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公开(公告)号：US09760772B2
公开(公告)日：2017-09-12
申请号：US14663771
申请日：2015-03-20
发明人： William Maher , Dixon Cleveland
CPC分类号： G06K9/00604 , G06T7/73 , G06T2207/10016
摘要： A system and method are disclosed for using a camera image of a user's eye as a visual stimulus for the calibration point in an eyetracking calibration system. A camera image of a user's eye is generated on a user display using an eyetracker. The camera image of the user's eye is used as a visual stimulus of a calibration point. In an embodiment, the center of the pupil of the camera image of the user's eye represents the coordinates of the calibration point on the user display. In another embodiment, the center of the corneal reflection of the camera image of the user's eye represents the coordinates of the calibration point on the user display.
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22.发明授权公开(公告)号：US09733214B2
公开(公告)日：2017-08-15
申请号：US15107455
申请日：2015-02-10
发明人： Christie L. Hunter , David M. Cox
CPC分类号： G01N27/622 , G01N30/7233 , H01J49/0027 , H01J49/004
摘要： MRM triggered MRM, where the triggered MRM transitions make use of mobility device parameter values for the same compound, is performed. A plurality of primary MRM transitions are received and stored together with a mobility device parameter value for each transition as an MRM cycle list. Control information instructs a mobility device and a mass spectrometer to interrogate each MRM transition on the MRM cycle list within an MRM cycle of the mass spectrometer. If a product ion intensity value of an MRM transition exceeds a threshold value for a primary MRM transition, a plurality of secondary MRM transitions of the primary MRM transition with different mobility device parameter values are added to the MRM cycle list. The intensities of the measured secondary MRM transitions provide information on the optimum mobility device parameter for each compound.
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公开(公告)号：US09691595B2
公开(公告)日：2017-06-27
申请号：US14964417
申请日：2015-12-09
CPC分类号： H01J49/0081 , H01J49/0027 , H01J49/0031 , H01J49/004
摘要： Systems and methods are used to analyze a sample using variable detection scan resolutions. A tandem mass spectrometer is instructed to perform at least two scans of a sample with different detection scan resolutions using a processor. The tandem mass spectrometer includes a mass analyzer that allows variable detection scan resolutions. The selection of the different detection scan resolutions can be based on one or more properties of sample compounds. The properties may include a sample compound molecular weight distribution that is calculated from a molecular weight distribution of expected compounds or is determined from a list of molecular weights for one or more known compounds. The tandem mass spectrometer can also be instructed to perform an analysis of the sample before instructing the tandem mass spectrometer to perform the at least two scans of the sample.
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公开(公告)号：US09685312B2
公开(公告)日：2017-06-20
申请号：US14887215
申请日：2015-10-19
发明人： Stephen A. Tate , Nic G. Bloomfield
CPC分类号： H01J49/06 , H01J49/0031 , H01J49/004 , H01J49/429
摘要： Systems and methods are used to band-pass filter ions from a mass range. A full spectrum is received for a full scan of a mass range using a tandem mass spectrometer. A mass selection window of the full spectrum is selected and a set of tuning parameter values is selected. The tandem mass spectrometer is instructed to perform a scan of the mass selection window using the set of tuning parameter values. A spectrum is received for the scan from the tandem mass spectrometer. A band-pass filtered spectrum is created for the mass range that includes values from the spectrum for the mass selection window of the mass range. Systems and methods are also used to band-pass filter ions from two or more mass selection windows across the mass range and to filter out ions from a mass selection window between two band-pass mass selection windows.
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公开(公告)号：US09491298B2
公开(公告)日：2016-11-08
申请号：US14977510
申请日：2015-12-21
申请人： Empire IP LLC
发明人： Timothy Salmon
CPC分类号： H04M3/533 , G10L15/26 , H04M1/7255 , H04M3/53333 , H04M3/53366 , H04M7/0054 , H04M2201/60 , H04M2203/4536 , H04W4/14
摘要： Described is a system and method for processing a voice mail. The method comprises receiving a voice mail, converting the voice mail into a text message using a predefined speech-to-text conversion algorithm and transmitting the text message to a wireless computing device.
摘要翻译： 描述了用于处理语音邮件的系统和方法。 该方法包括接收语音邮件，使用预定义的语音到文本转换算法将语音邮件转换成文本消息，并将文本消息发送到无线计算设备。
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26.发明授权公开(公告)号：US09390238B2
公开(公告)日：2016-07-12
申请号：US14365983
申请日：2012-11-28
CPC分类号： G06F19/703 , H01J49/0031 , H01J49/004
摘要： In a first location of a mass spectrometer, a plurality of ionized molecules of an ion source are selected that have mass-to-charge ratios within a mass-to-charge ratio window width. The plurality of selected ionized molecules are transmitted from a first to a second location. Reagent ions are transmitted to the second location to reduce a charge state of one or more of the plurality of selected ionized molecules. A mass analyzer is used to analyze the plurality of reduced ionized molecules and produce a mass spectrum. A compound is identified from a peak of the spectrum that has a mass-to-charge ratio less than or equal to the highest mass-to-charge ratio in the window width if the noise is multiply charged and greater than the highest mass-to-charge ratio in the window width if the noise is singly charged.
摘要翻译： 在质谱仪的第一位置，选择离子源的多个离子化分子，其具有在质荷比窗口宽度之内的质荷比。 多个选择的电离分子从第一位置传递到第二位置。 试剂离子被传递到第二位置以减少多个选定的电离分子中的一个或多个的电荷状态。 质量分析器用于分析多个还原离子化分子并产生质谱。 如果噪声是多次充电并且大于最高质量 - 到达的质量 - 荷电比，如果光谱的峰值具有小于或等于窗口宽度中的最高质荷比的化合物， 如果噪声被单独充电，则窗口宽度的充电比例。
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公开(公告)号：US09373486B2
公开(公告)日：2016-06-21
申请号：US14889137
申请日：2014-05-19
发明人： Stephen Lock
CPC分类号： H01J49/0036 , G01N33/12 , G01N33/6848 , H01J49/0031 , H01J49/004
摘要： Systems and methods are provided for species detection using mass spectrometry. In various embodiments, a multiple reaction monitoring (MRM) experiment is performed on a sample targeting one or more peptide transitions that are unique to one or more species using a tandem mass spectrometer. One or more measured product ion spectra are received from the tandem mass spectrometer using the processor. The one or more measured product ion spectra are compared to product ions of the one or more peptide transitions that are unique to one or more species using the processor. One or more species of the sample are detected by reporting product ions of the one or more peptide transitions that are unique to one or more species that match the one or more measured product ion spectra using the processor.
摘要翻译： 提供了使用质谱法进行物种检测的系统和方法。 在各种实施方案中，对使用串联质谱仪对一种或多种物种特有的一个或多个肽过渡的样品进行多重反应监测（MRM）实验。 使用处理器从串联质谱仪接收一个或多个测量的产物离子光谱。 将一个或多个测量的产物离子光谱与使用该处理器的一种或多种物种特有的一个或多个肽转换的产物离子进行比较。 通过报告使用处理器与一个或多个测量产物离子光谱相匹配的一种或多种物种独特的一个或多个肽转换的产物离子来检测样品的一种或多种。
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28.发明授权Data independent acquisition of product ion spectra and reference spectra library matching 有权数据独立采集产品离子谱和参考光谱库匹配公开(公告)号：US09343278B2
公开(公告)日：2016-05-17
申请号：US14741948
申请日：2015-06-17
发明人： Ronald F. Bonner , Stephen A. Tate , Rudolf Aebersold , Pedro Jose Navarro Alvarez , Oliver Rinner , Lukas Reiter , Ludovic Gillet
CPC分类号： H01J49/0036 , G01N30/7233 , G06F19/703 , G06F19/709 , H01J49/0031 , H01J49/004 , H01J49/0045 , H01J49/42
摘要： Systems and methods are disclosed for quantitating detectable compounds of a sample. Sample product ion spectra are received for each mass selection window for each time step. The received sample product ion spectra are searched for the presence of known compounds of interest with known product ion spectra by retrieving the known product ion spectra from a library, retrieving the sample product ion spectra corresponding to the precursor mass selection window expected to contain a precursor ion corresponding to the known product ion spectra, generating product ion traces in time for the sample product ion spectra for the known product ion spectra, calculating a score for the product ion traces and product ion spectra that represents how well known product ions and sample product ions match, and calculating a quantitative value for the known compound from the product ion traces when the score exceeds a threshold value.
摘要翻译： 公开了用于定量可检测的样品化合物的系统和方法。 为每个时间步长的每个质量选择窗口接收样品产品离子光谱。 通过从文库检索已知的产物离子光谱，检索所接收的样品产物离子光谱，获得已知产物离子光谱的已知化合物的存在，检索对应于期望含有前体的前体质量选择窗口的样品产物离子谱 离子对应于已知的产物离子光谱，为已知产物离子光谱的样品产物离子光谱及时产生产物离子痕迹，计算产物离子痕迹和产物离子光谱的得分，其表示众所周知的产物离子和样品产物 离子匹配，并且当分数超过阈值时，从产物离子迹线计算已知化合物的定量值。
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公开(公告)号：US09269553B2
公开(公告)日：2016-02-23
申请号：US13876349
申请日：2011-11-02
申请人： Ronald F. Bonner , Stephen A. Tate
发明人： Ronald F. Bonner , Stephen A. Tate
CPC分类号： H01J49/0045 , H01J49/0027 , H01J49/0031 , H01J49/04
摘要： Systems and methods are used to rapidly screening samples. A fast sample introduction device that is non-chromatographic is instructed to supply each sample of a plurality samples to a tandem mass spectrometer using a processor. The fast sample introduction device can include a flow injection analysis device, an ion mobility analysis device, or a rapid sample cleanup device. The tandem mass spectrometer is instructed to perform fragmentation scans at two or more mass selection windows across a mass range of each sample of the plurality of samples using the processor. The two or more mass selection windows across the mass range can have fixed or variable window widths. The tandem mass spectrometer can be instructed to obtain a mass spectrum of the mass range before instructing the tandem mass spectrometer to perform the fragmentation scans.
摘要翻译： 系统和方法用于快速筛选样品。 指示非色谱的快速样品引入装置使用处理器将多个样品的每个样品提供给串联质谱仪。 快速样品引入装置可以包括流动注射分析装置，离子迁移率分析装置或快速样品清除装置。 指示串联质谱仪在使用处理器的多个采样的质量范围的两个或更多个质量选择窗口上进行碎片扫描。 跨质量范围的两个或多个质量选择窗口可以具有固定或可变窗口宽度。 在指示串联质谱仪进行碎片扫描之前，可以指示串联质谱仪获得质量范围的质谱。
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30.发明授权Modulation of instrument resolution dependant upon the complexity of a previous scan 有权根据先前扫描的复杂度调制仪器分辨率公开(公告)号：US09236231B2
公开(公告)日：2016-01-12
申请号：US14401034
申请日：2013-04-19
CPC分类号： H01J49/0081 , H01J49/0027 , H01J49/0031 , H01J49/004
摘要： Systems and methods are used to analyze a sample using variable detection scan resolutions. A tandem mass spectrometer is instructed to perform at least two scans of a sample with different detection scan resolutions using a processor. The tandem mass spectrometer includes a mass analyzer that allows variable detection scan resolutions. The selection of the different detection scan resolutions can be based on one or more properties of sample compounds. The properties may include a sample compound molecular weight distribution that is calculated from a molecular weight distribution of expected compounds or is determined from a list of molecular weights for one or more known compounds. The tandem mass spectrometer can also be instructed to perform an analysis of the sample before instructing the tandem mass spectrometer to perform the at least two scans of the sample.
摘要翻译： 系统和方法用于使用可变检测扫描分辨率分析样本。 指示串联质谱仪使用处理器对具有不同检测扫描分辨率的样品进行至少两次扫描。 串联质谱仪包括质量分析仪，允许可变检测扫描分辨率。 不同检测扫描分辨率的选择可以基于样品化合物的一种或多种性质。 性质可以包括根据预期化合物的分子量分布计算的样品化合物分子量分布，或由一种或多种已知化合物的分子量列表确定。 也可以指示串联质谱仪在指示串联质谱仪进行样品的至少两次扫描之前对样品进行分析。
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