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公开(公告)号：US11820984B2
公开(公告)日：2023-11-21
申请号：US16963998
申请日：2019-01-29
申请人： BIONEER CORPORATION
发明人： Taewoo Lee , Jiwon Ryu , Eun Ji Im
IPC分类号： C12N15/113 , A61P35/00
CPC分类号： C12N15/1136 , A61P35/00 , C12N2310/141 , C12N2310/50
摘要： The present invention relates to a double-helix oligonucleotide construct comprising a double-stranded miRNA and a composition for preventing or treating cancer comprising the same. More particularly, the present invention relates to a double-helix oligonucleotide construct comprising miR-544a characterized by a method that effectively inhibits the proliferation of cancer cells or induces a voluntary death of cancer cells, and an anticancer composition comprising the construct.
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公开(公告)号：US20230332154A1
公开(公告)日：2023-10-19
申请号：US18330853
申请日：2023-06-07
申请人： Bioneer Corporation
发明人： Tae-Rim KIM , Pyoung Oh YOON , Youngho KO , Seon Joo BAE , Han-Oh PARK , Seung Seob SON , Jun-Hong PARK , Sung-Il YUN
IPC分类号： C12N15/113 , A61P11/00 , A61K9/19 , A61K31/713
CPC分类号： C12N15/1136 , A61P11/00 , A61K9/19 , A61K31/713 , C12N2310/14 , C12N2310/314 , C12N2310/322 , C12N2310/351 , C12N2310/3515
摘要： The present invention relates to a double-stranded oligonucleotide which can highly specifically and efficiently inhibit an amphiregulin expression and, preferably, a double-stranded oligonucleotide comprising a sequence in the form of RNA/RNA, DNA/DNA or DNA/RNA hybrid, a double-stranded oligonucleotide structure comprising the double-stranded oligonucleotide, nanoparticles comprising the double-stranded oligonucleotide structure, and a fibrosis or respiratory disease preventive or therapeutic use thereof.
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公开(公告)号：US20220074898A1
公开(公告)日：2022-03-10
申请号：US17309868
申请日：2019-10-24
申请人： BIONEER CORPORATION
发明人： Han-Oh PARK , Taeman KIM , Jong Rok AHN , Jae-Ha KIM
摘要： A heater integrated gas chromatography (GC) column device according to the present invention is capable of precisely and uniformly controlling a temperature by having a high thermal conductivity, and raising and lowering a temperature at a high speed by having a low thermal mass, such that a measuring time is significantly decreased. The GC column is in contact with a bobbin with a homogeneous temperature distribution, and thus a temperature is homogeneously distributed in each GC column. Further, the heater integrated GC column device according to the present invention has the above-described effects and may have a smaller size.
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公开(公告)号：US20210369758A1
公开(公告)日：2021-12-02
申请号：US17402081
申请日：2021-08-13
申请人： BIONEER CORPORATION
发明人： Taewoo LEE , Sanghyung Shim , Ungsik Yu , Han-Oh Park
IPC分类号： A61K31/713 , A61P35/00 , A61K31/25 , C12N15/113
摘要： The present invention relates to a double-stranded oligo RNA structure comprising double-stranded miRNA, and a composition for preventing or treating cancer, containing the same. More specifically, the present invention relates to an anti-cancer pharmaceutical composition, containing: a double-stranded oligo RNA structure comprising miR-3670, miR-4477a and miR-8078, and characterized by a method for effectively inhibiting cancer cell proliferation or inducing cancer cell apoptosis; and a pharmaceutically acceptable carrier.
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公开(公告)号：US20210233759A1
公开(公告)日：2021-07-29
申请号：US15734848
申请日：2019-06-04
申请人： BIONEER CORPORATION
发明人： Taeman KIM , Han-Oh PARK
摘要： An ion guide for transferring ions to a mass analyzer is disclosed. The ion guide is characterized in that a plurality of DC rings and a plurality of RF multi-pole rings with a plurality of electrodes are arranged alternatingly along a central axis between an inlet into which the ions move and an outlet for transferring the ions. The inner diameter of the DC rings is kept constant and the inner diameter of the RF multi-pole rings gradually decreases in a direction from the inlet to the outlet.
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公开(公告)号：US20210032628A1
公开(公告)日：2021-02-04
申请号：US16963998
申请日：2019-01-29
申请人： BIONEER CORPORATION
发明人： Taewoo LEE , Jiwon RYU , Eun Ji IM
IPC分类号： C12N15/113 , A61P35/00
摘要： The present invention relates to a double-helix oligonucleotide construct comprising a double-stranded miRNA and a composition for preventing or treating cancer comprising the same. More particularly, the present invention relates to a double-helix oligonucleotide construct comprising miR-544a characterized by a method that effectively inhibits the proliferation of cancer cells or induces a voluntary death of cancer cells, and an anticancer composition comprising the construct.
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公开(公告)号：US10441957B2
公开(公告)日：2019-10-15
申请号：US15103102
申请日：2014-12-05
申请人： BIONEER CORPORATION
发明人： Han Oh Park , Jong Kab Kim
摘要： The present invention relates to a magnetic particle separating device, and a method of separating and purifying nucleic acid or protein using the same. The device comprises: induction magnets (100); an induction magnet fixing part (200) having induction magnet fixing holes (210) for fixing the induction magnets (100); and a body (300) in which entry holes (310) are formed into which tubes (T) are inserted. Thus, the application and removal of a magnetic field to and from the body is made very convenient, so that the device can be very advantageously used in the separation and purification of nucleic acid or protein.
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28.发明授权公开(公告)号：US10287542B2
公开(公告)日：2019-05-14
申请号：US14648891
申请日：2013-11-29
申请人： BIONEER CORPORATION
发明人： Han Oh Park , Jong Kab Kim , Ji Won Han , You Sang Cho , Min Jung Kim , Ha Neul Kim , Yang Won Lee , Nam Il Kim
IPC分类号： C07K1/14 , C12M1/00 , C12M1/24 , C12M1/32 , C12M1/26 , C12M1/34 , C12P21/00 , C07K1/02 , C07K1/04 , C07K1/22 , C07K1/36
摘要： An automated cell-free protein production system comprises: a protein expression reaction unit comprising a reaction vessel that includes a plurality of dialysis tubes, each including a dialysis membrane and being open at its top; a reaction temperature control unit configured to heat or cool the reaction vessel; a pipette array comprising a plurality of pipettes and configured to suck or discharge solutions using the pipettes; a pipette array moving unit configured to move the pipette array in an upward and downward direction, a forward and backward direction or a left and right direction so as to move solutions; a protein purification unit including a magnetic field application device; and a multi-well plate mounting unit having mounted therein a multi-well plate kit configured to supply solutions that are used for protein production.
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公开(公告)号：US10022717B2
公开(公告)日：2018-07-17
申请号：US14875246
申请日：2015-10-05
申请人： BIONEER CORPORATION
发明人： Han Oh Park , Gu Young Song , Jung A Bae
摘要： A method of manufacturing a micro-chamber plate with a built-in sample, including: settling a micro-chamber plate for sample injection at a micro-chamber plate receiving part formed with an upper opening; disposing a cover for micro-chamber plate receiving part to cover the upper opening, the cover for micro-chamber plate receiving part having a provisional storing part and an auxiliary covering part connected with the provisional storing part and formed with a through-hole for auxiliary covering part; and manufacturing a micro-chamber plate with a built-in sample by putting the micro-chamber plate receiving part, on which the cover is disposed, into a centrifugal separator which can apply vacuum, applying centrifugal force and injecting a sample solution provisionally stored in the provisional storing part into the micro-chamber plate through a vessel communication part which is formed at the provisional storing part to be communicated with the micro-chamber plate receiving part.
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公开(公告)号：USRE46912E1
公开(公告)日：2018-06-26
申请号：US14537565
申请日：2014-11-10
申请人： Bioneer Corporation
发明人： Ji Hee Kang , Byeung I. You , Sung I. Yun , Han O. Park
IPC分类号： A61K35/74 , C12N1/20 , C12R1/225 , A23L33/18 , A23L33/135 , A23C9/123 , C07K14/335 , A61K38/00
CPC分类号： C12R1/225 , A23C9/1234 , A23L33/135 , A23L33/18 , A23Y2220/37 , A61K38/00 , C07K14/335 , C12N1/20
摘要： The present invention relates to a lactic acid bacterium isolated from human mother's milk, more precisely a Lactobacillus gasseri BNR17 strain that is isolated from Korean mother's milk and has excellent probiotic activity including acid resistance, bile acid resistance and antimicrobial activity and weight gaining inhibitory effect as well. Again, the Lactobacillus gasseri BNR17 of the present invention has excellent acid resistance, bile acid resistance, enteric absorption activity and antimicrobial activity against pathogenic microorganisms, in addition to the weight gaining inhibitory effect by synthesizing indigestible polysaccharides from monosaccharides included in food taken and releasing the synthesized polysaccharides out of the body. Therefore, the strain of the invention, owing to such beneficiary effects, can be effectively used not only for the production of fermented milk, other fermented food products and animal feeds but also for the production of live cell products and food additives for preventing weight gaining.
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