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公开(公告)号：US07335504B2
公开(公告)日：2008-02-26
申请号：US10872197
申请日：2004-06-18
IPC分类号： C12N9/64 , G01N33/567 , C12Q1/37 , C12P21/06 , C12P21/04
CPC分类号： C12N9/6424 , A61K8/64 , A61K38/482 , A61K38/4826 , A61K38/486 , A61K38/4873 , A61K38/488 , A61Q19/00 , C12N9/50 , C12N9/6472 , C12N9/6478 , C12N9/6489 , C12N15/1034 , C12N15/62 , C12P21/06 , C12Q1/37
摘要： The present invention provides engineered enzymes generated from protein scaffolds combined with Specificity Determining Regions, the production thereof and the use of said engineered enzymes for research, nutritional care, personal care and industrial purposes.
摘要翻译： 本发明提供由与特异性确定区组合的蛋白质支架产生的工程化酶，其生产和所述工程化酶用于研究，营养保健，个人护理和工业目的的用途。
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公开(公告)号：US20090208440A1
公开(公告)日：2009-08-20
申请号：US11969511
申请日：2008-01-04
申请人： Ulrich Haupts , Andre Koltermann , Andreas Scheidig , Christian Votsmeier , Ulrich Kettling , Oliver Kensch , Birgitta Leuthner
发明人： Ulrich Haupts , Andre Koltermann , Andreas Scheidig , Christian Votsmeier , Ulrich Kettling , Oliver Kensch , Birgitta Leuthner
CPC分类号： C12N9/6424 , A61K8/64 , A61K38/482 , A61K38/4826 , A61K38/486 , A61K38/4873 , A61K38/488 , A61Q19/00 , C12N9/50 , C12N9/6472 , C12N9/6478 , C12N9/6489 , C12N15/1034 , C12N15/62 , C12P21/06 , C12Q1/37
摘要： The present invention provides engineered enzymes generated from protein scaffolds combined with Specificity Determining Regions, the production thereof and the use of said engineered enzymes for research, nutritional care, personal care and industrial purposes.
摘要翻译： 本发明提供由与特异性确定区组合的蛋白质支架产生的工程化酶，其生产和所述工程化酶用于研究，营养保健，个人护理和工业目的的用途。
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公开(公告)号：US20050059126A1
公开(公告)日：2005-03-17
申请号：US10872197
申请日：2004-06-18
IPC分类号： A61K38/00 , A61K38/48 , C07H21/04 , C12N9/00 , C12N9/10 , C12N9/50 , C12N9/64 , C12N15/10 , C12N15/62 , C12P21/06 , C12Q1/37
CPC分类号： C12N9/6424 , A61K8/64 , A61K38/482 , A61K38/4826 , A61K38/486 , A61K38/4873 , A61K38/488 , A61Q19/00 , C12N9/50 , C12N9/6472 , C12N9/6478 , C12N9/6489 , C12N15/1034 , C12N15/62 , C12P21/06 , C12Q1/37
摘要： The present invention provides engineered enzymes generated from protein scaffolds combined with Specificity Determining Regions, the production thereof and the use of said engineered enzymes for research, nutritional care, personal care and industrial purposes.
摘要翻译： 本发明提供由与特异性确定区组合的蛋白质支架产生的工程化酶，其生产和所述工程化酶用于研究，营养保健，个人护理和工业目的的用途。
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公开(公告)号：US20050175581A1
公开(公告)日：2005-08-11
申请号：US11021951
申请日：2004-12-22
申请人： Ulrich Haupts , Andre Koltermann , Andreas Scheidig , Christian Votsmeier , Ulrich Kettling , Wayne Coco
发明人： Ulrich Haupts , Andre Koltermann , Andreas Scheidig , Christian Votsmeier , Ulrich Kettling , Wayne Coco
CPC分类号： C12N9/6427 , A61K38/482 , A61K38/4826 , A61K38/486 , A61K38/4873 , A61K38/488 , C12P21/06 , C12Q1/37
摘要： The present invention provides method for the treatment of a disease by applying a medicament comprising a protease with a defined specificity is capable to hydrolyze specific peptide bonds within a target substrate related to such disease. The proteases with such a defined specificity can further be used for related therapeutic or diagnostic purposes.
摘要翻译： 本发明提供了通过应用包含具有确定的特异性的蛋白酶的药物能够水解与这种疾病相关的靶基质内的特异性肽键来治疗疾病的方法。 具有这种确定的特异性的蛋白酶可进一步用于相关的治疗或诊断目的。
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5.发明申请Serine proteases with altered sensitivity to activity-modulating substances 审中-公开对活性调节物质敏感性高的丝氨酸蛋白酶公开(公告)号：US20060269538A1
公开(公告)日：2006-11-30
申请号：US11441635
申请日：2006-05-26
申请人： Andre Koltermann , Ulrich Kettling , Ulrich Haupts , Wayne Coco , Jan Tebbe , Christian Votsmeier , Andreas Scheidig
发明人： Andre Koltermann , Ulrich Kettling , Ulrich Haupts , Wayne Coco , Jan Tebbe , Christian Votsmeier , Andreas Scheidig
CPC分类号： C12Q1/37 , A61K38/00 , C12N9/64 , G01N2500/00
摘要： The present invention provides variants of serine proteases of the S1 class with altered sensitivity to one or more activity-modulating substances. A method for the generation of such proteases is disclosed, comprising the provision of a protease library encoding polynucleotide sequences, expression of the enzymes, screening of the library in the presence of one or several activity-modulating substances, selection of variants with altered sensitivity to one or several activity-modulating substances and isolation of those polynucleotide sequences that encode for the selected variants.
摘要翻译： 本发明提供对一种或多种活性调节物质敏感性改变的S1类丝氨酸蛋白酶的变体。 公开了产生这种蛋白酶的方法，包括提供编码多核苷酸序列的蛋白酶文库，酶的表达，在一种或几种活性调节物质存在下筛选文库，选择对 一种或几种活性调节物质以及编码所选变体的那些多核苷酸序列的分离。
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公开(公告)号：US20050002897A1
公开(公告)日：2005-01-06
申请号：US10872198
申请日：2004-06-18
CPC分类号： C12N9/6427 , A61K38/482 , A61K38/4826 , A61K38/486 , A61K38/4873 , A61K38/488 , C12P21/06 , C12Q1/37
摘要： The present invention provides method for the treatment of a disease by applying a medicament comprising a protease with a defined specificity is capable to hydrolyze specific peptide bonds within a target substrate related to such disease. The proteases with such a defined specificity can further be used for related therapeutic or diagnostic purposes.
摘要翻译： 本发明提供了通过应用包含具有确定的特异性的蛋白酶的药物能够水解与这种疾病相关的靶基质内的特异性肽键来治疗疾病的方法。 具有这种确定的特异性的蛋白酶可进一步用于相关的治疗或诊断目的。
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公开(公告)号：US20090208474A1
公开(公告)日：2009-08-20
申请号：US11963421
申请日：2007-12-21
CPC分类号： C12N9/6424 , A61K8/64 , A61K38/482 , A61K38/4826 , A61K38/486 , A61K38/4873 , A61K38/488 , A61Q19/00 , C12N9/50 , C12N9/6472 , C12N9/6478 , C12N9/6489 , C12N15/1034 , C12N15/62 , C12P21/06 , C12Q1/37
摘要： The present invention provides engineered enzymes generated from protein scaffolds combined with Specificity Determining Regions, the production thereof and the use of said engineered enzymes for research, nutritional care, personal care and industrial purposes.
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8.发明授权Thermostable xylanase for the selective hydrolysis of pentose-containing polysaccharides 有权用于选择性水解含糖的多糖的热稳定的木聚糖酶公开(公告)号：US08679795B2
公开(公告)日：2014-03-25
申请号：US13517344
申请日：2010-12-15
申请人： Andreas Kohl , Isabel Unterstrasser , Markus Rarbach , Andre Koltermann , Christoph Reisinger , Thomas Brück , Ulrich Kettling , Gudmundur O. Hreggvidsson , Olafur H. Fridjonsson
发明人： Andreas Kohl , Isabel Unterstrasser , Markus Rarbach , Andre Koltermann , Christoph Reisinger , Thomas Brück , Ulrich Kettling , Gudmundur O. Hreggvidsson , Olafur H. Fridjonsson
IPC分类号： C12N9/24
CPC分类号： C12N9/248
摘要： The present invention relates to polypeptides having xylanase activity and nucleic acid sequences encoding such polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid constructs as well as methods for producing and using the polypeptides. One specific application of the xylanase is the selective hydrolysis of pentose sugar components of hemicellulose-containing plant biomass. The nucleotide sequence may be used for the production of the xylanase or optimized mutants thereof.
摘要翻译： 本发明涉及具有木聚糖酶活性的多肽和编码此类多肽的核酸序列。 本发明还涉及包含核酸构建体的核酸构建体，载体和宿主细胞以及用于产生和使用多肽的方法。 木聚糖酶的一个具体应用是含有半纤维素的植物生物质的戊糖糖成分的选择性水解。 核苷酸序列可用于生产木聚糖酶或其优化的突变体。
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公开(公告)号：US20120301578A1
公开(公告)日：2012-11-29
申请号：US13232588
申请日：2011-09-14
申请人： Andrei Miasnikov , Vijay Kumar , Oliver Kensch , Klaus Pellangahr , Birgitta Leuthner , Ulrich Kettling , Andre Koltermann
发明人： Andrei Miasnikov , Vijay Kumar , Oliver Kensch , Klaus Pellangahr , Birgitta Leuthner , Ulrich Kettling , Andre Koltermann
CPC分类号： C12N9/16
摘要： The present invention relates to enzymes and processes. In particular, there is described an isolated polypeptide comprising the amino acid sequence corresponding to Citrobacter freundii phytase or a homologue, a modified form, a functional equivalent or an effective fragment thereof. There is also described a host cell transformed or transfected with a nucleic acid encoding a bacterial phytase enzyme or a modified form as well as the use of such a phytase or modified form in food or animal feed.
摘要翻译： 本发明涉及酶和方法。 特别地，描述了分离的多肽，其包含对应于弗氏柠檬酸杆菌植酸酶的氨基酸序列或其同源物，修饰形式，功能等同物或其有效片段。 还描述了用编码细菌植酸酶或修饰形式的核酸转化或转染的宿主细胞，以及在食物或动物饲料中使用这种植酸酶或修饰形式。
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公开(公告)号：US20120135475A1
公开(公告)日：2012-05-31
申请号：US13322395
申请日：2010-05-21
申请人： Andre Koltermann , Markus Rarbach , Thomas Bruck , Jochen Gerlach , Isabel Unterstrasser , Andreas Kohl , Zdravko Dragovic , Ulrich Kettling
发明人： Andre Koltermann , Markus Rarbach , Thomas Bruck , Jochen Gerlach , Isabel Unterstrasser , Andreas Kohl , Zdravko Dragovic , Ulrich Kettling
摘要： The invention is directed to a liquefied sugar beet and/or sugar cane biomass material as well as production methods and uses thereof. The liquefied biomass is storage stable and can be used for the production of a product resulting from fermentation.
摘要翻译： 本发明涉及液化甜菜和/或甘蔗生物质材料及其生产方法和用途。 液化生物质储存稳定，可用于生产发酵产物。
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