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251.发明申请COMPOSITIONS COMPRISING LECITHIN OILS AND NSAIDS FOR PROTECTING THE GASTROINTESTINAL TRACT AND PROVIDING ENHANCED THERAPEUTIC ACTIVITY 审中-公开包含LECITHIN油和NSAIDS的组合物，用于保护胃肠动态和提供增强的治疗活性公开(公告)号：US20150011507A1
公开(公告)日：2015-01-08
申请号：US14495525
申请日：2014-09-24
Inventor： Lenard M. LICHTENBERGER
IPC: A61K31/685 , A61K31/616 , A61K31/167 , A61K47/44 , A61K47/48 , A61K31/192 , A61K9/107
CPC classification number: A61K47/24 , A61K9/0053 , A61K9/107 , A61K9/1075 , A61K31/167 , A61K31/192 , A61K31/195 , A61K31/196 , A61K31/405 , A61K31/4152 , A61K31/5415 , A61K31/616 , A61K31/685 , A61K47/44 , A61K47/55
Abstract: A novel pharmaceutical composition is provided by which nonsteroidal anti-inflammatory drugs (NSAIDs) are added directly to phospholipid-containing oil such as lecithin oils or to a bio-compatible oil to which an phospholipid has been added to make a NSAID-containing formulation that possess low gastrointestinal (GI) toxicity and enhanced therapeutic activity to treat or prevent inflammation, pain, fever, platelet aggregation, tissue ulcerations and/or other tissue disorders. The composition of the invention are in the form of a non-aqueous solution, paste, suspension, dispersion, colloidal suspension or in the form of an aqueous emulsion or microemulsion for internal, oral, direct or topical administration.
Abstract translation: 提供了一种新的药物组合物，通过其将非甾体抗炎药（NSAID）直接加入到含磷脂的油例如卵磷脂油或已加入磷脂的生物相容性油中以制备含NSAID的制剂， 具有低胃肠道（GI）毒性和增强的治疗活性以治疗或预防炎症，疼痛，发热，血小板聚集，组织溃疡和/或其他组织疾病。 本发明的组合物为非水溶液，糊剂，悬浮液，分散体，胶体悬浮液或用于内部，口服，直接或局部给药的水性乳液或微乳液的形式。
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公开(公告)号：US20140364467A1
公开(公告)日：2014-12-11
申请号：US14310619
申请日：2014-06-20
Inventor： Jay Schneider , Jenny Hsieh , Douglas Frantz , Steven L. McKnight , Joseph M. Ready
IPC: C07D413/04 , C12N5/079 , C07D261/18
CPC classification number: C07D413/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07C311/49 , C07D231/12 , C07D261/08 , C07D261/18 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C12N5/0618 , C12N5/0657 , C12N2501/999
Abstract: The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy.
Abstract translation: 本发明涉及在正常神经干细胞和脑癌干细胞中诱导神经元分化的化合物和方法。 该方法可以在体外进行，例如在来自成年哺乳动物脑的分离物中，或在体内。 本文所述的化合物和方法可用于治疗神经变性和精神疾病，神经系统的修复和再生以及治疗神经恶性肿瘤。
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253.发明申请公开(公告)号：US20140323568A1
公开(公告)日：2014-10-30
申请号：US14259644
申请日：2014-04-23
Inventor： Jung-Mo AHN , Ganesh RAJ
IPC: A61K31/167 , C07C237/04 , A61F7/10 , A61K45/06 , A61N5/10 , C07C235/56 , A61K31/24
CPC classification number: C07C237/44 , A61B2017/00274 , A61F7/10 , A61K31/167 , A61K31/24 , A61K31/365 , A61K45/06 , A61N5/10 , C07C235/56 , C07C237/04 , A61K2300/00
Abstract: The present invention includes bis- and tris-benzamide compounds that block AR signaling and have activity against prostate cancer. Uses for these compounds, and pharmaceutical compositions containing the same, also are provided.
Abstract translation: 本发明包括阻断AR信号并具有抗前列腺癌活性的双 - 和三 - 苯甲酰胺化合物。 也提供了这些化合物的用途和含有它们的药物组合物。
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公开(公告)号：US20140288171A1
公开(公告)日：2014-09-25
申请号：US14298908
申请日：2014-06-07
Inventor： Kyumin Whang , H. Ralph Rawls , Barry K. Norling
IPC: A01N55/02
CPC classification number: A01N55/02 , A01N59/16 , A61L27/16 , A61L27/54 , A61L2300/104 , A61L2300/404 , A61L2300/624 , A61L2400/12 , A01N25/10 , A01N25/30 , A01N37/02 , A01N37/04 , A01N37/06 , A01N37/10 , A01N37/36 , A01N43/54 , A01N2300/00 , C08L33/10
Abstract: Methods of forming antimicrobial polymeric materials comprising metallic nanoparticles are disclosed. Such methods generally comprise: combining a metal-containing material with a resin in situ; and curing the resin in the presence of a metal-containing material. Antimicrobial polymeric materials formed by said methods are also disclosed.
Abstract translation: 公开了形成包含金属纳米颗粒的抗微生物聚合材料的方法。 这样的方法通常包括：将含金属的材料与树脂原位混合; 并在含金属材料的存在下固化树脂。 还公开了通过所述方法形成的抗微生物聚合物材料。
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255.发明申请公开(公告)号：US20140195094A1
公开(公告)日：2014-07-10
申请号：US13866513
申请日：2013-04-19
Inventor： Dan O. Popa , Rakesh Murthy , Aditya N. Das
CPC classification number: B25J9/1697 , B25J7/00 , B62D57/02
Abstract: Robots, controllers, systems, and methods for microcrawler robots (e.g., with stick-slip gaited locomotion and/or with power multiplexing between actuators).
Abstract translation: 用于微型履带式机器人的机器人，控制器，系统和方法（例如，具有粘滑步态运动和/或在致动器之间具有功率复用）。
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Patent Agency Ranking
公开(公告)号：US20140080772A1
公开(公告)日：2014-03-20
申请号：US14019258
申请日：2013-09-05
Inventor： Sean MORRISON , Elena PISKOUNOVA , Ugur ESKIOCAK
IPC: A61K31/7048 , A61N5/10 , A61K31/585 , A61K31/404 , A61K31/506
CPC classification number: A61K31/7048 , A61B18/1815 , A61B2018/1807 , A61F9/0079 , A61K31/404 , A61K31/506 , A61K31/585 , A61K31/655 , A61K45/06 , A61N5/10 , A61N2005/0661 , A61K2300/00
Abstract: The present invention relates to mono- and combination therapies for melanoma, and in particular, metastatic melanoma. Drugs for use in such therapies in include RO 31-8220, bafetinib, and cardiac glycosides.
Abstract translation: 本发明涉及黑素瘤，特别是转移性黑素瘤的单一和组合疗法。 用于此类疗法的药物包括RO 31-8220，巴菲替尼和强心苷。
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公开(公告)号：US08633634B2
公开(公告)日：2014-01-21
申请号：US13680043
申请日：2012-11-17
Inventor： Erika Fuentes-Fernandez , Pradeep Shah , Wardia Mechtaly-Debray , Bruce E. Gnade
IPC: H01L41/113 , H01L41/083
CPC classification number: H01L41/1136 , B81C1/00388 , B81C1/00539 , H01L41/0477 , H01L41/083 , H01L41/18 , H01L41/31 , H01L41/332 , H02N2/181 , H02N2/186
Abstract: The claimed invention is directed to integrated energy-harvesting piezoelectric cantilevers. The cantilevers are fabricated using sol-gel processing using a sacrificial poly-Si seeding layer. Improvements in film microstructure and electrical properties are realized by introducing a poly-Si seeding layer and by optimizing the poling process.
Abstract translation: 所要求保护的发明涉及集成的能量收集压电悬臂。 使用溶胶 - 凝胶加工制造悬臂，使用牺牲多晶硅接种层。 通过引入多晶硅晶种层并优化极化过程，可以实现薄膜微结构和电性能的改善。
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258.发明申请公开(公告)号：US20130302245A1
公开(公告)日：2013-11-14
申请号：US13864986
申请日：2013-04-17
Inventor： David J. YANG , Chang-sok OH , Saady KOHANIM , Dongfang YU , Richard MENDEZ , E. Edmund KIM
CPC classification number: A61K51/0497 , A61K31/165 , C07C235/34 , C07F13/00 , C07F13/005
Abstract: Compositions and methods for imaging and for chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns agents comprising a targeting moeity comprising a beta-adrenergic receptor targeting compound conjugated or embedded with ethylenediamine. The present invention also concerns methods of application of such agents for imaging and treatment of cardiovascular diseases, and kits for preparing a radiolabeled therapeutic or diagnostic agent.
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259.发明申请Methods and Apparatuses for Integrated Packaging of Microelectromechanical Devices 审中-公开微机电器件集成封装的方法与装置公开(公告)号：US20130260503A1
公开(公告)日：2013-10-03
申请号：US13903363
申请日：2013-05-28
Inventor： Donald P. Butler , Zeynep Celik-Butler , Murali M. Chitteboyina , Mohammad S. Rahman
IPC: B81C1/00
CPC classification number: B81C1/00134 , B81C1/00333 , B81C2203/0145
Abstract: Microelectromechanical systems (MEMS) packages, packaged MEMS devices, and methods for making the same are disclosed. The method may include forming a chamber sacrificial layer above an insulating layer that is coupled to a wafer. The method further may include forming a packaging layer above the chamber sacrificial layer. The method additionally may include forming one or more openings through the packaging layer. The method also may include removing the chamber sacrificial layer through the one or more openings. The method may include forming a sealing layer above the packaging layer such that the sealing layer substantially seals the one or more openings to form a hermetic cavity.
Abstract translation: 公开了微机电系统（MEMS）封装，封装的MEMS器件及其制造方法。 该方法可以包括在耦合到晶片的绝缘层上方形成腔室牺牲层。 该方法还可以包括在腔室牺牲层上方形成包装层。 该方法另外可以包括通过包装层形成一个或多个开口。 该方法还可以包括通过一个或多个开口去除腔室牺牲层。 该方法可以包括在包装层之上形成密封层，使得密封层基本上密封一个或多个开口以形成密封腔。
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公开(公告)号：US20130240483A1
公开(公告)日：2013-09-19
申请号：US13875871
申请日：2013-05-02
Applicant: The Board of Regents of the University of Texas System , THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
Inventor： Mauro FERRARI , Xuewu LIU , Alessandro GRATTONI , Daniel FINE , Randy GOODALL , Sharath HOSALI , Ryan MEDEMA , Lee HUDSON
IPC: A61M37/00
CPC classification number: A61M5/00 , A61K9/0097 , A61M5/14276 , A61M37/00 , B81B2201/058 , B81B2203/0338 , B81C1/00119 , B82Y5/00 , Y10T137/8593 , Y10T156/1064
Abstract: A nanochannel delivery device and method of manufacturing and use. The nanochannel delivery device comprises an inlet, an outlet, and a nanochannel. The nanochannel may be oriented parallel to the primary plane of the nanochannel delivery device. The inlet and outlet may be in direct fluid communication with the nanochannel.
Abstract translation: 一种纳米通道输送装置及其制造和使用方法。 纳米通道递送装置包括入口，出口和纳米通道。 纳米通道可以平行于纳米通道递送装置的主平面定向。 入口和出口可以与纳米通道直接流体连通。
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