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    LYOPHILIZATION METHOD AND DEVICE
    261.
    发明申请
    LYOPHILIZATION METHOD AND DEVICE 有权
    LYOPHILIZATION方法和设备

    公开(公告)号：US20100154245A1

    公开(公告)日：2010-06-24

    申请号：US12534730

    申请日：2009-08-03

    Applicant: Daniel Py

    Inventor： Daniel Py

    IPC: F26B5/04 ,  B65B31/02 ,  B65B1/04

    CPC classification number: B65B55/08 ,  A61J1/1425 ,  A61J1/1431 ,  A61J1/1468 ,  A61J1/1481 ,  A61J1/1487 ,  A61J1/18 ,  A61J1/2037 ,  A61J1/2041 ,  A61J1/2055 ,  A61J1/2096 ,  A61M2207/00 ,  B65B3/003 ,  B65D47/248

    Abstract: A lyophilization device configured for use in a lyophilization process has a body defining a chamber for receiving a liquid to be lyophilized, and a stopper creating a liquid-tight seal between the chamber and ambient atmosphere to form a sealed, empty sterile chamber. The stopper is adapted so that the chamber may be sterile filled with the substance through the stopper. A fluid passageway is formed through the stopper, through which the chamber is evacuated. The substance is lyophilized, the fluid passageway is closed, and the lyophilized substance is hermetically sealed within the chamber.

    Abstract translation: 构造成用于冻干过程的冻干装置具有限定用于接收要冷冻干燥的液体的室的主体和在室与环境大气之间形成液密密封的塞子，以形成密封的空的无菌室。 塞子适于使得腔室可以通过止动器无菌地填充物质。 通过塞子形成流体通道，通过该塞子抽空腔室。 物质被冻干，流体通道关闭，冻干物质密封在腔室内。

    Sealed containers and methods of making and filling same
    262.
    发明授权
    Sealed containers and methods of making and filling same 有权
    密封容器及其制造和填充方法

    公开(公告)号：US07726352B2

    公开(公告)日：2010-06-01

    申请号：US11515162

    申请日：2006-09-01

    Applicant: Daniel Py ,  Norbert M. Assion

    Inventor： Daniel Py ,  Norbert M. Assion

    IPC: B65B1/20 ,  B65B51/10

    CPC classification number: B65B3/003 ,  A61J1/1406 ,  A61J1/1412 ,  A61J1/1425 ,  A61J1/1431 ,  A61J1/1468 ,  A61J1/18 ,  A61J1/201 ,  A61J1/2013 ,  A61J1/2055 ,  A61J1/2075 ,  A61J1/2096 ,  A61M2207/00 ,  A61M2209/045 ,  B65B3/027 ,  B65B7/161 ,  B65B51/10 ,  B65B55/08 ,  B65B2039/009 ,  B65D51/002

    Abstract: Disclosed is a uniquely configured medicament vial assembly which includes a storage vial, a stopper member and a securing ring. The vial assembly is configured to improve healthcare worker safety by providing a shielded gripping location to aid in the reduction of accidental needle sticks. The storage vial has a body portion which defines an interior chamber for storing a predetermined medicament and a neck portion through which medicament is received into and withdrawn from the interior chamber. The stopper member is inserted into the mouth of the vial and establishes a first seal. The securing ring is engaged with the mouth of the vial and adapted and configured for retaining the stopper member within the vial mouth and effectuating a second seal. The securing ring is formed from a thermoplastic and/or elastic material. Preferably, the securing ring is formed by molding the thermoplastic and/or elastic material over a portion of the storage vial and stopper member when engaged within the vial mouth.

    Abstract translation: 公开了一种独特构造的药物小瓶组件，其包括存储小瓶，止动构件和固定环。 小瓶组件被配置成通过提供屏蔽夹持位置来帮助减少意外的针棒来改善医护人员的安全性。 存储小瓶具有主体部分，其限定用于存储预定药物的内部腔室和颈部部分，药物通过所述颈部部分容纳到内部腔室中并从内部腔室中排出。 止动件插入小瓶的口中并建立第一密封。 固定环与小瓶的口接合并适于和构造成将止动件保持在小瓶口内并实现第二密封。 固定环由热塑性和/或弹性材料形成。 优选地，固定环通过在接合在小瓶口中时将热塑性和/或弹性材料模制在存储小瓶和止动构件的一部分上而形成。

    Delivery device and method of delivery
    263.
    发明授权
    Delivery device and method of delivery 失效
    送货装置和送货方式

    公开(公告)号：US07678089B2

    公开(公告)日：2010-03-16

    申请号：US10990164

    申请日：2004-11-15

    Applicant: Daniel Py ,  Julian V. Chan ,  Jeffrey M. Atwood

    Inventor： Daniel Py ,  Julian V. Chan ,  Jeffrey M. Atwood

    IPC: A61H33/04 ,  A61M35/00 ,  B67D5/42 ,  G01F11/00

    CPC classification number: B05B11/007 ,  A61F9/0008 ,  A61M11/007 ,  A61M15/08 ,  A61M35/003 ,  A61M2210/0612 ,  B05B11/00412 ,  B05B11/00416 ,  B05B11/0056 ,  B05B11/0072 ,  B05B11/3004 ,  B05B11/3056 ,  B05B11/307 ,  B05B11/3074 ,  B05B11/3077

    Abstract: An ophthalmic delivery device includes a body defining a fluid reservoir and a pump in fluid communication with the reservoir. The delivery device also includes a nozzle that includes a dosage chamber for holding a dosage of fluid, a valve seat, and a valve cover. The valve cover extends about the valve seat and forms an interface therebetween and the valve seat includes an outlet aperture. The interface is in fluid communication with the outlet aperture and the dosage chamber, and at least part of the valve cover is movable between (i) a closed position with the valve cover engaging the valve seat to close the interface and form a fluid-tight seal therebetween, and (ii) an open position with at least part of the valve cover spaced away from the valve seat in response to fluid flowing through the outlet aperture at a pressure greater than a valve opening pressure to allow the passage of pressurized fluid therebetween. The valve seat and the valve cover are dimensioned to dispense the dosage of fluid through the interface at a velocity of equal to or less than 6 meters per second.

    Abstract translation: 眼科输送装置包括限定流体储存器的主体和与储存器流体连通的泵。 输送装置还包括喷嘴，该喷嘴包括用于保持一定量的流体的剂量室，阀座和阀盖。 阀盖围绕阀座延伸并且在它们之间形成界面，并且阀座包括出口孔。 所述界面与所述出口孔和所述剂量室流体连通，并且所述阀盖的至少一部分可在（i）与所述阀盖接合所述阀座的关闭位置之间移动以关闭所述界面并形成流体密封 密封在其间，和（ii）打开位置，其中阀盖的至少一部分响应于流体以大于阀打开压力的压力流过出口孔而与阀座间隔开，以允许加压流体在其间通过 。 阀座和阀盖的尺寸设计为以等于或小于6米/秒的速度通过界面分配流体的剂量。

    Sterile de-molding apparatus and method
    269.
    发明授权
    Sterile de-molding apparatus and method 有权
    无菌脱模装置及方法

    公开(公告)号：US07490453B2

    公开(公告)日：2009-02-17

    申请号：US11374522

    申请日：2006-03-13

    Applicant: Daniel Py ,  Benoit Adamo ,  John Guthy ,  Nathaniel Houle ,  Jeffrey Willey

    Inventor： Daniel Py ,  Benoit Adamo ,  John Guthy ,  Nathaniel Houle ,  Jeffrey Willey

    IPC: B65B3/02 ,  B65B5/02

    CPC classification number: B65B3/022

    Abstract: Apparatus for molding and filling a container having a container body defining an opening in communication with an interior chamber for receiving a substance therein, and a container closure including stopper receivable within the opening for sealing the opening and substance received in the container. A mold includes within the aseptic chamber plural mold cavities shaped to form the container closure and container body, and substantially sterile surfaces extending about and contiguous to the peripheries of the mold cavities. An assembly device including end-of-arm tooling having an engaging portion engageable with each of the container body and container closure is movable relative to the mold to engage and de-mold the substantially sterile container closure and container bodies from the mold cavities. Flexible barriers are coupled to the mold and the tool to substantially prevent the passage of contaminants from the molding machine and tool therethrough.

    Abstract translation: 用于模制和填充具有容器主体的容器的装置，所述容器主体限定与用于在其中容纳物质的内部腔室连通的开口，容器封闭件包括可接收在开口内的止动件，用于密封容纳在容器中的开口和物质。 模具包括在无菌室内的多个模腔，其形状形成容器封闭件和容器主体，以及基本上无菌的表面，其围绕并邻近模具腔的周边延伸。 一种组装装置，其包括具有可与容器主体和容器封闭件中的每一个接合的接合部分的臂端工具相对于模具可移动以将基本无菌的容器封闭物和容器主体与模腔接合和脱模。 柔性屏障耦合到模具和工具，以基本上防止污染物从模制机器和工具通过。

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