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公开(公告)号：US10377811B2
公开(公告)日：2019-08-13
申请号：US16267647
申请日：2019-02-05
发明人： Andrea Mahr , Toni Weinschenk , Anita Wiebe , Oliver Schoor , Jens Fritsche , Harpreet Singh
IPC分类号： C07K14/74 , C07K14/47 , C07K7/06 , C07K16/28 , C12N15/115 , C12N5/0783 , G01N33/574 , C12Q1/6886 , G01N33/50 , C07K7/08 , A61K39/00 , C07K14/725 , C07K16/30
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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22.发明授权公开(公告)号：US10377787B2
公开(公告)日：2019-08-13
申请号：US15112724
申请日：2014-12-23
发明人： Stefan Jennewein
摘要： The present application discloses a simple process for the purification of neutral human milk oligosaccharides (HMOs) produced by microbial fermentation. The process uses a combination of a cationic ion exchanger treatment, an anionic ion exchanger treatment, and a nanofiltration and/or electrodialysis step, which allows efficient purification of large quantities of neutral HMOs at high purity. Contrary to the purification currently used in fermentative production of neutral HMOs, the presented process allows the provision of HMOs without the need of a chromatographic separation. The so purified HMOs may be obtained in solid form by spray drying, as crystalline material or as sterile filtered concentrate. The provided HMOs are free of proteins and recombinant material originating from the used recombinant microbial strains and thus very well-suited for use in food, medical food and feed (e.g. pet food) applications.
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公开(公告)号：US10370014B2
公开(公告)日：2019-08-06
申请号：US16166945
申请日：2018-10-22
申请人： Bayer CropScience LP
发明人： Kris Matson , Pascal Day , Lloyd Hinnant , Alvaro Ortiz Fernandez , Eduardo Back , Jonathon Brent Slone
摘要： The present disclosure relates generally to vegetation detection and, in particular, to a vegetation detection and alert system for a railway vehicle.
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公开(公告)号：US10369542B2
公开(公告)日：2019-08-06
申请号：US15305341
申请日：2015-04-20
摘要： The present invention relates to a multistage stirred reactor, comprising a multiplicity of mutually adjacent reaction chambers and stirring elements for mixing the contents of at least one of the reaction chambers, wherein, between adjacent reaction chambers, there is in each case provided at least one opening that can be closed by means of closure means, such that in the open state there is a fluidic connection between the adjacent reaction chambers and in the closed state the adjacent reaction chambers are separated from one another. At least one of the closure means (300, 310, 320) is connected to an actuation rod (500, 510, 520) that is guided out of the stirred reactor. The actuation rod (500, 510, 520) can be moved back and forth between at least one first position and a second position, by rotation and/or displacement, wherein in the first position closure means (300, 310, 320) that are connected to the actuation rod (500, 510, 520) effect an open state of the opening assigned to them and in the second position closure means (300, 310, 320) that are connected to the actuation rod (500, 510, 520) effect a closed state of the opening assigned to them.
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25.发明授权公开(公告)号：US10364271B2
公开(公告)日：2019-07-30
申请号：US16179677
申请日：2018-11-02
IPC分类号： A61K38/00 , C07K7/06 , C12N5/0783 , C12Q1/6886 , G01N33/574 , G16B35/00 , G16C20/60 , C07K14/74 , C07K14/47 , A61K39/00
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to several novel peptide sequences and their variants derived from HLA class I and HLA class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
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公开(公告)号：US10357552B2
公开(公告)日：2019-07-23
申请号：US16054561
申请日：2018-08-03
发明人： Andrea Mahr , Toni Weinschenk , Oliver Schoor , Jens Fritsche , Harpreet Singh , Colette Song
IPC分类号： A61K39/00 , G16B25/00 , A61K35/17 , C07K16/18 , C12N5/0783 , C12N15/115 , C07K14/74 , C07K16/28 , C07K16/30 , C07K14/47 , A61K35/12 , C07K14/705
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US10335471B2
公开(公告)日：2019-07-02
申请号：US15249083
申请日：2016-08-26
发明人： Andrea Mahr , Toni Weinschenk , Oliver Schoor , Jens Fritsche , Harpreet Singh
IPC分类号： A61K39/00 , C12N15/115 , C07K7/06 , C07K7/08 , C07K14/725 , C07K14/74 , C07K16/30 , C12N5/0783 , C12Q1/6886 , G01N33/574 , C07K16/28
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US10334854B2
公开(公告)日：2019-07-02
申请号：US15568081
申请日：2016-04-25
发明人： Jörg Oeser , Petra Gür , Michael Schwarz
摘要： The present invention primarily relates to specific herbicide combinations comprising (i) glufosinate and/or salts thereof and (ii) indaziflam and to compositions comprising said specific herbicide combinations. The present invention further relates to a method of producing said specific herbicide combinations and compositions comprising said specific herbicide combinations. The present invention also relates to the use of said specific herbicide combinations and compositions comprising said specific herbicide combinations in the field of agriculture, in particular as plant growth regulators and for controlling harmful plants or undesired plant growth, as well as to corresponding methods.
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公开(公告)号：US10327449B2
公开(公告)日：2019-06-25
申请号：US15716218
申请日：2017-09-26
申请人： DSM IP ASSETS B.V.
摘要： A variant polypeptide having alpha-amylase activity, wherein the variant has an amino acid sequence which, when aligned with the alpha-amylase comprising the sequence set out in SEQ ID NO: 2, comprises at least one substitution of an amino acid residue. Such a variant polypeptide may be used in the preparation of a baked product.
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公开(公告)号：US10323355B2
公开(公告)日：2019-06-18
申请号：US16021387
申请日：2018-06-28
申请人： PLANTICS B.V.
摘要： A composite material comprising 10-98 wt. % of a bio-based particulate or fibrous filler and at least 2 wt. % of a polyester derived from an aliphatic polyalcohol with 2-15 carbon atoms and a polyacid, wherein the polyacid comprises at least 10 wt. % of tricarboxylic acid. Preferably, the filler is in the form of particles, fibers, and/or random or non-random layers. A plant-based filler may be used, in particular a cellulosic or lignocellulosic material, more in particular one or more materials selected from wood chips, wood flakes, sawdust, pulp, e.g., pulp of (recycled) paper or other fiber pulp, and plant-derived fibers such as cotton, linen, flax, and hemp. An animal-derived filler, in particular an animal-derived fiber such as wool, hair, silk, or feathers may also be used. Preferably the polyalcohol is selected from one or more of glycerol, sorbitol, xylitol, mannitol, 1,2-propane diol, 1,3-propane diol, and 1,2-ethane diol, in particular glycerol. The polyacid preferably is an aliphatic diacid or triacid with 3-15 carbon atoms. Examples of suitable acids include citric acid, succinic acid, and itaconic acid. The composite material according to the invention has fire-retardant properties, which makes it particularly suitable for applications where fire-retardancy is an issue.
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