公开(公告)号：US5056150A

公开(公告)日：1991-10-08

申请号：US433098

申请日：1989-11-08

Applicant: Tiecheng Yu ,  Ning Bi ,  Meiling Rong ,  Enyao Zhang

Inventor： Tiecheng Yu ,  Ning Bi ,  Meiling Rong ,  Enyao Zhang

IPC: G10L15/08 ,  G10L15/10 ,  G10L25/87

CPC classification number: G10L15/10 ,  G10L25/87

Abstract: A method and apparatus for real time speech recognition with and without speaker dependency which includes the following steps. Converting the speech signals into a series of primitive sound spectrum parameter frames; detecting the beginning and ending of speech according to the primitive sound spectrum parameter frame, to determine the sound spectrum parameter frame series; performing non-linear time domain normalization on the sound spectrum parameter frame series using sound stimuli, to obtain speech characteristic parameter frame series with predefined lengths on the time domain; performing amplitude quantization normalization on the speech characteristic parameter frames; comparing the speech characteristic parameter frame series with the reference samples, to determine the reference sample which most closely matches the speech characteristic parameter frame series; and determining the recognition result according to the most closely matched reference sample.

Abstract translation: 一种具有或不具有扬声器依赖性的实时语音识别的方法和装置，包括以下步骤。 将语音信号转换为一系列原始声谱参数帧; 根据原始声谱参数帧检测语音的开始和结束，确定声谱参数帧序列; 使用声音刺激对声谱参数帧序列进行非线性时域归一化，获得时域上具有预定长度的语音特征参数帧序列; 对语音特征参数帧执行振幅量化归一化; 将语音特征参数帧序列与参考样本进行比较，确定与语音特征参数帧序列最匹配的参考样本; 并根据最接近匹配的参考样本确定识别结果。

公开(公告)号：US4762417A

公开(公告)日：1988-08-09

申请号：US879000

申请日：1986-06-26

Applicant: Shudong Wu ,  Xiangzhen Chen ,  Xiou Tao

Inventor： Shudong Wu ,  Xiangzhen Chen ,  Xiou Tao

IPC: G01J9/02 ,  G01M11/00 ,  G01M11/02 ,  G01B9/02

CPC classification number: G01M11/0271 ,  G01J9/02 ,  G01M11/005 ,  G01J2009/0261

Abstract: A polarization fringe scanning digital interferometer includes an encoder r performing a phase polarization encoding on the wavefront coming from the optical component under test as it passes through the encoder. The encoded wavefront then passes through an analyzer into a video camera to produce electrical signals representing the interference pattern. The encoder includes in sequence, a polarizer having an adjustable polarization axis, a polarization film providing a polarization pinhole through the film and a quarter wave plate that preferably is a Fresnel plate.

Abstract translation: 偏振边缘扫描数字干涉仪包括编码器，用于在通过编码器的被测光学部件的波前对相位偏振编码进行相位偏振编码。 编码波阵面然后通过分析仪进入摄像机，以产生表示干扰图案的电信号。 编码器依次包括具有可调偏振轴的偏振器，通过该膜提供偏振针孔的偏振膜和优选为菲涅耳板的四分之一波片。

公开(公告)号：US20250099538A1

公开(公告)日：2025-03-27

申请号：US18686862

申请日：2022-08-26

Applicant: Academia Sinica

Inventor： Che-Kun James SHEN ,  Shih-Ling HUANG ,  Chun-Hao HUNG

IPC: A61K38/17 ,  A61K35/28 ,  A61P25/28 ,  C07K14/47

Abstract: Disclosed herein are methods of preventing or treating ALS by use of a modified EKLF polypeptide, a modified nucleic acid encoding the modified EKLF polypeptide, or modified bone marrow cells comprising the modified nucleic acid. According to embodiments of the present disclosure, the modified EKLF polypeptide comprises an amino acid modification that confers reduced sumoylation in a wild-type EKLF polypeptide.

公开(公告)号：US20250052993A1

公开(公告)日：2025-02-13

申请号：US18922794

申请日：2024-10-22

Applicant: Academia Sinica

Inventor： Jung-Chi LIAO ,  Yi-De CHEN ,  Chih-Wei CHANG ,  Weng Man CHONG

IPC: G02B21/36 ,  G02B21/06 ,  G02B21/26 ,  G06V10/141 ,  G06V10/25 ,  G06V20/69 ,  H04N23/56 ,  H04N23/74

Abstract: A system and method for image-guided microscopic illumination are provided. A processing module controls an imaging assembly such that a camera acquires an image or images of a sample in multiple fields of view, and the image or images are automatically transmitted to a processing module and processed by the first processing module automatically in real-time based on a predefined criterion so as to determine coordinate information of an interested region in each field of view. The processing module also controls an illuminating assembly to illuminate the interested region of the sample according to the received coordinate information regarding to the interested region, with the illumination patterns changing among the fields of view.

公开(公告)号：US12221613B2

公开(公告)日：2025-02-11

申请号：US17923455

申请日：2021-04-29

Applicant: Academia Sinica

Inventor： Su-Ying Yeh ,  Hsin-Hung Lin ,  Maurice S. B. Ku ,  Wen-Hsiung Li

IPC: C12N15/82

Abstract: A transgenic rice plant containing in its genome a recombinant DNA construct that includes a first nucleic acid having a sequence of a first Golden 2-like transcription factor (GLK) gene operably linked to its natural promoter and 5′ untranslated region (5′UTR), and a second nucleic acid having a sequence of a second GLK gene operably linked to its natural promoter and 5′UTR, the second GLK gene being distinct from the first GLK gene. The first GLK gene and the second GLK gene are both from a C4 plant and the transgenic rice plant exhibits a 65-106% increase in shoot biomass and a 50-95% increase in grain yield, as compared to an untransformed wild-type rice plant. Also provided is a method for producing the transgenic rice plant and a recombinant DNA construct that can be used in the method.

公开(公告)号：US20240400549A1

公开(公告)日：2024-12-05

申请号：US18689852

申请日：2022-09-07

Applicant: Academia Sinica

Inventor： Jen-Tse Joseph HUANG ,  Jim-Min FANG ,  Yi-Juang CHERN ,  Yu-Ling TSENG ,  Yung-An HUANG

IPC: C07D417/14 ,  A61K31/454 ,  A61K31/4545

Abstract: Disclosed herein are compounds designed and used in the degradation of pathogenic protein aggregates and oligomers, thus these compounds are suitable for use as medicaments for preventing and/or treating neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), Alzheimer's disease (AD), and Huntington's disease (HD).

公开(公告)号：US12103969B2

公开(公告)日：2024-10-01

申请号：US17266092

申请日：2018-09-25

Applicant: Academia Sinica

Inventor： Shie-Liang Hsieh ,  Tsung-Yu Tsai ,  An-Suei Yang ,  Chung-Ming Yu ,  Cheng-Yuan Peng

IPC: C07K16/28 ,  A61P25/28 ,  A61P31/20 ,  A61K39/00

CPC classification number: C07K16/2803 ,  A61P25/28 ,  A61P31/20 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/77

Abstract: Disclosed herein is a novel monoclonal antibody exhibiting binding affinity to Siglec-3 receptor. According to the embodiment, the monoclonal antibody is capable of reversing HBV-induced immunosuppression. Accordingly, also disclosed herein are the uses thereof in the treatment and/or prophylaxis of hepatitis B virus (HBV) infection.

公开(公告)号：US12099009B2

公开(公告)日：2024-09-24

申请号：US17282163

申请日：2019-10-03

Applicant: ACADEMIA SINICA

Inventor： Pei-Kuen Wei ,  Ming-Yang Pan ,  Kuang-Li Lee

IPC: G01N21/552

CPC classification number: G01N21/553

Abstract: A method and apparatus for surface plasmon resonance imaging are provided for imaging the surface plasmon resonance signals caused by the interaction of biomolecules. In particular, the method and apparatus can image the slightly spectral change in a surface plasmon resonance mode by comparing the light intensities of two bands in the frequency domain of the surface plasmon.

公开(公告)号：US20240283025A1

公开(公告)日：2024-08-22

申请号：US18582913

申请日：2024-02-21

Applicant: Academia Sinica

Inventor： Maw-Kuen WU ,  Feng-Yu WU ,  Po-Wei CHI ,  Phillip M WU

IPC: H01M10/0567 ,  H01M4/36 ,  H01M4/38 ,  H01M4/583 ,  H01M10/052 ,  H01M10/0568 ,  H01M10/0569

CPC classification number: H01M10/0567 ,  H01M4/362 ,  H01M4/382 ,  H01M4/583 ,  H01M10/052 ,  H01M10/0568 ,  H01M10/0569 ,  H01M2300/0037

Abstract: Disclosed is an electrolyte solution for a lithium metal battery, comprising: a lithium thiophosphate complex formed by phosphorus pentasulfide and lithium polysulfide. In addition, a lithium metal battery comprising the aforesaid electrolyte solution and a method for preparing the aforesaid electrolyte solution are also disclosed.

公开(公告)号：US20240274873A1

公开(公告)日：2024-08-15

申请号：US18433004

申请日：2024-02-05

Applicant: Academia Sinica

Inventor： Hsiao-Hua YU ,  Baskar SELVARAJ

IPC: H01M10/0565 ,  H01M50/426 ,  H01M50/449 ,  H01M50/497

CPC classification number: H01M10/0565 ,  H01M50/426 ,  H01M50/449 ,  H01M50/497

Abstract: Disclosed is a multifunctional interfacial layer, which includes a conducting fiber network and a polymer-based conductive medium. The conducting fiber network layer can serves as a physical barrier to contain lithium dendrites and provide mechanical strength. The polymer-based conductive medium can facilitate smooth contact with electrodes. Under thermal treatment, an interface additive included in the polymer-based conductive medium can diffuse to the surface of the electrode, resulting in formation of an in-situ interfacial layer on the electrode. Accordingly, the multifunctional interfacial layer can resolve the problems of poor mechanical property and chemical instability at elevated potential and temperature associated with PEO-succinonitrile solid polymer electrolyte and prevent dendritic growth of lithium anode.