公开(公告)号：US20210017488A1

公开(公告)日：2021-01-21

申请号：US17063322

申请日：2020-10-05

Applicant: Genentech, Inc.

Inventor： Natarajan VIJAYASANKARAN ,  Steven J. MEIER ,  Sharat VARMA ,  Yi YANG

IPC: C12N5/00 ,  C07K16/00

Abstract: Cell culture media comprising antioxidants are provided herein as are methods of using the media for cell culturing and polypeptide production from cells. Compositions comprising polypeptides, such as therapeutic polypeptides, produced by the methods herein are also provided.

公开(公告)号：US20210015919A1

公开(公告)日：2021-01-21

申请号：US16992966

申请日：2020-08-13

Applicant: Genentech, Inc.

Inventor： Mark C. Benyunes ,  Emma L. Clark ,  Graham A. Ross

IPC: A61K39/395 ,  A61K45/06 ,  C07K16/32 ,  A61K31/337

Abstract: The present application describes uses for Pertuzumab, a first-in-class HER2 dimerization inhibitor. In particular, the application describes methods for extending progression free survival in a HER2-positive breast cancer patient population; and combining two HER2 antibodies to treat HER2-positive cancer without increasing cardiac toxicity.

公开(公告)号：US20210015918A1

公开(公告)日：2021-01-21

申请号：US17033141

申请日：2020-09-25

Applicant: Genentech, Inc.

Inventor： Gwendolyn FYFE ,  Eric HOLMGREN ,  Robert D. MASS ,  William NOVOTNY

IPC: A61K39/395 ,  A61K45/06 ,  A61K31/522 ,  A61K38/50 ,  A61K31/525 ,  A61K31/573 ,  A61K38/09 ,  A61K38/21 ,  C07K16/22 ,  A61K31/282 ,  A61K31/4545 ,  A61K31/513 ,  A61K31/519 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/7068 ,  A61K9/00 ,  A61K31/555 ,  C07K16/30

Abstract: This invention concerns in general treatment of diseases and pathological conditions with anti-VEGF antibodies. More specifically, the invention concerns the treatment of human patients susceptible to or diagnosed with cancer using an anti-VEGF antibody, preferably in combination with one or more additional anti-tumor therapeutic agents.

公开(公告)号：US10882864B2

公开(公告)日：2021-01-05

申请号：US16460889

申请日：2019-07-02

Applicant: Genentech, Inc.

Inventor： Danial Beaudry ,  Theresa Cravillion ,  Francis Gosselin ,  Ngiap-Kie Lim ,  Sushant Malhotra ,  Qingping Tian ,  Haiming Zhang ,  Alexander Gmehling ,  Alec Fettes ,  Stephan Bachmann

IPC: C07D487/04 ,  B01J31/24

Abstract: Methods for preparing the Bruton's Tyrosine Kinase (“BTK”) inhibitor compound 2-{3′-hydroxymethyl-1-methyl-5-[5-((S)-2-methyl-4-oxetan-3-yl-piperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-[3,4′]bipyridinyl-2′-yl}-7,7-dimethyl-3,4,7,8-tetrahydro-2H,6H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one are provided. Methods for preparing tricyclic lactam compounds are also provided.

公开(公告)号：US10861584B2

公开(公告)日：2020-12-08

申请号：US15166939

申请日：2016-05-27

Applicant: Genentech, Inc.

Inventor： Vikas K. Sharma ,  Trevor E. Swartz ,  Thomas W. Patapoff

IPC: G16B15/00 ,  G16B35/00 ,  G16C20/60 ,  C07K16/00 ,  G01N33/531

Abstract: Apparatus, systems, computer-readable media, articles of manufacture and methods for selecting an antibody. Apparatus, systems, computer-readable media, articles of manufacture and methods for producing the selected antibody. The selecting may include determining one or more physiochemical characteristics of the antibody. The determining may be based on antibody structural parameters.

公开(公告)号：US10858324B2

公开(公告)日：2020-12-08

申请号：US16555842

申请日：2019-08-29

Applicant: GENENTECH, INC.

Inventor： Hans Iding ,  Reinhard Reents ,  Michelangelo Scalone ,  Francis Gosselin

IPC: A61K31/517 ,  C07D239/70 ,  C07C269/06 ,  C07C271/22 ,  C12P17/16

Abstract: The present invention relates to a process for the preparation of a compound of formula (I) wherein R1 is as defined herein, which is useful as an intermediate in the preparation of active pharmaceutical compounds.

公开(公告)号：US20200377582A1

公开(公告)日：2020-12-03

申请号：US16723550

申请日：2019-12-20

Applicant: GENENTECH, INC.

Inventor： Jillian Smith ,  Janice Smith ,  Geoff Kerchner

IPC: C07K16/18 ,  C07K16/00 ,  A61P25/28 ,  A61K9/00 ,  A61K31/13 ,  A61K31/185 ,  A61K31/405 ,  A61K31/4418 ,  A61K31/455 ,  A61K31/4745 ,  A61K31/519 ,  A61K39/395 ,  A61K45/06

Abstract: Methods of treating Alzheimer's Disease (AD) in patients suffering from early AD, including amyloid positive patients, ApoE4 positive patients, and patients suffering from prodromal or mild AD are provided.

公开(公告)号：US20200377463A1

公开(公告)日：2020-12-03

申请号：US16884679

申请日：2020-05-27

Applicant: Genentech, Inc.

Inventor： Michael F.T. Koehler ,  Peter Andrew Smith ,  Dana Winter ,  Boubacar Sow ,  Claudio Sturino ,  Guillaume Pelletier ,  Jonathan Boudreault

IPC: C07D239/42 ,  A61K45/06 ,  A61K31/505 ,  A61P31/04 ,  A61K31/702 ,  A61K31/4709 ,  A61K31/545 ,  A61K38/14 ,  A61K31/497 ,  A61K31/165 ,  A61K31/351 ,  A61K38/12 ,  A61K31/5377 ,  C07D239/28

Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidases SpsB and/or LepB, an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

公开(公告)号：US20200369670A1

公开(公告)日：2020-11-26

申请号：US16869512

申请日：2020-05-07

Applicant: Genentech, Inc.

Inventor： Kyle Bradley Pascual Clagg ,  Nicholas Andrew White ,  Haiming Zhang ,  Francis Gosselin ,  William Nack ,  Paul D. O'Shea

IPC: C07D487/04 ,  C07F9/24

Abstract: A method of regio-selectively synthesizing an imidazo-pyrimidine compound of formulae (XXa) or (XXb) comprising a step of coupling a first compound of formula XX-P1a or XX-P1b with a second compound of formula XX-P2 This annulation reaction between β-ethoxy acrylamides and phosphorylated aminoimidazoles to furnish imidazo[1,2-a]pyrimidin-amines relies on steering effects from endocyclic and exocyclic phosphorylated aminoimidazoles. The reaction furnishes either 2-amino or 4-amino constitutional isomers of imidazo[1,2-a]pyrimidines with good yields and ranges of 90:10-99:1 regio-selectivity. The reaction is useful in the synthesis of various tracer molecules used in the study of neurological conditions such as where R3 and R4 together with the imidazole ring atoms to which they are bonded form a phenyl ring and the products are substituted benzimidazopyrimidines. The reaction can be generalized to form imidazo[1,2-a]pyrimidines substituted at either of their 2- and 4-positions by alkoxy or thioalkyl groups.

公开(公告)号：US20200347118A1

公开(公告)日：2020-11-05

申请号：US16848564

申请日：2020-04-14

Applicant: Genentech, Inc.

Inventor： Amit MEHTA

IPC: C07K16/06 ,  C07K1/36 ,  C07K1/18 ,  C07K1/34

Abstract: The present invention relates to the field of protein purification. In particular, the invention concerns methods for increasing the filtration capacity of virus filters, by combined use of endotoxin removal and cation-exchange media in the prefiltration process.