公开(公告)号：US11597767B2

公开(公告)日：2023-03-07

申请号：US16957328

申请日：2018-12-25

Applicant: JOINT STOCK COMPANY “BIOCAD”

Inventor： Olga Vladimirovna Britanova ,  Mark Aleksandrovic Izraelson ,  Sergey Anatolievich Lukyanov

IPC: C07K16/28 ,  A61K39/395

Abstract: The invention relates to monoclonal antibodies which specifically bind to the TRBV9 family of human T-cell receptors. The invention also relates to a nucleic acid which codes for said antibody or for an antigen-binding fragment thereof, to an expression vector, to a method for producing the antibody, and to the use of said antibody for treating diseases or disorders associated with the family of human T-cell receptors. The invention is directed towards producing antibodies that can be used for eliminating T-cells carrying T-cell receptors of the TRBV9 family, in particular for treating ankylosing spondylitis, coeliac disease, and blood cancers, in the pathogenesis of which T-cell receptors of the TRBV9 family are involved.

公开(公告)号：US20220403369A1

公开(公告)日：2022-12-22

申请号：US17775626

申请日：2020-07-02

Applicant: JOINT STOCK COMPANY "BIOCAD"

Inventor： Konstantin Viktorovich SEVERINOV ,  Sergey Anatolievich SHMAKOV ,  Daria Nikolaevna ARTAMONOVA ,  Ignaty Igorevich GORYANIN ,  Olga Sergeevna MUSHAROVA ,  Julia Valerevna ANDREEVA ,  Tatiana Igorevna ZYUBKO ,  Iana Vitalevna FEDOROVA ,  Mikhail Alekseevich KHODORKOVSKII ,  George Evgenevich POBEGALOV ,  Anatoliy Nikolaevich ARSENIEV ,  Polina Anatolevna SELKOVA ,  Aleksandra Andreevna VASILIEVA ,  Tatiana Olegovna ARTAMONOVA ,  Marina Viktorovna ABRAMOVA

IPC: C12N15/10 ,  C07K14/00 ,  C12Q1/6806

Abstract: The present invention describes a novel bacterial nuclease of the CRISPR-Cas9 system from the bacterium P. pneumotropica, as well as the use thereof to form strictly specific double-strand breaks in a DNA molecule. This nuclease has unusual properties and may be used as a tool for modifying the genomic DNA sequence in the cell of a unicellular organism or a multicellular organism. Thus, the versatility of the available CRISPR-Cas9 systems is increased, which fact will enable the use of various variants of Cas9 nucleases for cutting genomic or plasmid DNA in various organisms, in a larger number of specific sites and/or under various conditions.

公开(公告)号：US20220112286A1

公开(公告)日：2022-04-14

申请号：US17417686

申请日：2020-02-20

Applicant: JOINT STOCK COMPANY "BIOCAD"

Inventor： Olga Vladimirovna BRITANOVA ,  Dmitry Borisovich STAROVEROV ,  Anna Valentinovna EVSTRATEVA ,  Alexey Konstantinovich MISORIN ,  Timofey Aleksandrovich NEMANKIN ,  Mariia Aleksandrovna SHCHEMELEVA ,  Anna Konstantinovna VLADIMIROVA ,  Arina Vitalevna ANIKINA ,  Roman Alekseevich IVANOV ,  Dmitry Valentinovich MOROZOV ,  Pavel Andreevich IAKOVLEV ,  Sergey Anatolievich LUKYANOV

IPC: C07K16/28

Abstract: The invention relates to a monoclonal humanized antibody or antigen-binding fragment thereof that specifically bind to the TRBV9 family of the human T cell receptor. The invention also relates to a nucleic acid encoding said antibody or antigen-binding fragment thereof, an expression vector, a method for preparing said antibody, and use of said antibody in treatment of diseases or disorders associated with the human T cell receptor family. The invention is directed to generation of antibodies that can be used for treating, in particular AS, celiac disease and malignant blood diseases, the pathogenesis of which involves the TRBV9 family TCRs.

公开(公告)号：US11236167B2

公开(公告)日：2022-02-01

申请号：US16605865

申请日：2018-04-11

Applicant: JOINT STOCK COMPANY “BIOCAD”

Inventor： Andrei Borisovich Ulitin ,  Viktoriia Mikhailovna Ekimova ,  Ekaterina Vladimirovna Sofronova ,  Yulia Sergeevna Chernykh ,  Sergei Andreevich Ageev ,  Anna Konstantinovna Vladimirova ,  Aleksei Aleksandrovich Aleksandrov ,  Pavel Alekseevich Grebnev ,  Valery Vladimirovich Solovyev ,  Iakov Iurevich Ustiugov ,  Pavel Andreevich Iakovlev ,  Timofey Aleksandrovich Nemankin ,  Dmitry Valentinovich Morozov

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06

Abstract: The present invention relates to the field of biotechnology and provides antibodies that specifically binds to PD-L1. The invention also relates to DNA encoding said antibodies, to corresponding expression vectors and to methods of producing, and to methods of treatment using said antibodies.

公开(公告)号：US20200332003A1

公开(公告)日：2020-10-22

申请号：US16957328

申请日：2018-12-25

Applicant: JOINT STOCK COMPANY "BIOCAD"

Inventor： Olga Vladimirovna BRITANOVA ,  Mark Aleksandrovic IZRAELSON ,  Sergey Anatolievich LUKYANOV

IPC: C07K16/28 ,  A61K39/395

Abstract: The invention relates to monoclonal antibodies which specifically bind to the TRBV9 family of human T-cell receptors. The invention also relates to a nucleic acid which codes for said antibody or for an antigen-binding fragment thereof, to an expression vector, to a method for producing the antibody, and to the use of said antibody for treating diseases or disorders associated with the family of human T-cell receptors. The invention is directed towards producing antibodies that can be used for eliminating T-cells carrying T-cell receptors of the TRBV9 family, in particular for treating ankylosing spondylitis, coeliac disease, and blood cancers, in the pathogenesis of which T-cell receptors of the TRBV9 family are involved.

公开(公告)号：US10442869B2

公开(公告)日：2019-10-15

申请号：US15254225

申请日：2016-09-01

Applicant: CLOSED JOINT STOCK COMPANY “BIOCAD”

Inventor： Andrey Borisovich Ulitin ,  Stanislav Rudolfovich Evdokimov ,  Valeriy Vladimirovich Soloviev ,  Yulia Sergeevna Chernyh ,  Olga Vladimirovna Goncharova ,  Dmitriy Valerievich Korzhavin ,  Tatyana Veniaminovna Chernovskaya ,  Timofey Aleksandrovich Nemankin ,  Roman Alexeevich Ivanov ,  Dmitriy Valentinovich Morozov ,  Victoria Mikhailovna Ekimova ,  Ekaterina Vladimirovna Sofronova ,  Yakov Yurevich Ustyugov

IPC: A61K39/395 ,  C07K16/46 ,  A61K45/06 ,  C07K16/24

Abstract: The monoclonal IgG-type antibodies were suggested comprising variable domains represented by a combination of VHH-derivative with a variable domain of the light chain VL. Said antibodies can comprise amino acid substitutions at positions 44 and 45 (Kabat numbering) or combinations thereof. Antibodies of the invention possess increased affinity and improved aggregation stability.

公开(公告)号：US11447574B2

公开(公告)日：2022-09-20

申请号：US16564148

申请日：2019-09-09

Applicant: JOINT STOCK COMPANY “BIOCAD”

Inventor： Andrey Borisovich Ulitin ,  Stanislav Rudolfovich Evdokimov ,  Valeriy Vladimirovich Soloviev ,  Yulia Sergeevna Chernykh ,  Olga Vladimirovna Goncharova ,  Dmitriy Valerievich Korzhavin ,  Tatyana Veniaminovna Chernovskaya ,  Timofey Aleksandrovich Nemankin ,  Roman Alexeevich Ivanov ,  Dmitriy Valentinovich Morozov ,  Victoria Mikhailovna Ekimova ,  Ekaterina Vladimirovna Sofronova ,  Yakov Yurevich Ustyugov

IPC: A61K39/395 ,  C07K16/46 ,  A61K45/06 ,  C07K16/24

Abstract: The monoclonal IgG-type antibodies were suggested comprising variable domains represented by a combination of VHH-derivative with a variable domain of the light chain VL. Said antibodies can comprise amino acid substitutions at positions 44 and 45 (Kabat numbering) or combinations thereof. Antibodies of the invention possess increased affinity and improved aggregation stability.

公开(公告)号：US20220098160A1

公开(公告)日：2022-03-31

申请号：US17052078

申请日：2019-02-28

Applicant: BIOCAD

Inventor： Aleksei Leonidovich MINDICH ,  Svetlana Leonidovna GORBUNOVA ,  Aleksandra Vladimirovna POPKOVA ,  Artsiom Evgenievich SHEKHAUTSOU ,  Andrei Ivanovich ALAFINOV ,  Mariia Andreevna KASATKINA ,  Natalia Vladimirovna KOZHEMYAKINA ,  Anna Sergeevna KUSHAKOVA ,  Elena Aleksandrovna MAKSIMENKO ,  Leonid Evgen`evich MIKHAYLOV ,  Mariia Sergeevna MISHINA ,  Anna Jur'evna CHESTNOVA ,  Dmitry Valentinovich MOROZOV

IPC: C07D239/80 ,  A61P35/00 ,  C07D239/95 ,  C07D237/28 ,  C07D215/48 ,  C07D471/04

Abstract: The present invention relates to novel compounds of formula (1), which have the properties of a CDK8/19 inhibitor, and to a pharmaceutical composition containing said compounds, and to the use of said compounds and composition as pharmaceutical preparations for treating diseases or disorders.

公开(公告)号：US20220064612A1

公开(公告)日：2022-03-03

申请号：US17276016

申请日：2019-09-13

Applicant: JOINT STOCK COMPANY "BIOCAD"

Inventor： Dmitriy Aleksandrovich MADERA ,  Aleksandr Vladimirovich KARABELSKII ,  Roman Alekseevich IVANOV ,  Dmitry Valentinovich MOROZOV ,  Konstantin Viktorovich SEVERINOV ,  Sergey Anatolevich SHMAKOV ,  Dmitrii Aleksandrovich SUTORMIN ,  Georgii Evgenevich POBEGALOV ,  Aleksandra Andreevna VASILEVA ,  Polina Anatolevna SELKOVA ,  Anatolii Nikolaevich ARSENIEV ,  Tatyana Igorevna ZYUBKO ,  Iana Vitalevna FEDOROVA

IPC: C12N9/22 ,  C12N15/79

Abstract: The present invention relates to the field of biotechnology, molecular biology and medicine, in particular to nuclease enzyme and use thereof. More specifically, the present invention relates to PaCas9 nuclease enzyme. The invention also relates to a nucleic acid encoding said nuclease, a genetic construct, an expression vector, a delivery vector, which comprise said nucleic acid, a liposome comprising said nuclease or nucleic acid encoding said nuclease, a method for producing a nuclease, methods for delivery, and a host cell comprising a nucleic acid encoding said nuclease.

公开(公告)号：US20220056133A1

公开(公告)日：2022-02-24

申请号：US17417570

申请日：2019-12-24

Applicant: JOINT STOCK COMPANY "BIOCAD"

Inventor： Olga Vladimirovna BRITANOVA ,  Dmitry Borisovich STAROVEROV ,  Anna Valentinovna EVSTRATEVA ,  Alexey Konstantinovich MISORIN ,  Timofey Aleksandrovich NEMANKIN ,  Mariia Aleksandrovna SHCHEMELEVA ,  Anna Konstantinovna VLADIMIROVA ,  Arina Vitalevna ANIKINA ,  Roman Alekseevich IVANOV ,  Dmitry Valentinovich MOROZOV ,  Pavel Andreevich IAKOVLEV ,  Sergey Anatolievich LUKYANOV

IPC: C07K16/28 ,  A61K45/06 ,  A61K39/395

Abstract: The invention relates to a monoclonal humanized antibody or antigen-binding fragment thereof that specifically bind to the TRBV9 family of the human T cell receptor. The invention also relates to a nucleic acid encoding said antibody or antigen-binding fragment thereof, an expression vector, a method for preparing said antibody, and use of said antibody in treatment of diseases or disorders associated with the human T cell receptor family. The invention is directed to generation of antibodies that can be used for treating, in particular AS, celiac disease and malignant blood diseases, the pathogenesis of which involves the TRBV9 family TCRs.