公开(公告)号：US20150292964A1

公开(公告)日：2015-10-15

申请号：US14434313

申请日：2013-10-07

Applicant: Scott SIBBETT ,  STC.UNM

Inventor： Scott Sibbett

IPC: G01L1/22 ,  G01L1/04

CPC classification number: G01L1/22 ,  B25J13/084 ,  B25J19/02 ,  G01L1/04 ,  G01L1/18 ,  G01L1/205 ,  G01L5/162 ,  G06F3/041 ,  G06F3/0414 ,  G06F3/045

Abstract: A pliable pressure sensitive sensor device and method of making the same is provided. The sensor includes first and second pliable protective layers, which cover sets of conductive fibers that spatially separated by an electrically conductive pliable layer, which deforms in response to a pressure event. The fiber sets form a grid pattern and are in electrical communication with sets of electrical contacts located in predetermined locations along the fibers. In response to a pressure event in proximity to the contact, the pliable layer deforms and increases the amount of surface area in contact with an electrical contact whereby an electrical resistance at an individual electrical contact decreases in response to the pressure event.

Abstract translation: 提供了一种柔韧的压敏传感器装置及其制造方法。 传感器包括第一和第二柔性保护层，其覆盖由导电柔性层空间分隔的导电纤维组，其响应于压力事件而变形。 光纤组形成网格图案，并且与位于沿着光纤的预定位置的电触点组电连通。 响应于接触点处的压力事件，柔性层变形并增加与电接触件接触的表面积的量，由此响应于压力事件，单独电接触处的电阻降低。

公开(公告)号：US20150275265A1

公开(公告)日：2015-10-01

申请号：US14434509

申请日：2013-10-08

Applicant: STC.UNM

Inventor： Graham Timmins ,  Louis Pete Silks

IPC: C12Q1/04

CPC classification number: C12Q1/04 ,  A61B5/082 ,  A61B5/0836 ,  A61B5/14507 ,  A61B5/14546 ,  A61B5/207 ,  C12Q1/02 ,  G01N33/497 ,  G01N33/56911 ,  G01N33/60 ,  G01N2333/33 ,  G21H5/02

Abstract: The present invention is directed to methods of determining the presence or absence of a bacterial infection in a patient using isotopically-labeled tyrosine and/or isotopically-labeled p-hydroxyphenylacetic acid.

Abstract translation: 本发明涉及使用同位素标记的酪氨酸和/或同位素标记的对羟基苯基乙酸来测定患者中细菌感染的存在或不存在的方法。

公开(公告)号：US09111059B2

公开(公告)日：2015-08-18

申请号：US14069822

申请日：2013-11-01

Applicant: STC.UNM

Inventor： Marios Stephanou Pattichis ,  Yuebing Jiang ,  Daniel Rolando Llamocca Obregon

IPC: G06F9/455 ,  G06F17/50 ,  H03H17/06 ,  H03H17/02

CPC classification number: G06F9/4401 ,  G06F17/5054 ,  G06F2217/08 ,  H03H17/0241 ,  H03H17/0294 ,  H03H17/06 ,  H04N19/625

Abstract: A dynamically reconfigurable framework manages processing applications in order to meet time-varying constraints to select an optimal hardware architecture. The optimal architecture satisfies time-varying constraints including for example, supplied power, required performance, accuracy levels, available bandwidth, and quality of output such as image reconstruction. The process of determining an optimal solution is defined in terms of multi-objective optimization using Pareto-optimal realizations.

Abstract translation: 动态可重构框架管理处理应用程序，以便满足时变约束以选择最佳硬件体系结构。 最优架构满足时变约束，包括例如所提供的功率，所需性能，精度水平，可用带宽以及诸如图像重建的输出质量。 确定最优解的过程是使用帕累托最优实现的多目标优化来定义的。

公开(公告)号：US20150196673A1

公开(公告)日：2015-07-16

申请号：US14669313

申请日：2015-03-26

Applicant: STC.UNM

Inventor： Jeffrey P. Norenberg

IPC: A61K51/08 ,  A61K31/7068 ,  A61K45/06

CPC classification number: A61K51/08 ,  A61K31/7068 ,  A61K38/31 ,  A61K45/06 ,  A61K51/083 ,  A61K51/088 ,  A61K2300/00

Abstract: A subject afflicted with a cancer or precancerous condition is treated by administering an agent that increases expression of somatostatin receptors, and a cytotoxic recognition ligand. In an alternative embodiment, somatostatin analogs, which are radiolabeled are used to treat cancer or precancerous conditions.

Abstract translation: 通过施用增加生长抑素受体表达的试剂和细胞毒性识别配体来治疗患有癌症或癌前病症的受试者。 在替代实施方案中，放射性标记的生长抑素类似物用于治疗癌症或癌前病症。

公开(公告)号：US20150104819A1

公开(公告)日：2015-04-16

申请号：US14404134

申请日：2013-03-07

Applicant: STC.UNM ,  THE JOHNS HOPKINS UNIVERSITY

Inventor： Graham Timmins ,  Seong Choi ,  Zachary Sharp ,  Viorel Atudorei ,  Mamoudou Maiga ,  William Bishai

IPC: C12Q1/04 ,  C12Q1/28

CPC classification number: C12Q1/04 ,  C12Q1/28 ,  C12Q2304/48 ,  G01N33/5695 ,  G01N33/60 ,  G01N2333/35

Abstract: The present invention is directed to methods of diagnosing the presence or absence of a bacterial infection in a patient, in particular, a tuberculosis infection, by measuring exhaled, isotopically labeled nitrogen gas after administration of isotopic ally labeled isoniazid.

Abstract translation: 本发明涉及通过在施用同位素标记的异烟肼之后测量呼出的同位素标记的氮气来诊断患者中细菌感染的存在或不存在，特别是结核病感染的方法。

公开(公告)号：US09005540B2

公开(公告)日：2015-04-14

申请号：US14092409

申请日：2013-11-27

Applicant: University of Florida Research Foundation, Inc. ,  STC.UNM

Inventor： Kirk S. Schanze ,  Motokatsu Ogawa ,  Jonathan Robert Sommer ,  David G. Whitten ,  Thomas S. Corbitt

IPC: A61L2/00 ,  H01B1/04 ,  A01N25/28 ,  A01N25/00 ,  A01N25/10 ,  A01N25/34 ,  A01N43/90 ,  A61L2/23

CPC classification number: A01N25/28 ,  A01N25/00 ,  A01N25/10 ,  A01N25/34 ,  A01N43/90 ,  A61L2/23 ,  Y10S977/712 ,  Y10S977/903 ,  Y10T428/2982 ,  A01N41/04 ,  A01N2300/00

Abstract: Hollow conjugated polyelectrolyte (HCPE) microcapsules contain at least one conjugated polyelectrolyte and at least one other polyelectrolyte of complementary charge and the microcapsule has a hollow core. The conjugated polyelectrolyte is a polymer with a multiplicity of charged repeating units where a portion of the charged repeating units form a pi-conjugated sequence. The complementary polyelectrolyte is a polymer with a complementary charged repeating unit to the charged repeating units of the conjugated polyelectrolyte. The HCPE microcapsules can be formed by successively coating a sacrificial core with alternating layers of complementary polyelectrolytes, at least one of which is a conjugated polyelectrolyte. The sacrificial core can be removed to form the hollow center of a HCPE microcapsule. The HCPE microcapsules can be contacted with a medium containing microbes where the HCPE microcapsules associate with the microbes and efficiently kill the microbes when irradiated with light or other electromagnetic radiation.

Abstract translation: 中空共轭聚电解质（HCPE）微胶囊含有至少一种共轭聚电解质和至少一种其他互补电荷的聚电解质，微胶囊具有中空芯。 共轭聚电解质是具有多个带电重复单元的聚合物，其中一部分带电重复单元形成π-共轭序列。 互补聚电解质是与共轭聚电解质的带电重复单元具有互补的带电重复单元的聚合物。 HCPE微胶囊可以通过连续地涂覆具有互补聚电解质交替层的牺牲芯形成，其中至少一种是共轭聚电解质。 可以去除牺牲芯以形成HCPE微胶囊的中空中心。 HCPE微胶囊可以与含有微生物的培养基接触，其中HCPE微胶囊与微生物结合，并在用光或其他电磁辐射照射时有效杀死微生物。

公开(公告)号：US20150054709A1

公开(公告)日：2015-02-26

申请号：US14373974

申请日：2013-03-15

Applicant: STC.UNM

Inventor： Youssef A. Tawk ,  Christos G. Christodoulou ,  Joseph Costantine

IPC: H01Q1/50 ,  H01Q1/24

CPC classification number: H01Q1/50 ,  H01Q1/24 ,  H01Q13/085 ,  H01Q15/24

Abstract: Embodiments relate to systems and methods for a frequency reconfigurable filtenna system. Implementations incorporate a reconfigurable band-pass filter within the feeding line of an antenna structure. The combination of the filter and the antenna may be referred to as a “filtenna”. Implementations integrate both the band-pass filter and the antenna within the same substrate, permitting easier, more efficient and more compact integration in the transceiver hardware. Moreover, by using this configuration, the biasing of the switching elements are not present in the radiating plane of the antenna. This reduces the negative effect of the biasing lines on the antenna radiation performance, as we!! as provides a tunable filtered antenna radiation characteristic.

Abstract translation: 实施例涉及用于频率可重构的文件系统的系统和方法。 实现在天线结构的馈电线内并入可重构带通滤波器。 滤波器和天线的组合可以被称为“滤波器”。 实现将带通滤波器和天线集成在相同的基板内，允许在收发器硬件中更容易，更有效和更紧凑的集成。 此外，通过使用这种结构，开关元件的偏置不存在于天线的辐射平面中。 这减少了偏置线对天线辐射性能的负面影响，因为我们！ 提供可调滤波天线辐射特性。

公开(公告)号：US20140371057A1

公开(公告)日：2014-12-18

申请号：US14376146

申请日：2013-02-01

Applicant: STC.UNM

Inventor： Alexey Serov ,  Barr Halevi ,  Kateryna Artyushkova ,  Plamen B Atanassov

IPC: H01M4/90 ,  H01M4/88

CPC classification number: H01M4/90 ,  B01J23/70 ,  B01J37/08 ,  H01M4/8605 ,  H01M4/88 ,  H01M8/02 ,  H01M8/1007 ,  Y02E60/521

Abstract: A method of preparation of metal-chalcogen-nitrogen-carbon (M-Ch-N—C) catalytic material utilizing a sacrificial support approach and using inexpensive and readily available precursors is described. Furthermore, the catalytic materials synthesized using the disclosed methods include multiple types of active sites.

Abstract translation: 描述了利用牺牲支撑方法制备金属 - 硫属 - 氮 - 碳（M-Ch-N-C）催化材料并使用便宜且容易获得的前体的方法。 此外，使用所公开的方法合成的催化材料包括多种类型的活性位点。

公开(公告)号：US20140341806A1

公开(公告)日：2014-11-20

申请号：US14451916

申请日：2014-08-05

Applicant: STC.UNM

Inventor： Jeffrey P. Norenberg ,  Richard S. Larson

IPC: C07F5/00

CPC classification number: C07F5/003 ,  A61K47/22 ,  A61K49/106 ,  A61K51/0474 ,  A61K51/0482 ,  A61K51/0485 ,  A61K51/0497 ,  C07F9/94

Abstract: The present invention is directed to novel non-invasive diagnostic tools to image cancers, especially, leukemia and non-Hodgkin's lymphomas (NHL) with minimal toxicity in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probe is capable of detecting precancerous cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and staging of NHL using non-invasively molecular imaging techniques. This novel probe will also be useful to monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of NHL. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.

Abstract translation: 本发明涉及用于对癌症特别是白血病和非霍奇金淋巴瘤（NHL）进行成像的新型非侵入性诊断工具，其体内毒性最小。 本发明代表了目前依赖于组织活检以诊断这些癌症的本领域的明显进步。 该新型成像探针能够检测癌前细胞，以及它们在组织中的转移扩散。 这代表了使用非侵入性分子成像技术在NHL的诊断和分期中向前推进的量子进程。 该新型探针也可用于监测患者对化疗治疗的反应和用于治疗NHL的其他干预措施或疗法。 根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。

公开(公告)号：US20140329712A1

公开(公告)日：2014-11-06

申请号：US14347690

申请日：2012-09-28

Applicant: STC.UNM

Inventor： Jeremy Edwards ,  Payman Zarkesh-Ha ,  Steven R.J. Brueck

IPC: C12Q1/68

CPC classification number: C12Q1/6869 ,  C12Q1/6806 ,  C12Q1/6874 ,  G01N27/414 ,  G01N27/4145 ,  Y10T436/143333 ,  C12Q2531/125 ,  C12Q2535/122

Abstract: This disclosure describes, in one aspect, a method for preparing DNA molecule for sequencing. Generally, the method includes fragmenting the DNA molecule into double-stranded fragments; amplifying at least a portion of the double-stranded fragments; circularizing the fragments so that the first end of the fragment comprises a first loop connecting the strands and the second end of the fragment comprises a second loop connecting the strands; annealing a first sequencing primer to the first loop oriented to sequence at least a portion of one strand of the fragment; and annealing a second sequencing primer to the second loop oriented to sequence at least a portion of the other strand of the fragment. In another aspect, this disclosure describes a method for sequencing a DNA molecule. Generally, the method includes fragmenting the DNA molecule into double-stranded fragments; amplifying at least a portion of the double-stranded fragments; circularizing the fragments so that the first end of the fragment comprises a first loop connecting the strands and the second end of the fragment comprises a second loop connecting the strands; and sequencing at least one of the DNA strands.

Abstract translation: 本公开一方面描述了用于测序的DNA分子的制备方法。 通常，该方法包括将DNA分子片段化成双链片段; 扩增至少一部分双链片段; 使片段环化，使得片段的第一端包含连接线束的第一环和片段的第二端包括连接线的第二环; 将第一测序引物退火至所述第一环，其定向为序列所述片段的一条链的至少一部分; 以及将第二测序引物退火至所述第二环，其定向为序列所述片段的另一条链的至少一部分。 在另一方面，本公开描述了用于测序DNA分子的方法。 通常，该方法包括将DNA分子片段化成双链片段; 扩增至少一部分双链片段; 使片段环化，使得片段的第一端包含连接线束的第一环和片段的第二端包括连接线的第二环; 并测序至少一个DNA链。