LUNG CANCER MODELING USING NORMAL LUNG ORGANOID WITH LUNG CANCER CELLS

    公开(公告)号:US20230416687A1

    公开(公告)日:2023-12-28

    申请号:US18342930

    申请日:2023-06-28

    CPC classification number: C12N5/0688 C12N2502/30 C12N2503/02

    Abstract: The present invention relates to a lung cancer model based on a normal lung organoid, prepared by fusing cancer cells to the normal lung organoid. By using the lung cancer model according to the present invention, it is possible not only to observe the progression or metastasis pattern of lung cancer from the early stage of proliferating lung cancer cells to the stage of forming a tumor but also to compare the effect of an anticancer agent at each stage, and thus the information on an appropriate therapeutic agent may be provided according to the stage of cancer development.
    In addition, since the lung cancer model according to the present invention includes a normal lung organoid and cancer cells, which are fused, it can be effectively used to confirm the effect of an anticancer agent on normal tissue and the effect of cancer cell-specific apoptosis. In addition, since a conventional method of injecting human lung cancer cells into a mouse has a problem in that unpredictable reactions are caused by immune responses or the like, the present invention is expected to be effectively used as a human lung cancer model.

Patent Agency Ranking