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公开(公告)号：US08859247B2
公开(公告)日：2014-10-14
申请号：US13143019
申请日：2009-12-28
Applicant: Andre Koltermann , Ulrich Kettling , Volker Sieber
Inventor： Andre Koltermann , Ulrich Kettling , Volker Sieber
Abstract: An enzymatic process is described for the production of chemicals from carbon sources. In particular, according to one aspect, a process for the production of a target organic compound from a carbon source by a cell-free enzyme system is disclosed.
Abstract translation: 描述了从碳源生产化学品的酶法。 特别地，根据一个方面，公开了一种通过无细胞酶系统从碳源生产目标有机化合物的方法。
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公开(公告)号：US08470963B2
公开(公告)日：2013-06-25
申请号：US12305898
申请日：2007-07-02
Applicant: Andre Koltermann
Inventor： Andre Koltermann
IPC: C07K14/00
CPC classification number: C07K7/64 , A61K47/641 , A61K47/6425 , A61K47/646 , C07K7/06 , C07K7/08
Abstract: The invention relates to a synthetic bifunctional non-antibody compound comprising one or more effector moieties and one or more binder moieties, wherein the effector moieties are operably linked to the binder moieties via a linker, the effector moieties are ligands to at least one pathogen pattern recognition receptor (PRR) and the binder moieties bind to a marker of a tumor cell.
Abstract translation: 本发明涉及包含一个或多个效应部分和一个或多个粘合剂部分的合成双功能非抗体化合物，其中效应部分通过连接体可操作地连接到粘合剂部分，效应部分是至少一种病原体模式的配体 识别受体（PRR）和粘合剂部分结合于肿瘤细胞的标志物。
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公开(公告)号：US20130123115A1
公开(公告)日：2013-05-16
申请号：US13578291
申请日：2011-02-11
Applicant: Ulrich Kettling , Christoph Reisinger , Thomas Brück , Andre Koltermann , Jochen Gerlach , Isabel Unterstrasser , Lutz Röcher , Markus Rarbach , Jörg Claren , Andreas Kohl , Jan Carsten Pieck , Dominik Schlosser
Inventor： Ulrich Kettling , Christoph Reisinger , Thomas Brück , Andre Koltermann , Jochen Gerlach , Isabel Unterstrasser , Lutz Röcher , Markus Rarbach , Jörg Claren , Andreas Kohl , Jan Carsten Pieck , Dominik Schlosser
IPC: C12N9/42
CPC classification number: C12N9/2437 , C12N9/24 , C12Y302/01091
Abstract: The invention discloses cellulase enzymes with optimized properties for processing of cellulose- and lignocellulose-containing substrates. In particular, cellobiohydrolase enzymes with preferred characteristics are disclosed. The present invention provides fusion, insertion, deletion and/or substitution variants of such enzymes. Enzyme variants have enhanced thermostability, proteolytic stability, specific activity and/or stability at extreme pH. Nucleic acid molecules encoding said enzymes, a composition comprising said enzymes, a method for preparation, and the use for cellulose processing and/or for the production of biofuels are disclosed.
Abstract translation: 本发明公开了具有优化的用于加工含纤维素和木质素纤维素的底物的纤维素酶。 特别地，公开了具有优选特性的纤维二糖水解酶。 本发明提供了这种酶的融合，插入，缺失和/或取代变体。 酶变体在极端pH下具有增强的热稳定性，蛋白水解稳定性，比活度和/或稳定性。 公开了编码所述酶的核酸分子，包含所述酶的组合物，制备方法以及用于纤维素加工和/或生产生物燃料的用途。
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公开(公告)号：US08143045B2
公开(公告)日：2012-03-27
申请号：US11696162
申请日：2007-04-03
Applicant: Andrei Miasnikov , Vijay Kumar , Oliver Kensch , Klaus Pellangahr , Birgitta Leuthner , Ulrich Kettling , Andre Koltermann
Inventor： Andrei Miasnikov , Vijay Kumar , Oliver Kensch , Klaus Pellangahr , Birgitta Leuthner , Ulrich Kettling , Andre Koltermann
CPC classification number: C12N9/16
Abstract: The present invention relates to enzymes and processes. In particular, there is described an isolated polypeptide comprising the amino acid sequence corresponding to Citrobacter freundii phytase or a homologue, a modified form, a functional equivalent or an effective fragment thereof. There is also described a host cell transformed or transfected with a nucleic acid encoding a bacterial phytase enzyme or a modified form as well as the use of such a phytase or modified form in food or animal feed.
Abstract translation: 本发明涉及酶和方法。 特别地，描述了分离的多肽，其包含对应于弗氏柠檬酸杆菌植酸酶的氨基酸序列或其同源物，修饰形式，功能等同物或其有效片段。 还描述了用编码细菌植酸酶或修饰形式的核酸转化或转染的宿主细胞，以及在食物或动物饲料中使用这种植酸酶或修饰形式。
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公开(公告)号：US20110312052A1
公开(公告)日：2011-12-22
申请号：US13143019
申请日：2009-12-28
Applicant: Andre Koltermann , Ulrich Kettling , Volker Sieber
Inventor： Andre Koltermann , Ulrich Kettling , Volker Sieber
Abstract: An enzymatic process is described for the production of chemicals from carbon sources. In particular, according to one aspect, a process for the production of a target organic compound from a carbon source by a cell-free enzyme system is disclosed.
Abstract translation: 描述了从碳源生产化学品的酶法。 特别地，根据一个方面，公开了一种通过无细胞酶系统从碳源生产目标有机化合物的方法。
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Patent Agency Ranking
公开(公告)号：US20110237833A1
公开(公告)日：2011-09-29
申请号：US13121827
申请日：2009-09-16
Applicant: Andre Koltermann , Ulrich Kettling , Michael Kraus
Inventor： Andre Koltermann , Ulrich Kettling , Michael Kraus
IPC: C07C209/84 , C07C41/36 , C07C29/76 , C07C45/79
CPC classification number: B01D53/02 , B01D53/04 , B01D53/72 , B01D2253/102 , B01D2253/104 , B01D2253/108 , B01D2253/11 , B01D2253/202 , B01D2257/7022 , B01D2259/40088
Abstract: The invention concerns a process for the recovery of an organic moiecule from the overhead vapor phase of aqueous media by adsorbing onto an adsorbent, wherein no additional thermal energy for said vaporization is provided, and wherein the organic molecule is recovered afterwards by desorbing from the adsorber.
Abstract translation: 本发明涉及通过吸附在吸附剂上从水介质顶部蒸气相中回收有机物的方法，其中没有提供用于所述蒸发的附加热能，并且其中有机分子之后通过从吸附器解吸而被回收 。
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27.发明授权公开(公告)号：US07507582B2
公开(公告)日：2009-03-24
申请号：US10333034
申请日：2001-07-18
Applicant: Katrin Heinze , Petra Schwille , Andre Koltermann , Ulrich Kettling
Inventor： Katrin Heinze , Petra Schwille , Andre Koltermann , Ulrich Kettling
IPC: G01N21/64
CPC classification number: G01N21/6408 , B82Y10/00 , B82Y20/00 , G01J2003/2866 , G01N2021/6441 , Y10T436/13
Abstract: A method of fluorescence measurement on analytes, marked with different fluorescent markers, which have spectrally different fluorescence emissions, in a sample is described, having the following steps: illumination of the sample in the measurement volume using a laser to excite the fluorescence emission of the at least two fluorescent markers, the illumination of the measurement volume being performed with a maximum of one single laser line, having an excitation intensity sufficiently high that the fluorescent markers are jointly excited through 2-photon absorptions, detection of the fluorescence emission using at least two detector devices which are designed for light detection in different spectral ranges in accordance with the spectral fluorescence properties of the fluorescent markers, and performance of a cross-correlation and/or coincidence analysis of detector signals of the detector devices. A measurement device for performing the method is also described.
Abstract translation: 描述了在样品中具有不同荧光标记的分析物上荧光测量的方法，所述分析物具有不同的荧光发射，具有以下步骤：使用激光照射测量体积中的样品以激发荧光发射 至少两个荧光标记物，用最大量的一条单一激光线照射测量体积，具有足够高的激发强度，使得荧光标记物通过双光子吸收共同激发，至少使用至少检测荧光发射 两个检测器装置被设计用于根据荧光标记的光谱荧光特性在不同光谱范围内进行光检测，以及执行检测器装置的检测器信号的互相关和/或重合分析。 还描述了用于执行该方法的测量装置。
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28.发明授权Multi-parameter fluorimetric analysis in a massively parallel multi-focal arrangement and the use thereof 失效多参数荧光分析在大规模并行多焦点布置中的应用及其应用公开(公告)号：US07170598B2
公开(公告)日：2007-01-30
申请号：US10688101
申请日：2003-10-17
Applicant: Peter Jomo Walla , Andre Koltermann , Ulrich Kettling , Mathias Scharte
Inventor： Peter Jomo Walla , Andre Koltermann , Ulrich Kettling , Mathias Scharte
IPC: G01J3/30
CPC classification number: G01J3/4406 , G01N21/6408 , G01N21/6456 , G01N21/718 , G01N2021/178 , G01N2021/1789
Abstract: A method for analyzing properties of a sample by measuring fluorescence parameters in multiple foci, comprises the steps of splitting a collimated primary laser beam with a splitting device into at least two collimated secondary laser beams and deflecting the secondary laser beams such that they propagate at different propagation angles with respect to an optical axis of a focussing optic, focussing the secondary laser beams with the focussing optic into at least two volume elements in the sample, detecting light emitted from the volume elements with a detecting device, and evaluating the detected light for obtaining the properties to be analyzed. Furthermore, a device for implementing this method is described. The invention is particularly suited for high-throughput screening applications.
Abstract translation: 通过测量多个焦点中的荧光参数来分析样品的性质的方法包括以下步骤：将具有分裂装置的准直主激光束分成至少两个准直的次级激光束并使次级激光束偏转，使得它们在不同的 相对于聚焦光学器件的光轴的传播角度，将具有聚焦光学器件的次级激光束聚焦到样品中的至少两个体积元件中，用检测装置检测从体积元件发射的光，并且将检测到的光用于 获得待分析的属性。 此外，描述了用于实现该方法的装置。 本发明特别适用于高通量筛选应用。
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29.发明申请Serine proteases with altered sensitivity to activity-modulating substances 审中-公开对活性调节物质敏感性高的丝氨酸蛋白酶公开(公告)号：US20060269538A1
公开(公告)日：2006-11-30
申请号：US11441635
申请日：2006-05-26
Applicant: Andre Koltermann , Ulrich Kettling , Ulrich Haupts , Wayne Coco , Jan Tebbe , Christian Votsmeier , Andreas Scheidig
Inventor： Andre Koltermann , Ulrich Kettling , Ulrich Haupts , Wayne Coco , Jan Tebbe , Christian Votsmeier , Andreas Scheidig
CPC classification number: C12Q1/37 , A61K38/00 , C12N9/64 , G01N2500/00
Abstract: The present invention provides variants of serine proteases of the S1 class with altered sensitivity to one or more activity-modulating substances. A method for the generation of such proteases is disclosed, comprising the provision of a protease library encoding polynucleotide sequences, expression of the enzymes, screening of the library in the presence of one or several activity-modulating substances, selection of variants with altered sensitivity to one or several activity-modulating substances and isolation of those polynucleotide sequences that encode for the selected variants.
Abstract translation: 本发明提供对一种或多种活性调节物质敏感性改变的S1类丝氨酸蛋白酶的变体。 公开了产生这种蛋白酶的方法，包括提供编码多核苷酸序列的蛋白酶文库，酶的表达，在一种或几种活性调节物质存在下筛选文库，选择对 一种或几种活性调节物质以及编码所选变体的那些多核苷酸序列的分离。
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公开(公告)号：US20050002897A1
公开(公告)日：2005-01-06
申请号：US10872198
申请日：2004-06-18
Applicant: Ulrich Haupts , Andre Koltermann , Andreas Scheidig , Christian Votsmeier , Ulrich Kettling
Inventor： Ulrich Haupts , Andre Koltermann , Andreas Scheidig , Christian Votsmeier , Ulrich Kettling
CPC classification number: C12N9/6427 , A61K38/482 , A61K38/4826 , A61K38/486 , A61K38/4873 , A61K38/488 , C12P21/06 , C12Q1/37
Abstract: The present invention provides method for the treatment of a disease by applying a medicament comprising a protease with a defined specificity is capable to hydrolyze specific peptide bonds within a target substrate related to such disease. The proteases with such a defined specificity can further be used for related therapeutic or diagnostic purposes.
Abstract translation: 本发明提供了通过应用包含具有确定的特异性的蛋白酶的药物能够水解与这种疾病相关的靶基质内的特异性肽键来治疗疾病的方法。 具有这种确定的特异性的蛋白酶可进一步用于相关的治疗或诊断目的。
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