiment, the application discloses a composition for the reduction of an organic compound comprising a nitro group to form an organic compound comprising an amine group, the composition comprising: a) a transition metal salt; b) an iron salt; and c) a reducing agent; and methods for the use of such compositions, including Click chemistry and cross coupling reactions.

公开(公告)号：US20160347677A1

公开(公告)日：2016-12-01

申请号：US15167952

申请日：2016-05-27

Applicant: MyCell Technologies, LLC

Inventor： Volker Berl

IPC: C07B37/00 ,  B01J31/24 ,  B01J31/18 ,  B01J31/28 ,  B01J31/02 ,  C07C1/32 ,  C07D211/02 ,  C07D223/04 ,  C07F7/18 ,  C07C67/343 ,  C07C41/30 ,  C07D213/74 ,  C07C209/10 ,  C07C17/26 ,  C07C209/18 ,  C07C209/08 ,  C07C221/00 ,  C07C231/12 ,  C07F7/08 ,  C07C273/18 ,  C07C253/30 ,  C07D249/06 ,  C07F5/02 ,  B01J31/22

CPC classification number: C07D311/72 ,  B01J31/0209 ,  B01J31/1805 ,  B01J31/22 ,  B01J31/2208 ,  B01J31/2278 ,  B01J31/24 ,  B01J31/2414 ,  B01J31/28 ,  B01J2231/4216 ,  B01J2231/4261 ,  B01J2231/4266 ,  B01J2231/44 ,  B01J2231/543 ,  B01J2531/824 ,  C07C1/321 ,  C07C2/861 ,  C07C17/26 ,  C07C41/30 ,  C07C67/343 ,  C07C209/08 ,  C07C209/10 ,  C07C209/16 ,  C07C209/18 ,  C07C221/00 ,  C07C227/18 ,  C07C231/12 ,  C07C253/30 ,  C07C273/1854 ,  C07C2531/24 ,  C07C2601/16 ,  C07C2603/74 ,  C07D211/02 ,  C07D213/74 ,  C07D223/04 ,  C07D249/06 ,  C07F7/1892 ,  C07C69/618 ,  C07C69/734 ,  C07C43/215 ,  C07C43/225 ,  C07C43/205 ,  C07C15/12 ,  C07C13/21

Abstract: In one embodiment, the present application discloses mixtures comprising (a) water in an amount of at least 1% wt/wt of the mixture; (b) a transition metal catalyst; and (c) one or more solubilizing agents; and methods for using such mixtures for performing transition metal mediated bond formation reactions.

Abstract translation: 在一个实施方案中，本申请公开了包含（a）至少1重量％/重量比混合物的水的混合物; （b）过渡金属催化剂; 和（c）一种或多种增溶剂; 以及使用这种混合物进行过渡金属介导的键形成反应的方法。

公开(公告)号：US20160038926A1

公开(公告)日：2016-02-11

申请号：US14654061

申请日：2013-12-20

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  UNIVERSITÉ PAUL SABATIER TOULOUSE 3

Inventor： Montserrat GOMEZ ,  Emmanuelle TEUMA ,  Isabelle FAVIER ,  Faouzi CHAHDOURA

IPC: B01J35/00 ,  B01J31/06 ,  B01J31/28 ,  B01J23/44 ,  B01J23/46 ,  B01J23/72 ,  C07C41/20 ,  C07C45/62 ,  C07C67/303 ,  C07D209/08 ,  C07D211/62 ,  C07C209/60 ,  C07D295/135 ,  C07D295/096 ,  C07C319/18 ,  C07D307/79 ,  C07D307/89 ,  C07D401/06 ,  C07C45/64 ,  C07D249/04 ,  C07D403/14 ,  C07D307/84 ,  C07D493/04 ,  C07D405/06 ,  C07D493/14 ,  C07D493/18 ,  C07D211/94 ,  C07D401/04 ,  C07C5/03 ,  B01J31/02

CPC classification number: B01J35/0013 ,  B01J23/44 ,  B01J23/464 ,  B01J23/72 ,  B01J31/0202 ,  B01J31/0267 ,  B01J31/0271 ,  B01J31/06 ,  B01J31/24 ,  B01J31/2404 ,  B01J31/28 ,  B01J35/023 ,  B01J2231/34 ,  B01J2231/4211 ,  B01J2231/4216 ,  B01J2231/4227 ,  B01J2231/4261 ,  B01J2231/4266 ,  B01J2231/4283 ,  B01J2231/4294 ,  B01J2231/641 ,  B01J2231/645 ,  B01J2531/16 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/90 ,  B01J2540/32 ,  B22F1/0022 ,  B22F1/0062 ,  B22F9/26 ,  B82Y30/00 ,  B82Y40/00 ,  C07B37/04 ,  C07C5/03 ,  C07C41/20 ,  C07C45/62 ,  C07C45/64 ,  C07C67/303 ,  C07C209/60 ,  C07C319/18 ,  C07C2531/02 ,  C07C2531/28 ,  C07C2601/14 ,  C07D209/08 ,  C07D211/62 ,  C07D211/94 ,  C07D249/04 ,  C07D295/096 ,  C07D295/135 ,  C07D307/79 ,  C07D307/84 ,  C07D307/89 ,  C07D401/04 ,  C07D401/06 ,  C07D403/14 ,  C07D405/06 ,  C07D493/04 ,  C07D493/14 ,  C07D493/18

Abstract: A catalytic system which is a suspension in glycerol of metal nanoparticles in at least one transition metal. The suspension also includes at least one compound stabilizing the metal nanoparticles, soluble in glycerol. The suspensions are obtained directly in glycerol. These are stable systems that can catalyse a reaction from an organic substrate, with high yields and activity, and excellent selectivity. Additionally, the use of the catalytic system for performing organic transformations such as hydrogenation or coupling reactions (formation of C—C, C—N, C—O, C—S . . . bonds), and for synthesizing polyfunctionnal molecules, in a single reactor, by multi-step, sequential or cascade reactions.

Abstract translation: 催化体系，其是在至少一种过渡金属中的金属纳米颗粒的甘油中的悬浮液。 悬浮液还包括至少一种稳定金属纳米颗粒的化合物，其可溶于甘油。 悬浮液直接在甘油中获得。 这些是可以以高产率和活性以及优异选择性催化有机底物的反应的稳定体系。 另外，使用用于进行有机转化如氢化或偶联反应（形成C-C，C-N，C-O，C-S键）的催化体系，并用于合成多官能分子 单反应器，通过多步，顺序或级联反应。

公开(公告)号：US08735630B2

公开(公告)日：2014-05-27

申请号：US13768124

申请日：2013-02-15

Applicant: Massachusetts Institute of Technology

Inventor： Stephen L. Buchwald ,  Kevin W. Anderson

IPC: C07F9/50

CPC classification number: C07C51/367 ,  B01J31/2404 ,  B01J2231/4211 ,  B01J2231/4227 ,  B01J2231/4266 ,  B01J2531/0266 ,  B01J2531/824 ,  B01J2531/847 ,  B01J2531/96 ,  C07B37/04 ,  C07B43/04 ,  C07C41/30 ,  C07C51/353 ,  C07C51/363 ,  C07C227/16 ,  C07C231/12 ,  C07C303/22 ,  C07C303/40 ,  C07D409/06 ,  C07F9/5022 ,  C07C65/105 ,  C07C63/331 ,  C07C63/72 ,  C07C311/16 ,  C07C229/60 ,  C07C233/65 ,  C07C309/30 ,  C07C43/215

Abstract: One aspect of the present invention relates to ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in various transition-metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject methods provide improvements in many features of the transition-metal-catalyzed reactions, including the range of suitable substrates, number of catalyst turnovers, reaction conditions, and efficiency. For example, improvements have been realized in transition metal-catalyzed: aryl amination reactions; aryl amidation reactions; Suzuki couplings; and Sonogashira couplings. In certain embodiments, the invention relates to catalysts and methods of using them that operate in aqueous solvent systems.

Abstract translation: 本发明的一个方面涉及过渡金属配体。 本发明的第二方面涉及包含这些配体的催化剂在各种过渡金属催化的碳 - 杂原子和碳 - 碳键形成反应中的用途。 本发明的方法提供了过渡金属催化反应的许多特征的改进，包括合适底物的范围，催化剂周转数，反应条件和效率。 例如，在过渡金属催化下已经实现了改进：芳基胺化反应; 芳基酰胺化反应; 铃木联轴器 和Sonogashira联轴器。 在某些实施方案中，本发明涉及在含水溶剂系统中使用它们的催化剂和使用它们的方法。

公开(公告)号：US20130178632A1

公开(公告)日：2013-07-11

申请号：US13768124

申请日：2013-02-15

Applicant: Massachusetts Institute of Technology

Inventor： Stephen L. Buchwald ,  Kevin W. Anderson

IPC: C07C51/367 ,  C07C41/30 ,  C07D409/06 ,  C07C51/353

CPC classification number: C07C51/367 ,  B01J31/2404 ,  B01J2231/4211 ,  B01J2231/4227 ,  B01J2231/4266 ,  B01J2531/0266 ,  B01J2531/824 ,  B01J2531/847 ,  B01J2531/96 ,  C07B37/04 ,  C07B43/04 ,  C07C41/30 ,  C07C51/353 ,  C07C51/363 ,  C07C227/16 ,  C07C231/12 ,  C07C303/22 ,  C07C303/40 ,  C07D409/06 ,  C07F9/5022 ,  C07C65/105 ,  C07C63/331 ,  C07C63/72 ,  C07C311/16 ,  C07C229/60 ,  C07C233/65 ,  C07C309/30 ,  C07C43/215

Abstract: One aspect of the present invention relates to ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in various transition-metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject methods provide improvements in many features of the transition-metal-catalyzed reactions, including the range of suitable substrates, number of catalyst turnovers, reaction conditions, and efficiency. For example, improvements have been realized in transition metal-catalyzed: aryl amination reactions; aryl amidation reactions; Suzuki couplings; and Sonogashira couplings. In certain embodiments, the invention relates to catalysts and methods of using them that operate in aqueous solvent systems.

公开(公告)号：US08378145B2

公开(公告)日：2013-02-19

申请号：US12502749

申请日：2009-07-14

Applicant: Stephen L. Buchwald ,  Kevin W. Anderson

Inventor： Stephen L. Buchwald ,  Kevin W. Anderson

IPC: C07F9/50

CPC classification number: C07C51/367 ,  B01J31/2404 ,  B01J2231/4211 ,  B01J2231/4227 ,  B01J2231/4266 ,  B01J2531/0266 ,  B01J2531/824 ,  B01J2531/847 ,  B01J2531/96 ,  C07B37/04 ,  C07B43/04 ,  C07C41/30 ,  C07C51/353 ,  C07C51/363 ,  C07C227/16 ,  C07C231/12 ,  C07C303/22 ,  C07C303/40 ,  C07D409/06 ,  C07F9/5022 ,  C07C65/105 ,  C07C63/331 ,  C07C63/72 ,  C07C311/16 ,  C07C229/60 ,  C07C233/65 ,  C07C309/30 ,  C07C43/215

Abstract: One aspect of the present invention relates to ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in various transition-metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject methods provide improvements in many features of the transition-metal-catalyzed reactions, including the range of suitable substrates, number of catalyst turnovers, reaction conditions, and efficiency. For example, improvements have been realized in transition metal-catalyzed: aryl amination reactions; aryl amidation reactions; Suzuki couplings; and Sonogashira couplings. In certain embodiments, the invention relates to catalysts and methods of using them that operate in aqueous solvent systems.

公开(公告)号：US07847130B2

公开(公告)日：2010-12-07

申请号：US12438228

申请日：2007-08-21

Applicant: David Cole-Hamilton ,  Simon Laurent Desset

Inventor： David Cole-Hamilton ,  Simon Laurent Desset

IPC: C07C45/28 ,  C07C5/03 ,  C09K3/00

CPC classification number: C07D233/58 ,  B01J31/0239 ,  B01J31/0244 ,  B01J31/0268 ,  B01J31/0284 ,  B01J31/2404 ,  B01J2231/321 ,  B01J2231/323 ,  B01J2231/4211 ,  B01J2231/4255 ,  B01J2231/4261 ,  B01J2231/4266 ,  B01J2231/645 ,  B01J2231/72 ,  B01J2531/822 ,  B01J2531/985 ,  B01J2540/32 ,  C07B37/04 ,  C07C5/03 ,  C07C45/50 ,  C07C211/63 ,  C07D213/20 ,  C07D233/54 ,  C07C47/02

Abstract: An additive for improving the rate of catalysis in biphasic reaction systems is disclosed. The additive is an ionic molecule comprising an organic cation such as a heterocyclic compound or a quaternary ammonium or phosphonium cation, and an anion which may be organic or inorganic. A process for improved catalysis in an aqueous biphasic system wherein the catalyst is substantially dissolved in the aqueous phase and the substrate is substantially contained in the non-aqueous phase is also described. A suitable additive is 1-octyl-3-methylimidazolium halide. Examples of suitable catalytic reactions include the hydrogenation, hydrosilation, hydroboration, hydrovinylation, hydroformylation, oxidation and hydroxycarbonylation of alkenes, and Heck, Suzuki, Stille, and Sonigashira coupling.

Abstract translation: 公开了用于提高双相反应体系中催化速率的添加剂。 添加剂是包含有机阳离子如杂环化合物或季铵或鏻阳离子的离子分子，以及可以是有机或无机的阴离子。 还描述了在水相双相系统中改进催化的方法，其中催化剂基本上溶解在水相中，并且底物基本上包含在非水相中。 合适的添加剂是1-辛基-3-甲基咪唑鎓卤化物。 合适的催化反应的实例包括氢化，硅氢化，氢化，氢化，加氢甲酰化，烯烃的氧化和羟基羰基化，以及Heck，Suzuki，Stille和Sonigashira偶联。

公开(公告)号：US07847126B2

公开(公告)日：2010-12-07

申请号：US11810374

申请日：2007-06-05

Applicant: Florian Rampf ,  Hans-Christian Militzer

Inventor： Florian Rampf ,  Hans-Christian Militzer

IPC: C07F9/54 ,  C07F5/02 ,  C07F7/28

CPC classification number: C07B37/04 ,  B01J31/24 ,  B01J31/2404 ,  B01J31/2409 ,  B01J31/2414 ,  B01J31/2447 ,  B01J2231/4211 ,  B01J2231/4233 ,  B01J2231/4238 ,  B01J2231/4255 ,  B01J2231/4261 ,  B01J2231/4266 ,  B01J2231/4283 ,  B01J2231/4288 ,  B01J2231/4294 ,  B01J2531/0205 ,  C07F9/5068 ,  C07F9/5442

Abstract: The invention relates to a process for synthesizing tertiary phosphines by reacting halophosphines with organomagnesium compounds in the presence of copper compounds and optionally of salts.

Abstract translation: 本发明涉及在铜化合物和任选的盐存在下使卤代膦与有机镁化合物反应合成叔膦的方法。

公开(公告)号：US20090318734A1

公开(公告)日：2009-12-24

申请号：US12438228

申请日：2007-08-21

Applicant: David Cole-Hamilton ,  Simon Laurent Desset

Inventor： David Cole-Hamilton ,  Simon Laurent Desset

IPC: C07C45/28 ,  C07C5/03 ,  C09K3/00

CPC classification number: C07D233/58 ,  B01J31/0239 ,  B01J31/0244 ,  B01J31/0268 ,  B01J31/0284 ,  B01J31/2404 ,  B01J2231/321 ,  B01J2231/323 ,  B01J2231/4211 ,  B01J2231/4255 ,  B01J2231/4261 ,  B01J2231/4266 ,  B01J2231/645 ,  B01J2231/72 ,  B01J2531/822 ,  B01J2531/985 ,  B01J2540/32 ,  C07B37/04 ,  C07C5/03 ,  C07C45/50 ,  C07C211/63 ,  C07D213/20 ,  C07D233/54 ,  C07C47/02

Abstract: An additive for improving the rate of catalysis in biphasic reaction systems is disclosed. The additive is an ionic molecule comprising an organic cation such as a heterocyclic compound or a quaternary ammonium or phosphonium cation, and an anion which may be organic or inorganic. A process for improved catalysis in an aqueous biphasic system wherein the catalyst is substantially dissolved in the aqueous phase and the substrate is substantially contained in the non-aqueous phase is also described. A suitable additive is 1-octyl-3-methylimidazolium halide. Examples of suitable catalytic reactions include the hydrogenation, hydrosilation, hydroboration, hydrovinylation, hydroformylation, oxidation and hydroxycarbonylation of alkenes, and Heck, Suzuki, Stille, and Sonigashira coupling.

Abstract translation: 公开了用于提高双相反应体系中催化速率的添加剂。 添加剂是包含有机阳离子如杂环化合物或季铵或鏻阳离子的离子分子，以及可以是有机或无机的阴离子。 还描述了在水相双相系统中改进催化的方法，其中催化剂基本上溶解在水相中，并且底物基本上包含在非水相中。 合适的添加剂是1-辛基-3-甲基咪唑鎓卤化物。 合适的催化反应的实例包括氢化，硅氢化，氢化，氢化，加氢甲酰化，烯烃的氧化和羟基羰基化，以及Heck，Suzuki，Stille和Sonigashira偶联。