公开(公告)号：US11297810B2

公开(公告)日：2022-04-12

申请号：US16296033

申请日：2019-03-07

申请人： Kymab Limited

发明人： Allan Bradley ,  E-Chiang Lee ,  Qi Liang ,  Wei Wang ,  Dominik Spensberger ,  Hui Liu ,  Jasper Clube

IPC分类号： A01K67/027 ,  C12P21/00 ,  C07K16/06 ,  C07K16/12 ,  C07K16/18 ,  C07K16/46 ,  C07H21/04 ,  C12N15/85

摘要： The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising the antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in the methods.

公开(公告)号：US11277365B2

公开(公告)日：2022-03-15

申请号：US17131735

申请日：2020-12-22

申请人： Mimecast North America, Inc.

发明人： Paul Everton

IPC分类号： H04L12/58 ,  G06Q10/10 ,  G06Q50/30 ,  H04L51/10 ,  H04L51/00 ,  H04L51/42

摘要： A mail transfer agent comprises processing circuitry, storage circuitry, and networking circuitry. The storage circuitry holds a database. The networking circuitry is operable to receive, via a network connection, an email message. The processing circuitry is operable to analyze the email message to detect an image present in the email message. The processing circuitry is operable to determine, based on one or more records of the database, that the detected image is associated with a particular brand, and process the email message based on whether one or more characteristics of the email message are associated with the particular brand in the database. The one or more characteristics of the email message may comprise one or more of: sender domain, sender subdomain, and sender IP address.

公开(公告)号：US11250529B2

公开(公告)日：2022-02-15

申请号：US15263958

申请日：2016-09-13

申请人： Intergraph Corporation

发明人： Heather Ruth Kyemba ,  Joshua Bret Cooley

IPC分类号： G06Q50/26 ,  G06Q10/06 ,  G06Q10/04 ,  G06Q10/08

摘要： Embodiments of the present invention disclose a computer-implemented methodology for automatically indicating in a computer-aided dispatch system for a plurality of assignable participants, such as emergency vehicles, to be dispatched to one of a plurality of facilities, whether a facility is in a diverting status or a receiving status. A centralized database receives a change in status for a vehicle for use in determining the status of a facility. In response to receiving the change in status for the vehicle, the status information about the vehicle including a current status and a prior status is transmitted to one or more client programs. A client program receives the current status and the prior status of the vehicle and uses the current status and prior status of the vehicle along with a criteria set to determine if any of the plurality of facilities' status should be changed from receiving to diverting or from diverting to receiving.

公开(公告)号：US11222161B1

公开(公告)日：2022-01-11

申请号：US16920066

申请日：2020-07-02

申请人： Hexagon Technology Center GmbH

发明人： Keith D. Harvey

IPC分类号： G06F40/103 ,  G06F16/22 ,  G06F16/2457 ,  G06F16/25

摘要： Various embodiments improve the legibility of a column of data, displayed at an initial size in a grid, by magnifying the column, while maintaining neighboring columns at their initial size, and maintaining the magnified column in the context of neighboring columns.

公开(公告)号：US11205858B1

公开(公告)日：2021-12-21

申请号：US16653348

申请日：2019-10-15

申请人： Anokiwave, Inc.

发明人： Jason Durbin ,  Nitin Jain

IPC分类号： H01Q21/22 ,  H01Q3/26 ,  H01Q3/24

摘要： This patent application describes systems, devices, and methods for element-level self-calculation of phased array vectors by a beam forming ASIC using direct calculation such as for fast beam steering.

公开(公告)号：US11198950B2

公开(公告)日：2021-12-14

申请号：US16811926

申请日：2020-03-06

申请人： M7D Corporation

发明人： John P. Ciraldo ,  Jonathan Levine-Miles

IPC分类号： C30B25/22 ,  C30B25/12 ,  C30B29/04 ,  C30B29/68

摘要： A method of forming a plurality of diamonds provides a base, epitaxially forms a first sacrificial layer on the base, and then epitaxially forms a first diamond layer on the first sacrificial layer. The first sacrificial layer has a first material composition, and the first diamond layer is a material that is different from the first material composition. The method then epitaxially forms a second sacrificial layer on the first diamond layer, and epitaxially forms a second diamond layer on the second sacrificial layer. The second sacrificial layer has the first material composition. The base, first and second sacrificial layers, and first and second diamond layers form a heteroepitaxial super-lattice.

公开(公告)号：US11168315B2

公开(公告)日：2021-11-09

申请号：US16790315

申请日：2020-02-13

申请人： Lallemand Hungary Liquidity Management LLC

发明人： John McBride ,  Erin Wiswall

IPC分类号： C12N9/30 ,  C12N15/00 ,  C12N1/20 ,  C12N9/42 ,  C12N15/81 ,  C12P7/10 ,  C12P19/14 ,  C07C29/86 ,  C12P19/02

摘要： The present invention provides for heterologous expression of beta-glucosidase (BGL) polypeptides encoded by Humicola grisea, Candida wickerhamii, Aspergillus aculeatus, Aspergillus oryzae, Penicillium decumbens, Chaetomium globosum, Neocallimastix frontalis, Debaryomyces hansenii, Kluyveromyces marxianus, or Phytophthora infestans in host cells, such as the yeast Saccharomyces cerevisiae. The expression in such host cells of the corresponding genes, and variants and combinations thereof, result in improved specific activity of the expressed BGL. Thus, such genes and expression systems are useful for efficient and cost-effective consolidated bioprocessing systems.

公开(公告)号：US11148455B2

公开(公告)日：2021-10-19

申请号：US16906666

申请日：2020-06-19

申请人： Rocket Innovations, Inc.

发明人： Jacob Epstein ,  Joseph Lemay

IPC分类号： B42D13/00 ,  B42F11/04 ,  B42F9/00 ,  B42D1/06 ,  B42F1/00 ,  B42D3/12

摘要： A modular notebook system includes a cover having a plurality of surfaces. The system also includes a binding coupled to the plurality of surfaces via a flexible and/or foldable material. The binding forms a magnetic spine by having at least one magnetic pad configured to receive a magnetically attractive binding element.

公开(公告)号：US11144184B2

公开(公告)日：2021-10-12

申请号：US14162613

申请日：2014-01-23

申请人： Mineset, Inc.

发明人： Marc Hansen

IPC分类号： G06F16/26 ,  G06F3/0484

摘要： A user of a graphical visualization program controls what data is selectable through the program interface. Data for display may be grouped and assigned an opacity value. The opacity value may correspond to the number of data points within an n-dimensional grouping, a particular type or other grouping parameter. Two or more data groupings may overlap within the interface. The visualization program may set a threshold selectability level, for example based on user input. The input may be received based on an selection threshold slide bar within a graphical portion of the display. When a user selects a data grouping at a point where two or more data groupings overlap, the data groupings that satisfy the threshold selection level may be selected. Data groupings that do not satisfy the threshold selection level will not be selectable.

公开(公告)号：US11135242B2

公开(公告)日：2021-10-05

申请号：US16241127

申请日：2019-01-07

申请人： Eyeon Particle Sciences LLC

发明人： Eugene Rex Cooper ,  David Maxwell Kleinman ,  Andrew Loxley ,  Mark Mitchnick

IPC分类号： A61K31/785 ,  A61K47/10 ,  A61K47/38 ,  A61K47/44 ,  A61K9/00 ,  A61K47/34 ,  A61K47/18 ,  A61P27/00 ,  A61K9/08 ,  A61L12/14 ,  B82Y5/00 ,  A61P27/04

摘要： The invention contemplates a copolymer which is a graft or block copolymer useful to change the ocular surface temperature and other characteristics of biological or contact lens surfaces. Methods for use of these formulations and coatings to increase the temperature of the skin, mucous membranes, eye or eyelids will help treat many conditions including blepharitis and non-healing ulcers. Methods to decrease evaporation, improve wettability and stabilize the tear film, and lubricate biological surfaces in a subject, for example, in the treatment of dry eye syndrome, and to improve contact lens tolerability, are provided.