公开(公告)号：US08620422B2

公开(公告)日：2013-12-31

申请号：US11862508

申请日：2007-09-27

Applicant: Robert S. Kieval ,  Martin Rossing ,  Adam Cates ,  Alejandro Covalin

Inventor： Robert S. Kieval ,  Martin Rossing ,  Adam Cates ,  Alejandro Covalin

IPC: A61N1/36

CPC classification number: A61N1/0551 ,  A61N1/0556 ,  A61N1/0558 ,  A61N1/36114 ,  A61N1/36117

Abstract: A tissue stimulation device includes an electrode array having at least four independently switchable electrodes. In one embodiment, the electrode array comprises a flexible base to which the electrodes are fixed that flexes to encompass at least a portion of an artery or other elongate biological structure. The electrodes are electrically coupled to and energized by a signal generator coupled to a control system. In one embodiment, the array of electrodes are configured such that a suitable signal pattern for stimulation pulses between or among a set of the switchable electrodes may be determined without having to reposition the electrode assembly by using a series of signal patterns activating different combinations of switchable electrodes in response to sub-stimulation test signals to determine a signal pattern that provides suitable patient response. In another embodiment, the array of electrodes includes an array of selectively activatable multi-polar electrodes.

Abstract translation: 组织刺激装置包括具有至少四个可独立切换的电极的电极阵列。 在一个实施例中，电极阵列包括柔性基座，电极被固定到柔性基座上，该电极弯曲以包围动脉或其他细长生物结构的至少一部分。 电极电耦合到耦合到控制系统的信号发生器并由其激励。 在一个实施例中，电极阵列被配置为使得可以确定用于在一组可切换电极之间或之间进行刺激脉冲的合适信号图案，而不必通过使用一系列信号图案来激活电极组件，所述信号图案激活不同的可切换组合 电极响应亚刺激测试信号以确定提供合适的患者反应的信号图案。 在另一个实施例中，电极阵列包括可选择性激活的多极电极的阵列。

公开(公告)号：US08380315B2

公开(公告)日：2013-02-19

申请号：US12898686

申请日：2010-10-05

Applicant: Christopher DeGiorgio ,  Ian A. Cook ,  Alejandro Covalin ,  Patrick R. Miller ,  Lara Schrader

Inventor： Christopher DeGiorgio ,  Ian A. Cook ,  Alejandro Covalin ,  Patrick R. Miller ,  Lara Schrader

IPC: A61N1/00

CPC classification number: A61N1/36082 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/0492 ,  A61N1/0504 ,  A61N1/0529 ,  A61N1/0551 ,  A61N1/36014 ,  A61N1/36021 ,  A61N1/36025 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36075 ,  A61N1/36096 ,  A61N1/36157 ,  A61N1/3616 ,  A61N1/36171 ,  A61N1/36175

Abstract: The present disclosure relates to methods, devices and systems used for the treatment of mood, anxiety, post traumatic stress disorder, and cognitive and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.

Abstract translation: 本公开涉及通过刺激三叉神经（TNS）的表面元件而用于治疗情绪，焦虑，创伤后应激障碍以及认知和行为障碍（统称为神经精神障碍）的方法，装置和系统。 更具体地说，皮肤刺激面部以外的三叉神经的浅表分支的皮肤刺激方法，即眶上，sup ital，眶下，z atic，z atic，z atic，眶下，鼻和精神神经（也统称为 浅表三叉神经）。

公开(公告)号：US20110218590A1

公开(公告)日：2011-09-08

申请号：US12898686

申请日：2010-10-05

Applicant: Christopher DEGIORGIO ,  Ian A. COOK ,  Alejandro COVALIN ,  Patrick R. MILLER ,  Lara SCHRADER

Inventor： Christopher DEGIORGIO ,  Ian A. COOK ,  Alejandro COVALIN ,  Patrick R. MILLER ,  Lara SCHRADER

IPC: A61N1/36 ,  A61N1/05

CPC classification number: A61N1/36082 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/0492 ,  A61N1/0504 ,  A61N1/0529 ,  A61N1/0551 ,  A61N1/36014 ,  A61N1/36021 ,  A61N1/36025 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36075 ,  A61N1/36096 ,  A61N1/36157 ,  A61N1/3616 ,  A61N1/36171 ,  A61N1/36175

Abstract: The present disclosure relates to methods, devices and systems used for the treatment of mood, anxiety, post traumatic stress disorder, and cognitive and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.

Abstract translation: 本公开涉及通过刺激三叉神经（“TNS”）的表面元件用于治疗情绪，焦虑，创伤后应激障碍以及认知和行为障碍（统称为神经精神障碍）的方法，装置和系统。 。 更具体地说，皮肤刺激面部以外的三叉神经的浅表分支的皮肤刺激方法，即眶上，sup ital，眶下，z atic，z atic，z atic，眶下，鼻和精神神经（也统称为 浅表三叉神经）。

公开(公告)号：US20110218589A1

公开(公告)日：2011-09-08

申请号：US12898675

申请日：2010-10-05

Applicant: Christopher DeGIORGIO ,  Ian A. COOK ,  Alejandro COVALIN

Inventor： Christopher DeGIORGIO ,  Ian A. COOK ,  Alejandro COVALIN

IPC: A61N1/36 ,  A61N1/04

CPC classification number: A61N1/36082 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/0492 ,  A61N1/0504 ,  A61N1/0529 ,  A61N1/0551 ,  A61N1/36014 ,  A61N1/36021 ,  A61N1/36025 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36075 ,  A61N1/36096 ,  A61N1/36157 ,  A61N1/3616 ,  A61N1/36171 ,  A61N1/36175

Abstract: The present disclosure relates to methods, devices, and systems used for the treatment of and/or promoting recovery from various neurological disorders and conditions, including epilepsy and other seizure disorders and movement and other related disorders; for promoting recovery from acute or chronic brain injury (e.g. stroke, hypoxia/ischemia, head trauma, subarachnoid hemorrhage, and other forms of brain injury, for awakening and/or promoting the recovery of patients in various levels of coma, altered mental status or vegetative state); or for promoting recovery from chronic daily headache and migraine and related disorders via external (cutaneous) stimulation of the sensory branches of the trigeminal nerve in the face and forehead. More specifically, devices and electrode assemblies configured for stimulation of the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, nasal and infratrochlear nerves are disclosed.

Abstract translation: 本公开涉及用于治疗和/或促进从各种神经障碍和病症恢复的方法，装置和系统，包括癫痫和其他癫痫发作障碍以及运动和其它相关疾病; 用于促进急性或慢性脑损伤（例如中风，缺氧/缺血，头部创伤，蛛网膜下腔出血和其他形式的脑损伤）的恢复，用于唤醒和/或促进各种昏迷水平的患者的恢复，改变的精神状态或 营养状态）; 或通过外部（皮肤）刺激面部和额头中三叉神经的感觉分支来促进慢性日常头痛和偏头痛及相关疾病的恢复。 更具体地，公开了配置用于刺激眶上，眶上，眶下，z骨，z骨，z骨，z骨，鼻和神经性神经的装置和电极组件。