公开(公告)号：US09653877B1

公开(公告)日：2017-05-16

申请号：US14537574

申请日：2014-11-10

Applicant: STC.UNM

Inventor： Ladan Arissian ,  Jean-Claude Diels

IPC: G01N21/41 ,  H01S3/106

CPC classification number: H01S3/1112 ,  G01N21/41 ,  G01N21/4133 ,  G01N2201/06113 ,  H01S3/0014 ,  H01S3/0957 ,  H01S3/105 ,  H01S3/1062 ,  H01S3/1106

Abstract: Apparatus, systems, and methods of generating multi combs can be used in a variety of applications. In various embodiments, a passive resonator can be disposed in the laser cavity of a mode-locked laser to generate a nested frequency comb. The passive resonator can be a sample under investigation, where a characteristic of the sample is determined using the generated nested frequency comb. Additional apparatus, systems, and methods are disclosed.

公开(公告)号：US20170112813A1

公开(公告)日：2017-04-27

申请号：US15287323

申请日：2016-10-06

Applicant: STC.UNM

Inventor： Vojo Deretic ,  Eliseo Castillo ,  Steven Bradfute ,  Larry A. Sklar

IPC: A61K31/436 ,  A61K31/136 ,  A61K31/12 ,  A61K31/4184

CPC classification number: A61K31/436 ,  A61K31/12 ,  A61K31/136 ,  A61K31/4184 ,  A61K31/4365 ,  A61K31/4535 ,  A61K31/472 ,  A61K31/473 ,  A61K31/517 ,  A61K31/519 ,  A61K31/522 ,  A61K31/54 ,  A61K31/546 ,  A61K31/5685 ,  A61K31/585 ,  A61K31/65 ,  C07K16/18 ,  G01N33/56972 ,  G01N33/6893 ,  G01N2333/9015

Abstract: The invention provides methods of treating autophagy mediated diseases and disorders and related pharmaceutical compositions, diagnostics, screening techniques and kits. In one embodiment, the invention provides a method of determining whether a subject suffers from, or is at risk of developing, and autophagy mediated disease state and/or condition by evaluating LC3 levels.

公开(公告)号：US20170110602A1

公开(公告)日：2017-04-20

申请号：US15389936

申请日：2016-12-23

Applicant: STC.UNM

Inventor： Sang Eon Han ,  Brittany R. Hoard ,  Sang M. Han ,  Swapnadip Ghosh

IPC: H01L31/0236 ,  G02B1/00 ,  H01L31/20 ,  H01L31/0747 ,  H01L31/18

CPC classification number: H01L31/02363 ,  G02B1/005 ,  H01L31/0747 ,  H01L31/1804 ,  H01L31/202 ,  H01L31/208 ,  H03H9/10 ,  H03H9/145 ,  H03H9/25 ,  Y02E10/547 ,  Y02P70/521

Abstract: Provided is a method for fabricating a nanopatterned surface. The method includes forming a mask on a substrate, patterning the substrate to include a plurality of symmetry-breaking surface corrugations, and removing the mask. The mask includes a pattern defined by mask material portions that cover first surface portions of the substrate and a plurality of mask space portions that expose second surface portions of the substrate, wherein the plurality of mask space portions are arranged in a lattice arrangement having a row and column, and the row is not oriented parallel to a [110] direction of the substrate. The patterning the substrate includes anisotropically removing portions of the substrate exposed by the plurality of spaces.

公开(公告)号：US09610371B2

公开(公告)日：2017-04-04

申请号：US14669313

申请日：2015-03-26

Applicant: STC.UNM

Inventor： Jeffrey P. Norenberg

IPC: A61K51/00 ,  A61M36/14 ,  A61K51/08 ,  A61K31/7068 ,  A61K38/31 ,  A61K45/06

CPC classification number: A61K51/08 ,  A61K31/7068 ,  A61K38/31 ,  A61K45/06 ,  A61K51/083 ,  A61K51/088 ,  A61K2300/00

Abstract: A subject afflicted with a cancer or precancerous condition is treated by administering an agent that increases expression of somatostatin receptors, and a cytotoxic recognition ligand. In an alternative embodiment, somatostatin analogs, which are radiolabeled are used to treat cancer or precancerous conditions.

公开(公告)号：US09606129B2

公开(公告)日：2017-03-28

申请号：US14677053

申请日：2015-04-02

Applicant: STC.UNM

Inventor： Ke Jian Liu ,  Wenlan Liu ,  Graham Timmins ,  Rong Pan

IPC: A61K39/395 ,  G01N33/68

CPC classification number: G01N33/6893 ,  G01N2333/4703 ,  G01N2800/2871 ,  G01N2800/52

Abstract: Methods and apparatus for determining blood brain barrier (BBB) damage and treating patients who may have suffered from BBB damage due to an ischemic event are provided. The methods and apparatus involve detecting the presence of cleaved occludin fragments in a sample of blood. According to some embodiments, the method further provides determining the degree of BBB damage based on the concentration of occludin fragments in the sample. In further embodiments the present disclosure provides kits for detecting the presence of occludin fragments in a blood sample.

公开(公告)号：US09546186B2

公开(公告)日：2017-01-17

申请号：US14451916

申请日：2014-08-05

Applicant: STC.UNM

Inventor： Jeffrey P. Norenberg ,  Richard S. Larson

IPC: A61K51/00 ,  A61M36/14 ,  C07F5/00 ,  C07F9/94 ,  A61K49/10 ,  A61K51/04

CPC classification number: C07F5/003 ,  A61K47/22 ,  A61K49/106 ,  A61K51/0474 ,  A61K51/0482 ,  A61K51/0485 ,  A61K51/0497 ,  C07F9/94

Abstract: The present invention is directed to novel non-invasive diagnostic tools to image cancers, especially, leukemia and non-Hodgkin's lymphomas (NHL) with minimal toxicity in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probe is capable of detecting precancerous cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and staging of NHL using non-invasively molecular imaging techniques. This novel probe will also be useful to monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of NHL. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.

Abstract translation: 本发明涉及用于对癌症特别是白血病和非霍奇金淋巴瘤（NHL）进行成像的新型非侵入性诊断工具，其体内毒性最小。 本发明代表了目前依赖于组织活检以诊断这些癌症的本领域的明显进步。 该新型成像探针能够检测癌前细胞，以及它们在组织中的转移扩散。 这代表了使用非侵入性分子成像技术在NHL的诊断和分期中向前推进的量子进程。 该新型探针也可用于监测患者对化疗治疗的反应和用于治疗NHL的其他干预措施或疗法。 根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。

公开(公告)号：US20160375158A1

公开(公告)日：2016-12-29

申请号：US15186764

申请日：2016-06-20

Applicant: STC.UNM

Inventor： Yubin Miao ,  Haixun Guo

IPC: A61K51/08 ,  A61K45/06 ,  A61K9/00

CPC classification number: A61K51/088 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0053 ,  A61K45/06 ,  C07K14/685 ,  G01N33/5743 ,  G01N33/60

Abstract: The present invention is directed to novel non-invasive diagnostic tools/compounds comprising a cyclic peptide wherein the compound binds to a MSH receptor to image and treat cancers, especially, melanoma, including metastatic melanoma in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probes are capable of detecting cancerous melanoma cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention will also be useful to initiate therapy for melanoma as well as monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.

Abstract translation: 本发明涉及包含环肽的新型非侵入性诊断工具/化合物，其中所述化合物结合MSH受体以在体内成像和治疗癌症，特别是黑素瘤，包括转移性黑素瘤。 本发明代表了目前依赖于组织活检以诊断这些癌症的本领域的明显进步。 新型成像探针能够检测癌细胞黑素瘤细胞，以及它们在组织中的转移扩散。 这代表了使用非侵入性分子成像技术在黑素瘤的诊断和治疗中包括转移性黑素瘤的量子进步。 本发明的新型探针也可用于启动黑素瘤的治疗以及监测患者对化疗治疗的反应和用于治疗黑素瘤/转移性黑色素瘤的其它干预或治疗。 根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。

公开(公告)号：US09515323B2

公开(公告)日：2016-12-06

申请号：US14376146

申请日：2013-02-01

Applicant: STC.UNM

Inventor： Alexey Serov ,  Barr Halevi ,  Kateryna Artyushkova ,  Plamen B Atanassov

IPC: B01J38/02 ,  B01J27/057 ,  B01J27/20 ,  B01J27/24 ,  H01M4/90 ,  B01J37/08 ,  B01J23/70 ,  H01M8/02 ,  H01M8/10 ,  H01M4/86 ,  H01M4/88

CPC classification number: H01M4/90 ,  B01J23/70 ,  B01J37/08 ,  H01M4/8605 ,  H01M4/88 ,  H01M8/02 ,  H01M8/1007 ,  Y02E60/521

Abstract: A method of preparation of metal-chalcogen-nitrogen-carbon (M-Ch-N—C) catalytic material utilizing a sacrificial support approach and using inexpensive and readily available precursors is described. Furthermore, the catalytic materials synthesized using the disclosed methods include multiple types of active sites.

Abstract translation: 描述了利用牺牲支撑方法制备金属 - 硫属 - 氮 - 碳（M-Ch-N-C）催化材料并使用便宜且容易获得的前体的方法。 此外，使用所公开的方法合成的催化材料包括多种类型的活性位点。

公开(公告)号：US20160346334A1

公开(公告)日：2016-12-01

申请号：US15116579

申请日：2015-02-05

Applicant: STC.UNM

Inventor： Kristina Trujillo

IPC: A61K35/55 ,  A61K9/00 ,  A61K45/06

CPC classification number: A61K35/55 ,  A61K9/0019 ,  A61K31/138 ,  A61K31/337 ,  A61K31/513 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K45/06 ,  A61K2300/00

Abstract: In one embodiment, the invention provides substantially purified exosomes which induce apoptosis in breast cancer cells and which are derived from a cultured medium of histologically normal breast tissue cells that are obtained from tumor-adjacent normal breast tissue. Related methods of treating breast cancer and pharmaceutical formulations are also provided.

Abstract translation: 在一个实施方案中，本发明提供了在乳腺癌细胞中诱导细胞凋亡的基本上纯化的外来体，其衍生自从肿瘤相邻的正常乳腺组织获得的组织学上正常的乳腺组织细胞的培养基。 还提供了治疗乳腺癌和药物制剂的相关方法。

公开(公告)号：US20160341687A1

公开(公告)日：2016-11-24

申请号：US15115033

申请日：2015-01-29

Applicant: David A. WALL ,  STC.UNM

Inventor： Robert L. Rubin ,  Konstantin N. Konstantinov ,  David A. Wall

IPC: G01N27/327 ,  G01N33/543

CPC classification number: G01N27/3273 ,  G01N27/3276 ,  G01N33/5438

Abstract: This disclosure describes, in one aspect, a device for electrochemical quantitation of autoantibodies. Generally, the device includes a housing that defines a plurality of channels and at least two reaction zones. A first reaction zone includes a porous membrane and a first electrode assembly in fluid communication with a first channel. The first reaction zone also includes a first plurality of autoantigens immobilized to the porous membrane. The first electrode assembly is in communication with an amperometric reader. A second reaction zone includes a porous membrane and a second electrode assembly in fluid communication with a second channel. The second reaction zone includes a second plurality of autoantigens immobilized to the porous membrane. The second electrode assembly is in communication with the amperometric reader. Finally, the device includes a source of negative pressure in fluid communication with the first reaction zone and the second reaction zone.

Abstract translation: 本公开在一个方面描述了一种用于自身抗体的电化学定量的装置。 通常，该装置包括限定多个通道和至少两个反应区的外壳。 第一反应区包括多孔膜和与第一通道流体连通的第一电极组件。 第一反应区还包括固定在多孔膜上的第一组多个自身抗原。 第一电极组件与电流读数器连通。 第二反应区包括多孔膜和与第二通道流体连通的第二电极组件。 第二反应区包括固定在多孔膜上的第二多个自身抗原。 第二电极组件与电流读数器连通。 最后，该装置包括与第一反应区和第二反应区流体连通的负压源。